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Alleles in Medical News

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

... has found that homologous immunoglobulin (lg) alleles pair up in the nucleus at stages that coincide ... preventing simultaneous recombination on both alleles and thus reducing the chance of translocations. ... researchers propose that homologous pairing of alleles undergoing recombination has a number of ...

The HLA-DRB1 gene and premature death in rheumatoid arthritis

... having the shared epitope (SE)a group of HLA-DRB1 alleles with kindred amino acid traitsplus anti-cyclic ... researchers analyses, having two copies of the SE alleles increased the risk of death from all causes and ... and smoking. Current smokers who carried 2 SE alleles and had anti-CCP antibodies had the highest risk ...

Researchers estimate risk of transmission of Huntington's disease to offspring among male carriers

... HD. While several studies suggest that male carriers of high normal alleles have a low probability of transmitting an expanded HD allele in the ... rate, frequency of no family history of HD, and frequency of high normal alleles in the general population. "The estimated probability that a male high ...

Understanding the have-knots: The role of stress in just about everything

... and his colleagues subsequently reported that children with two short alleles of the 5HTTLPR gene, whose mothers also reported receiving low social ... receiving high support did not show the tendency, and those with the long alleles but receiving low support also appeared protected by their genetic makeup. ...

Schizophrenia candidate genes affect even healthy individuals

... of these genes, called alleles. While many people who possess these risk alleles do not end up with schizophrenia, this does not mean they are unaffected ... study showed that apparently normal individuals who posses several risk alleles within these susceptibility schizophrenia genes, have indeed minute ...

Genetic marker may predict early onset of prostate cancer

... 631 men enrolled in the Prostate Cancer Risk Assessment Program at Fox Chase. Overall, while there were differences in the distribution of the alleles by race, the risk allele did not have a major contribution to disease in 400 African American men or in 231 Caucasian men with a family history of ...

ASHG hosts fourth annual DNA Day essay contest, supports genetics education efforts

... Modes of inheritance like co-dominance, incomplete dominance, and epistasis involve intricate interactions between the expression of multiple alleles and/or genes that often result in the existence of three or more varieties of traits, such as human blood markers and flower color." Molina concluded ...

Quest Diagnostics Discovers New Genetic Mutations Affecting Cystic Fibrosis Screening

... the widespread and thoughtful experience with [cystic fibrosis] mutation testing and screening continues to reveal new insights about the mutational alleles of the CFTR gene and further refinements in how best to detect them and assure appropriate quality control while doing so," said Wayne W. Grody, ...

Throwing the micro switch: MicroRNA may link smoking risk gene to neurobiology of addiction

... of the major receptors in the brain that mediate the actions of the neurotransmitter dopamine, is associated with tobacco dependence, and that two alleles of a variant within this gene are differentially expressed. "In the current study, we demonstrated that such differential expression of DRD1 is ...

Genetic risk factors play role in autoantibody-negative rheumatoid arthritis

... in disease susceptibility that can be explained by genetic factors - was about 66 percent for both ACPA-positive and ACPA-negative RA. The HLA SE alleles contributed 11 percent to the total genetic variance of RA, 18 percent to the genetic variance of ACPA-positive RA, and only about 2 percent to the ...

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Alleles in Medical Technology

Research Explores the Effects of Stem Cell Source and Patient Age on Stem Cell Transplantation Outcomes

... most closely genetically matched the patient were selected for transfusion. All non-cultured cord blood stem cells were matched for four out of six alleles for each patient. For the cultured cord blood cells, two patients received a five-out-of-six allele match and four patients received a ...

The Past, Present and Future of HLA Typing

... Each locus is highly polymorphic; for example, there appear to be 300+ alleles in the HLA-B or DRB1 loci. A clear understanding of the differences ... to the range of HLA polymorphisms, it is possible to detect the HLA alleles directly by PCR. In fact, this technique was used in the first ...
Alleles in Medical Products

DPB1 SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible ...
Company:Dynal Biotech, LLC

DQB1 SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible ...
Company:Dynal Biotech, LLC

DQA1 SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible ...
Company:Dynal Biotech, LLC

DRB96 SSP UniTray

Description:... resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products ...
Company:Dynal Biotech, LLC

B Locus High Res SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible ...
Company:Dynal Biotech, LLC

Cw High Res SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible ...
Company:Dynal Biotech, LLC

A Locus High Res SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible ...
Company:Dynal Biotech, LLC

OLERUP SSP™ HLA Kits

Features:... Complete set of reagents included in all licensed kits, just add DNA and water to complete. Complete coverage of WHO recognized alleles in new lots as soon as new nomenclature updates are released, the most up-to-date SSP products available. Completely compatible with NMDP medium ...
Company:QIAGEN

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Alleles in Biological News

Researchers take first look at the genetic dynamics of inbreeding depression

... are called alleles. If the maternal and paternal alleles differ, one of them usually dominates, conferring ... silenced allele is called "recessive." Some alleles are detrimental to health. Most of these are ... copies of them one from each parent. When the alleles differ, one (the dominant allele) often masks the ...

Immune genes adapt to parasites

... fungi than by that of worms. SNPs in some of these genes are known risk alleles for inflammatory bowel diseases, such as Crohn's and celiac disease. These "risky" alleles were probably maintained during evolution because they promote the kind of ...

Boy or girl? It's in the father's genes

... m allele, so his children are more likely to have the mm combination of alleles themselves. As a result, those sons may also have only sons (as shown). ... is ff, so all his children are female, they have the ff combination of alleles because their father and mother were both ff. One of the female children ...

HapMap browsing and DDDP methods for genetic analysis featured in CSH Protocols

... polymorphisms (SNPs) in the immediate vicinity, what those SNPs' alleles are, and the relative frequencies of the alleles in the population. The protocol is freely accessible on the website for ...

Mate choice in plants

... at the chromosomal region called the S locus, which contains numerous alleles that control recognition specificity. These genes code for S-locus ... on the pollen side are the SLF (S-locus, F-box) alleles. If the S alleles of the pollen match those in the stylar ECM, the pollen is rejected. If ...

Known genetic risk for Alzheimer's in whites also places blacks at risk

... on dementia. Alzheimer's disease is the most common form of dementia. alleles are different variants of a gene. Everyone has the APOE gene, but what ... have: epsilon 2, epsilon 3 or epsilon 4. In addition, each person has two alleles of the gene -- one from the mother and one from the father. Having at ...

Mutation of the COX2 gene can double or treble a woman's risk of ovarian cancer

... there are two copies of the sequence and these copies are called alleles. alleles may be identical or different. Dr Pereira explained: The C and G are alleles that can be inherited, one from each parent. As everyone carries two ...

Measuring intellectual disability

... disorders, but also developmental delay, behavioral difficulties, anxiety, ADHD, and mood. Involvement among carriers of smaller (premutation) alleles can also involve developmental delays and/or autism spectrum disorders." In future studies, Dr. Hagerman and colleagues plan to explore "further ...

Penn researchers discover genetic risk factor for testicular cancer

... required in conjunction with KITLG for disease development. This remains to be determined." Only a small proportion of men who carry the high-risk alleles will develop the disease. The key now, the researchers say, is to find out what modifies the genetic risks and pushes one individual toward cancer ...

A genome may reduce your carbon footprint

... soil, temperature, and moisture conditions. It is still largely undomesticated and thus large gains might be realized through fixation of beneficial alleles in breeding populations. There are likely to be a few genes with large effects that will dramatically impact yields once incorporated into breeding ...

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Alleles in Biological Technology

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

... and reliable tool in analyzing DNA variations, especially where the mutant alleles are at a very low concentration within the sample (less than 1% of the ... Cold-PCR protocols preferentially amplify heteroduplexes such that mutant alleles become enriched compared to normal alleles. The range of enrichment ...

Honey bee invaders exploit the genetic resources of their predecessors

... from throughout the Africanized honey bee genome showed that most of the alleles were common to African honey bees. But of the alleles common to European bees, those found in functional parts of the genome (in ...

ProImmune Launches New MHC-Peptide Binding Assay for Class II HLA Alleles

... available from the Company. The Class II REVEAL(TM) binding assay for HLA alleles DR1-4, is a powerful cell-free in vitro assay that can rapidly predict ... extension of its range of MHC Class II Ultimer(TM) staining reagents with alleles DR2 and DR3 to cover HLA DR1 to 4. Class II Ultimers(TM) can be used ...

New Study Raises Questions About Prostate Cancer Therapies Targeting Insulin-Like Growth Factor Receptor

... IGF1 signaling. To test their reasoning they conducted a second experiment by crossing mice carrying the prostate-specific IGF-1R knockout alleles with transgenic mice that develop spontaneous prostate cancer when p53 and select other genes are compromised. The results were as predicted: ...

SNPs Powerful Tools for Association Studies

... to 28 human samples) that revealed seven alleles at frequencies of 48%, 25%, 12%, 5%, 3%, 3%, and ... bi-allelic (i.e., there are only two possible alleles at the locus). Because people have two copies of ... although this is extremely rare for minor alleles that occur at low frequencies. In the Applera ...

Separation of HLA-DRB Alleles by Denaturing Gradient Gel Electrophoresis using the DCode System

... (DGGE). When separation of HLA-DRB alleles is followed by direct sequencing, this ... rapid way of identifying all HLA-DRB alleles for high-resolution tissue typing. ... had been typed previously for HLA-DRB alleles using both PCR-SSCP and cloning and sequencing ...

Detection of Variation in Highly Polymorphic Mhc Genes by Denaturing Gradient Gel Electrophoresis Using the DCode System

... network of control alleles, 22 of these alleles can be rapidly and accurately resolved ... the amplified chinook salmon A1 chinook alleles (5, 9, and 10), differing from one ... curves indicated that all three A1 alleles melted at different concentrations of denaturant ...

Superior Gene Silencing Using Adenoviral Vectors

... Reduce Expression from Transgenic alleles in vivo To demonstrate that ... type 3. In 70% of diseased carriers, alleles contain a G to C mutation. Dr. ... or mutant polyglutamine (polyQ) alleles (Atx-Q166-GFP) containing a CAG ...

Microfluidic analysis of multiplex PCR products for the genotyping of Helicobacter pylori

... all mPCR reactions including all involved alleles showed the separation of seven different ... with possible disease outcome are the various alleles of the vacA gene, the presence of the cagA gene ... the combined analysis of the five different alleles (vacA s1 or s2, cagA, vacA m1 or m2) ...

QIAGEN Multiplex PCR Handbook

... 90 seconds to 3 minutes. However, some alleles may not be detectable when using low ... are often highly polymorphic, with many different alleles present within a population. alleles may also differ in the number of copies of a ...

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Alleles in Biological Definition

Allele

... that gene. An organism which has two different alleles of the gene is said to be heterozygous . Often ... (sometimes called blending inheritance ) when alleles blend their traits in the phenotype . An ... flowers with codominant "blue" and "purple" alleles for petal color, the resulting offspring would ...

Allele frequency

... an allele that has a frequency of 20%. However, alleles distribute randomly only in the absence of ... equilibrium . The frequencies of all the alleles of a given gene often are graphed together as an ... to changes in the distribution and frequencies of alleles -- in other words, to evolution . Besides ...

Evolution

... specifically as a change in the frequency of alleles in a population from one generation to the ... of traits While mutation can create new alleles , other factors influence the frequency of ... between successive generations may result in some alleles disappearing from the population. Two separate ...

Gene

... Variants of a single gene are known as alleles , and differences in alleles may give rise to differences in traits, for ... allele is called the wild type allele, and rare alleles are called mutants . Normally, RNA is an ...

Genetic drift

... acts on populations , altering the frequency of alleles and the predominance of traits amongst members ... fluctuations (sampling error ). When the alleles of a gene do not differ with regard to fitness, ... small, genetic drift will be stronger. Drifting alleles usually have a finite lifetime. As the frequency ...

Genetic recombination

... refers to the molecular process by which alleles at two genes in a linkage group can become separated. In this process alleles are replaced by different alleles from the same genes thereby preserving the ...

Hardy-Weinberg principle

... In the simplest case of a single locus with two alleles A and a with allele frequencies of p and q ... 5.1 Generalization for more than two alleles 5.2 Generalization for polyploidy 5.3 ... statistical description for the HWP, is that the alleles for the next generation for any given individual ...

Homozygote

... are diploid or polyploid and have the same alleles at a locus (position) on homologous ... occurs when a particular locus comprises two alleles for the dominant trait (e.g. AA ). A ... occurs when a particular locus comprises two alleles for the recessive trait (e.g. aa ). See ...

Major histocompatibility complex

... HLA-DRB1, have roughly 250, 500, and 300 known alleles respectively -- diversity which is truly ... classical loci routinely find tens to a hundred alleles -- still highly diverse. And perhaps even more remarkable is that many of these alleles are quite ancient: it is often the case that an ...

Mendelian inheritance

... in inherited characters. This is the concept of alleles . alleles are different versions of genes that impart the ... comes from the mother, one from the father. These alleles may be the same (true-breeding organisms, e.g. ...

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Alleles in Biological Dictionary

VNTR

... show variations in length ... VNTR alleles are hypervariable regions of human DNA that ... for any one VNTR locus, a number of different alleles may exist, each with ... If the fragments of DNA containing the VNTR alleles are to be separated on the ... VNTR . The ...

Multiple alleles

... from Multiple ... In other words, alleles are members of a gene that produce different traits in a ... Multiple alleles | Macmillan Genetics. Multiple alleles summary with 2 pages of encyclopedia entries, ...

Linkage disequilibrium

... disequilibrium is the non-random association of alleles at two or more loci, not necessarily on the same ... a population of certain combinations of linked alleles in That is where linkage disequilibrium ... (LD), defined as non-random association of alleles at two ... 5. Linkage disequilibrium in ...

Incomplete dominance

... n. A heterozygous condition in which both alleles at a gene locus are partially expressed, ... is no dominant allele. ... be expected if the alleles showed incomplete dominance . ... Part of ... phenotypes. ... Incomplete Dominance . • The alleles for curly hair and straight ... incomplete ...

Homozygote

... homozygote n. An organism that has the same alleles at a particular gene locus on homologous ... ... - (genetics) an organism having two identical alleles of a particular ... Encyclopedia article ... inherited ... An organism that has two identical alleles of a gene. ... Homozygote cells are ...

Heterozygous

... ... heterozygous adj. Having different alleles at one or more corresponding chromosomal loci. ... English ... heterozygous - having dissimilar alleles at corresponding chromosomal loci; ... One ... (het-ur-oh-zy-gus) Having two different alleles for a given genetic character. ... ...

Heterozygote

... ( ) n. An organism that has different alleles at a particular gene locus on homologous ... ... are diploid or polyploid and have different alleles at a ... human is referred to as a ... - (genetics) an organism having two different alleles of a ... ... in the heterozygote ... ...

Genetic drift

... due to random sampling and chance: the alleles in offspring are a random sample of those in ... drift is the random change in the frequency of alleles in a population ... 3 Genetic drift and ... In a population model with genetic drift , alleles will eventually become "fixed" ... Genetic ...

Gene frequency

... allele divided by the number of copies of all alleles at the genetic place (locus) in a population. ... due to random sampling and chance: the alleles in offspring are a random sample of those in ... gene frequency of the various alternative alleles ... Britannica online encyclopedia article on ...

Alleles

... of a gene detected as different phenotypes. alleles are now understood to ... In classical ... a relationship between different forms ( alleles ) of a gene at a particular physical location ...e... Brief and Straightforward Guide: What are alleles ? ... For example, the ...

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