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Amaurosis in Medical News

QLT announces completion of Phase Ia safety trial of its synthetic retinoid product

... drug is being developed for the potential treatment of Leber's Congenital amaurosis (LCA), an inherited progressive retinal degenerative disease that leads to ... responses to light in both models of LCA. About Leber's Congenital amaurosis LCA is an inherited degenerative retinal disease characterized by ...

Gene-Transfer Proves Safe for Vision Problem

... says. The patients, all in their early 20s, have Leber congenital amaurosis type 2 (LCA2), a disease in which photoreceptor cells cannot respond to ... This trial to treat vision loss from the condition of Leber congenital amaurosis is an important demonstration of proof of principle and shows that we are ...

Safety study indicates gene therapy for blindness improves vision

... 24 years old with a type of hereditary blindness called Leber congenital amaurosis type 2 volunteered to test the safety of an experimental gene-transfer ... This trial to treat vision loss from the condition of Leber congenital amaurosis is an important demonstration of proof of principle and shows that we are ...

Retinal Gene Is Linked to Childhood Blindness

... has been identified by an international team of researchers. The discovery of the link between the retinal gene SPATA7 and Leber congenital amaurosis (LCA) and retinitis pigmentosa is important because it pinpoints a new retinal metabolic disease pathway that might be crucial for many patients, ...

CA$2.4 million toward gene therapy for human degenerative retinal diseases

... "We hope to begin a human gene-therapy trial in Canada within five years for three specific degenerative retinal diseases: Leber Congenital amaurosis (LCA), Stargardt macular dystrophy and retinitis pigmentosa," Dr. Koenekoop explained. "Previous attempts with the gene named RPE65 have been highly ...

New Web Community Brings Together Parents of Visually Impaired Children

... and truly allows families to connect with one another and to resources." Patty Bushland, Arkansas Daughter Mary Rose, age 2, Leber's Congenital amaurosis (LCA) "When I found out my baby was visually impaired, I immediately went to the Internet to find out everything I could about her condition and ...

Gene therapy safety trial for childhood blindness under way

... from the National Eye Institute of the National Institutes of Health. A young adult with a form of hereditary blindness called Leber congenital amaurosis type 2, or LCA2, received an injection of trillions of replacement genes into the retina of one eye this month, making the volunteer one of the first ...

Ocular Pharma Company Charlesson Announces $2.35MM in New Funding

... was also awarded $135,000 from OCAST to utilize this gene- delivery method for treating hereditary retinal degenerations, such as Leber's Congenital amaurosis and Retinitis Pigmentosa. This seed money from OCAST will aid in the development of preclinical data to support future SBIR grant applications to the ...

World’s First Attempt To Restore Sight Using Gene Therap

... in an attempt to cure a serious sight disorder- Leber's Congenital amaurosis or LCA. The group operated on 12 young adults with LCA, a type of ... blindness caused by a single abnormal gene. Leber's Congenital amaurosis is not a single specific disorder. It is the term used for a group of ...

Enzyme Responsible For Congenital Blindness

... study regarding the congenital blinding disease // called Leber congenital amaurosis is published in the August issue of the journal Cell. Researchers ... gene, which should provide more data on the cause of Leber congenital amaurosis and on how the Rpe65 protein works. The researchers are also examining the ...

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Amaurosis in Medical Technology

Encouraging Gene Therapy Results in Genetic Form of Blindness

... adeno-associated virus-based gene therapy to treat Leber congenital amaurosis (LCA), an incurable genetic disorder that results in blindness, had ... did not change. In a paper entitled, "Phase I Trial of Leber Congenital amaurosis due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated ...

Gene Therapy Improves Vision in Patients with Congenital Retinal Disease

... Center for Molecular Ophthalmology at Penn's Scheie Eye Institute, have been researching inherited retinal degenerations such as Leber congenital amaurosis (LCA), for 18 years. LCA is a group of inherited blinding diseases that damages light receptors in the retina. It usually begins stealing sight in ...

Gene Therapy Provides Vision to People who Were Nearly Blind

... -- Scientists employing a gene therapy have provided partial vision to patients who were nearly blind from a condition known as Leber congenital amaurosis (LCA) -- a severe form of retinitis pigmentosa. Initial results from the clinical trial, which was funded in part by the Foundation Fighting ...
Amaurosis in Medical Definition

Pathology

... insufficiency - Internuclear ophthalmoplegia - Aniseikonia Visual disturbances and blindness Amblyopia - Leber's congenital amaurosis - Subjective ( Asthenopia , Hemeralopia , Photophobia , Scintillating scotoma ) - Diplopia - Scotoma - Anopsia ( Binasal hemianopsia , ...
Amaurosis in Medical Dictionary

Amaurosis fugax

... amaurosis fugax Definition: amaurosis fugax involves loss of vision in one eye ... lack of blood flow to the retina . amaurosis fugax is thought to result from a clot of ...
Amaurosis in Biological News

UCLA researchers identify key enzyme linked to childhood blindness

... treasure, then discovering it in your own back yard." Leber congenital amaurosis is an inherited disease that is believed to cause up to 20 percent of all ... gene, which should provide more data on the cause of Leber congenital amaurosis and on how the Rpe65 protein works. The researchers are also examining the ...

'Lucky 13' as new gene discovery offers further hope for childhood blindness

... which is essential to photoreceptors in the eye, the cells that "see" light. The finding, the thirteenth gene to be linked to Leber’s congenital amaurosis (LCA), comes at a time of hope for the people born with the disorder. Scientists at Moorfields Eye Hospital, London, recently announced the start of ...

First clinical trial of gene therapy for childhood blindness

... a significant impact on future treatments for eye disease. The trial involves adults and children who have a condition called Leber’s congenital amaurosis (LCA), which is a type of inherited retinal degeneration. This disease causes progressive deterioration in vision, due to an abnormality in a ...

UF scientists restore sight to chickens with blinding disease

... that prevents it from producing an enzyme essential for sight. The condition closely models a genetic disease in humans that causes Leber congenital amaurosis type 1, or LCA1. About 2,000 people in the United States are blind because they have a disease that falls in the LCA family. "Enabling chickens ...
Amaurosis in Biological Technology

Discovery of a new retinal gene involved in childhood blindness

... Children's Hospital played a crucial role in the international collaboration that led to the discovery of a new gene that causes Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP), two devastating forms of childhood blindness. This finding of this new gene, called SPATA7, is remarkable ...

Statement from Lighthouse International About the Study on Gene Therapy Concerning Leber's Congenital Amaurosis

... genetic eye diseases that affect children." According to Yocasta Urena, 28, an employee of Lighthouse International who has Leber's Congenital amaurosis and whose 4-year-old daughter has the same condition, "This research is a ray of hope for me and certainly for my daughter's future." Her daughter, ...
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