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Androgen in Medical News

Scientists discover key event in prostate cancer progression

... 24, 2009, issue of the journal Cell , focuses on androgen receptors, molecules located in the nucleus of ... that in androgen-independent prostate cancer, androgen receptors are reprogrammed to regulate a group of ... "Some late-phase prostate cancer does not require androgen hormones for tumor growth, but it does ...

UT Southwestern researcher named HHMI Early Career Physician-Scientist

... of cancer death in men becomes resistant to androgen deprivation therapy. The most well-known androgen is the male sex hormone testosterone. Although prostate cancer initially responds to androgen withdrawal, these tumors eventually become ...

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

... Ga. A protein that helps regulate expression of androgen receptors could prove a new focal point for ... cells while expression of testosterone-fed androgen receptors is higher, they report in Proceedings ... this week. "An increase in the number of androgen receptors is believed responsible for prostate ...

Prostate cancer therapy increases risk of fractures and cardiovascular-related death

... that decrease testosterone levelscalled androgen deprivation therapy (ADT)are important and ... mortality are low among men treated with androgen deprivation therapy, preventive treatments may ... risk of these serious adverse outcomes related to androgen deprivation therapy," the authors wrote. They ...

Drug shows activity in men with advanced prostate cancer

... tumor growth. Many of these drugs disrupt the androgen (male hormone) receptor, which helps regulate ... that CRPC cells have increased expression of the androgen receptor and that overexpression of this receptor ... mouse models engineered to highly express the androgen receptor, mimic progression to ...

A potential new target for treatment of hormone refractory prostate cancer

... new study identifies a protein that modifies the androgen receptor (AR) and influences its ability to ... recurrent cancers, which no longer respond to androgen blockade and are resistant to current therapy." ... prostate cancer tissues that do not respond to androgen ablation and is required for prostate tumor ...

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Androgen in Medical Technology

Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

... 1-2 trial evaluating MDV3100, a next-generation androgen receptor antagonist, in castration-resistant ... contrast to those achieved with first-generation androgen receptor antagonists." In vitro data ... mechanism of action is unlike that of the leading androgen receptor antagonist, bicalutamide. Specifically, ...

Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy

... investigate the use of degarelix for intermittent androgen deprivation therapy (IADT) in patients with ... The study will compare IADT to continuous androgen deprivation therapy (ADT) for 14 months with ... measured by PSA suppression. "Intermittent androgen deprivation therapy is a commonly employed ...

AndroScience Corporation Announces Phase 2a Study Results on ASC-J9(TM) for the Treatment of Acne

... and commercialization. Through enhancing androgen receptor protein degradation, ASC-J9(TM) ... effect of androgens (male hormones), through the androgen receptor, a key causative factor in the ... mechanism of action, which selectively enhances androgen receptor degradation (ARD) to ...

Medivation Completes Enrollment of Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients

... a poor prognosis. Overexpression of the androgen receptor is believed to contribute to ... cancer. MDV3100 is a novel small-molecule androgen receptor antagonist that inhibits androgen receptor function by blocking nuclear ...

Radius Selects First Preclinical Candidate From SARM Discovery Program for the Treatment of Muscle Loss and Other Musculoskeletal Conditions

... from its internal nonsteroidal selective androgen receptor modulator ("SARM") discovery program, ... trials in 2009." About SARMs Selective androgen receptor modulators (SARMs) are a novel class ... androgen receptors to promote or inhibit specific androgen action in different tissues. SARMs have the ...

Research Explains How Advanced Prostate Cancer Becomes Resistant to Androgen-Deprivation Therapy

... Findings suggest androgen production occurs within metastatic prostate ... found that despite the suppression of circulating androgen levels to very low or castrate levels, metastatic ... prostate tissue in men with normal circulating androgen levels (collected at the time of ...

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Androgen in Medical Products

DHEA RIA Test

Description:... children and in adult women, DHEA is an important androgen as circulating DHEA levels may be several-fold ... of serum DHEA is a useful marker of adrenal androgen synthesis. Abnormally low levels may occur in ... of DHEA levels may aid in the localization of androgen source in virilizing conditions. Dorfman RI, ...
Company:Diagnostic Systems Laboratories, Inc.

DHEA EIA Test

Description:... children and in adult women, DHEA is an important androgen as circulating DHEA levels may be several-fold ... of serum DHEA is a useful marker of adrenal androgen synthesis. Abnormally low levels may occur in ... of DHEA levels may aid in the localization of androgen source in virilizing conditions. Dorfman RI, ...
Company:Diagnostic Systems Laboratories, Inc.

Testosterone RIA Test

Description:... elevated testosterone levels are found in precocious puberty [7] and in androgen receptor defects [5]. In adult males, low testosterone levels are ... J. Cin Endocrinol Metab 61: 873-876, 1985. Griffin JE & Wilson JD, The androgen resistance syndroms: 5alpha-reductase deficiency, testicular feminization, ...
Company:Diagnostic Systems Laboratories, Inc.

DHT RIA Test

Description:... 5a-Dihydrotestosterone (DHT) is a potent naturally occurring androgen produced from testosterone through the action of cholestenone 5a-reductase ... DHT exerts its biological action by intracellular binding to the androgen receptor; and this complex is then transferred to the nucleus where ...
Company:Diagnostic Systems Laboratories, Inc.

DHEA-S-7 RIA Test

Description:... [2]. Measurement of serum DHEA-S is a useful marker of adrenal androgen synthesis. Abnormally low levels may occur in have been reported in ... by the gonads, measurement of DHEA-S levels may aid in the localization of androgen source in virilizing conditions [2,3]. Dorfman RI, Shipley RA: ...
Company:Diagnostic Systems Laboratories, Inc.

DHEA-S-7 EIA Test

Description:... [2]. Measurement of serum DHEA-S is a useful marker of adrenal androgen synthesis. Abnormally low levels may occur in have been reported in ... by the gonads, measurement of DHEA-S levels may aid in the localization of androgen source in virilizing conditions [2,3]. Dorfman RI, Shipley RA: ...
Company:Diagnostic Systems Laboratories, Inc.

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Androgen in Medical Definition

Pathology

... - Precocious puberty Other Autoimmune polyendocrine syndrome - Carcinoid syndrome - Laron syndrome - Psychogenic dwarfism - androgen insensitivity syndrome - Progeria v • d • e Nutritional pathology ( E40-68 ) Malnutrition ...
Androgen in Medical Dictionary

Alopecia

... Totalis - Front View of the Head ... androgen IC ALOPECIA - Hair loss in women that may be associated with aging , hormone s ( androgen s), or genetic predisposition. The pattern of ... For the treatment of male pattern hair loss ( androgen etic alopecia ) on the vertex and the anterior ...

Androgen

... androgen suppression: Treatment designed to suppress or block the production of male hormone s. androgen suppression can be achieved by surgical removal ... by taking other drugs called antiandrogens. androgen insensitivity syndrome Definition: ...

Baldness

... testosterone . Male pattern baldness ( androgen ic alopecia ) is considered normal in adult ... the scalp. Hereditary pattern baldness , or androgen etic alopecia - In men, hair loss may follow ... a probable genetic predisposition. The anti androgen spironolactone (Aldactazide), which is usually ...

Hair Loss

... hyperactivity , or extreme fatigue . androgen IC ALOPECIA - Hair loss in women that may be associated with aging , hormone s ( androgen s), or genetic predisposition. The pattern of ... For the treatment of male pattern hair loss ( androgen etic alopecia ) on the vertex and the anterior ...

Luteinizing hormone

... -releasing hormone (LH-RH) antagonists Anti - androgen s Castration ( orchiectomy ) ... ... Antiandrogens can block the action of androgen s ( hormone s that promote male sex ... l ultrasound Laparoscopy Ovarian biopsy androgen ( testosterone ) levels elevated Urine ...

Male pattern baldness

... Participants ... Male pattern baldness ( androgen ic alopecia ) is considered normal in adult ... common cause of baldness among white males. androgen ic alopecia - The most common type of hair ... in clinical trials for the treatment of androgen etic alopecia ( male pattern baldness ). ...

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Androgen in Biological News

Study reveals a reprogrammed role for the androgen receptor

... BOSTONThe androgen receptor a protein ignition switch for prostate ... When drug therapy deprives the receptor of androgen hormones, thereby halting cell proliferation, the ... cell growth occurs, in part, because the androgen receptor switches on an entirely different set of ...

3-D research model tackles prostate cancer spread

... removal surgery should have low levels of androgen and the cancer cells should be suppressed. ... fact that the cancer cells are very sensitive to androgen and even low levels of androgen in the body could promote the growth of these ...

New drug shows promise in treating drug-resistant prostate cancer

... compounds, MDV3100 and RD162, which block the androgen receptor (AR) in CRPC cells, and report results ... was "designed as a very strong antagonist of the androgen receptor to stop the growth of any prostate ... cancer cells begin to increase production of the androgen receptor, Sawyers said. When the level ...

New medications show promise in treating drug-resistant prostate cancer

... cancer cells begin to increase production of the androgen receptor, said Sawyers. When the level of androgen receptors on the cells' surface reaches a certain ... scientists have questioned whether blocking the androgen receptor is a wise course of action. But Sawyers ...

Why a common treatment for prostate cancer ultimately fails

... help explain the process by showing that the androgen receptor, through which male hormones like ... in men. Understanding the effects of the androgen receptor gives physicians a toehold in efforts to ... One form of hormone therapy works by blocking the androgen ....

Important new hair-loss gene discovered

... in hair-loss. "In one of these conspicuous regions lies the gene for the androgen receptor", Dr. Axel Hillmer of the Life&Brain Forschungszentrum (research ... inheritance of baldness in that hitherto the only known risk gene for the androgen receptor lay on the X-chromosome, and was thus inherited from the mother ...

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Androgen in Biological Technology

Medivation Announces New Positive Efficacy Data From Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients

... Phase 1-2 clinical trial of the Company's novel androgen receptor antagonist MDV3100 in ... and a poor prognosis. Overexpression of the androgen receptor is believed to contribute to the ... cancer. MDV3100 is a novel small-molecule androgen receptor antagonist that ...

Medivation Announces Presentation of Positive MDV3100 Clinical Data in Castration-Resistant Prostate Cancer Patients

... clinical trial showed that the Company's novel androgen receptor antagonist, MDV3100, continued to reduce ... declines were consistent with the inhibition of androgen receptor signaling. MDV3100 continued to be ... presentation, entitled "Phase I-II study of the androgen receptor antagonist MDV3100 in ...

New Report Just Published: World Prostate Cancer Therapeutics Market Report

... (IMRT) II-43 Benefits of IMRT II-44 Drawbacks of IMRT II-44 androgen Deprivation Therapy (ADT) II-44 High Dose Radiation (HDR) Monotherapy ... Therapeutics Reveals Phase 2 Clinical Trial Results of XYOTAX(TM) in androgen Independent Prostate Cancer Patients II-56 Sanofi-Aventis' Taxotere(R) ...

Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients

... have few treatment options and a poor prognosis. Overexpression of the androgen receptor is believed to contribute to the progression of castration-resistant prostate cancer. MDV3100 is a novel small- molecule androgen receptor antagonist that inhibits androgen receptor function by blocking ...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

... novel cancer drug candidates from Santaris Pharma and Enzon has announced the targets for four of these compounds: Her3, beta catenin, PIK3CA and the androgen receptor. Pipeline Summary In H1 2009 Santaris Pharma continued the progress for both the drug discovery programs and the drug ...

Caraco Pharmaceutical Laboratories, Ltd. Markets Generic Casodex(R) Tablets

... Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for generic Casodex(R) tablets. Bicalutamide tablets are an androgen receptor inhibitor indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D2 ...
Androgen in Biological Products

PolarScreen Androgen Receptor Competitor Assay Kit, Red from Molecular Probes (Invitrogen)

Description:... The PolarScreen androgen Receptor (AR) Competitor Assay Kits provide a ... (His-GST)], and a novel, selective fluorescent androgen ligand (Fluormone AL Green in the green assay kit ... compounds for AR-LBD (His-GST). The PolarScreen androgen Receptor Competitor Assay Kits include purified, ...
Company:Molecular Probes (Invitrogen)
Androgen in Biological Definition

X chromosome

... category is vitamin D resistant rickets . The following genetic disorders are associated with the X chromosome: Alport syndrome androgen insensitivity syndrome Charcot-Marie-Tooth disease Coffin-Lowry syndrome Fabry disease fragile X syndrome hemophilia ...
Androgen in Biological Dictionary

Androgens

... androgen is the generic term for any natural or synthetic ... about Androgens , male sex hormone androgen ... Bioidentical Androgens Used to Enhance ... may cause hyperandrogenic symptoms while low androgen levels may cause low libido during and after ...

Receptor

... may attach. A molecule which binds to a receptor is called ... The androgen receptor (AR), also known as NR3C4, is a type of nuclear receptor ... of the androgenic hormones testosterone or dihydrotestosterone. The androgen receptor is most ... Receptor Hardware Plug-in Player. ...

Gene amplification

... drug ... News release issued by the National Human Genome Research Institute in June 1995 on the discovery that the amplification of the androgen receptor (AR) gene may ... Easy-to-use, talking glossary of genetic terms, produced by the National Human Genome Research Institute. ... ...

Cell growth

... The outermost circle represents the various cell types in C. elegans in which ... genes that promote cancer cell growth in the androgen independent state. ... One cannot watch cells crawling, dividing, segregating their chromosomes, or rearranging their surface without feeling ...
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