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Adenovirus in Medical News

Eliminating Cell Receptor Prevents Infections in Animal Study

... and Microbe , focused on the coxsackievirus and adenovirus receptor (CAR), which Bergelson discovered in ... identified in cultured cells. For instance, adenovirus infects the liver, but it bypasses identified adenovirus receptors in that organ. Instead the virus ...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... pancreatic cancer cells such as the coxsackie and adenovirus receptor (CAR). Circumventing CAR-mediated entry ... affinity, was inserted into the HI loop of the adenovirus serotype 5 fiber knob. To further increase the ... native adenoviral receptors, the coxsackie and adenovirus receptor (CAR) and integrin, were ablated from ...

New Study Shows Probiotic Strain Effective in Boosting Immune Response

... immune marker, versus control upon exposure to adenovirus and influenza A in healthy adults who consumed a ... in blood TNF-alpha levels upon exposure to adenovirus and influenza A in 10 healthy adults prior to and ... showed a 250% increase in TNF-alpha levels with adenovirus and a 1709% increase in TNF-alpha levels with ...

Barr's BLA for Adenovirus Type 4 and 7 Live Oral Vaccines Accepted for Filing by FDA

... for review Duramed Pharmaceuticals, Inc.'s adenovirus Types 4 and 7 Live Oral Vaccines Biologics ... Drug User Fee Action (PDUFA) date for the adenovirus BLA is July 31, 2009. "We are very ... data supporting the Company's BLA for the adenovirus (ADV) Vaccines, Types 4 and 7 resulted from a ...

Gene therapy increases survival for end-stage head and neck cancer

... of its phase III trial of Advexin(r), a modified adenovirus that expresses the tumor-suppressing gene p53, ... All basic and preclinical work on the modified adenovirus was done at M. D. Anderson. The first phase I ... p53. When injected into a tumor, the p53 adenovirus burrows into the cancer cell's nucleus. But ...

Smallpox Drug May Protect Against Common Cold

... It reduced ability of adenovirus to replicate in key organs TUESDAY, ... model (Syrian golden hamsters) suitable for adenovirus testing and a drug that successfully attacks adenovirus in the hamsters. The drug -- ...

Scientists discover a mechanism that can send cells on the road to cancer

... can promote cancer under certain conditions. adenovirus carries a number of cooperating genes that ... cant reproduce on their own. A DNA virus like adenovirus is little more than a tiny, double-stranded ... machinery in order to reproduce itself. Its not adenovirus itself, but the things it does when it enters a ...

In blood vessel stents, innovative materials allow better control, delivery of gene therapy

... scaffolds inside the carotid arteries of rats. adenovirus served as a gene therapy vector to carry genes ... layer of protein, one molecule thick, containing adenovirus vectors that delivered genes that successfully ... and acidity levels, and was useable only with adenovirus vectors. The new formulation, said Levy, is ...

Fallout From Failed AIDS Vaccine Could Dampen Research

... earlier studies. The vaccine used a harmless adenovirus -- a type of cold virus -- as a "vector" to ... had higher levels of preexisting immunity to the adenovirus before vaccination were actually much more prone ... male volunteers with a high level of preexisting adenovirus immunity, 21 of those vaccinated are now ...

PATH Malaria Vaccine Initiative and Crucell to test new malaria vaccine approach

... studies. Using Crucell's AdVac technology with two different vectorsthe adenovirus serotypes Ad35 and Ad26 as delivery mechanisms, this approach seeks to ... Carter Diggs at the USAID MVDP said, "We are pleased to support this adenovirus approach, which could play a vital role in malaria vaccine development." ...

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Adenovirus in Medical Technology

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

... scaffolds inside the carotid arteries of rats. adenovirus served as a gene therapy vector to carry genes ... when it can have the maximum benefit." The adenovirus vector carries genes that code for inducible ... animals. Although this particular study used adenovirus vectors, said Levy, the synthetic formulation ...

Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa

... is specifically designed to manage the problem of pre-existing immunity in humans against the most commonly used recombinant vaccine vector, adenovirus serotype 5 (Ad5), without compromising large-scale production capabilities or the immunogenic properties of Ad5. AdVac(R) technology is based on ...

GeoVax Labs, Inc. Comments on Discontinuance of Merck's HIV Vaccine Trial

... mobilize and then contract into a state called "central memory" from which they rapidly expand to fight the appearance of HIV. Merck's vaccines use adenovirus instead of poxvirus vectors. Adenovirus vectors provide more prolonged AIDS virus antigen exposure than the GeoVax poxvirus vectors. Prolonged ...

Introgen and Clinical Collaborators to Report New Results with Advanced-Stage Cancer Therapies at Upcoming Medical Meetings

... -- Role of the Immune System in Replicating adenovirus Using a Permissive Immune Competent Syrian ... and Anti-Tumor Immunity on the Efficacy of adenovirus Vectors in Immunocompetent Syrian Hamster Model, ... of Medicine -- Anticancer Activity of Oncolytic adenovirus Vector Armed with IFN-alpha and ADP is Enhanced ...

GenVec Announces New Research at AACR on Selectivity and Mechanism of Action of TNF-Based Anti-Cancer Therapy

... researchers presented a poster entitled, "Selective delivery of tumor necrosis factor to disseminated tumors in the peritoneal cavity using targeted adenovirus vectors," (Abstract #3310) which confirmed the ability of its molecularly targeted adenovectors to selectively deliver genes to cancer cells in ...
Adenovirus in Medical Products

Rotavirus & Adenovirus 40-41 Antigens

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories
Adenovirus in Medical Dictionary

Adenovirus

... adenovirus es are a group of virus es that typically cause ... of the lower airway s), or pneumonia . adenovirus es . adenovirus es were first identified in 1953 from infected ...

Chlamydia

... a week or two of treatment . aureus, Chlamydia trachoma tis and adenovirus also cause infections of the eye . Your friend and you have probably ... Chlamydia pneumonia , psittacosis , Myco plasma , influenza A or B, adenovirus , and Legionella. Antibiotics will be necessary in all but the mildest ...

Parainfluenza

... syncytial virus , parainfluenza and influenza virus es, and adenovirus ). More than 95 per cent of cases of croup are because of a virus ... of the time) caused by parainfluenza virus es, but RSV, measles , adenovirus , andinfluenzacan all cause croup . Bronchiolitis , Viral - An ...

Acromegaly

... myelin olysis Cerebral aneurysm Cushing's syndrome ... Acromegaly Acro phobia Addiction --see Alcohol; Drug abuse Addison's Disease adenovirus Adhesion Adrenal glands and indications for surgery Ad renal surgery , pre and post -operative instructions Adrenalectomy, discharge ...

Adenoviruses

... virus es, and the poxviruses. Major groups of single-stranded DNA virus es (class II virus es) include the parvoviruses and coliphages. adenovirus : Any virus from the family Adenoviridae. More than 40 adenoviruses are known to infect people, causing upper respiratory tract, ...

Common cold

... by a variety of microorganism s. Most cases are caused by a virus , including the virus causing the common cold , flu ( influenza virus ), adenovirus , mononucleosis , HIV , and various others. Vesicant A medication or agent that may cause blister ing. Virus A tiny infectious agent that is ...

Eye infections

... infections . Makeup, and contact lens solutions, as well as nutrition al products for the eye . os.websitesummary.com (sponsored listing) ... adenovirus : Any virus from the family Adenoviridae. More than 40 adenoviruses are known to infect people, causing upper respiratory tract, ...

Gastroenteritis

... masses. who have an intestinal virus known as gastroenteritis . who have an upper respiratory tract infection , including infection with adenovirus . who have just finished taking chemotherapy for cancer . ENTERO VIRUS - A Picorna virus , small, single-stranded RNA virus that can ...

Herpes

... of the eye - conjunctiva , iris , eyelids, etc. Several virus es have been identified as the causative agents. Among these are Herpes virus , adenovirus , Pox virus , and Myxo virus . ...

Herpesvirus

... of the eye - conjunctiva , iris , eyelids, etc. Several virus es have been identified as the causative agents. Among these are Herpesvirus , adenovirus , Pox virus , and Myxo virus . fever s, sore throat , and swollen lymph glands , especially in the neck. It is typically caused by the ...

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Adenovirus in Biological News

New vaccine developed for preventing 'uncommon cold' virus

... cold turned out to be something more? Human adenovirus type-3 is known as the "uncommon cold" because ... Disease Control and Prevention (CDC), the human adenovirus was first seen in the 1950s and is associated ... with even more expected to be isolated. adenovirus outbreaks are difficult to control because the ...

Gamma globulin effective in treating eye infections caused by adenoviruses

... and prevention of eye diseases caused by adenovirus infections, such as conjunctivitis. ... The most common cause of conjunctivitis is adenovirus infection. Unfortunately, current treatments for ... of gamma globulin (Ig) on human wild-type adenovirus as well ...

Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols

... Health Research Institute provide "Construction and Characterization of adenovirus Vectors," a set of detailed instructions for the generation, propagation, purification, and characterization of adenovirus vectors. This method is freely accessible on the website for Cold Spring ...

Tips from the Journals of the American Society for Microbiology

... and proteins from all four dengue virus types as well as incorporating an adenovirus agent. Following intramuscular vaccination, rhesus macaques showed high ... K. Porter. 2008. A tetravalent dengue virus vaccine based on a complex adenovirus vector provides significant protection in rhesus monkeys against all four ...

New vaccine may give long-term defense against deadly bird flu and its variant forms

... system for important genes from two types of the H5N1 avian influenza. The adenovirus is incapable of multiplying and so cannot cause illness to people. By using the adenovirus vector technology, a couple of problems with existing vaccines used to ...

Penn-Wistar team gains insight into HIV vaccine failure

... infection in at-risk individuals. It was noted that a subset of participants who had previous immunity in the form of neutralizing antibodies to the adenovirus 5 (Ad5) vector used to deliver the vaccine actually showed a trend toward an increased rate of HIV infection. Finding an explanation for this ...

Gene therapy appears safe to regenerate gum tissue

... incident highlighting the safety concerns of gene therapy research and treatment occurred several years ago when a teenager died when given the adenovirus during a gene therapy clinical trial at the University of Pennsylvania. The U-M therapy also uses the adenovirus, Giannobile said, but the big ...

Potential new herpes therapy studied

... that it can be active once inside is "the hard part" of these types of experiments. The University of Florida team packaged the enzyme inside an adenovirus the type of virus that causes the common cold and injected it into the mice. Afterward, the animals were infected with potentially lethal doses of ...

New type of vaccines deliver stronger and faster immune response

... attached to a gene of the virus being vaccinated against. This genetic cocktail is then inserted into an incapacitated flu-like virus such as the adenovirus and injected into the body, where it triggers a broader and more aggressive immune response, enabling the immune system to quickly seek out and ...

Gene therapy anti-cancer research featured in Scientific American

... that make tumor cells more susceptible to existing chemotherapies. Curiel and Alvarez have been testing this concept with a virus compound called adenovirus in women with recurrent ovarian or other gynecological cancers. The clinical trial is still in the early stages, yet the compound has shown ...

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Adenovirus in Biological Technology

Avian Adenovirus Genotyping Diagnostic Service

... service to facilitate the identification of avian adenovirus from tissue samples taken from commercial poultry ... a novel genetic typing analysis service for avian adenovirus infections in domestic poultry. Although ... to screen and classify different types of Fowl adenovirus A based on hexon loop (L1) genotyping. The ...

Oncolytics Biotech Inc. Announces Issuance of 26th U.S. Patent

... cells that have an activated Ras pathway. "This patent expands our adenovirus portfolio both geographically and with respect to which adenovirus variants can be used," said Mary Ann Dillahunty, Vice President of ...

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

... Growth Factor-B Gene Delivery Sustains Gingival Fibroblast Signal Transduction, (Lin, et al., J Periodont Res , 2008; 43: 440-449); and (4) adenovirus Encoding Human Platelet-Derived Growth Factor-B Delivered to Alveolar Bone Defects Exhibits Safety and Biodistribution Profiles Favorable for ...

Tips from the journals of the American Society for Microbiology

... animal viruses. When compared with a benchmark alcohol-based hand sanitizer, results showed higher levels of reduced infectivity of human rotavirus, adenovirus type 5, poliovirus type 1, and norovirus, as well as feline calicivirus and murine norovirus type 1 from the new ethanol-based sanitizer. ...

Tips from the journals of the American Society for Microbiology

... animal viruses. When compared with a benchmark alcohol-based hand sanitizer, results showed higher levels of reduced infectivity of human rotavirus, adenovirus type 5, poliovirus type 1, and norovirus, as well as feline calicivirus and murine norovirus type 1 from the new ethanol-based sanitizer. ...

Tips from the journals of the American Society for Microbiology

... animal viruses. When compared with a benchmark alcohol-based hand sanitizer, results showed higher levels of reduced infectivity of human rotavirus, adenovirus type 5, poliovirus type 1, and norovirus, as well as feline calicivirus and murine norovirus type 1 from the new ethanol-based sanitizer. ...

Barr Reports First Quarter 2008 GAAP Earnings of $0.21 Per Share; Adjusted Earnings of $0.57 Per Share

... version of Allegra(R) tablets, and higher reimbursements under its Shire development agreement, which more than offset lower reimbursements under its adenovirus agreement with the Department of Defense, as the Company completed Phase III clinical trial for Adenovirus during the quarter. Other Revenue ...

Genzyme and Sunway to Collaborate on Gene Therapy Program in China

... in 1995. It is one of only two companies in the world to have successfully developed and commercialized a gene therapy product. Sunway's H101, an adenovirus agent for the treatment of head and neck cancer, was approved in China in 2005. With strong technical, regulatory, manufacturing and clinical ...

The Genesis of Gendicine: The Story Behind the First Gene Therapy

... Gendicine binds to the coxsakie adenovirus receptor (CAR) on tumor cells. ... Therefore, Gendicine will not cause horizontal adenovirus infection or environmental contamination. ... viruses, and level of replication-competent adenovirus (RCA). For example, our released final product ...

Performance of Ad-A-Gene Cyclic AMP Response Element-Nitroreductase (CRE-NTR): an adenoviral vector gene delivery system

... images of U2OS cells transduced with the CRE-NTR adenovirus vector acquired on the IN Cell Analyzer 1000. ... a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36 , 59–74 ... of complementing E1, E4, and protein IX defective adenovirus type 5 mutants. Hum. Gene Ther. 6 , ...

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Adenovirus in Biological Products

Mouse Anti-Adenovirus Type 7 hexon C11 Monoclonal Antibody, Unconjugated, Clone 1-N-14 from GeneTex

Description:... Mouse monoclonal [1-N-14] to adenovirus Type 7 hexon C11 Immunogen: Purified adenovirus type 7 Specificity: This antibody is specific for adenovirus type 7 hexon ....
Company:GeneTex

293 cell line slides ( human: kidney; transformed with adenovirus 5 DNA ) from GeneTex

Description: Human 293 cells were cultured in Minimum Essential Medium (Eagle) with 2 mM L-glutamine and harvested at the log phase of growth. In order to keep the antigens in their native forms, cells were fixed in acetone-methanol. The cells are arrayed on a 12-well (5 mm) adhesive coated slide, with each ...
Company:GeneTex
Adenovirus in Biological Definition

Gene therapy

... when the cell is about to undergo cell division. So the descendants of that cell will not have the extra gene. This means that treatment with the adenovirus will require regular doses to add the missing gene every time new cells are produced without the gene. Adeno-associated viruses ...
Adenovirus in Biological Dictionary

Shuttle vector

... (a) a region ... Its use in Shuttle Vector Construction, 1989, Plasmid 22: 193-202. ... Provided are replication competent, recombinant adenovirus vectors containing mutations in the E1B region which permit the easy deletion of a gene or genes therein, ... GenScript's codon ...

RNA polymerase

... of RNA polymerase are known, all catalyze the ... See also: Structure of RNA Polymerase , Interactions with Promoters, Initiation ... ... adenovirus type 5-infected cells, RNA polymerase III transcription of a gene ... Although the RNA polymerase III transcripts were present at ...

Primary transcript

... transcript (pri-miRNA) becomes a microRNA (miRNA) after processing. Researchers found that the primary RNA transcript produced by adenovirus type 2 ... The primary transcript of this gene contains an intron with two possible ... PLoS ONE: an inclusive, peer-reviewed, ...

HnRNA

... of both ends ... ESTABLISHING A CELL CULTURE LAB AT MIT: pre-rRNA, hnRNA , AND POLYRIBOSOMAL mRNA ... CAPS AND POLY(A) IN LARGE hnRNA AND THE adenovirus MAJOR LATE TRANSCRIPT ... ... of hnRNA . ... hnRNA is the primary transcript that is subsequently spliced and processed to form ... measures ...

Encapsidation

... The present invention relates to a system for replication and encapsidation of recombinant DNA fragments into virus particles comprised of adenovirus associated ... HBV encapsidation signal. ... interaction, which leads to encapsidation of the pgRNA and ... The -apical loop is, however, ...

Directional cloning

... into a ... for directional cloning into the supplied. topoisomerase-charged vectors. ... Efficient directional cloning of recombinant adenovirus vectors using DNA-protein complex. ... allows the directional cloning of genes into adenoviral ... Directional cloning was carried out ...
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