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biosynthesis in Medical News

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

... which is an early and rate limiting step in the biosynthesis of cholesterol. Lovastatin is ... and other products of the cholesterol biosynthesis pathway are essential components for fetal ... and possibly other products of the cholesterol biosynthesis pathway, MEVACOR is contraindicated during ...

Researchers genetically engineer micro-organisms into tiny factories

... the National Science Foundation to focus on the biosynthesis of a popular group of flavonoids called ... enzymes and natural feedstocks, microbial biosynthesis reduces or eliminates the need for petrochemical ... to identifying the pathways that lead to the biosynthesis of precursors for desired compounds. Further ...

A new class of anti-inflammatory drugs

... print]). Aspirin and the related NSAR drugs act on the arachidonic acid biosynthesis cascade, which plays a central role in the onset of pain and inflammation. ... of this new class of drugs is that they not only specifically target the biosynthesis of prostaglandin, but also of leukotrienes, which are metabolites in the ...

Existing anti-obesity drugs may be effective against flu, hepatitis and HIV

... acid metabolism could stop viral replication, because fatty acid biosynthesis is not essential in adult humans. It does appear, however, to be essential ... the American Cancer Society. "Recent studies have shown that fatty acid biosynthesis is important for the replication of diverse enveloped viruses," Munger ...

Researchers find possible target to treat deadly bloodstream infections

... the building blocks of DNA and RNA. The result suggested that the biosynthesis nucleotides is crucial for the growth of the bacteria in human blood, ... bacteria detected in their blood. Mankin said the enzymes of nucleotide biosynthesis could make excellent antibiotic targets. The UIC Center for Pharmaceutical ...

Scientists strike blow in superbugs struggle

... Micklefield, Smith and colleagues were the first to engineer the biosynthesis of lipopeptide antibiotics of this class back in 2002. They have now ... genetics. It follows the tradition of pioneering work in natural product biosynthesis and engineering that has come out of the UK. Scientists in Manchester ...

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biosynthesis in Medical Technology

VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease

... from the Agency on the Company's Phase 3 trial design. VIA-2291 is a selective and reversible inhibitor of 5 Lipoxygenase, a key enzyme in the biosynthesis of leukotrienes, which are important mediators of the inflammation believed to be involved in the development and progression of atherosclerosis. The ...

VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease

... cardiac events, including heart attack and stroke. VIA-2291 is designed to be a selective and reversible inhibitor of 5-LO, a key enzyme in the biosynthesis of leukotrienes, that are important mediators of inflammation believed to be involved in the development and progression of atherosclerosis. ACS ...

VIA Pharmaceuticals Completes Patient Visits in Phase 2 Carotid Endarterectomy (CEA) Trial

... of inflammation. About VIA-2291 VIA-2291 is a selective and reversible inhibitor of 5-LO, which is believed to be a key enzyme in the biosynthesis of leukotrienes (important mediators of inflammation involved in the development and progression of atherosclerosis). Potentially a complement to ...

VIA Pharmaceuticals Completes Enrollment in Phase 2 Acute Coronary Syndrome (ACS) Trial

... in the third quarter. About VIA-2291 VIA-2291 is a selective and reversible inhibitor of 5-LO, which is believed to be a key enzyme in the biosynthesis of leukotrienes (important mediators of inflammation involved in the development and progression of atherosclerosis). Potentially a complement to ...

VIA Pharmaceuticals Announces Updated DSMB Safety Results for VIA-2291 Ongoing Phase 2 Clinical Program

... of VIA Pharmaceuticals. About VIA-2291 VIA-2291 is a selective and reversible inhibitor of 5-LO, which is believed to be a key enzyme in the biosynthesis of leukotrienes (important mediators of inflammation involved in the development and progression of atherosclerosis). Potentially a complement to ...

VIA Pharmaceuticals Completes Enrollment In Phase 2 Carotid Endarterectomy (CEA) Trial

... of our lead compound." About VIA-2291 VIA-2291 is a selective and reversible inhibitor of 5-LO, which is believed to be a key enzyme in the biosynthesis of leukotrienes (important mediators of inflammation involved in the development and progression of atherosclerosis). Potentially a complement to ...
biosynthesis in Medical Dictionary

Bleeding time

... ... resistance : The inability of aspirin to produce an anticipated effect on one or more tests of platelet function, such as inhibiting the biosynthesis of thromboxane, inhibiting platelet aggregation, and causing a prolongation of the bleeding time . High doses have also been associated with ...

Gene

... The Gene Chip: The Future of Lymphoma Diagnosis ? Summary & Participants ... GENE : 1. A unit of DNA that carries information for the biosynthesis of a specific product in the cell . 2. Ultimate unit by which inheritable characteristics are transmitted to succeeding generations in all living ...

Gland

... sodium /iodide symporter, the protein that mediates the accumulation of iodide in the thyroid gland . Iodide uptake is the first step in the biosynthesis of the thyroid hormone s T3 and T4. Common causes include an enlarged prostate gland in older men, sagging pelvic muscle s in older women, ...

Hormone

... growing in early childhood but retains normal body proportion, mental capacity, and sexual development. Iodide uptake is the first step in the biosynthesis of the thyroid hormone s T3 and T4. Although the remarkable capability of the thyroid for iodide uptake is well established, almost no detailed ...

Sodium

... sodium /iodide symporter, the protein that mediates the accumulation of iodide in the thyroid gland . Iodide uptake is the first step in the biosynthesis of the thyroid hormone s T3 and T4. Cromolyn Salts, Cromolyn Sodium , Nedocromil Sodium One way to stop histamine from being released would ...

Thyroid gland

... sodium /iodide symporter, the protein that mediates the accumulation of iodide in the thyroid gland . Iodide uptake is the first step in the biosynthesis of the thyroid hormone s T3 and T4. It may also be a sign of overactivity of the thyroid gland or underlying disease . Flutters, and the even ...

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biosynthesis in Biological News

Experts from Stevens, Merck, publish joint paper, 'Biosynthetic Studies of Platensimycin'

... academia and industry). It reports biosynthesis of a novel antibiotic, said Attygalle. It is the ... biosynthetic pathways leading to the biosynthesis of both compounds is a prerequisite for combinatorial biosynthesis and is also helpful for improvement of the titer ...

U Alberta researcher in same group as Darwin and Hawking

... antibiotics. Currently, more than 50 per cent of hospital-acquired infections are resistant to common antibiotics. Veredas' work also centres around biosynthesis by fungi of important metabolites including cholesterol-lowering drugs such as statins. "The appointment is a great honour and I was very ...

Comprehensive genetic study paves way for new blood-pressure medicines

... several genes that probably play a role in regulating blood pressure. The CYP17A1 gene on chromosome 10q24, for instance, plays a key role in the biosynthesis of glucorticoid hormones, which influence the metabolism of salt. In another area on chromosome 1p36 there are genes for two peptides with ...

A new way to assemble cells into 3-D microtissues

... applications. Beyond that, Bertozzi hopes to refine the present method of modifying cell-surface DNA. "As it stands, the need for unnatural sugar biosynthesis limits the kinds of cells that we can use in microtissue construction," she says. "There are other ways in which DNA can be conjugated to cells, ...

A new gene silencing platform -- silence is golden

... RNAi." Gunderson went on to say that the range of possible targets is very broad due to the mechanism of action in which inhibition occurs during the biosynthesis of mRNA at the near universal 3' end processing step. Perhaps the most interesting aspect of this technology is that U1 Adaptors can possibly inhibit ...

American Chemical Society's Weekly PressPac -- Jan. 7, 2009

... perhaps in a class of its own." JS ARTICLE #4 FOR IMMEDIATE RELEASE "Salicylic Acid sans Aspirin in Animals and Man: Persistence in Fasting and biosynthesis from Benzoic Acid" DOWNLOAD FULL TEXT ARTICLE http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/jf800974z CONTACT: Gwen Baxter, ....

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biosynthesis in Biological Technology

New Insights into the Mechanism of Action of Antipsychotic Drugs

... Society, of a manuscript entitled "Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid ... (1) Polymeropoulos M.H. et al., "Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid ...

Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting

... receptor 2 gene on iloperidone efficacy for the treatment of patients with schizophrenia. NR7-009 Common effect of antipsychotics on biosynthesis and regulation of fatty acids and cholesterol supports a role of lipid homeostasis in schizophrenia. NR1-092 Selective estrogen ...

VIA Pharmaceuticals Announces Complete Enrollment in FDG-PET Phase 2 Study of VIA-2291 in Cardiovascular Patients

... report data in the second half of 2009. VIA-2291 is designed to be a selective and reversible inhibitor of 5 Lipoxygenase, a key enzyme in the biosynthesis of leukotrienes, which are important mediators of inflammation believed to be involved in the development and progression of atherosclerosis. The ...

Dow AgroSciences Confirms Efficacy of Zinc Finger Nucleases for Precise Genome Modification in Maize

... herbicide tolerance gene was targeted to disrupt ZmIPK1 in corn, an especially attractive choice because ZmIPK1 encodes an enzyme that is involved in biosynthesis of phytate, a component of feed corn that is particularly difficult to digest for certain animals like pigs and chickens causing excess phosphate ...

Chromatide and Novasep Have Extended Their Partnership to Develop Large Scale Solid Phase Peptide and Oligonucleotide Synthesis Technology.

... and Dr. Saeed Gulzar, formerly Custom Peptide Synthesis Manager at Avecia/Zeneca. The IP-driven company is highly innovative, specialising in novel biosynthesis and purification technologies designed to facilitate, and reduce costs, of the processes involved in production of biomolecules in the biotechnology ...

Evotec Appoints Mario Polywka and Klaus Maleck to the Management Board

... doctorate from the University of Oxford in mechanistic organometallic chemistry and continued at Oxford with post-doctoral studies on aspects of the biosynthesis of penicillins. Dr Klaus Maleck, 35, has served as Executive Vice President Finance and a member of Evotec's Executive Committee since April 2007. ...
biosynthesis in Biological Definition

Protein biosynthesis

... Protein biosynthesis is the process in which cells build proteins ... and ending with translation . Protein biosynthesis although very similar, differs between ... 2 Translation 3 Events following biosynthesis 4 External links Transcription ...

Signal transduction

... ." Hormone-initiated signal transduction takes the following steps: biosynthesis of a hormone Storage and secretion of the hormone. ... strength is the hormone concentration, which is regulated by : biosynthesis and secretion of hormones in the endocrine tissue . As an example, the ...

Alternative splicing

... different ripe mRNA molecules and therefore to different proteins. Also viruses have adapted to this biochemical process when using the protein biosynthesis apparatus. When the pre-mRNA has been transcribed from the DNA , it includes several introns and exons . In nematodes , the mean is 4-5 exons ...

Cell biology

... in cell biology Movement of proteins Proteins are synthesized by ribosomes in the cytoplasm . This process is also known as protein biosynthesis or simply protein translation . Some proteins, such as those to be incorporated in membranes ( membrane proteins ), are transported into the ER ...

Cytoskeleton

... encoding actin-like proteins, and these proteins form a helical network beneath the cell membrane that guides the proteins involved in cell wall biosynthesis . Some plasmids encode a partitioning system that involves an actin-like protein ParM . Filaments of ParM exhibit dynamic instability , and may ...

Endosymbiont

... amino acids , and (2) after the Buchnera genome was sequenced, analysis uncovered a large number of genes that likely code for amino acid biosynthesis genes; most bacteria that live inside other organisms do not have such genes, so their existence in Buchnera is noteworthy. Similarly, the primary ...

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biosynthesis in Biological Dictionary

Protein biosynthesis

... acid synthesis ... Category: Protein biosynthesis . From Wikipedia, the free encyclopedia. Jump ... search ... Pages in category " Protein biosynthesis " ... Protein biosynthesis . DNA. Transcription. Translation. DNA ... The ...

Translocation

... in plants, transport of food or pesticides through phloem or xylem. Protein translocation or protein targeting, a process in protein biosynthesis ... reciprocal translocation ( ri′siprəkəl ′tranzlō′kāshən ) ( cell and molecular biology ) The special case of translocation in which two ...

Suberin

... water ... Very long chain aliphatic compounds occur in the suberin polymer and associated wax. Up to now only few genes involved in suberin biosynthesis have been identified. ... ...

Small nuclear RNA

... RNA (snRNA) ... Small Nuclear RNA (snRNA) ... Small Nucleolar RNA (snoRNA) ... BioInfoBank Library :: RNA , Small Nuclear :: biosynthesis :: RNA interference by small hairpin RNAs synthesised under control of the human 7S K RNA promoter. TFIID ... BioInfoBank Library :: ...

Secondary metabolite

... can be classified by their chemical structure or physical ... WARF Technology Summary P02379US: A Global Regulator of Secondary Metabolite biosynthesis in Fungi ... Secondary metabolites display a broad range of ... Prkofiles of secondary metabolites of fusarium spp. ... Secondary ...

Recombinant DNA

... ... The RWJMS Recombinant DNA form should be completed and submitted to the IBC, ... Formation of recombinant DNA containing genes for the biosynthesis of toxin ... Recombinant DNA summary with 15 pages of encyclopedia entries, essays, summaries, research information, and more. ... Get ...

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