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Antisense in Medical News

Isis Pharmaceuticals to Present at Canaccord Adams' 29th Annual Global Growth Conference

... Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management ... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ... and cancer. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...

Isis Pharmaceuticals to Present at Jefferies' 3rd Annual Healthcare Conference

... Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management ... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ... and cancer. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...

Isis Pharmaceuticals to Present at Needham's 8th Annual Life Sciences Conference

... Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management ... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ... diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...

Isis Pharmaceuticals to Present at Goldman Sachs' 30th Annual Global Healthcare Conference

... Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management ... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ... diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...

Isis Highlights New Clinical Data on Anti-Cancer Antisense Drugs Featured at ASCO

... a variety of cancers. OGX-011 and OGX-427 are antisense drugs co-discovered by Isis and OncoGenex ... from a Phase 1 trial evaluating LY2181308, an antisense drug discovered by Isis and licensed to Eli Lilly ... to expand the scope of diseases we can treat with antisense drugs," said Brett Monia, Ph.D., Vice President ...

Scientists find shared genetic link between the dental disease periodontitis and heart attack

... is located in a genetic region that codes for an antisense DNA called ANRIL", said Dr. Schaefer, "and that ... messenger RNA, and will express a protein. antisense RNA is complementary to the mRNA, and is often ... RNA to form a duplex. Through this binding, the antisense strand inhibits the protein expression of the ...

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Antisense in Medical Technology

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

... the versatility and broad applicability of antisense drugs to inhibit targets that could offer new ... and the momentum to realize the full potential of antisense as a drug discovery technology," concluded Ms. ... Isis' partnered pipeline continues to mature as antisense drugs that Isis' satellite companies are ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... Inc. (Nasdaq: ISIS ) announced today that Isis' antisense drugs were highlighted with eight presentations ... that reducing levels of these targets with antisense drugs can significantly lower blood glucose ... Isis' anti-obesity drug discovery program showing antisense drugs reduced fat mass and body weight in animals ...

Isis and Collaborators Present New Research at the ATVB Annual Conference

... two late-stage research programs, one on a direct antisense inhibitor of apoC-III, which may provide a ... drug to lower triglycerides, and a second on an antisense inhibitor to Factor XI, which has the potential ... Isis and collaborators also presented data on antisense inhibitors against 11 beta-HSD1 and apoF, ...

Isis Announces That OGX-011 Has Shown Overall Survival Advantage in Prostate Cancer Compared to Standard Therapy in a Randomized Phase 2 Study

... "The progress our partners are making with antisense drugs discovered using Isis' antisense technology demonstrates the value of our ... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ...

ATL/TV1102 Trial Results Presented at World Congress on Treatment and Research in Multiple Sclerosis

... Calif., Sept. 22 /PRNewswire-FirstCall/ -- antisense Therapeutics Ltd. (ASX: ANP) and ... for the first time, that a second-generation antisense drug designed to specifically inhibit the ... Mark Diamond, Chief Executive Officer of antisense Therapeutics, said, "We are delighted to have our ...

Isis Initiates Clinical Trial of CRP Drug

... has initiated a Phase 1 study of ISIS 353512, an antisense drug that inhibits the production of C-reactive ... ISIS 353512 Targets CRP ISIS 353512 is an antisense drug that targets CRP. For many years, CRP has ... has successfully commercialized the world's first antisense drug and has 18 drugs in development. Isis' drug ...

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Antisense in Medical Dictionary

AIDS

... the body susceptible to many other disease s. Acute A sudden onset of symptoms or disease . Adenocarcinoma See Carcinoma . GEM 91: An antisense compound in Phase Ib/II clinical trials (91-006 and 91-007) for the treatment of HIV infection and AIDS . GEM 92: In development related to ...

Antibiotic

... called quinolone antibiotic s . OGX-011 A substance that is being studied as a treatment for cancer . It belongs to the family of drugs called antisense oligonucleotides. An antibiotic , such as tetracycline, will be prescribed. Do not discontinue medicine until healing is complete or when advised ...

Hiv infection

... . Rockville, MD: U.S. Department of Health and Human Services, Agency for Health Care Policy and Research, 1994. Huber, Jeffrey T. GEM 91: An antisense compound in Phase Ib/II clinical trials (91-006 and 91-007) for the treatment of HIV infection and AIDS . GEM 92: In development related to ...

Retinitis

... Psaume syndrome ; Papillon-Leage, E; Papillon-Lefevre syndrome ; Papillon, M; papillo retinitis ; ... Vitravene (fomivirsen sodium injectable) antisense drug for the treatment of AIDS -related cytomegalovirus (CMV) retinitis . Retinitis pigmentosis, a hereditary and degenerative eye ...
Antisense in Biological News

Newly discovered gene plays vital role in cancer

... that Wrap53 gives rise to a molecule, called antisense RNA, the presence of which is necessary for the ... The study is also one of the first to show how antisense RNA regulates genes in the human body. It is ... usually proteins on gene expression. With antisense regulation, control is effected instead through ...

UD researchers discover novel 'gene toggles' in world's top food crop

... long, these novel molecules, called natural antisense microRNAs (nat-miRNAs), target the genes sitting ... are a special type of microRNA that have an antisense configuration relative to their targets. It's an ... the unique new group of molecules called natural antisense microRNAs. When a gene is ready to produce a ...

Making sense of antisense microRNAs

... Eric Lai (MSKCC) and colleagues, both reveal that antisense transcription of the Hox miRNA locus, miR-iab-4, ... the opposite strand. Furthermore, the loss of the antisense miRNA causes subtle derepression of a hox gene ... mutant flies. The identification of additional antisense miRNAs in Drosophila and mammals suggests this as ...

ISU researchers find possible treatment for spinal muscular atrophy

... protein because of the presence of a specific intronic sequence in the gene or DNA. To make SMN2 behave as SMN1, Singh has introduced a small antisense oligonucleotide that blocks this specific intronic sequence. When the intronic sequence is blocked, SMN2 produces normal proteins and acts, in ...

A new gene silencing platform -- silence is golden

... Gene silencing molecules also have potential prophylactic and therapeutic applications based upon ongoing clinical trials using RNAi and traditional antisense approaches. For some genes that cause disease, these other approaches may not be effective enough and U1 Adaptors may provide a novel solution.' ...

Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy

... copy of the gene to include the missing piece. Dr. Krainer and his team sought to change the splicing by introducing synthetic molecules, called antisense oligonucleotides or ASOs, that precisely match various sections of the RNA. They reasoned that if these molecules stuck to the right part of the RNA, ...

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Antisense in Biological Technology

Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting

... Isis and its collaborators presented results on antisense inhibition of novel targets that could offer new ... also presented new preclinical data showing that antisense inhibition of STAT5 resulted in potent anti-tumor ... sigma RNA, a Marker for Carcinomas" showed that antisense inhibition of Malat-1 altered the splicing of ...

Isis Pharmaceuticals to Present at the 4th Annual Citi Biotech Day

... Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management ... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ... diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...

Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug

... ISIS-SGLT2Rx - Isis' first kidney-targeted antisense drug for type 2 diabetes enters clinical ... has initiated a Phase 1 study of ISIS-SGLT2Rx, an antisense drug that inhibits the production of sodium ... "ISIS-SGLT2Rx is among the most potent antisense drugs Isis has yet evaluated in preclinical ...

Aegera Therapeutics Initiates A Randomized Phase 2 Combination Study of AEG35156 for 1st Line Treatment of Non-Small Cell Lung Cancer

... Phase 2 study of AEG35156, their targeted antisense therapeutic in mid-stage development for multiple ... of the X-Linked Inhibitor of Apoptosis (XIAP) antisense AEG35156 Given In Combination With ... apoptotic triggers. AEG35156, a second generation antisense which targets XIAP, is designed to lower the ...

Aegera Therapeutics' phase 1/2 clinical trial results selected for oral presentation at 2008 ASH Annual Meeting

... from its phase 1/2 clinical trial of the XIAP antisense oligonucleotide, AEG35156, will be highlighted in ... is entitled "Phase I/II Trial of the XIAP antisense Oligonucleotide (AEG35156) in Combination with ... Study of Phase 1/2 Trial of the XIAP antisense Oligonucleotide (AEG35156) in Combination with ...

Isis Reports Financial Results and Highlights for Third Quarter of 2008

... because of the speed and productivity of our antisense drug discovery platform, which enables us ... million in sublicensing revenue from Alnylam and antisense Therapeutics Limited (ATL). Operating Expenses ... and initiated clinical studies on two exciting antisense drugs. We continue to make progress in every ...

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Antisense in Biological Products

Silencer Pre-designed siRNA, HPLC purified, annealed from Ambion

Description:... silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your ...
Company:Ambion

Silencer Pre-designed siRNA, standard purity from Ambion

Description:... silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your ...
Company:Ambion

Custom siRNA, PAGE purified from Ambion

Description:... silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your ...
Company:Ambion

Silencer Pre-designed siRNA, HPLC purified from Ambion

Description:... silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your ...
Company:Ambion

Custom siRNA, PAGE purified, annealed from Ambion

Description:... silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your ...
Company:Ambion

Antisense oligonucleotides from Thermo Scientific

Description:... to prevent enzymatic degradation and chain elongation.Lit: J.F.R. Ortigao, H. Rosch, H. Selter, A. Frohlich, A. Lorenz, M. Montenarh, and H. Seliger, antisense Res. & Dev., 1992, 2, 129-146 2-O-Methyl-RNA Oligos from 10 to 105 bases, purified by HPLC and MS-checked.The methyl residue at the 2-OH of the ...
Company:Thermo Scientific

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Antisense in Biological Definition

DNA

... nomenclature (5' and 3') 7.2 Sense and antisense 7.3 An exception: viruses 7.4 As viewed by ... strand is said to be descending. Sense and antisense As a result of their antiparallel arrangement ... or translatable, and they call its complement " antisense ". It follows then, somewhat paradoxically, that ...

Exon

... so that targeted exons are excluded from mature mRNA transcripts by blocking the access of splice-directing proteins to pre-mRNA using Morpholino antisense oligos. This has become a standard technique in developmental biology . See also Peptide External links and references Walter ...

Gene therapy

... supplement a defective mutant allele with a functional one. Although the technology is still in its infancy, it has been used with some success. antisense therapy is not strictly a form of gene therapy, but is often lumped together with them. Contents showTocToggle("show","hide") 1 ...

Reverse genetics

... relies on systems within the cell for efficacy (e.g. the dicer proteins, the RISC complex) a simple alternative for gene knockdown is Morpholino antisense oligos. While RNAi acts by directing cellular systems to degrade target messenger RNA (mRNA), Morpholinos bind and block access to the target mRNA ...
Antisense in Biological Dictionary

Sense strand

... the sense strand is complementary to the antisense strand or nonsense strand . The sense ... ... each fragment then separate — releasing the antisense strand . ... There is no need to invoke ... " sense " because it results in a gene ... the antisense strand so that it can bind to the ...

Non-coding strand

... ... anticoding strand definition. AKA: antisense strand , non - coding strand , template ... non - coding a) there are 15 bases ... antisense strand . Definition(s) The non - coding strand in double-stranded DNA. The antisense strand serves as the template for mRNA ...

Anti-sense strand

... Depending on the context within ... antisense RNA is single-stranded RNA that is complementary ... RNA (mRNA) strand transcribed within a cell. antisense RNA may be introduced into a cell to inhibit ...occurring... The second strand is called the antisense strand because its sequence of ... The two ...

Antisense strand

... is called the transcribed strand with antisense sequence and ... through sense- antisense strand pairing followed by target mRNA ... by ... The second strand is called the antisense strand because its sequence of ... The two ...

Antisense

... antisense molecules interact with complementary strands of nucleic acids, ... Enzyme-dependent antisense includes forms dependent on RNase H activity to ... antisense therapy is a form of treatment for genetic ...

Oligodeoxyribonucleotide

... of oligodeoxyribonucleotide –oligo spermine conjugates ... An antisense oligonucleotide phosphorothioate, previously shown to inhibit HIV-1 ... infected H9 cells, was fluorescently labeled to ... ... modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic ... ...

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