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Ataxia in Medical News

Repligen Reports Second Quarter Fiscal Year 2009 Financial Results

... (p=0.04). HDAC Inhibitors for Friedreich's ataxia and Huntington's Disease We are currently ... neurodegenerative diseases such as Friedreich's ataxia and Huntington's disease. We have identified ... and a $125,000 grant from the Friedreich's ataxia Research Alliance and ...

Scientists Track Impact of DNA Damage in the Developing Brain

... evidence linking single-strand DNA damage with human diseases, including ataxia with oculomotor apraxia (AOA1) and spinocerebellar ataxia with axonal neuropathy (SCAN1). Both disorders are inherited and are ...

You can teach an old dog new tricks: anti-malarial prevents cancer in mice

... mouse models of two distinct human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia. As discussed in the accompanying commentary by Chi Dang, ... the development of lymphomas in ATM-deficient mice (a mouse model of ataxia telangiectasia). By contrast, chloroquine did not inhibit the development ...

JCI table of contents: Dec. 20, 2007

... mouse models of two distinct human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia. As discussed in the accompanying commentary by Chi Dang, ... the development of lymphomas in ATM-deficient mice (a mouse model of ataxia telangiectasia). By contrast, chloroquine did not inhibit the development ...

Repligen Reports Second Quarter Fiscal Year 2008 Financial Results

... Medical Research Institute. Transcription Activators for Friedreich's ataxia In April, we acquired the rights to intellectual property ... this family of compounds for activity in animal models of Friedreich's ataxia and other neurodegenerative diseases. In September, we received a $100,000 ...

U-M Researchers ID Gene Involved in Pancreatic Cancer

... Center have identified a gene that is overexpressed in 90 percent of pancreatic cancers, the most deadly type of cancer. Expression of the gene, ataxia Telangiectasia Group D Complementing gene, called ATDC, is on average 20 times higher in pancreatic cancer cells than in cells from a normal ....

Stemedica Medical Team Cautions Patients About Stem Cell Therapy & Comments on PLoS Medicine Article

... by visiting www.fda.gov/cber/compliance.htm . The report in PLoS, Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an ataxia Telangiectasia Patient , describes the development of multifocal glioneuronal neoplasms along the spinal nerves and brain stem in a 13-year-old ...

Tumors Linked to Fetal Stem Cell Transplant

... the brain and spine of a boy about four years after he began receiving the neural fetal stem cell treatment for a rare neurodegenerative disease, ataxia telangiectasia, that also weakens the immune system. Israeli researchers from Sheba Medical Center in Tel Aviv studied the surgically removed spinal ...

Dr. Huda Zoghbi to receive 2009 Vilcek Prize in biomedical research

... to wait, however, as too little data was available at the time to make it the launch point of her new career. Instead, she focused on spinocerebellar ataxia type 1 (SCA1), a crippling, neurodegenerative disease that affects balance and coordination. In 1988, she set up her own laboratory at Baylor College ...

Breakthrough in cell-type analysis offers new ways to study development and disease

... development and examine the detailed properties of cells as they succumb to the pathological events occurring in neurological diseases such as ataxia telangiectasia, autism and Rett syndrome," says Heintz. "We are very excited by the opportunities this offers to us and our colleagues for ...

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Ataxia in Medical Technology

Boston University and The Center for Human Genetics, Inc. Announce Change in Testing Services

... gene, Duchene's muscular dystrophy, myotonic dystrophy (DM1), Freidreich's ataxia (FRDA), hereditary neuropathy with pressure palsies, polycystic kidney disease, spinal muscular atrophy (SMN1), spinocerebellar ataxia (SCA1, 2, 3, 6, 7 and 8) and tuberous sclerosis (type 2). This decision ...

Study Shows How Defective DNA Repair Triggers Two Neurological Diseases

... St. Jude scientists' findings in ataxia telangiectasia-like disease and Nijmegen breakage syndrome offer insight into the links between brain disease and cancer vulnerability in people ...

Retigabine Significantly Reduces the Number of Seizures in Adults With Inadequately Controlled Partial-Onset Epilepsy

... trials occurring in greater than or equal to 10 percent of patients included dizziness, somnolence, fatigue, confusion, dysarthria (slurred speech), ataxia (loss of muscle coordination), urinary tract infection, blurred vision, tremor, and nausea. Urinary bladder effects, while monitored during the ...

CellCept(R) and a Reduced Level of CNI Shows Trend Towards Preservation of Kidney Function Versus a Standard-Dose CNI

... (PML), sometimes fatal, have been reported in patients treated with CellCept. Hemiparesis, apathy, confusion, cognitive deficiencies and ataxia were the most frequent clinical features observed. The reported cases generally had risk factors for PML, including treatment with ...

Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function

... (PML), sometimes fatal, have been reported in patients treated with CellCept. Hemiparesis, apathy, confusion, cognitive deficiencies and ataxia were the most frequent clinical features observed. The reported cases generally had risk factors for PML, including treatment with ...
Ataxia in Medical Definition

Familial isolated vitamin e deficiency

... Familial Isolated Vitamin E Deficiency is a rare autosomal recessive neurodegenerative disease. Symptoms are much like those of Friedreich ataxia and is caused by mutations in the gene for a-tocopherol transfer protein. ...
Ataxia in Medical Dictionary

Ataxia

... ataxia , which affects about 150,000 Americans, isn't a ... , but a sign of an underlying problem. The term " ataxia " describes a lack of muscle coordination when ... s. It may affect any part of the body. ataxia Related Category: Pathology (tk´s), lack ...

Ataxia Telangiectasia

... ataxia telangiectasia mutated: See: ATM. Search All of ... For: search help Printer-Friendly Format ... ataxia Telangiectasia : Genetics Basal Cell Nevus ... Adenoma tous Polyp osis (FAP) ... What is ataxia telangiectasia ? National Institute of ...

Cerebellum

... of the basilar artery . Spinocerebellar ataxia : ataxia with malfunction of the cerebellum . Search All ... with progressive dementia , spasticity , and ataxia . Brain stem, spinal cord, and cerebellum all ...

Telangiectasia

... of telangiectases or angioma s. Thymus ... ataxia telangiectasia mutated: See: ATM. Search All ... skin or mucous membrane s. temoporfin ... ataxia Telangiectasia : Genetics Basal Cell ... the face, especially on the cheeks. What is ataxia telangiectasia ? National Institute of ...

Asymptomatic bacteriuria

... At Risk for Fetal Alcohol Syndrome ( Fetal Alcohol Syndrome ) ataxia - Acute Cerebellar ( Acute Cerebellar ataxia ) ... Asymptomatic bacteriuria Atherosclerosis - illustration of ...

Autosomal recessive

... Infants with A-T initially often appear very healthy. At around age two, ataxia and nervous system abnormalities becomes apparent. PKD is mainly ... with only one gene for the disorder, are physically unaffected. ataxia - telangiectasia is transmitted as an autosomal recessive trait. The ...

Bacteriuria

... At Risk for Fetal Alcohol Syndrome ( Fetal Alcohol Syndrome ) ataxia - Acute Cerebellar ( Acute Cerebellar ataxia ) ... Urethra l syndrome is the presence of symptoms of a urinary ...

Amnesia

... disorders of micturition and/or defecation, visual disturbances, hypotension , anterograde amnesia , psychological dependence , confusion , ataxia , ... Regional anesthesia can either be used alone or combined with general anesthesia . Sedation, or monitored anesthesia care, provides ...

Angelman Syndrome

... syndrome : An important genetic syndrome characterized by severe motor and intellectual retardation , microcephaly (abnormally small head), ataxia , frequent jerky limb movement s and flapping of the arms and hands, hypotonia (floppiness), ... Angelman syndrome (AS) is a neurological ...

Antigen

... destroying connective tissue . Antigen Any substance (such as a toxin or enzyme ) capable of stimulating an immune response in the body. ataxia ... antigen A foreign agent capable of starting an immune response or causing the body to produce antibodies. antiserum ... ANTIGEN : ...

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Ataxia in Biological News

'Deranged calcium signaling' contributes to neurological disorder, UT Southwestern researchers find

... study. The disease, called spinocerebellar ataxia 3 also known as SCA3, or Machado-Joseph disease ... is one of the most common inherited forms of ataxia and most frequently affects people of Portuguese ... diseases such as spinocerebellar ataxia type 2 and Alzheimer's disease. ...

Molecular basis for neurodegeneration in Ataxia telangiectasia

... into the pathogenesis of neurodegeneration in ataxia telangiectasia. ataxia telangiectasia (A-T) is a rare, genetic ... A-T is caused by recessive mutations in the ataxia telangiectasia mutated (ATM) gene. While ...

Protein 'chatter' linked to cancer activation

... non-curable cancer-predisposed human disorders: ataxia telangiectasia, ataxia telangiectasia-like disorder, and Nijmegen ... risk of cancer. Zhu adds that patients with ataxia ...

Scientists track impact of DNA damage in the developing brain

... evidence linking single-strand DNA damage with human diseases, including ataxia with oculomotor apraxia (AOA1) and spinocerebellar ataxia with axonal neuropathy (SCAN1). Both disorders are inherited and are ...

U-M researchers ID gene involved in pancreatic cancer

... Center have identified a gene that is overexpressed in 90 percent of pancreatic cancers, the most deadly type of cancer. Expression of the gene, ataxia Telangiectasia Group D Complementing gene, called ATDC, is on average 20 times higher in pancreatic cancer cells than in cells from a normal ....

International team discovers gene associated with epilepsy

... came from one of three family lines. Of the 47 individuals in the three family lines, 23 had a form of progressive myoclonus epilepsy accompanied by ataxia -- a condition that causes imbalance. One family line has been extensively described by Hatem El-Shanti, M.D., a University of Iowa adjunct ...

Seemingly suicidal stunt is normal rite of passage for immune cells

... outside of the previously recognized responses to DNA damage? We don't know yet." The finding immediately improved scientists' understanding of ataxia telangiectasia, a rare genetic disorder that, among other symptoms, can weaken the immune system. Patients with the disorder have a mutation in a ...

Moonlighting enzyme linked to neurodegenerative disease

... Friedreich's ataxia is one of those diseases few have heard of unless ... what is happening to them." Friedreich's ataxia is an inherited neurodegenerative disease of ... says Dr. Isaya. The severity of Friedreich's ataxia is proportional to the decrease in the levels of ...

U of MN researchers identify ataxia gene

... and gives us new insight into the causes of ataxia and other neurodegenerative diseases, an ... Genetics, and posted online Jan. 22, 2006. ataxia is a hereditary disease that causes loss of ... a genetic form of ataxia. Spinocerebellar ataxia type 5 (SCA5) is a dominant gene disorder; if a ...

Study ties 'new' cell-death mechanism to developmental and degenerative brain disorders

... lead to different disease manifestations. The Filipino family's ataxia is an adult-onset type with prominent motor coordination symptoms and cerebellar atrophy. The French family's ataxia is a childhood-onset type, with mental retardation and seizures in some ...

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Ataxia in Biological Technology

Repligen Receives Research Grants to Support Friedreich's Ataxia Development Program

... Research Foundation (FARA) and the National ataxia Foundation (NAF). The grants will further the ... Muscular Dystrophy Association, the Friedreich's ataxia Research Foundation and the National Ataxia ... for human clinical trials." Friedreich's ataxia is an inherited neurodegenerative disease in ...

European EMEA Acceptance of Marketing Authorization Application Filing for SNT-MC17 in Friedreich's Ataxia by Santhera

... by Takeda) for the treatment of Friedreich's ataxia (FRDA). SNT-MC17, which has been granted orphan ... that we may be able to provide Friedreich' ataxia patients with the first pharmaceutical product ... Muscular Dystrophy (DMD). About Friedreich's ataxia (FRDA) ...

Repligen Reports Fourth Quarter and Fiscal Year 2009 Financial Results

... in the U.S. have bipolar disorder. HDAC Inhibitors for Friedreich's ataxia and Huntington's Disease We are currently developing inhibitors of ... the treatment of inherited neurodegenerative diseases such as Friedreich's ataxia and Huntington's disease. Preclinical studies have shown that HDAC ...

Repligen Reports Third Quarter Fiscal Year 2009 Financial Results

... MADRS (p=0.01) and the CGI-BP-C (p=0.04). RG2833 for Friedreich's ataxia and Huntington's Disease We are currently developing inhibitors of ... progressive, inherited neurodegenerative diseases such as Friedreich's ataxia and Huntington's disease. We have identified several potential clinical ...

Large-scale genetic study sheds new light on lung cancer

... characterized by unchecked growth of tissue of the nervous system. ataxia Telengiectasia Mutated (ATM). ATM mutations have previously been shown to play a role in ataxia telangiectasia, which is a rare inherited neurological disorder of ...

Repligen Reports First Quarter Fiscal Year 2010 Financial Results

... would remain in force until at least 2025. More than five million adults worldwide have bipolar disorder. HDAC Inhibitors for Friedreich's ataxia We are currently developing inhibitors of histone deacetylase enzymes (HDACs) for the treatment of inherited neurodegenerative diseases such as ...

Repligen Announces Publication of Positive Results with Proprietary HDAC Inhibitor in Huntington's Disease Model

... of Repligen Corporation. "We plan to continue to evaluate the utility of our novel HDAC inhibitors as a potential treatment for both Friedreich's ataxia and Huntington's disease." Huntington's disease is caused by a trinucleotide repeat expansion in the Huntington's disease gene (Htt) that results ...

Repligen Reports Fourth Quarter and Fiscal Year 2008 Financial Results

... which may be useful in monitoring the biochemical activity and guiding the dosing frequency of a clinical candidate in patients. Go FAR (Friedreich's ataxia Research) is a fundraising organization headquartered in Turin, Italy formed by the non-profit group RUDI Onlus Committee, dedicated to raising ...

Historic Breakthrough in Fighting Children's Batten Disease as China Stem Cells Give New Lease on Life to 6 Year Old California Boy

... rapidly and always ends in death sometime between ages 8 and 12. The typical early signs of this type of NCL are loss of muscle coordination known as ataxia and seizures, along with progressive mental deterioration. Blake has suffered all these symptoms in the past year. Batten Disease/NCL as a whole ...

Stem Cell Leader Beike Biotech and China's Tsinghua University Receive US$4 Million for Stem Cell Reprogramming Laboratory

... suffering from a range of debilitating illnesses, such as spinal cord injury, cerebral palsy, optic nerve hypoplasia, multiple sclerosis and ataxia stand to benefit from a new laboratory, established with a Chinese Government grant. Such a facility will put China at the forefront of the global ...
Ataxia in Biological Definition

Diabetes mellitus

... , hepatic steatosis (fatty liver), cystic fibrosis , several mitochondrial neuropathies and myopathies, myotonic dystrophy , Friedreich's ataxia , some of the inherited forms of neonatal hyperinsulinism and many others. Risk of diabetes is higher with chronic use of several medications, ...
Ataxia in Biological Dictionary

Cyanobacteria

... of the cyanobacteria are joined in threads that are surrounded by a ... Intoxication with cyanobacteria is characterized by convulsions, ataxia (in ... Cyanobacteria congregate on or near the water surface. ... Cyanobacteria (blue-green algae) Mitochondria and Chloroplasts. Properties ...
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