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Antibodies in Medical News

Micromet, Inc. Reports Second Quarter 2009 Financial Results

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... of preclinical data on EGFR-targeting BiTE antibodies as well as Micromet's BiTE antibody MT110, which ... in vivo and in vitro of EGFR-targeting BiTE antibodies against KRAS- and BRAF-mutated human colorectal ...

Anti-growth factor drugs raise hope and concern for treatment of children's eye diseases

... Calif., discusses issues related to the use of antibodies against vascular endothelial growth factor (VEGF) in pediatric ophthalmology. The two anti-VEGF antibodies available so farbevacizumab and ranibizumabhave ... cause of vision loss in older adults. The antibodies work by blocking the development of new blood ...

Bcl6 gene sculpts helper T cell to boost antibody production

... that fuels rapid growth and diversification of antibodies in a cellular structure implicated in autoimmune ... the B cells expand and produce a large volume of antibodies to destroy an intruder. Tfh cells are ... said. "These mutations also allow production of antibodies with stronger affinity for their target ...

Tips from the journals of the American Society for Microbiology

... deadly form of skin cancer, in mice by eliciting antibodies that target a gastrin-releasing peptide which is ... cell production and tumor formation. Anti-GRP antibodies have displayed promising antitumoral activity and ... injections induced high levels of specific antibodies against GRP as well as suppressed the growth of ...

QuikByte Software, Inc. and Sorrento Therapeutics, Inc. Announce Merger Agreement

... into the growing pharmaceutical field of human antibodies with an experienced team led by Drs. Schuh and ... for the generation of fully human monoclonal antibodies based on its proprietary technology. Sorrento ... provider and developer of fully human monoclonal antibodies for research, diagnostic and therapeutic use. ...

Peregrine Pharmaceuticals Reports Financial Results for Fiscal Year 2009

... us to expand the evaluation of our anti-PS antibodies as potential broad spectrum agents for the ... contract to assess bavituximab and other anti-PS antibodies for biodefense applications against viral ... broad claims covering anti-viral applications of antibodies that directly bind to aminophospholipids, ...

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Antibodies in Medical Technology

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... Its product development pipeline includes novel antibodies generated with its proprietary BiTE(R) antibody ...

Micromet Presents Update on Blinatumomab's Response Rate and Duration in a Phase 1 Study in Non-Hodgkin's Lymphoma Patients

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... Its product development pipeline includes novel antibodies generated with its proprietary BiTE(R) antibody ...

Affitech-Discovered Anti-PS Antibodies in Development by Peregrine Pharmaceuticals Show Excellent Functionality in Preclinical Studies

... on two fully human anti-PS (phosphatidylserine) antibodies were presented by its collaboration partner ... that the anti-tumor effects observed with anti-PS antibodies reflect their immunomodulatory mechanism of ... in a preclinical model of prostate cancer. Both antibodies were isolated using Affitech's unique MBAS ...

Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... data presented at AACR demonstrated that BiTE antibodies developed from the EGFR-specific monoclonal antibodies Erbitux(R) (cetuximab) and Vectibix(R) ...

Data Presented at AACR Annual Meeting Show Anti-Tumor Activity of Peregrine's Fully Human Anti-PS Antibody in Prostate Cancer Model

... Anti-Tumor Potential of Fully Human Anti-PS antibodies and Expand the Company's PS-Targeting Platform- ... biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and serious virus ... its fully human phosphatidylserine (PS)-targeting antibodies demonstrated encouraging signs of efficacy in a ...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... data indicate that after Micromet developed BiTE antibodies from the EGFR-specific monoclonal antibodies Erbitux(R) (cetuximab) and Vectibix(R) ...

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Antibodies in Medical Products

Infectious Mono - Rapid Test

Description:... in vitro assay for detection of heterophile antibodies associated with infectious mononucleosis ... diagnosis of IM is based on detection of serum antibodies associated with the infection, such as the heterophile antibodies present in the sera of IM ....
Company:Bio-Quant, Inc.

Sm/RNP Anti-Extractable Nuclear Antigen (ENA) Antibodies Kit

Description:... assays for the detection and quantitation of IgG antibodies to extractable nuclear antigens (ENA)RNP, Sm in human serum. antibodies to Sm aid in the diagnosis of systemic lupus erythematosus (SLE). RNP antibodies aid in the diagnosis of mixed connective tissue ...
Company:IMMCO Diagnostics

Iso-Insulin ELISA

Description:... direct sandwich technique in which two monoclonal antibodies are directed against separate antigenic ... react with peroxidase-conjugated anti-insulin antibodies and anti-insulin antibodies bound to microtitration ....
Company:IDS Ltd

Viroclear ToRCH

Description:... assurance reagent in assays detecting IgG and IgM antibodies to Toxoplasma gondii (TOXO IgG and TOXO IgM), IgG and IgM antibodies to rubella virus (rubella IgG and rubella IgM), IgG and IgM antibodies to cytomegalovirus (CMV IgG and IgM), and IgG and ...
Company:Blackhawk BioSystems, Inc.

Virotrol® ToRCH-M

Description:... assurance reagent in assays detecting IgG and IgM antibodies to Toxoplasma gondii (TOXO IgG and TOXO IgM), IgG and IgM antibodies to rubella virus (rubella IgG and rubella IgM), IgG and IgM antibodies to cytomegalovirus (CMV IgG and CMV IgM), and ...
Company:Blackhawk BioSystems, Inc.

Viroclear® ToRCH

Description:... assurance reagent in assays detecting IgG and IgM antibodies to Toxoplasma gondii (TOXO IgG and TOXO IgM), IgG and IgM antibodies to rubella virus (rubella IgG and rubella IgM), IgG and IgM antibodies to cytomegalovirus (CMV IgG and IgM), and IgG and ...
Company:Blackhawk BioSystems, Inc.

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Antibodies in Medical Definition

Artificial induction of immunity

... immune system to recognize the toxin and produce antibodies against it. However, heating the tetanus toxin ... externally produced immune molecules, known as antibodies or immunoglobulins . This was first performed ... the fraction of the blood which contains antibodies (known as the serum ), and injecting this serum ...

Heterophile

... United States. Medical Heterophile antibodies are antibodies induced by external antigens (Heterophile ... cross-react with self-antigens. For example antibodies against Group A Streptococcus cell walls can also ...

Central tolerance

... • Complement system ( Classical , Alternative , Lectin , Anaphylatoxins ) • Cytokines • White blood cells • Antibody ( Monoclonal antibodies , Autoantibody ) • Antigen • APC • MHC Immunity • Autoimmunity • Tolerance ( Central ) • Immunodeficiency Phagocyte • ...

Hematopathology

... , T cell lymphomas , and NK cell lymphomas . The hematopathologist uses immunohistochemistry and flow cytometry , techniques using antibodies to specific lymphocyte surface markers , to determine the type of lymphoma in the pathology specimen . Notes ^ Jaffe, ES, ...
Antibodies in Medical Dictionary

Allergy

... or dust, by producing specific protein s called antibodies that are capable of binding to identifying ... symptoms is a true allergic reaction (involving antibodies and histamine release). Allergy FAQs ... that are characterized by the production of antibodies that react with host tissue s or immune ...

Antibody

... Antibody screening tests are done to detect antibodies against red blood cells. antibodies are protein s produced by the immune system . Normally, antibodies bind to foreign substances, such as bacteria ...

Antigen

... resulting virus es cannot be inhibited well by antibodies against previous strains making it easier for ... that causes your immune system to produce antibodies against it. HLA antigen s are the major ... or stimulates the immune system to produce antibodies (ie, protein s that fight antigen s). Antigen ...

Autoimmune disease

... abnormal conditions caused when the body produces antibodies to its own substances. Autoimmune disease s ... immune system reacts against itself and produces antibodies to attack its own healthy cells and tissue . ... allergy , Self- Allergy The condition in which antibodies are produced against the body's own tissue s. An ...

Autoimmune Diseases

... immune system reacts against itself and produces antibodies to attack its own healthy cells and tissue . ... allergy , Self- Allergy The condition in which antibodies are produced against the body's own tissue s. An ... it creates protein -like substances called antibodies and immunoglobulin s to protect the body against ...

ELISA

... immunoassay (EIA) to determine the presence of antibodies to HIV in the blood or oral fluids. ELISA ... test Diagnostic test detects the presence of antibodies associated with Wegener granulomatosis. Hycor ... Lyme disease is the ELISA test. It detects antibodies to B. burgdorferi, the bacterium that causes ...

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Antibodies in Biological News

New cancer drug delivery system is effective and reversible

... cancer drug into the cell. Developing such antibodies is costly and time-consuming, however, and the ... them to liposomes is difficult to control. antibodies spur an immune response, requiring extra steps to ... agents, but those now in use are not as good as antibodies at binding to cancer cells. To solve the ...

Penn-Wistar team gains insight into HIV vaccine failure

... had previous immunity in the form of neutralizing antibodies to the adenovirus 5 (Ad5) vector used to deliver ... immune gatekeeper in most vaccine strategies. antibodies produced in response to previous infection ... to indicate that pre-existing neutralizing antibodies correlated with numbers of activated CD4 T-cells ...

LSUHSC's Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia

... National Institutes of Health to study whether antibodies that recognize carbohydrate (sugars) and proteins ... research by Dr. Kolls found that carbohydrate antibodies are part of the natural response to the ... Theses preliminary studies show that these antibodies participate in early clearance of the organism ...

UT scientist receives hemophilia research award

... resistant to replacement Factor VIII and produce antibodies that attack the synthetic protein. "Current therapies to treat these antibodies are expensive and often unsuccessful," Smith ... trigger the production of the anti-Factor VIII antibodies in people with Hemophilia A, which in turn would ...

Major breakthrough in early detection and prevention of AMD

... in the living eyes of mice by attaching anti-CCR3 antibodies to tiny semiconductor nanocrystals called "quantum dots" and injecting these into the mice. The antibodies cause the quantum dots to attach to CCR3 on the ... blood vessels in the eye. Thus the same anti-CCR3 antibodies used to detect CNV could potentially be useful as ...

Princeton team's analysis of flu virus could lead to better vaccines

... naturally produced defensive proteins called antibodies that fight infection. By manipulating this ... a human, the body mounts a defense, producing antibodies custom-designed to attach themselves to the ... noticed a perplexing pattern. He found that antibodies were often better at protecting against a ...

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Antibodies in Biological Technology

Micromet Closes $80.5 Million Public Offering of Common Stock

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... Its product development pipeline includes novel antibodies generated with its proprietary BiTE(R) antibody ...

Biotech Hot in July Driven by Positive Drug Data and Acquisitions

... cancers. Bristol also gains rights to seven antibodies in clinical trials under Medarex's sole sponsorship and three other antibodies being co-developed with other partners, and ... by Medarex - in particular, monoclonal antibodies focused in oncology and immunology. It ...

Micromet Receives European Orphan Drug Designation for Treatment of Acute Lymphoblastic Leukemia with BiTE Antibody Blinatumomab

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... Its product development pipeline includes novel antibodies generated with its proprietary BiTE(R) antibody ...

Micromet Announces Pricing of Public Offering of Common Stock

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... Its product development pipeline includes novel antibodies generated with its proprietary BiTE(R) antibody ...

Debiopharm and MSM Protein Technologies Sign Agreement for Research and Development of Debio 0929, a Novel Oncology Biologic

... and MSM haveformed a partnership to select antibodies against the GPCR. Upon completion of ... and their expertise in the generation of antibodies aimed at GPCRs," said Rolland-Yves Mauvernay, ... Boston, MA. MSM is the leader in the discovery of antibodies targeting multispanning membrane proteins. The ...

Micromet Announces Public Offering of Common Stock

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... Its product development pipeline includes novel antibodies generated with its proprietary BiTE(R) antibody ...

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Antibodies in Biological Products

Immunochemistry 1 from Promega

Description:... production of high-quality antibodies, the use of antibodies in immunoassays, the standardisation of antibodies and antigens, the latest ELISA techniques ... immunoassays, the incorporation of antibodies and their fragments into immunotoxins and the use ...
Company:Promega

Polyclonal Antibody Production from Agro-Bio

Description:... in time, quantity of antigen and quality of the antibodies obtained. We recommend the use of 2 animals per ... In most cases high titer polyclonal chicken antibodies can be obtained in one month immunization ... in time, quantity of antigen and quality of the antibodies obtained. The average serum yield on a 77-day ...
Company:Agro-Bio

Anti-Rat HRP-DAB Cell & Tissue Staining Kit from R&D Systems

Description:... These kits may be used with primary IgG antibodies manufactured by either R&D Systems or by other ... of the Avidin-Biotin Complex (ABC) with primary antibodies that reacted with tissue antigens under study. ... by using high quality Secondary Biotinylated antibodies and High Sensitivity Streptavidin conjugated to ...
Company:R&D Systems

Anti-Rat HRP-AEC Cell & Tissue Staining Kit from R&D Systems

Description:... These kits may be used with primary IgG antibodies manufactured by either R&D Systems or by other ... of the Avidin-Biotin Complex (ABC) with primary antibodies that reacted with tissue antigens under study. ... by using high quality Secondary Biotinylated antibodies and High Sensitivity Streptavidin conjugated to ...
Company:R&D Systems

PicTure - Double Staining Kit from Invitrogen

Description:... can be identified using two different primary antibodies from mouse (or rat) and rabbit (or guinea pig) ... mouse (or rat) and rabbit (or guinea pig) primary antibodies to be applied simultaneously on tissue ... multiple enzymes and Fab fragments of second antibodies to provide excellent sensitivity. In addition, ...
Company:Invitrogen

Custom Antibody Production Services from Aves Labs, Inc.

Description:... and immune eggs, and express-mail these antibodies to you. This standard protocol typically takes ... 90% pure IgY. Unless otherwise requested, your antibodies are in phosphate buffered isotonic saline (PBS) ... your specifications and your timetable. These antibodies can be made against recombinant proteins, ...
Company:Aves Labs, Inc.

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Antibodies in Biological Definition

Affinity chromatography

... for the procedure is the affinity purification of antibodies from blood serum. If serum is known to contain antibodies against a specific antigen (for example if the ... against a GST-fusion protein it will produce antibodies against the fusion-protein, and ...

Antibody

... it mediates different physiological effects of antibodies ( opsonization , cell lysis , mast cell, ... often neglected.) Other immune cells partner with antibodies to eliminate pathogens depending on which IgG, ... receptors it can express on its surface. The antibodies a single B lymphocyte produces can differ in ...

B cell

... types of B cells: Plasma B cells secrete antibodies which effect the destruction of antigens by ... specific. Humoral immunity (the creation of antibodies that circulate in blood plasma and lymph ) ... how B cells create the enormous diversity of antibodies from only a few genes. See also T ...

Molecular biology

... Main article: Western blot antibodies to most proteins can be created by injecting ... such as a mouse, rabbit, sheep, or donkey. These antibodies can be used for a variety of analytical and ... can then be probed with solutions of antibodies. antibodies that specifically bind to the protein of interest ...

Monoclonal antibody

... Monoclonal antibodies ( mAb ) are antibodies that are identical because they were produced by ... substance, it is possible to create monoclonal antibodies that specifically bind to that substance; they ...

Blood type

... types along with their respective antigens and antibodies : Individuals with type A blood have red ... cells with antigen A on their surface and produce antibodies against antigen B in their blood serum. Using the ... arrangement, antigen B on the cell and produce antibodies to substance A in their serum. Type AB people ...

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Antibodies in Biological Dictionary

Western blotting

... test for HIV exposure that identifies antibodies to HIV proteins and ... The western blot ... in a ... Some high affinity monoclonal antibodies can also be used for Western blots . ... ... Weight Standards ... Isotype-Specific Secondary antibodies for Western Blotting ... If you think you ...

Western blot

... test for HIV exposure that identifies antibodies to HIV proteins and ... The western blot ... Weight Standards ... Isotype-Specific Secondary antibodies for Western Blotting ... Misc. Western ... us • Ubiquitination Antibody • Western Blot antibodies • Acetylation ... ...

Sequential Epitope

... epitope is an epitope that is recognized by antibodies by its linear sequence of amino acids, or primary structure. In contrast, most antibodies recognize a conformational epitope that has a ... epitope is an epitope that is recognized by antibodies ... ... La/SSB epitope anchored to ...

Polyclonal Antibody

... Polyclonal antibodies (or antisera) are antibodies that are derived from different B cell lines. ... recognizing a different epitope. Polyclonal antibodies This article deals exclusively with the ...

Polyclonal antibodies

... Polyclonal antibodies (or antisera) are antibodies that are derived from different B cell lines. ... custom antibody production, polyclonal antibodies and immunochemistry services ... Polyclonal ...

Monoclonal Antibody

... Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are identical because they are produced by ... antibody therapy is the use of monoclonal antibodies (or mAb) to specifically target cells. The main ...

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