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Binding in Medical News

Stopping harmful oral bacteria in its path is goal for Case Western Reserve researcher

... in the genes of F. nucleatum . This adhesin, or binding agent, on the bacteria allows them to connect ... In tests, bacteria without FadA had less binding capability compared to those with the adhesin, ... Her research group will look not only at the binding agent but the receptors on the host epithelial ...

Novo Nordisk Insulin Analogs Have Proven Safety Profiles

... analogs have been tested for IGF-1 receptor binding in the early research phase and only insulins with a binding ratio between the insulin and IGF-1 receptors ... development(3). Studies on receptor binding and cell growth together show that insulin ...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... gene therapy because of the absence of adenoviral binding sites on pancreatic cancer cells such as the ... further increase the specificity of this vector, binding sites for native adenoviral receptors, the ... They found that ablation of native cellular binding sites reduced adenoviral transduction at least ...

New antibiotics could come from a DNA binding compound that kills bacteria in 2 minutes

... A synthetic DNA binding compound has proved surprisingly effective at binding to the DNA of bacteria and killing all the bacteria it touched within two minutes. The DNA binding properties of the compound were first discovered ...

Blood protein may hold key to stopping tumor growth in cancer patients

... for tumor growth, researchers found that the binding of the two proteins actually assists in new blood ... hypothesis that if they can somehow prevent the binding of ferritin and HKa, it will allow HKa to prevent ... It is therefore possible that by increasing the binding of ferritin to HKa, one could increase the rate ...

Important new model shows how proteins find the right DNA sequences

... to look through the millions of nearly identical binding alternatives and find the right place to bind. ... it would simply be impossible for them to find a binding place in a reasonable time, since the proteins ... so many DNA-binding proteins also bind auxiliary binding sites close to the regulatory site, thus forming ...

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Binding in Medical Technology

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... demonstrating that antisense reduction of retinal binding protein 4 (RBP4) caused significant improvements ... Antisense Inhibition of cAMP Response Element binding Protein (CREB) Expression Lowers Plasma ... Knockdown of Carbohydrate Response Element binding Protein (ChREBP) in Liver Protects Against ...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

... "The data we present show the monovalent binding to normal cells of other antibodies confirming ... normal cells because it is capable of monovalent binding to very low expressions of EGFR whereas nimotuzumab's monovalent binding is transient. It is this transient ...

Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)

... such as Parkinson's disease, where metal binding is believed to induce the pathological aggregation of proteins. The discovery regarding the metal binding properties of OXIGON(TM) was reported by ... interested to learn that OXIGON(TM) has metal binding properties." Dr. Chain added: "These data fit ...

deCODE Files IND for DG071, a Novel PDE4 Modulator Being Developed for Alzheimer's and Other Cognitive Disorders

... side effects were closely correlated with the binding of these molecules in the PDE4 enzymatic active ... the deCODE chemistry team to identify a novel binding site for allosteric modulators in the PDE4 regulatory domain. binding of an allosteric modulator at that site ...

Genmab A/S - Company Announcement: Novel Insights into HuMax-EGFr Mechanisms of Action Published in PNAS

... EGFr is central to its role in signaling, and binding of HuMax-EGFr (zalutumumab) results in effective ... EGFr is central to its role in signaling, and binding of HuMax-EGFr (zalutumumab) results in effective ... activity known as ADCC, block growth factor binding to EGF receptors, and we now established that ...

Shire Strives to Increase Adherence Among Chronic Kidney Disease Stage 5 Patients

... to develop individualized plans is the phosphate binding ratio (PBR). PBR signifies the number of grams ... lanthanum, which has a high PBR. In addition, the binding power of FOSRENOL, in vitro, was not ... has a high affinity for phosphate and works by binding to dietary phosphorus in the gastrointestinal ...

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Binding in Medical Products

IGFBP-4 ELISA Test

Description:... Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24 kDa protein which ... IGFBP-4 appears to be inhibitory to IGF action by binding the IGFs and preventing their interaction with ... P. The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating ...
Company:Diagnostic Systems Laboratories, Inc.

hGH IRMA Test

Description:... of IGF-I and IGF-II, and their associated binding proteins. GH apparently stimulates IGF production after binding to specific cell surface receptors in the liver ... GH in circulation is bound to a high affinity GH binding protein (GHBP), which represents the ...
Company:Diagnostic Systems Laboratories, Inc.

hGH, Ultra-Sensitive ELISA Test

Description:... of IGF-I and IGF-II, and their associated binding proteins. GH apparently stimulates IGF production after binding to specific cell surface receptors in the liver ... GH in circulation is bound to a high affinity GH binding protein (GHBP), which represents the ...
Company:Diagnostic Systems Laboratories, Inc.

Placental Growth Hormone ELISA Test

Description:... of IGF-I and IGF-II, and their associated binding proteins. GH apparently stimulates IGF production after binding to specific cell surface receptors in the liver ... GH in circulation is bound to a high affinity GH binding protein (GHBP), which represents the ...
Company:Diagnostic Systems Laboratories, Inc.

Bioactive hGH ELISA Test

Description:... of IGF-I and IGF-II, and their associated binding proteins. GH apparently stimulates IGF production after binding to specific cell surface receptors in the liver ... GH in circulation is bound to a high affinity GH binding protein (GHBP), which represents the ...
Company:Diagnostic Systems Laboratories, Inc.

hGH ELISA Test

Description:... of IGF-I and IGF-II, and their associated binding proteins. GH apparently stimulates IGF production after binding to specific cell surface receptors in the liver ... GH in circulation is bound to a high affinity GH binding protein (GHBP), which represents the ...
Company:Diagnostic Systems Laboratories, Inc.

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Binding in Medical Definition

Thymocyte

... be arranged (T cell receptor beta) is capable to binding a pre-T cell receptor alpha protein and ... which have a T cell receptor capable of binding MHC. The T cell receptor requires CD8 as a ... thymocytes that have a T cell receptor capable of binding MHC class I or class II with even a weak affinity ...
Binding in Medical Dictionary

TIBC

... is a blood test that measures the total iron binding capacity ( TIBC ) as an indirect measure of ... By completely saturating all the available binding sites, it is possible to measure the total iron binding capacity ( TIBC ). This is really a measure of ...

Albumin

... is a protein that is made in the liver . It helps to retain elements like calcium , some hormone s, and certain drugs in the circulation by binding to them to prevent their being filtered out by the kidney s. Albumin is produced mainly in the liver . It helps keep the blood from leaking ...

Allergy

... responds to foreign microorganism s and particles, like pollen or dust, by producing specific protein s called antibodies that are capable of binding to identifying molecules, ... Allergy testing Food allergies are usually tested by using various elimination diets -- the suspected foods ...

Bilirubin

... is part of the bile , which is made in the liver and is stored in the gallbladder . The abnormal buildup of bilirubin causes jaundice . binding agent ... Bilirubin A reddish-yellow waste product produced by the liver that colors urine and is involved in the formation of some ...

Carbon monoxide

... same poison ous gas given off by car exhausts and faulty gas fires. Carbon monoxide prevents the blood from carrying oxygen round the body by binding itself to the blood 's haemoglobin. Carbon monoxide , nicotine , and other substances in tobacco smoke can promote atherosclerosis and ...

Central nervous system

... IgA may also be an important and effective antibody in sites other than mucosa l tissue s, such as the central nervous system . IgA inhibits the binding of micro- organ isms to mucosa l surfaces, thus preventing entry. Other microorganism s elude treatment by hiding in hard to reach areas such ...

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Binding in Biological News

Flexible neck in cell-receptor DC-SIGN targets more pathogens

... show that flexibility in the region near the binding sites of DC-SIGN plays a significant role in ... to block this interaction." To study the binding behavior of DC-SIGN (Dendritic Cell-Specific ... When the protein binds to a pathogen, binding sites on the cell receptor rearrange slightly, to ...

Computers aid in cracking deception in plants

... protein candidates by identifying protein binding sites in the soybean that match with those in the ... our case, we're trying to find a specific protein binding site among a group of proteins from the nematode that match a particular binding site in the soybean using a set of chemical ...

International team tracks clues to HIV

... virus, HIV-1 PR, by attaching themselves to its binding pocket. "There are a lot of people doing this ... strong, but there's potentially a very strong binding effect. The problem is, it's not the perfect ... about a very simple experiment to calculate the binding efficiency of a molecule in the HIV pocket, then ...

Princeton team's analysis of flu virus could lead to better vaccines

... suggest that if a way can be found to weaken the binding of the less effective antibodies, then this might ... ones that are well matched to and good at binding to the infecting virus, and ineffective ones that are poorly matched to and bad at binding to the infecting virus, and consequently stay out ...

6 young ASU faculty earn NSF Career awards

... is for $600,000 and will be used to study the binding mechanism of sequence specific DNA-binding ... initiation and DNA replication. Their binding is characterized by large conformational changes, ... It is not understood how the folding, bending and binding are coupled, and it is not understood what ...

Genetic switch potential key to new class of antibiotics

... change their spatial organization, which entails binding to a small signaling partner, promises to inform ... tRNA for protein building. The mRNA's ribosome binding site is instead locked up by the preQ1 ... it stacks on the RNA bases in the riboswitch binding pocket with high affinity, adding stability to ...

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Binding in Biological Technology

Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation

... technologies. "The determination of ligand binding affinity has been used to delineate the ligand binding site of GPCRs through a site-directed mutagenesis ... unique. It has aided the determination of ligand binding affinities without the use of radioactivity and ...

Pre-Clinical Data on CEA-specific BiTE Antibody Published in Journal of Immunotherapy Demonstrate Potent Control of Tumor Growth

... the potent anti-tumor activity of a BiTE antibody binding to carcinoembryonic antigen (CEA) and to CD3 on T ... can be blocked by soluble CEA and prevented from binding to CEA on the surface of cancer cells, thereby ... T cells lack the appropriate receptors for binding antibodies. Previous attempts have shown the ...

Fitting pieces for biosensors

... identify and bind certain target molecules. These binding abilities allow, for instance, tracing, detecting ... an in vitro method, researchers select the best binding partners for the target molecule from a huge pool ... the enrichment of those which exhibit best binding and detecting abilities to the given target. The ...

International Guidelines for First-Line use of Freelite(TM) in Diagnosis and Management of Multiple Myeloma to be Published in "Leukemia"

... England, January 28 /PRNewswire/ -- The binding Site Limited ("The binding Site" or the "Company"), a privately-owned ... is a unique assay, developed and marketed by The binding Site, used for the diagnosis and monitoring of ...

The Binding Site Announces Trading Update for Year Ended September 30th 2008

... up 26%, Freelite(TM) Sales up More Than 50% The binding Site Limited ("The binding Site" or the "Company"), a privately-owned ... year, strongly outperforming their market as The binding Site gained market share and increased its level ...

GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology

... a change in 3-D structure of the protein receptor binding site. The biochemical and structural modifications induced in the protein binding site provide for superior anti-HCV efficacy using ... a change in 3-D structure of the protein receptor binding site. The biochemical and structural ...

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Binding in Biological Products

PureLink 96 PCR Purification Kit from Invitrogen

Description:... bind/wash/elute procedure: provides two binding Buffer options for fragments >100 bp or >300 bp* ... of different purification requirements. Use the binding Buffer for routine purifications of double-stranded DNA fragments from 100 bp to 12 kb. Use binding Buffer HC for removal of primer dimers (<300 bp), ...
Company:Invitrogen

PureLink PCR Purification Kit from Invitrogen

Description:... bind/wash/elute procedure: provides two binding Buffer options for fragments >100 bp or >300 bp* ... of different purification requirements. Use the binding Buffer for routine purifications of double-stranded DNA fragments from 100 bp to 12 kb. Use binding Buffer HC for removal of primer dimers (<300 bp), ...
Company:Invitrogen

T7 Phage Capture Plate from Novagen

Description:... is immobilized by a method that retains maximal binding activity. The antibody specifically recognizes ... per well and low non-specific binding. Phage binding is linear over two orders of magnitude. ... Phage Capture Plate can be used in a variety of binding assays where reliable, specific immobilization ...
Company:Novagen

ImmunoPure IgM Purification Kit from Pierce Biotechnology, Inc.

Description:... to purify IgM. This matrix, an immobilized mannan binding protein (MBP) support, is most effective for ... MBP does not bind F(ab)2 and Fab. Mannan binding Protein is immobilized on two supports: agarose ... at least 10 times with no apparent loss of binding capacity. The figure below demonstrates the high ...
Company:Pierce Biotechnology, Inc.

Apoptotic Cell Isolation Kit from MBL International

Description:... Annexin V is a Ca2+-dependent phospholipid binding protein with high affinity for phosphatidylseri ... Annexin V is a Ca2+-dependent phospholipid binding protein with high affinity for phosphatidylserine ... on the cell surface, PS becomes available for binding to annexin V and any of its ....
Company:MBL International

UltraLink Immobilized NeutrAvidin from Pierce Biotechnology, Inc.

Description:... When nonspecific binding is a problem in your application, Pierce offers a ... protein with exceptionally low nonspecific binding properties. NeutrAvidin does not contain ... detection of the ligand in the assay system. binding biotinylated compounds to NeutrAvidin provides a ...
Company:Pierce Biotechnology, Inc.

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Binding in Biological Definition

Affinity chromatography

... from the initial mixture, then once the initial binding has been achieved, the material of interest is ... which allows it to be selected for affinity binding (if the molecule is a protein these are called ... the target antibody. Batch verses column binding to the solid phase may be achieved by column ...

Allostery

... activity or efficiency changes in response to the binding of an effector molecule at a so-called ... favors the T state over the R state The binding of substrate to one subunit causes all other ... change to adjacent subunits. Instead, substrate binding at one subunit only slightly alters the structure ...

Allostery

... activity or efficiency changes in response to the binding of an effector molecule at a so-called ... favors the T state over the R state The binding of substrate to one subunit causes all other ... change to adjacent subunits. Instead, substrate binding at one subunit only slightly alters the structure ...

Antibody

... of the immune system. B cells are activated upon binding to their specific antigen. In some cases the ... the light chain, which together shape the antigen binding site at the amino terminal end of the monomer. ... reason that the human immune system is capable of binding so many antigens is the variable region of the ...

ATP synthase

... Contents showTocToggle("show","hide") 1 binding change mechanism 2 Physiological role 3 ... 6 See also 7 External links binding change mechanism In the 1960s through the 1970s, Paul Boyer developed his binding change, or flip-flop, mechanism, which postulated ...

Polymerase chain reaction

... to duplicate DNA when cells divide. It works by binding to a single DNA strand and creating the ... the annealing step can result in primers not binding to the template DNA at all, or binding at random. Time: 1-2 minutes. (3) Finally, the ...

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Binding in Biological Dictionary

Zona pellucida

... caused by direct titration of zona pellucida binding sites is suggested as an ... the structure and ... ... THE ZONA PELLUCIDA : ... binding of sperm to the zona pellucida is a ... also stimulates ... The zona pellucida binding assay assesses the ability of ... to spermatozoa ...

Z-DNA

... ... a b "Entrez Gene: ZBP1 Z - DNA binding protein 1" ... Nature is the ... was recently described. ... Comparison of Z-DNA binding by DLM-1 and ADAR1 reveals a common structure ... ... (interacts with human), anti-ZBP1, ZBP1 ( Z-DNA binding protein 1) antibody, rabbit polyclonal ...

UvrA

... the TFO was dissociated from its duplex binding site by UvrA and UvrB. ... In this process, ... that the UvrA dimer has a high preference of binding the end of a ... The UvrA protein on its ... Dimerization of Escherichia coli UvrA and its binding to undamaged and ... UvrA and UvrB proteins ...

TATA box

... genes in eukaryotes and Archaea. The TATA binding protein (TBP) is a transcription factor that ... start site in ... TATA Box binding Protein. The TATA box can be found in various ... box from Baker's Yeast ... The TATA box binding protein has a relatively simple shape with only ...

Ribosome binding site

... A ribosomal binding site (RBS) is a sequence on mRNA that is ... tRNA is formed in the ribosome . ... This binding is facilitated by elongation factor-Tu (EF-Tu), ... and other additional information on Ribosome binding site from Biology-Online.org dictionary. ... ...

Response element

... "AHR" redirects here. ... 3.3 DNA binding (xenobiotic response element - XRE) ... ... gene. ... the zinc-finger domain needed for DNA binding (to the response element ) ... The cAMP ... ... Homo sapiens metal response element binding transcription factor 2, mRNA (cDNA ... ...

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Other Contents
(Date:7/13/2014)... editorial published today in The Lancet Neurology ... consideration the long term neurological problems that repeated ... most common form of sports-related traumatic brain injury ... may include dementia, amyotrophic lateral sclerosis, and other ... is perhaps more concerning, is that even when ...
(Date:7/13/2014)... identifies a novel genetic and molecular pathway ... opening up potential new therapeutic strategies for an ... is a chronic inflammatory disorder of the esophagus. ... certain foods and an over-accumulation in the esophagus ... the body,s immune system). EoE can cause a ...
(Date:7/13/2014)... July 13, 2014 The North American water ... in 2013 to $5,450 million by 2018, at a CAGR ... market is expanding at a rapid pace in North America. ... tightening laws on water & wastewater storage and collection, and ... The market is expanding at a healthy rate in Canada, ...
(Date:7/13/2014)... July 13, 2014 According to ... and Computing Market by Component (processor, GPU, DSP, ... MDA, Medical), and Geography - Forecast and Analysis ... Mobile Processing & Computing Market is expected to ... CAGR of 20.75% from 2014 to 2020. , ...
(Date:7/13/2014)... WA (PRWEB) July 13, 2014 Athletes ... longer recovery period from concussions, according to research presented ... ( AOSSM ) Annual Meeting. The research marks the ... concussion based on the known physical events that occur ... patients with a long allele in the (GT)n genotype ...
Breaking Medicine News(10 mins):Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 2Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 3Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 3Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 4Health News:Genetic Factors May Be Responsible for Slowing Concussion Recovery in Athletes 2
(Date:7/11/2014)... Researchers from Salk Institute for Biological Studies, BGI, ... the safety and reliability of the existing targeted ... method, TALEN-HDAdV, which could significantly increased gene-correction efficiency ... study published online in Cell Stell Cell ... cell-based gene therapy. , The combination of stem ...
(Date:7/11/2014)... The increased risk of kidney injury related to the ... the mass of HES molecules, according to a report ... the International Anesthesia Research Society (IARS). , The "total ... HES on cultured human renal proximal tubule cells (PTCs), ... colleagues of University Hospital Wrzburg, Austria. Other factorssuch ...
(Date:7/11/2014)... July 11, 2014 Research and Markets ... Biometrics Technology Market - Industry Analysis Size Share Growth ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... has created a need for high level security in ... personnel authentication such as username and passwords, tokens etc. ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2
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