Nose-spray vaccine against botulism effective in first tests

... own reproductive genes have been removed. Past studies have shown that adenoviruses expressing protein antigens can be delivered by the mucosal route. In addition, adenoviruses can be quickly and inexpensively mass produced, making them an attractive ...

Researchers Report Stem Cell Advance

... their colleagues circumvented this problem by delivering the genes using adenoviruses instead, which do not insert their viral DNA into a cell's chromosomes. ... Though he praised the study, Eggan noted several caveats. First, though adenoviruses do not normally integrate their DNA into the host cell's chromosomes, ...

PATH Malaria Vaccine Initiative and Crucell to test new malaria vaccine approach

... novel prime-boost vaccine approach against the malaria parasite, Plasmodium falciparum. This approach uses Crucell's proprietary recombinant adenoviruses (a type of virus associated with the common cold and other mild respiratory infections) to deliver a malaria antigen to the immune system. Dr. ...

Now we know what blocks the effects of a newly developed anticancer therapy

... therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to block tumor cell killing by adenoviruses might provide a way to predict the response of patients to adenovirus-based therapies, and that these proteins might provide targets for the ...

JCI online early table of contents: May 1, 2009

... therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to block tumor cell killing by adenoviruses might provide a way to predict the response of patients to adenovirus-based therapies, and that these proteins might provide targets for the ...

Milestone tumor virus publication by Elsevier journal Virology

... state-of-the-art publication. In the field of viral oncology, particularly the studies of the small DNA tumor viruses (the polyomaviruses, the adenoviruses and the papillomaviruses) have led to fundamental discoveries that have advanced our understanding of basic biology. They have helped unravel some of ...

NovaBay Pharmaceuticals Announces New Preclinical Data to be Presented at the American Academy of Dermatology (AAD) 67th Annual Meeting

... broad therapeutic index with broad spectrum activity against bacteria of all types, including multidrug resistant species, shedding viruses including adenoviruses and herpes viruses, yeasts and fungi. In addition, NVC-422 has previously shown, in-vivo , to be safe at expected therapeutic doses in the nose, ...

Scientists discover a mechanism that can send cells on the road to cancer

... is very important in terms of regulating cell growth in normal and cancer cells, Dr. Tansey said. So were taking a cue from the history of work on adenoviruses and were leaving E1A behind to concentrate on Myc and p400. For us, now, the next step is to learn more about the p400-Myc connection. ...

In blood vessel stents, innovative materials allow better control, delivery of gene therapy

... local release of therapeutic genes at a disease site. In an animal study, the research team used their new synthetic formulation to bind adenoviruses to bare metal stents, tiny metal scaffolds inside the carotid arteries of rats. Adenovirus served as a gene therapy vector to carry genes for an ...

Scientists shine new light on inflammatory diseases

... pathogenesis of inflammatory diseases such as rheumatoid arthritis. The mechanism may also shed some light on why gene therapy experiments that use adenoviruses to deliver genes to humans have run into problems. The study will appear online on March 16 in the journal Nature Immunology. Tumor necrosis ...

Adenoviruses in Medical Technology

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

... local release of therapeutic genes at a disease site. In an animal study, the research team used their new synthetic formulation to bind adenoviruses to bare metal stents, tiny metal scaffolds inside the carotid arteries of rats. Adenovirus served as a gene therapy vector to carry genes for an ...

Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa

... serotype 5 (Ad5), without compromising large-scale production capabilities or the immunogenic properties of Ad5. AdVac(R) technology is based on adenoviruses that do not regularly occur in the human population, such as Ad35. In contrast to, for instance, Ad35 antibodies, antibodies to Ad5 are widespread ...

Adenoviruses in Medical Products

VIKIA Rota-Adeno

Description:... chromatographic immunoassay which simultaneously detects rotaviruses and adenoviruses in stool specimens. Rotaviruses and adenoviruses are responsible for the majority of pediatric diarrhea ....
Company:bioMerieux, Inc.

Adenoviruses in Medical Dictionary

Adenoviruses

... adenoviruses are a group of virus es that typically cause ... of the lower airway s), or pneumonia . adenoviruses . adenoviruses were first identified in 1953 from infected ...

Eye infections

... A group of virus es that cause respiratory tract and eye infections . adenoviruses used in gene therapy are altered to carry a specific tumor -fighting ... ADENOVIRUS : Any virus from the family Adenoviridae. More than 40 adenoviruses are known to infect people, causing upper respiratory tract, ...

Norwalk

... These viral infections include the Norwalk virus , rotavirus es, adenoviruses and other agents. Noroviruses, also called Norwalk -like virus es, ... different virus es can cause gastroenteritis , including rotavirus es, adenoviruses , and the Norwalk virus . Gastroenteritis is caused by swallowing one ...

Rotavirus

... These viral infections include the Norwalk virus , rotavirus es, adenoviruses and other agents. The most common virus is the rotavirus , ... different virus es can cause gastroenteritis , including rotavirus es, adenoviruses , and the Norwalk virus . Gastroenteritis is caused by swallowing one ...

Enteritis

... and all treatment options with your healthcare professional. Many different virus es can cause gastro enteritis , including rotavirus es, adenoviruses , and the Norwalk virus . Gastro enteritis is caused by swallowing one of these virus es. ENTERITIS : Inflammation of the intestine . ...

Retrovirus

... Many gene therapy clinical trials rely on retrovirus es to de liver the desired gene . Other virus es used as vector s include adenoviruses , adeno-associated virus es, lentiviruses, poxviruses, and herpes virus es. No matter what name is applied, it is a retrovirus . (A ...

Viral gastroenteritis

... digestive tract are often responsible for mild episodes of gastroenteritis . These viral infections include the Norwalk virus , rotavirus es, adenoviruses and other agents. The most common cause of diarrhea is a mild viral infection that resolves on its own within a few days. This is called ...

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Adenoviruses in Biological News

Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols

... Harbor Protocols . Genetically modified adenoviruses serve as one of the most versatile and efficient ... use today. Laboratories throughout the world use adenoviruses for the delivery of DNA to cells for basic ... therapy applications. Unlike most other vectors, adenoviruses can infect post-mitotic cells, which makes them ...

Researchers engineer pancreatic cell transplants to evade immune response

... them from rejection. They did so by harnessing the innate ability of adenoviruses to evade the body's immune surveillance system. (Adenoviruses infect ... tract, eyes, intestines, and urinary tract). After infecting cells, adenoviruses produce proteins that prevent the cells from signaling the immune system ...

Gene therapy anti-cancer research featured in Scientific American

... 1940s, virotherapy now relies heavily on adenoviruses, a cause of the common cold that has been studied and altered extensively for medical research. adenoviruses have the ability to shuttle targeted segments of DNA into a tumor cell and make biochemical changes that minimize damage to healthy cells. ...

Gamma globulin effective in treating eye infections caused by adenoviruses

... Dr. Gambotto is only slightly surprised by the results. We use this compound in our laboratory on a regular basis to block the activity of the adenoviruses that we use in gene therapy experiments. So, we were pretty sure it would have some antiviral effects. We were not prepared, however, for it to be ...

Contagious obesity? Identifying the human adenoviruses that may make us fat

... study, "Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals," in the January ... want to ensure that all the serotypes of human adenoviruses responsible for human obesity were covered in the ... testing, screening of the approximately 50 human adenoviruses might be accelerated, shortening the time ...

Polymer gel can block toxic leakage problem in gene therapy

... gene therapy that uses relatively harmless adenoviruses to infect tumor cells. Once in a targeted tumor, ... blood vessel walls and other access points, these adenoviruses cannot reach the majority of tumor cells by being ... In that study, the researchers injected adenoviruses that produce glowing proteins in order to trace ...

Targeted virus compels cancer cells to eat themselves

... team also clarified the mechanism by which such conditionally replicating adenoviruses (CRAs) infect and kill cancer cells. Autophagy is a protective process ... of hTERT-Ad on average lived 53 days. Those receiving the control adenoviruses lived on average 29 days. Two of the hTERT-Ad mice survived 60 days and ...

Three-in-one virus killer prevents common, often fatal infections

... and more practical than cell-based therapies that target EBV and CMV separately, both of which are carried in roughly 80 percent of all people. adenoviruses are common viruses carried in all populations. "There is no safe and effective therapy for patients with adenovirus infections at the moment, so ...

Adenoviruses in Biological Technology

Avian Adenovirus Genotyping Diagnostic Service

... of breeding birds, clear diagnosis of the presence of pathogenic adenoviruses (and hence their appropriate control) has been difficult historically due ... vein, determination of the relationship (or lack of) between source flock adenoviruses and those isolated in progeny flocks and the resultant causal relationship ...

Oncolytics Biotech Inc. Announces Issuance of 26th U.S. Patent

... announced that it has been granted U.S. Patent 7,344,711 entitled "Use of adenoviruses Mutated in the VA Genes for Cancer Treatment." The claims describe methods of treating cancer using adenoviruses that are modified to selectively replicate in cancer cells that have an ...

Superior Gene Silencing Using Adenoviral Vectors

... been described in the literature (1). Recombinant adenoviruses have several advantages over ... in vivo To demonstrate that adenoviruses are useful for decreasing gene ... of Iowa, injected recombinant adenoviruses expressing siRNAs targeting green fluorescent ...

Delivering siRNA Using Adenoviral Vectors

... variety of animal species. adenoviruses are popular gene delivery ... independent of cell cycle, so adenoviruses can be used to express RNA ... fact that most recombinant adenoviruses elicit an immune response in animal ...

Generate Adenovirus Vectors in E. coli by Homologous Recombination with the AdEasy Adenoviral Vector System

... Tanya Hosfield Lisa Eldridge Stratagene Recombinant adenoviruses provide a versatile means of gene delivery and expression. We describe ... more quickly and easily than traditional methods. Recombinant adenoviruses are a versatile tool for gene delivery and expression. Several features ...

Adenoviruses in Biological Definition

Gene therapy

... in gene therapy 3.1 Retroviruses 3.2 adenoviruses 3.3 Adeno-associated viruses 4 ... which look promising — retroviruses and adenoviruses . Retroviruses are small RNA based viruses. ... growing and were broken down by the body. adenoviruses are larger, DNA-based viruses, which can carry ...

Virus classification

... Family Circoviridae Family Nanoviridae Family Parvoviridae - e.g. Parvovirus B19 (most depend on coinfection with adenoviruses for growth) Unassigned genera Anellovirus ; type species: Torque teno virus RNA viruses Group III - dsRNA viruses ...