New pathways for autoimmune treatment identified
...trigger a host of diseases from type 1 diabetes to alopecia has helped explain the imbalance of immune regulator and killer cells in autoimmune disease. Mutation in the Aire gene causes APS1, a disease causing two out of three problems ?an underactive parathyroid, yeast infection of the skin and/or mucous m...Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein
... thin coat of fragile hair, a condition resembling alopecia or thinning, balding hair. That the hair is fragile is not surprising given that K17 is a keratin protein, known to provide structure and strength, says Coulombe. Hair follicle cells cycle continuously through three phases - growth, death and restin...First demonstration of new hair follicle generation in an animal model
...le with hair and scalp disorders, such as scarring alopecia where the skin scars, and hair overgrowth....Breakthrough in cancer therapy
...s type of hair loss, known as chemotherapy-induced alopecia (CIA), is a frequent side effect of cancer therapy and is often very distressing for patients at a vulnerable time in their lives.// Currently, there is no effective way to stop this type of hair loss. The only way doctors can attempt to minimise ha...Anticancer Properties of Vitamin D Could Be Separated From Other Functions
... “We found a mutation which caused rickets but not alopecia but which still allowed beta catenin to bind to the vitamin D receptor.” If indeed a drug highlighting the anti-cancer property of the vitamin can be developed, it could be useful in early stage cancers, but not in advanced or terminal cancers, “That...Anticancer Properties of Vitamin D Revealed
...ptor. Most of these patients had both rickets and alopecia (baldness). However a small number of families had... “We found a mutation which caused rickets but not alopecia but which still allowed beta catenin to bind to the vitamin D receptor,” he said. This suggested to ......air follicle and replaces it with scar tissue, and alopecia areata, an autoimmune skin disease resulting in hair loss, to more common disorders such as male pattern hair loss and women who have too much hair. Session topics include chemotherapy-induced hair loss, tissue engineering of hair follicles, nutritio...Positive ZIO-201 Interim Phase II Sarcoma Data Presented at European Society for Medical Oncology
...Idose with no significant bone marrow suppression, alopecia (hairloss) or neurotoxicity reported. Based on this encouraging data,enrollment has been expanded to include additional patients. "Ifosfamide is one of the few effective standard therapiesavailable for most sarcomas," commented Dr. Chugh. "Having ...... 3/4:14%); myalgia/arthralgia 49% (Grade 3/4: 8%); alopecia 48% (Grade3/4: 0%); nausea 42% (Grade 3/4: 2%); stomatitis/mucositis 29%(Grade 3/4: 7%); vomiting 29% (Grade 3/4: 1%); diarrhea 22% (Grade3/4: 1%); and musculoskeletal pain 20% (Grade 3/4: 3%).Treatment-related hematological adverse events greater th......esult inbleeding), skin rash, flu-like symptoms or alopecia (hair loss);all of these toxicities occur frequently with many of the currentlyavailable treatments for cancer. The main side effects ofperifosine are nausea, vomiting, diarrhea and fatigue, but theseare either mild or non-existent in doses that are ......servation arm. Theincidence of nausea/vomiting and alopecia were low and manageable;21 percent of patients exp...pically occurring on thehands and feet), rash, and alopecia (hair loss). About Schering-Plough Schering-Plough Corporation is a global science-based healthcar......overall survival was 16.8 months Neurotoxicity and alopecia wereminimal and there were no cases of hand–foot syndromereported in this study. Study author, Dr. Hamid Y. Sheikh of the Christie Hospital inManchester, UK, commented: “Our findings point to thepotential of this regimen in the first-lin...