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Androgens in Medical News

Androgen Production Continues in Prostate Cancer Tumors

... a critically important reason behind why those androgens are there -- the discovery that the gene pathways for synthesizing androgens from cholesterol appear to be present in the ... start honing in on the specific source of those androgens and how we can eliminate them," Mostaghel said. ...

How advanced prostate cancer becomes resistant to androgen-deprivation therapy

... So far weve targeted systemic, or circulating, androgens in men with advanced prostate cancer, Mostaghel ... a critically important reason behind why those androgens are there the discovery that the gene pathways for synthesizing androgens from cholesterol appear to be present in the ...

New research may show why some prostate cancer recurs after treatment

... to stop the production of testosterone and other androgens that fuel cancer cell growth. New research has ... treatments that could block the development of androgens in the cancer cells. The study, funded by the ... have the ability to adapt and produce their own androgens that permit these cancer cells to survive, ...

Standard treatment for prostate cancer may encourage spread of disease

... he says. Speculating that depriving cells of androgens might also, however, affect nestin expression, ... on a prostate cancer cell line that depends on androgens to grow. When they removed androgens from the chemical mixture that the cells live in, ...

Hormonal Therapies Offer Effective Solutions for Many Adult Women With Acne

... thereby contributing to the formation of acne lesions. For example, when androgens (the male hormones present in both men and women) over-stimulate the oil ... The estrogen component decreases the production of testosterone and other androgens by the ovaries and decreases the amount of active testosterone in the ....

Why prostate cancer patients fail hormone deprivation therapy

... continually receiving androgensturning on at least 20 genes that rely on androgens for activationeven though no androgens were present. The results suggest that hormone therapy might encourage ...

Radiation Plus Hormone Therapy Cuts Prostate Cancer Deaths

... randomly assigned to receive either the drug flutamide (Eulexin), to block androgens (male hormones), or hormone therapy along with radiation. androgens are thought to encourage the spread of prostate cancer, so blocking their ...

Scientists discover key event in prostate cancer progression

... journal Cell , focuses on androgen receptors, molecules located in the nucleus of cells of the prostate gland and other tissues. Male sex hormones androgens bind with these receptors to activate genes that control cell growth. The researchers show that in androgen-independent prostate cancer, androgen ...

Changing Paradigms in Hereditary Angioedema: A Focus on Timely Diagnosis and New Therapies

... HAE causes recurrent attacks of intense localized edema involving the skin, airway, and visceral organs. While chronic therapy with attenuated androgens or plasmin inhibitors has been the mainstay of HAE therapy, many new therapies for prophylaxis and acute treatment are on the horizon. It is ...

Prostate screening studies reviewed in European Urology July issue

... Prostate Cancer: Revisiting Old Paradigms" by H. Isbarn et al. The notion that pathologic prostate growth, benign or malignant, can be stimulated by androgens is a commonly held beliefbut one without scientific basis. In the article, Dr. Isbarn writes that, "We therefore conducted a Medline search to ...

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Androgens in Medical Technology

Research Explains How Advanced Prostate Cancer Becomes Resistant to Androgen-Deprivation Therapy

... "So far we've targeted systemic, or circulating, androgens in men with advanced prostate cancer," Mostaghel ... a critically important reason behind why those androgens are there -- the discovery that the gene pathways for synthesizing androgens from cholesterol appear to be present in the ...

Neurocrine Biosciences Presents Elagolix Data

... that transient inhibition of plasma testosterone and intra-prostatic androgens results in the reduction of prostate weight, a reduction in epithelial ... preclinical results are replicated in men, daily transient inhibition of androgens with a GnRH antagonist may constitute a new paradigm for the treatment of ...

Changing Paradigms in Hereditary Angioedema: A Focus on Prompt Diagnosis and New Therapies

... the skin, airway, and visceral organs. Left untreated, most patients will suffer at least one acute attack per month. Chronic therapy with attenuated androgens or plasmin inhibitors has been the mainstay of therapy. However, many new therapies are on the horizon, offering hope to thousands who suffer from ...

AndroScience Corporation Announces Phase 2a Study Results on ASC-J9(TM) for the Treatment of Acne

... Through enhancing androgen receptor protein degradation, ASC-J9(TM) represents the first topical agent directed at modulating the effect of androgens (male hormones), through the androgen receptor, a key causative factor in the pathogenesis of acne. Charles Shih, Ph.D., Chief Executive Officer ...

BN ImmunoTherapeutics Announces Positive Mature Phase II Results From Newly Acquired Prostate Cancer Vaccine

... growth by stopping or blocking testosterone from entering the cancer cells. Prostate cancer cells are typically dependent on testosterone or other androgens as growth factors. Thus, although initially effective, hormone therapy becomes ineffective after a period of time. Chemotherapy for disseminated ...

Bavarian Nordic Announces Positive Mature Phase II Results From Newly Acquired Prostate Cancer Vaccine

... growth by stopping or blocking testosterone from entering the cancer cells. Prostate cancer cells are typically dependent on testosterone or other androgens as growth factors. Thus, although initially effective, hormone therapy becomes ineffective after a period of time. Chemotherapy for disseminated ...

Preventing Prostate Cancer and BPH: Prostate-Health Expert Available (National Men's Health Week Is June 9-15)

... which increase the activity of enzymes that can both detoxify cancer-promoting compounds and decrease the concentration of active androgens (steroid hormones) in the prostate. -- Dietary supplementation with selenium and vitamin E may significantly reduce the risk of prostate ...

Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ASCO Annual Meeting

... Oral Dosing of an Irreversible CYP17 Inhibitor, Abiraterone, in Castration-Resistant Prostate Cancer Patients Incorporating the Evaluation of androgens and Steroid Metabolites in Plasma and Tumor and the Study of Circulating Tumor Cells The Phase I/II trial of CB7630 was conducted at The Institute ...
Androgens in Medical Products

Androstanediol Glucuronide RIA Test

Description:... e.g. idiopathic hirsutism and polycystic ovary disease. Serum 3alpha-diol G may be elevated in the presence of normal levels of other circulating androgens [1,5,6]. Therefore, measurement of serum 3alpha-diol G levels may be useful in the clinical evaluation and management of hirsutism and other ...
Company:Diagnostic Systems Laboratories, Inc.

Androstanediol Glucuronide EIA Test

Description:... e.g. idiopathic hirsutism and polycystic ovary disease. Serum 3alpha-diol G may be elevated in the presence of normal levels of other circulating androgens [1,5,6]. Therefore, measurement of serum 3alpha-diol G levels may be useful in the clinical evaluation and management of hirsutism and other ...
Company:Diagnostic Systems Laboratories, Inc.

DHEA RIA Test

Description:... as circulating DHEA levels may be several-fold higher than testosterone concentrations, and rapid peripheral tissue conversion to more potent androgens (androstenedione and testosterone) and estrogens may occur. In addition, DHEA has a relatively low affinity for sex-hormone binding globulin. DHEA is ...
Company:Diagnostic Systems Laboratories, Inc.

DHEA EIA Test

Description:... as circulating DHEA levels may be several-fold higher than testosterone concentrations, and rapid peripheral tissue conversion to more potent androgens (androstenedione and testosterone) and estrogens may occur. In addition, DHEA has a relatively low affinity for sex-hormone binding globulin. DHEA is ...
Company:Diagnostic Systems Laboratories, Inc.

Free Testosterone RIA Test

Description:... DC & Wall SR. J Clin Endocrinol Metab 61:873-876, 1985. Westphal U. Steroid-Protein Interactions. Springer-Verlag, Berlin, 1986 Pugeat M, et al.: androgens in polycystic ovarian syndrome. IN Tolis G, Bringer J, Chrousos GP (eds): Intraovarian regulators and polycystic ovarian syndrome. NY Academy of ...
Company:Diagnostic Systems Laboratories, Inc.

Testosterone RIA Test

Description:... Testosterone, (17-Hydroxy-4-androstene-3-one), a C19 steroid, is one of the most potent naturally secreted androgens [1]. In postpubertal males, testosterone is secreted primarily by the testes with only a small amount derived from peripheral conversion of ...
Company:Diagnostic Systems Laboratories, Inc.

LH ELISA Test

Description:... luteum formation and stimulation of ovarian progesterone synthesis. During ovarian follicular growth, LH acts to stimulate theca cell production of androgens which are aromatized to estrogens in the granulosa cells. In the late follicular phase, the increased amounts of estrogen exert positive feedback on ...
Company:Diagnostic Systems Laboratories, Inc.

LH IRMA Test

Description:... luteum formation and stimulation of ovarian progesterone synthesis. During ovarian follicular growth, LH acts to stimulate theca cell production of androgens which are aromatized to estrogens in the granulosa cells. In the late follicular phase, the increased amounts of estrogen exert positive feedback on ...
Company:Diagnostic Systems Laboratories, Inc.

Testosterone EIA Test

Description:... Testosterone, (17-Hydroxy-4-androstene-3-one), a C19 steroid, is one of the most potent naturally secreted androgens [1]. In postpubertal males, testosterone is secreted primarily by the testes with only a small amount derived from peripheral conversion of ...
Company:Diagnostic Systems Laboratories, Inc.

Free Testosterone EIA Test

Description:... Wall SR. J Clin Endocrinol Metab 61:873-876, 1985. Westphal U. Steroid-Protein Interactions. Springer-Verlag, Berlin, 1986 Pugeat M, et al.: androgens in polycystic ovarian syndrome. IN Tolis G, Bringer J, Chrousos GP (eds): Intraovarian regulators and polycystic ovarian syndrome. NY Academy of ...
Company:Diagnostic Systems Laboratories, Inc.

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Androgens in Biological News

HWI scientist first in world to unravel structure of key breast cancer target enzyme

... Estrogen is a female sex hormone and androgens are the male sex hormones. Regardless of gender, everyone has some percentage of both estrogens and androgens in their bodies. Each of the enzymes discussed ... chemical mechanism involved in the conversion of androgens to estrogens. He also will be working with ...

BioScience tip sheet, December 2008

... and Men (and Mosquitofish): Antiandrogens and androgens in the Environment. Andrew K. Hotchkiss, Gerald ... Jensen, Dalma Martinovic, and Leon E. Gray Jr. androgens are hormones essential to the formation of the ... reproductive tract in vertebrates. Environmental androgens have caused adverse effects in several fish ...

New prostate cancer research findings

... use of therapies designed to stop the production of testosterone and other androgens that fuel cancer cell growth. New research has now detected that ... directions for research into treatments to block the development of these androgens in cancer cells. (Embargoed until 6:00pm EDT October 11th) WHO: The ...

New medications show promise in treating drug-resistant prostate cancer

... new cases of prostate cancer are diagnosed each year in the United States. The male hormones testosterone and dihydrotestosterone -- also known as androgens -- spur the growth of prostate cells, and drugs that block the receptors for these hormones are the most common treatment for the disease in its ...

Sex hormones link to heart risk

... disease such as stroke or myocardial infarction". "We examined associations of circulating estrogens (estradiol and estrone) as well as androgens (testosterone and androstenedione) with major cardiovascular risk factors (lipids, blood pressure, body mass) in 933 young (median age 19 years), ...

Monitoring poisons in the environment -- a woolly matter

... of the sheep ?values for wool concentration of both lead and copper were significantly higher in male sheep, which has been linked to the effect of androgens on metabolism. Dr Sneddon comments, "Sheep wool evidently has potential as a bio-indicator of naturally occurring heavy metal concentrations in ...

Spike in testicular cancer is focus

... information on various major suspected risk factors, such as past medical history, history of hernia, venereal diseases, and any medication with androgens and other hormones. They will also examine lifetime occupational history, tobacco smoking, alcohol consumption and dietary information. “Recent ...

Sex chromosome genes influence aggression andmaternal behavior, say UVa researchers

... gene Sry on the male Y chromosome from other sex chromosome genes. The presence of Sry leads to the development of the testes and high levels of androgens in males, which is partly responsible for aggression. Sry was deleted from the Y chromosome and replaced by a transgenic copy. In their ...

Macrophage signaling may affect hormone resistance in prostate tumors

... cancer, according to a new study by researchers at the University of California, San Diego (UCSD) School of Medicine. Male hormones called androgens are essential for the physiological function and growth of the prostate gland, and anti-androgen treatment, which blocks the expression of androgen ...

Hyena mothers give their cubs a helpful dose of hormones

... State University's Kay Holekamp, together with her colleagues, spent almost 10 years sampling androgen levels from free-ranging hyenas in Kenya. androgens are hormones, such as testosterone, that control development of typically masculine characteristics like aggression, muscle development and sexual ...

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Androgens in Biological Technology

Follica Raises $5.5 M To Advance New Treatment for Androgenetic Alopecia Into the Clinic

... 4 /PRNewswire/ -- Follica Inc., a privately held developer of a novel therapy for androgenetic alopecia (male and female pattern hair loss caused by androgens in genetically susceptible men and women) and other hair follicle disorders, today announced a $5.5 million Series A financing round. Interwest ...
Androgens in Biological Definition

Hormone

... hormone (TRH) Steroid hormones : Glucocorticoids cortisol Mineralocorticoids aldosterone Sex steroids androgens testosterone dehydroepiandrosterone (DHEA) dehydroepiandrosterone sulfate (DHEAS) androstenedione dihydrotestosterone (DHT) ...
Androgens in Biological Dictionary

Androgens

... by binding to ... Information about androgens , male sex hormone androgen ... Bioidentical androgens Used to Enhance Performance and Risks Associated ... androgens excess in women may cause hyperandrogenic ...

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