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Anaplastic in Medical News

Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology

... subset of patients with anaplastic Gliomas NEW YORK, Nov. 19 ... malignant glioblastoma (GBM) and malignant anaplastic gliomas (AA). Ph II Study - Interim Results ... 14 0 2 (14%) 2 (14%) anaplastic Glioma 9 6 2* (33%) ...

'Sharing Miracles' Television Program to Feature Boston Red Sox Star Pitcher Jon Lester

... only nine games with the Sox, he was diagnosed with cancer - specifically, anaplastic large cell lymphoma, a type of non-Hodgkin's lymphoma. In this ... Institute, more than 66,000 new cases of non-Hodgkin's lymphoma (of which anaplastic large cell lymphoma is one) were diagnosed in 2008. Today, America's ...

European Commission and United States Food and Drug Administration (FDA) Both Approve New Options for Patients With Certain Primary Brain Tumors

... as monotherapy, and for patients with malignant gliomas, such as GBM or anaplastic astrocytoma (AA), showing recurrence or progression after standard ... TEMODAR is indicated for the treatment of adult patients with refractory anaplastic astrocytoma, i.e., patients who have experienced disease progression on a ...

2 gene mutations linked to most common brain cancers -- and longer survival

... Medicine. Further analysis of their data showed that glioblastoma and anaplastic astrocytoma patients carrying the mutations survived longer than those who ... or IDH2 was 31 months versus 15 months for those lacking the mutations. anaplastic astrocytoma patients carrying the mutations were found to have a median ...

Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program

... in this deadly disease. Cotara has been granted orphan drug status and fast track designation for the treatment of glioblastoma multiforme and anaplastic astrocytoma by the U.S. Food and Drug Administration. A Phase I dosimetry trial in GBM patients in the U.S. has completed patient enrollment and a ...

Delivering Chemo Directly Into Brain Tumors Shows Promise

... to the brain. The patients had two types of tumors: 10 had a glioblastoma multiforme (GBM), an invasive and fast-growing tumor, while six had anaplastic glioma. "Topotecan by convection-enhanced delivery has significant anti-tumor effects at doses that are not harmful to normal brain tissue," Bruce ...

Avastin effective at delaying brain tumor progression in recurrent disease

... conducted by a researcher at the Seattle Cancer Care Alliance. The patients all had a recurrent malignant glioma known as alkylator-refractory anaplastic oligodendroglioma (AO), for which there is no existing standard therapy. Oligodendrogliomas begin in brain cells called oligodendrocytes, which ...

Red Sox Pitcher Jon Lester Wins 2008 Hutch Award(R)

... "I'm humbled to know that legends such as Mickey Mantle, Sandy Koufax and Lou Brock have won this award in the past." Lester was diagnosed with anaplastic large-cell lymphoma in August 2006. Referred to the Seattle Cancer Care Alliance, the treatment arm of Fred Hutchinson Cancer Research Center, he ...

Silicone Breast Implants Might Raise Risk of Rare Lymphoma

... other health problems. Researchers have identified previous cases of non-Hodgkin lymphoma in women with breast implants, and most of these were anaplastic large T-cell lymphoma (ALCL). Normally, ALCL is exceedingly rare, representing 3 percent or less of all non-Hodgkin lymphoma in adults, and there ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

... adenosine monophosphate (AMP); alpha5beta1 integrin; alphanubeta3 integrin; alphanubeta5 integrin; alpha-fetoprotein (AFP) receptor (RECAF); Akt; anaplastic lymphoma kinase (ALK); androgen receptor (Ar); angiopoietin-1; angiopoietin-2; APEX; ATP synthase [alpha] subunit; axl; Bap31; Bcl-xL; Bcl-2; ...
Anaplastic in Medical Technology

Clinical Proof of Concept for TGF-beta 2-Inhibitor AP 12009 in Phase Iib EMEA provides Guidance on Phase III Design and Approval Requirements

... Phase III study in recurrent or refractory anaplastic astrocytoma patients. Furthermore, ... over chemotherapy. In recurrent or refractory anaplastic astrocytoma, 83.3% of the patients treated with ... for 10 μM AP 12009 in recurrent or refractory anaplastic astrocytoma, with up to 42% at 14 months. At the ...

Long-Term Data from a Landmark Phase III Trial Show Survival Benefit at Three- and Four-Years in Patients with Glioblastoma multiforme

... in 14 percent of patients treated with temozolomide. In refractory anaplastic astrocytoma, Grade 3/4 neutropenia occurred in 14 percent and Grade 3/4 ... for the treatment of malignant glioma, such as glioblastoma multiforme and anaplastic astrocytoma (AA), showing recurrence or progression after standard ....

CHMP Recommends Approval in the European Union (EU) for New Options for Patients With Certain Primary Brain Tumors

... multiforme (GBM) concomitantly with radiotherapy and subsequently as monotherapy, and for patients with malignant gliomas, such as GBM or anaplastic astrocytoma (AA), showing recurrence or progression after standard therapy. The CHMP recommendation serves as the basis for a European Commission ...

Gene That Causes Childhood Cancer Neuroblastoma Is Found

... first discovered that a region of chromosome 2 was associated with the disease. Further sequencing of that region identified mutations in the anaplastic lymphoma kinase (ALK) gene in eight families with familial neuroblastoma. "This finding means that it is possible to offer simple, ...

Data To Be Presented at ASCO Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

... in this deadly disease. Cotara has been granted orphan drug status and fast track designation for the treatment of glioblastoma multiforme and anaplastic astrocytoma by the U.S. Food and Drug Administration. Cotara is in a Phase I dosimetry trial in GBM patients in the U.S. and a Phase II safety and ...

Eisai's Commitment to Oncology Demonstrated by Clinical Data to be Presented at ASCO Annual Meeting

... of Adults with Newly Accepted for (polifeprosan 20 Diagnosed Glioblastoma publication with carmustine Multiforme or anaplastic only. implant) Astrocytoma with Surgery, Gliadel Wafers and Limited Field ...

Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

... lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell NHLs include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas related to lymphoproliferative disorders following bone marrow or stem cell ...

Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India

... academic brain cancer centers. Cotara has been granted orphan drug status and fast track designation for the treatment of glioblastoma multiforme and anaplastic astrocytoma by the U.S. Food and Drug Administration. About Peregrine Pharmaceuticals Peregrine Pharmaceuticals, Inc. is a biopharmaceutical ...

Antisense Pharma: Promising Phase IIb Results of Targeted Therapy with AP 12009 in Recurrent Anaplastic Astrocytoma

... criteria. The response rate for AP 12009 10 ?M in anaplastic astrocytoma patients steadily increased in the ... (10 ?M) for patients with recurrent or refractory anaplastic astrocytoma in study centers at North America, ... (3, 4). General Background on High-Grade Glioma anaplastic astrocytoma and glioblastoma are the two most ...
Anaplastic in Medical Dictionary

Anaplastic thyroid cancer

... anaplastic thyroid cancer grows very rapidly and is an ... Thyroid function tests are usually normal. anaplastic Thyroid Cancer Standard treatment options: ... symptoms caused by the tumor mass.[1,2] ... anaplastic thyroid cancer , which mostly occurs in people ...

IV

... United States population and 54% of all AIDS cases. Stage IV Papilla ry and Follicular Thyroid Cancer Medulla ry Thyroid Cancer anaplastic Thyroid Cancer ... For an IV P , dye is injected into a vein , and x-ray pictures are taken at 0, 5, 10, and 15 minutes to see the ...
Anaplastic in Biological News

A new radiation therapy treatment developed for head and neck cancer patients

... (a highly malignant brain tumour) and another clinical trial that assesses safety and efficacy of BNCT in the treatment of glioblastomas and anaplastic astrocytomas (a type of brain tumour) that have recurred after conventional radiation therapy. Our plan is to investigate BNCT in the treatment of ...

Inflammation and drugs to control this activity studied in a variety of tumors sites

... The majority ?339 ?were high-grade glioblastomas; 117 were mid-grade, or anaplastic astrocytoma; and 154 cases were low-grade. The scientists found that ... antihistamine use was associated with an increased risk for developing anaplastic astrocytomas and low-grade brain tumors. "To our knowledge, this report ...
Anaplastic in Biological Technology

Data Presented at Society of Nuclear Medicine 2009 Annual Meeting Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

... in this deadly disease. Cotara has been granted orphan drug status and fast track designation for the treatment of glioblastoma multiforme and anaplastic astrocytoma by the U.S. Food and Drug Administration. A Phase I dosimetry trial in GBM patients in the U.S. is in the final stages of patient ...

OncoGenex receives completed Special Protocol Assessment for primary registration study of lead drug candidate OGX-011

... clusterin production is observed in many human cancers, including prostate, non-small cell lung, breast, ovarian, bladder, renal, pancreatic, anaplastic large cell lymphoma and colon cancers and melanoma. Increased clusterin production is linked to faster rates of cancer progression, treatment ...

OncoGenex reports lead drug candidate OGX-011 achieved primary endpoint in Phase 2 Trial with second-line chemotherapy for prostate cancer

... clusterin production is observed in many human cancers, including prostate, non-small cell lung, breast, ovarian, bladder, renal, pancreatic, anaplastic large cell lymphoma and colon cancers and melanoma. Increased clusterin production is linked to faster rates of cancer progression, treatment ...

ONCOSCIENCE AG, THE EUROPEAN PARTNER OF YM BIOSCIENCES, ANNOUNCES COMPLETION OF PATIENT ENROLLMENT IN PHASE III BRAIN CANCER TRIAL OF NIMOTUZUMAB

... multiforme (GBM), the level of expression is even higher. A study involving 29 adults with newly diagnosed high-grade gliomas, including both anaplastic astrocytomas (AA) and GBM, who were treated with surgery, external beam radiotherapy and nimotuzumab showed that the treatment was well tolerated, ...
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