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Ammonia in Medical News

Hyperion Therapeutics Raises $60 Million Series C

... pathway to the urea cycle for the disposal of ammonia through the renal excretion of ... can cause dangerously heightened levels of ammonia in the bloodstream (hyperammonemia) resulting in ... brain is exposed to gut-derived toxins such as ammonia that are normally removed from the blood by a ...

Results From Phase 1 Clinical Study of PEG-PAL in PKU and Update on Phase 2 Clinical Study

... of PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) for the treatment of phenylketonuria ... PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) is an investigational enzyme substitution ... PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is in clinical development for the ...

Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis

... PAGN mediates waste nitrogen excretion and ammonia removal. The extent of plasma exposure to PAA ... brain is exposed to gut-derived toxins such as ammonia that are normally removed from the blood by a ... can cause dangerously heightened levels of ammonia in the bloodstream (hyperammonemia) resulting in ...

UCR chemists use 'green chemistry' to produce amines, chemical compounds used widely in industry

... organic compounds derived from ammonia that have wide industrial applications such as ... gold compound readily catalyzes the addition of ammonia a colorless, pungent gas composed of nitrogen ... compounds. One such chemical reaction involves ammonia combining with acetylene to produce an amine ...

Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy

... systematically evaluating our hypothesis that ammonia plays an important role in the pathogenesis of ... experimental and clinical data suggest that ammonia is a contributing pathogenic factor. There are no ... nitrogen excretion and thus attenuate the risk of ammonia and glumatine-induced toxicity. AMMONUL ...

Hyperion Therapeutics Completes Phase 2 Data Analysis and Schedules End of Phase 2 Meeting With FDA for HPN-100 in the Chronic Treatment of Urea Cycle Disorders

... untreated, urea cycle disorders can cause dangerously heightened levels of ammonia in the bloodstream (hyperammonemia) resulting in brain damage, coma, ... or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. Use with great ...

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Ammonia in Medical Technology

Hyperion Therapeutics Announces Results for Phase II Study in Urea Cycle Disorders

... abstract is entitled " Phase 2 Study of A Novel ammonia Scavenging Agent In Adults With Urea Cycle ... on their stable dose of BUPHENYL and 24-hour PK, ammonia measurements, amino acids, and urine collections ... No SAEs occurred during 100% HPN-100 treatment. ammonia values were ~30% lower on HPN-100 assessed as ...

Hyperion Therapeutics Announces Enrollment of First Patient in Phase 1/2 Clinical Trial of GT4P in Patients With Urea Cycle Disorders

... designed to evaluate the safety, tolerability and ammonia scavenging effects of GT4P compared to ... UCDs can cause dangerously heightened levels of ammonia in the bloodstream (hyperammonemia) resulting in ... these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' ...

Hyperion Therapeutics Receives Orphan Drug Designation for HPN-100 for the Treatment of Urea Cycle Disorders

... untreated, urea cycle disorders can cause dangerously heightened levels of ammonia in the bloodstream (hyperammonemia) resulting in brain damage, coma, ... or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. Use with great ...

Hyperion Therapeutics Completes Enrollment in Phase 1/2 Clinical Trial in Patients With Urea Cycle Disorders

... disorder. Left untreated, UCDs can cause dangerously heightened levels of ammonia in the bloodstream (hyperammonemia) resulting in brain damage, coma, ... or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. Use with great ...

BioMarin Initiates Phase 1 Clinical Study of PEG-PAL in PKU

... the Phase 1 clinical study of PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) for the treatment of phenylketonuria (PKU). The study is expected ... with PKU. About PEG-PAL PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) is an investigational enzyme substitution therapy for the treatment ...

BioMarin Initiates Phase 1/2 Clinical Trial for GALNS for Morquio A Syndrome

... with Merck Serono, a division of Merck KGaA of Darmstadt, Germany. Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase 1 clinical development for the treatment of PKU. For additional information, please visit www.BMRN.com . ...
Ammonia in Medical Products

Infinity™ Ammonia

Description:... The Infinity ammonia single liquid stable reagent is intended for the in vitro quantitative determination of ammonia in plasma. Infinity ammonia reagent patented formulation not only provides ...
Company:ThermoFisher Scientific

Ammonia/Alcohol Control

Description:... Ammonia/Alcohol Control is intended as a means of monitoring various ammonia and ethanol assay methods. This ready-to-use, three-level control is targeted at clinically significant levels of ammonia and alcohol. Assay values are provided for the following instruments: AU ...
Company:Quantimetrix Corporation

Ammonia (NH3)

Description:... For the quantitative in vitro determination of ammonia in ...
Company:Randox Laboratories Ltd.

Pyrex brand blood chemistry (Ostwald-Folin) pipette, color-coded, Class A

Description:... The short and compact design makes this pipette useful for total nitrogen determination, urea and ammonia in urine, and blood serum tests. They are calibrated "To Deliver" by blowing out the last drop. Comp Dim: L 275 mm Color: orange Measur range: ...
Company:Sigma-Aldrich

Liquichek Ethanol/Ammonia Control

Description:... Liquichek™ Ethanol/Ammonia Control is a liquid product used to monitor ethanol and ammonia test procedures in the clinical ....
Company:Bio-Rad Laboratories

Ammonia Standard

Description:... Intended for the quantitative determination of ammonia in plasma. Two vials, dry powder reagents. Method: Enzymatic, alphaketoglutarate. Uses NADPH to eliminate interferences from other plasma compounds. ...
Company:Hemagen Diagnostics, Inc.

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Ammonia in Medical Definition

Tincture

... opium tincture ( paregoric ) An herbal extract The multiple plant extract Iberogast Examples of spirits include: Spirit of ammonia (also called spirit of hartshorn ) Spirit of camphor Spirit of ether, a solution of diethyl ether in alcohol "Spirit of Mindererus", ...
Ammonia in Medical Dictionary

Ammonia

... ammonia some household cleaners some liniments some ... Note: This list may not be all inclusive. ammonia levels in the blood rise when the liver is not able to convert ammonia to urea. This may be caused by cirrhosis or ...

Poisoning

... acid , sulf uric acid ), alkali (lye, ammonia ), or a volatile hydrocarbon such as gasoline . ... prompt treatment . blood pressure ... ammonia Poisoning ammonia is a product of waste from a fish’s ...

Acute renal failure

... Chronic renal failure (can cause breath to smell like ammonia Diabetes (fruity or "sweet chemical" smell with keto acidosis ) ... Bronchiectasis Chronic renal failure (can cause breath to smell like ammonia ) Diabetes (fruity or "sweet chemical" smell with keto acidosis ) ...

Asphyxia

... impaired. These factors may result in fatal asphyxia ... Increased ammonia levels cause a decreased immune response in the inhabitants of the aquarium, and if the condition is not corrected, can cause death either by ammonia poisoning itself via asphyxia tion or indirectly by secondary ...

Diaper rash

... than bacterial or candida l infection . Common irritants include ammonia from the breakdown of urine , acids in the stool , and soaps used in ... a diaper rash , is on antibiotics , or has thrush . DIAPER RASH ( ammonia cal Dermatitis ) SYMPTOMS"A reddish rash affecting the diaper region, ...

Oven cleaners

... tissue just as much as actual flames do. Dishwasher soap, bleach and ammonia are all toxic if swallowed. Corramedan ( Cardiac Glycosides) ... disinfectant s, solvents, cosmetics, drain cleaners , oven cleaners , ammonia and bleach . In agricultural settings, fertilizers or pesticides can ...

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Ammonia in Biological News

Glutamine supplements show promise in treating stomach ulcers

... work demonstrated that the damaging effects of ammonia on gastric cells could be reversed completely by ... explains Hagen. "The amino acid stimulated ammonia detoxification in the stomach as it does in the liver so that the effective concentration of ammonia was reduced, thereby blocking cell damage." ...

Texas researchers provide emissions data for livestock industry

... Protection Agency to begin reporting ammonia and hydrogen sulfide emissions. The EPA issued ... to operations that can emit 100 pounds or more of ammonia or hydrogen sulfide during any 24-hour period, ... on their teams, worked to distill the collective ammonia results on short notice. "We needed to convey ...

New method monitors critical bacteria in wastewater treatment

... as nitrifying bacteria because they convert toxic ammonia from human wastes and fertilizer runoff into ... the wastes. The "filtering flux sensor" measures ammonia and nitrite to reveal the ion flux, or how many ... have never been used this way to measure biofilm ammonia and nitrite flux. Self referencing has been used ...

Seabird ammonia emissions contribute to atmospheric acidity

... Amsterdam, September 23, 2008 ammonia emissions from seabirds have been shown to be a ... and acidification in ecosystems. While most ammonia emissions originate from domesticated animals ... seabirds are the most significant emitters of ammonia to the atmosphere in remote regions. A ...

Iowa State engineer works to clean and improve engine performance

... fuel. And they're studying the combustion of ammonia in engines. ammonia is relatively easy to store, is fairly dense with ... greenhouse gases when it burns. So burning ammonia in engines could be an early step to developing a ...

Ocera Therapeutics licenses novel treatment for acute hepatic encephalopathy from UCLB

... a study which demonstrated an acute and sustained reduction of systemic ammonia levels as well as decreased intracranial pressure in models of AHE in ... and cirrhosis. With severe liver impairment, toxic substances such as ammonia that are normally removed by the liver accumulate in the blood and impair ...

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Ammonia in Biological Technology

New clues about a hydrogen fuel catalyst

... other atoms. The catalyst chemically reacts with ammonia borane, a molecule that stores hydrogen densely, ... that contains hydrogen atoms, in this case ammonia borane, serves as a sort of structural support. The catalyst plucks the hydrogen from the ammonia borane as needed to run the device. The PNNL ...

N-Viro Fuel Technology Receives Alternative Energy Status From the U.S. Environmental Protection Agency

... of the waste biomass-derived fuel is the ammonia that is released from the wastes in the process. This ammonia is available to be used as a substitute for ammonia or urea for NOx removal. About N-Viro ...

Bion Outlines Differences between its Patented Comprehensive Livestock Environmental Treatment Technology and Anaerobic Digesters

... application of digested manure, specifically ammonia releases and other emissions." Dr. Morris ... livestock waste, including nutrient discharges, ammonia and other air emissions, which AD does ... treatment desired. Bion's technology also reduces ammonia emissions greater than 90% and provides ...

Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference

... the urea cycle by breaking down urea into metabolites that include ammonia and hydroxyl ions. By doing so at the site of cancerous tissues in the ... to be necessary for cancer cell survival. As well, the local production of ammonia at the site of cancerous tissues is thought to readily diffuse into the ...

Proplant Awarded Qatar Project

... it has been awarded an EPC contract by Qatar Fertiliser Company for their ammonia and urea plants Steam Integration Project. QAFCO operates the world's largest single site fertilizer complex with four ammonia and urea plants. Proplant will perform engineering, procurement and ...

Bion Announces PENNVEST Board Approves $7.8 Million Financing for Kreider Farms Dairy Project

... significantly, a majority of these credits will be generated from airborne ammonia reductions. ammonia air emissions from CAFOs are for the most part quickly re-deposited onto ...

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Ammonia in Biological Products

DNA120 OP SpeedVac System from Thermo Scientific

Description:... oligos. Its sturdy design incorporates a glass cover and a post-trap with ammonia neutralizing solution for fully automated, unattended, odor-free ... Comes standard with a glass lid for improved chemical resistance and ammonia post trap Dual Digital Timers for independent control of RUN and ...
Company:Thermo Scientific
Ammonia in Biological Definition

Amine

... ammonia Amines are organic compounds containing ... group. Amines have structures resembling ammonia , where one or more hydrogen atoms are replaced ... following pictures, if only one the hydrogens in ammonia is replaced by a carbon based group, then it is a ...

Osmoregulation

... vacuole to collect excretory waste, such as ammonia , from the intracellular fluid by both diffusion ... Waste products of nitrogen metabolism ammonia is a toxic by-product of protein metabolism and ... it is produced then excreted; mammals convert ammonia to urea while birds and reptiles form uric acid ...

Urea cycle

... reactions occurring in many animal organisms that produces urea from ammonia . This cycle, also known as ornithine cycle, was the first metabolic cycle ... than ammonia, therefore organisms which can't easily and quickly remove ammonia usually have to convert it to some other substance, like urea or uric ...

Bacterium

... kill bacteria or other pathogens to prevent contamination and risk of infection. In soil, microorganisms help in the transformation of nitrogen to ammonia with enzymes secreted by these microbes, which reside in the rhizosphere (a zone that includes the root surface and the soil that adheres to the ...

Carbohydrate

... . The brain can only utilize carbohydrates for energy, and protein may not supply enough in many cases. The increase in protein means that more ammonia groups need to be removed from the blood. Catabolism There are three metabolic pathways of carbohydrate catabolism : glycolysis ...

Enzyme

... enzymes which transfer phosphate groups to a tyrosine residue in a protein Tyrosinase Urease : hydrolizes urea into carbon dioxide and ammonia Xanthine oxidase : oxidizes hypoxanthine to xanthine and further to uric acid Purification Since enzymes are proteins , enzyme ...

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Ammonia in Biological Dictionary

Urea cycle

... reactions occurring in many animals that produces urea (NH2)2CO from ammonia (NH3). This cycle was the first metabolic cycle discovered . In ... one of the enzymes in the urea cycle which is responsible for removing ammonia from the blood stream. The urea cycle involves ... urea cycle n. ...

Urea

... compound to be synthesized ... Synthetic urea is created from synthetic ammonia and carbon ... Urea is a nitrogen-based waste product secreted by the ... ... The commercial synthesis of urea involves the combination of ammonia and carbon ... Urea -formaldehyde resin is created when the two (2) ...

Deamination

... nitrogenous waste comes from the breakdown of amino acids. This occurs by deamination . Deamination of amino acids results in the production of ammonia (NH3) ... Information on EC 3.8.1.8 - atrazine chlorohydrolase ... deamination . 687391. 0.02. 2-(N-ethylamino)-4-hydroxy ...

Decomposers

... in the form of dead wood, leaf litter, plant ... ... is carried out mainly by bacterial and fungal decomposers . ... present to detoxify the ammonia produced by the fish and decomposers in the tank. ... Decomposers . Kenny Hood's ... DECOMPOSERS in the food chain. So hard to see ... ...

Collecting tubules

... of portions of the loops of Henle and the collecting tubules . ... Collecting tubules are not considered part of the nephron; ... ... of ammonia were examined in rabbit cortical collecting tubules perfused in vitro. ... restricted diffusion in the collecting tubules ; this may account ...

Autotrophic

... ) and animals (heterotrophic) organisms, ... Autotrophic vs. Heterotrophic Bacteria. Fritz Industries. There's a lot of ... level of ammonia conversion that is attained by true autotrophic nitrifiers. ... ... development, whereas it is autotrophic , when its source of carbon ... ...

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