Gene therapy converts dead bone graft to new, living tissue
...ically target the genes to the edge of the damaged cartilage during arthroscopic surgery, but we're looking to use the same idea of triggering the cartilage to remake itself." Schwarz's work on bone revitalization and LAGT has just been recognized as one o...Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
... kidney disease late in life, but also may lead to cartilage degeneration and impaired memory and learning abil...aintenance of cognitive function and prevention of cartilage degeneration," Sonntag and his colleagues reported in an article in Endocrinology, published on-line...Gene therapy promising for growing tooth-supporting bone
...P-7 is part of a family of proteins that regulates cartilage and bone formation. Recent studies have shown that BMPs are present in tooth development and periodontal repair. This study mixed BMP-7 genes with an inactivated virus in a gel-like carrier and injected it into wounds. Giannobile said using a virus,...Nano-bumps could help repair clogged blood vessels
...ave shown in a series of experiments that bone and cartilage cells in petri dishes attach better to materials that possess smaller surface bumps than are found on conventional materials used to make artificial joints. The smaller features also stimulate the growth of more new bone tissue, which is critical for...Scientists discover that three overlapping signals in embryo help get the backbone right
...nt, this protein factor is critical in laying down cartilage to make joints, and even plays an important role after birth. Recently, he and Stanford University colleagues showed that noggin may be important in preventing the premature fusion of the bones in the skull, and thus may be critical to allowing the b...Human BMP-5 ELISA development Kit, DuoSet Economy Pack from R&D Systems
...ere originally identified as protein regulators of cartilage and bone formation. They are also involved in embryogenesis and morphogenesis of various tissues and organs. BMPs regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hem...Map and Link Human Genetic Disorders with SSLP Analysis
...o analyze linkage studies of families with cartilage hair hypoplasia (CHH), an autosomal recessive skeletal dysplasia characterized by dwarfism, decreased immunity, and fine, sparse hair. 8 CHH was previously linked to chromosome 9p13. 9 D9S165 was analyzed as one of a number ...Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples
...mice were shown to have structuralabnormalities in cartilage [5]. Materia...IA was also investigated as a potential marker for cartilage tissue engineeringand cartilage damage. In cell culture of chondrocytes and tissue...Phillips Plastics to help develop orthopedics with stem cells
...or cell differentiated into bone (osteoblasts) and cartilage (chondrocytes) progenitor cells, along with a number of other cell and tissue precursors. The progenitor cells, Haider said, appear to be versatile in their ability to develop into a variety of tissue types, including bone and cartilage, and they can...GE Healthcare introduces MR imaging product
...RI) product that helps clinicians assess damage to cartilage in the knee. The product, called CartiGram, was o...e ability to monitor the progression of changes in cartilage composition can result in more treatment options, reduce the need for knee arthroscopy, and optimize......upporting cells, smooth muscle cells, and bone and cartilage cells. The conditions to which they can be applied include several that have been identified as targets of embryonic stem cell research. Subsets of the cells express markers for the nerve-supporting cells that are essential for proper neuron func...Another ray of hope for Arthritis Sufferers
...regenerate connective tissue, and may help prevent cartilage breakdown. One reason for the popularity of glucosamine among doctors and patients is the publication of the best-selling book, "The Arthritis Cure," by Jason Theodosakis, a medical doctor. Written in conjunction with Brenda Adderly and Barry Fox, th...Naked DNA Vaccination May Conquer Arthritis and Multiple Sclerosis
...es falls victim, while in RA, it is the joints and cartilage that are attacked. The damage is done by small proinflammatory peptides called proinflammatory cytokines and chemokines. One way these diseases could be controlled is by immunizing patients with neutralizing antibodies directed against one or more of...Creating brain cells from bone marrow
...ons. Normally such stem cells form muscle, bone, cartilage and fat. The researchers say they were very surprised to find the cells could be persuaded to turn into neurons//, it flies in the face of much of what we know about development of tissues and organs. However, once the right growth factor cocktail ......teoarthritis is a progressive deterioration in the cartilage of certain joints. Unlike rheumatoid arthritis, which is an inherited autoimmune disease, osteoarthritis results from overuse of joints, and can be a byproduct of strenuous sports, obesity or aging. Pharmacia Corp. makes the drug, Bextra (valdecoxib......is in later life.// People who severely damage the cartilage in their joints in their 20s and 30s are at greate...ity is currently financing work into a new type of cartilage transplant surgery aimed specifically at younger people with sports injuries. It is also funding ext...IGF-1 EIA Endocrine Function 026-AC-27F1 Insulin Growth Factor
..., including mitogenic effects and the promotion of cartilage sulphation. It also mediates growth promoting actions of growth hormone on skeletal and other body fluids. Almost all (>95%) of serum IGF-1 circulates bound to specific IGF binding proteins, of which six classes (IGF-BPs 1-6) are now recognised. ...... surgery, doctors remove scar tissue and destroyed cartilage and insert a joint replacement implant in place of the damaged wrist. Doctors stabilize the implant by cementing its stems inside the bones with bone cement.......m scaphoids to OCDs where there exists significant cartilage surrounding the bones, to phalangeal fusions where their headless design eliminates soft tissue irritation.......ence and offset the tunnel 2 mm from the articular cartilage margin, or as a visual aid that simulates exact tunnel position and size. The guides will mimic the subsequent drill hole and, therefore, make exact tunnel placement possible....Stainless steel cartilage scissors....The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem Cells Work Better
...oping cutting-edgetherapies to regenerate bone and cartilage and to repair damagedmuscle. The application of th... heart attack to the repair ofsports-related bone, cartilage and muscle injuries. For more information about Dr. Huard's research, please visit<a target="_b...New Phase IV Clinical Study Indicates LidoSite Provides Rheumatology Patients Superior Pain Relief
...s andosteoarthritis risk further loss of articular cartilage in theknee." The study, involving six study sites and 14 physicians, followed63 patients over the course of two routine injections of hyaluronicacid for the treatment of osteoarthritis. During the first treatment, patients either received no loca...