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aberrant in Medical News

Major 'missed' biochemical pathway emerges as important in virtually all cells

... -- all of these diseases are linked to aberrant nitric-oxide-based signaling. An important ... years. Now we will need to study whether the aberrant cell signals are a matter of too much NO being ... are major drug targets, Stamler said. aberrant dephosphosphorylation causes disease. Expect the ...

JCI table of contents: Nov. 21, 2007

... with AML indicated that disease associated with aberrant expression of the gene PRDM16 was accompanied by ... of primary breast cancer are characterized by aberrant expression of the protein c-Rel. A causal role ... observed to be lower in mammary tumors induced by aberrant expression of c-Rel than in normal mammary ....

Misplaced metamorphosis

... metamorphosis, indicting the immune system as a critical trigger in the aberrant bone-forming process. The current study links the inflammatory ... from blood-vessel linings in this study are a major contributor to the aberrant bone growth, the researchers say they account for only half of the cells ...

Tumor suppressor may attenuate fibrotic disease

... animals. The researchers found that elevated PDGFR? signaling led to aberrant overgrowth of connective tissue. In adults, this led to a progressive ... animal model for testing novel therapeutic approaches for blocking aberrant PDGFR? signaling in human disease." ...

New guidelines for prescribing opioid pain drugs published

... Periodic drug screens should be ordered for patients at risk for aberrant drug behavior. "Regular monitoring of chronic opioid therapy patients ... known to be diverting their medication or in those engaging in serious aberrant behaviors. Breakthrough Pain: As-needed opioids can be prescribed ...

New guideline for prescribing opioid pain drugs published

... Periodic drug screens should be ordered for patients at risk for aberrant drug behavior. Other recommendations in the APS/AAPM clinical practice ... known to be diverting their medication or in those engaging in serious aberrant behaviors. Breakthrough Pain: As-needed opioids can be prescribed ...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology Meeting

... age-related macular degeneration or diabetic retinopathy, it is clear that aberrant retinal vascularization occurs in a manner not unlike that of other ... tend to be leaky, structurally aberrant, inefficient and fragile. These aberrant capillaries induce or promote a variety of pathological conditions ...

Novel discovery by Einstein scientists could lead to much-needed kidney failure treatment

... is crucial in podocyte development, the Einstein researchers reasoned that aberrant Notch signaling might play a role in causing kidney disease. The Notch ... the observations made in the Einstein study offer strong evidence that aberrant Notch signaling is also involved in diabetic nephropathy (DNP) and focal ...

JCI table of contents: Feb. 21, 2008

... Further investigation revealed that the balance disorder was caused by the aberrant development of gravity-sensing organs due to inactivation of an NADPH ... might provide a new approach to treating human conditions associated with aberrant blood clot formation, such as several forms of heart diseases and strokes, ...

Scientific poster abstracts from the 24th annual meeting of the American Academy of Pain Medicine

... Philadelphia VA Medical Center: Characteristics of Patients Referred with aberrant Behavior or At Risk for Substance Misuse 182 Predictors of the Resolution of aberrant Drug Behavior in a Sample of Patients Treated in the Opioid Renewal Clinic ...

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aberrant in Medical Technology

Preliminary Phase 2 Results of R788 in Lymphoma Show Benefit in Diffuse Large B-Cell and SLL/CLL

... by the Syk enzyme, which signals the growth/survive mechanism of the aberrant cells. By inhibiting Syk, that signal is curtailed and the aberrant cells cannot proliferate. In 2006, lymphoma affected an estimated ...

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

... differentiation, proliferation and survival/apoptosis. Dysregulation of the PI3 kinase signaling cascades can lead to cancer and aberrant PI3K pathway activity is observed with high frequency in a variety of tumor types. PI3K signaling through its downstream effectors AKT and mTOR is ...

Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting

... differentiation, proliferation and survival/apoptosis. Dysregulation of the PI3 kinase signaling cascades can lead to cancer and aberrant PI3K pathway activity is observed with high frequency in a variety of tumor types. PI3K signaling through its downstream effectors AKT and mTOR is ...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

... animal models of ocular disease and in human clinical trials. The inhibition of both TORC1 and TORC2 should result in more complete inhibition of aberrant PI3K/Akt/mTOR signaling and are therefore of active interest for pharmaceutical development. Palomid 529 is a first-in-class dual TORC1/TORC2 ...

Alba Therapeutics Corporation Announces the Next Clinical Trial of Its Lead Compound, Larazotide Acetate and Promotions

... of pharmaceutical products to treat autoimmune and inflammatory diseases and is based in Baltimore, Maryland. Genetics, environment, aberrant immune response, and barrier dysfunction are all required for autoimmunity. Alba's technology platform is based on modifying disease state ...

Clinical Lab Products Magazine Features Biomoda

... at a reasonable cost. The non-invasive test, originally developed at Los Alamos National Laboratory, allows clinicians to identify cancerous or aberrant cells extracted from samples of lung sputum; cancerous cells in the sputum exposed to the assay glow red under fluorescent light and can be detected ...

FDA Reviewing Biomoda Submission for Cancer Screening Study

... at a reasonable cost. The non-invasive test, originally developed at Los Alamos National Laboratory, allows clinicians to identify cancerous or aberrant cells extracted from samples of lung sputum; cancerous cells in the sputum exposed to the assay glow red under fluorescent light and can be detected ...

Small Business Innovation Research Program Awards Grant to Biomoda

... is designed for early lung cancer screening of large populations at a reasonable cost. With the technology, clinicians can identify cancerous or aberrant cells extracted from samples of lung sputum; cancerous cells glow red under fluorescent light and can be detected under a microscope. Earlier this ...

Presentation of Data on Progen's Cancer Epigenetic Targets Platform

... DNA sequence itself, but rather are associated with changes in the activation and regulation of gene transcription. Its role in cancer, through the aberrant silencing or repression of gene expression, is now recognized and a number of epigenetic targets in oncology have now been identified. LSD-1 is the ...

Biomoda to Present Paper on Enhanced Technology for Early Detection of Lung Cancer at Annual SWARM Meeting

... porphyrin molecule that preferentially binds to cancerous or aberrant cells extracted from the body as sputum, blood or urine. Cancerous or aberrant cells that bind porphyrin glow red under ultraviolet light; non-cancerous cells do not fluoresce. Current diagnostic methods for lung cancer -- the ...

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aberrant in Medical Definition

Numbering aberrant rhythms

... be quadrigeminal. Typically, if every fifth or more beat is abnormal, the aberrant beat would be termed occasional. Bigeminy is contrasted with Couplets ... Ventricular tachycardia or NS-VT. PVC's are not the only aberrant beat that makes use of these adjectives; others are premature atrial ...

Proteopathy

... by a similar mechanism, including AA amyloidosis, apolipoprotein AII amyloidosis, and Aβ amyloidosis. [9] [10] In all of these instances, an aberrant form of the protein itself appears to be the pathogenic agent. Proteopathy Major aggregating protein Alzheimer's disease, Cerebral ...
aberrant in Medical Dictionary

Drug Addiction

... of Psychiatry volume 158, issue 3, (March 2001). Kelly, Timothy. " Addiction : A Booming $800 Billion Industry." The World and I (July 1, 2000). aberrant drug -taking behavior in cancer pain management is generally related to pre morbid history of drug addiction and the likelihood of other ...

Thalassemia

... from the nucleus to the cytoplasm, and in the control of mRNA stability. Polyadenylation is a key regulatory step in the expression of many genes . aberrant polyadenylation has been shown to cause disease s such as thalassemia ... ...
aberrant in Biological News

Cancer's distinctive pattern of gene expression could aid early screening and prevention

... an eye on early identification of some of the aberrant adjustments that enable cancer cells to thrive. ... disorders. Because tumor cells that result from aberrant changes shed their DNA into bodily fluids, ... single tumor that anybody has looked at has aberrant change in DNA methylation. It's clearly not ...

SUMO protein guides chromatin remodeler to suppress genes

... diseases such as Alzheimer's, where aberrant gene expression and altered SUMO function are ... this enzyme complex is responsible for preventing aberrant expression. aberrant gene expression is a common feature of cancer and ...

Karen Beemon wins the 2007 Retrovirology Prize

... in establishing that one of the important transformation mechanisms is the aberrant phosphorylation of cellular proteins on tyrosine residues. Dr Beemon ... that transformation mechanisms of multiple classes of retroviruses involve aberrant phosphorylation of cellular proteins at tyrosine residues. Over the last ...

SRI announces selection by the National Cancer Institute as a Chemical Biology Consortium center

... medicinal chemists with expertise in fundamental and applied cancer research, focuses on the study of tumor microenvironment, tumor metabolism, and aberrant signaling pathways that cause cancer. Through collaborative partnerships, SRI's Center for Cancer Research has been successful in generating an ...

UCLA researchers discover new molecular pathway for targeting cancer, disease

... the next stages of research finding a pharmaceutical drug or substance molecule to act as an agonist, which would stimulate LXR activity to inhibit aberrant Hh signaling. "The hedgehog Hh signaling pathway is an important regulator of tumor formation, and these findings suggest that LXR agonists ...

Chromosomal problems affect nearly all human embryos

... of human embryos used low resolution techniques on embryos derived from couples with fertility problems who are at risk for embryonic aneuploidy, an aberrant number of chromosomes, such as three copies of chromosome 21 that results in Down's syndrome. Therefore, little was known about the frequency and ...

The battle for CRTC2: How obesity increases the risk for diabetes

... how a condition known as ER (endoplasmic reticulum) stress, which is induced by a high fat diet and is overly activated in obese people, triggers aberrant glucose production in the liver, an important step on the path to insulin resistance. In healthy people, a "fasting switch" only flips on glucose ...

Drug prevents seizure progression in model of epilepsy

... an experimental model for epilepsy, Barth asked whether paxilline could reduce or prevent experimentally induced seizures, as it could normalize aberrant brain activity induced by previous seizures. Remarkably, Barth and colleagues Jesse Sheehan and Brett Benedetti discovered that the compound was ...

CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments

... is concentrated at (and supports the structure of) the centromere, the bow's central "knot." Since centromeres are crucial for genomic integrity, aberrant heterochromatin formation can result in genetic anomalies and diseases such as cancer. Heterochromatin depends on the density of chemical "marks" ...

Malfunction of the respiratory epithelium is a cause of allergy?

... (1) Allergy , and (2) Journal of Allergy and Clinical Immunology . Research on the mechanisms of allergy has focused on the understanding of aberrant immunoresponses. Only lately the role of epithelium as the first line of defense against allergens has been realized. So far, we do not know why and ...

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aberrant in Biological Technology

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... PX-866 is an inhibitor of the PI-3-kinase/PTEN/AKT pathway, an important survival signaling pathway that is activated in many types of human cancer. aberrant activation and regulation of PI-3 kinase is implicated in a large proportion of human cancers including breast, glioma, colon, ovarian, prostate and ...

NeurogesX Receives European Commission Approval for Qutenza(TM)

... nervous systems. Peripheral neuropathic pain is an inappropriate sensation of pain that results when injured or dysfunctional nerve endings send aberrant pain signals to the brain, in the absence of harmful stimuli. It can result from viruses, in cases of postherpetic neuralgia (PHN) and painful ...

Oncothyreon's PX-866 is effective in preclinical model of pulmonary fibrosis

... PX-866 is an inhibitor of the PI-3-kinase/PTEN/AKT pathway, an important survival signaling pathway that is activated in many types of human cancer. aberrant activation and regulation of PI-3 kinase is implicated in a large proportion of human cancers including breast, glioma, colon, ovarian, prostate and ...

NeurogesX Presents Two Posters at 61st Annual American Academy of Neurology Annual Meeting

... nervous systems. Peripheral neuropathic pain is an inappropriate sensation of pain that results when injured or dysfunctional nerve endings send aberrant pain signals to the brain, in the absence of harmful stimuli. It can result from viruses, in cases of PHN and painful HIV-distal sensory ...

Groundbreaking Research Begins for Pancreatic and Lung Cancers

... a surgical oncologist with an extensive background in basic and translational research, are applying state-of-the-art technologies toward identifying aberrant molecular and cellular mechanisms. Using microarray technology, gene expression patterns in pancreatic tumor tissue are compared with those present ...

NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union

... nervous systems. Peripheral neuropathic pain is an inappropriate sensation of pain that results when injured or dysfunctional nerve endings send aberrant pain signals to the brain, in the absence of harmful stimuli. It can result from viruses, in cases of postherpetic neuralgia (PHN) and painful ...

TauTaTis Discovers Potent Inhibitor of Parkinson's Disease Gene Activity

... http://www.tautatis.com ) is an early stage company centered on the preclinical and clinical development of compounds, which directly interfere with aberrant biochemical processes in degenerating nerve cells. Its lead compound is the result of an optimization process conducted over more than a decade ...

Tigris Pharmaceuticals Files IND Application for GGTI-2418

... field of geranylgeranylation inhibitors. I look forward to the fruitful translation of our preclinical work to target patients whose tumors harbor aberrant signal transduction pathways most likely to respond to GGTI-2418," stated Said M. Sebti, Ph.D., Director of the Drug Discovery Program at the Moffitt ...

Cordex Pharma Presents 'New Frontiers in Cardiovascular Medicines' on January 29

... numerous enzymes that are now known to be regulated by S-nitrosylation. Accumulating evidence suggests that many disease states are associated with aberrant protein S-nitrosylation. Dr. Stamler's group also identified the enzyme responsible for bioactivation of nitroglycerin, the ability of red blood ...

Cylene Pharmaceuticals Initiates Phase II Clinical Trial of Quarfloxin (CX-3543) in Patients With Carcinoid/Neuroendocrine Tumors

... therapeutics act indirectly on rRNA Biogenesis through upstream modulators, but quarfloxin is the first agent to directly target this cancer-specific aberrant cell function. About Cylene Pharmaceuticals, Inc. Cylene Pharmaceuticals is a biotech pharmaceutical company dedicated to the ...

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aberrant in Biological Definition

Cancer

... material) through genetic and environmental factors , leading to aberrant growth regulation of cells. Cell multiplication ( proliferation ) is a ... Cancer can also occur in young children, particularly infants. Here, the aberrant genetic processes that fail to safeguard against the clonal proliferation ...

Promoter

... 2.2 Eukaryotic promoters 3 Binding 4 Diseases Associated with aberrant Promoter Function Promoter elements Core promoter ... K = 10E7 RP(closed) RP(open). K = 10E-2 Diseases Associated with aberrant Promoter Function Though OMIM is a major resource for gathering ...
aberrant in Biological Dictionary

Dicentric

... Dicentric chromosome is an aberrant chromosome having two centromeres. Dicentric chromosomes form when two ... ... Dicentric chromosome Dicentric chromosome is an aberrant chromosome having two centromeres. ... Dicentric chromosomes form ...

Dehiscent

... about Dehiscent in the free online English dictionary and ... This aberrant dehiscent facial nerve was discovered during a routine tympanoplasty. ...... Meaning of dehiscent medical term. What does dehiscent mean? ... This aberrant dehiscent facial nerve was discovered during a routine ... dehiscent ...

Thymus gland

... thymus gland , in response to acute stress such as an ... Get information, facts, and pictures about thymus gland at Encyclopedia.com. ... aberrant thymus and parathyroid gland presenting as a recurrent lateral neck ... Hellinger Life Saving Procedure for the Thymus Gland to boost ...

Post-meiotic segregation

... segregation (PMS) tetrads, with GC tetrads representing repair ... Post meiotic segregation (PMS) events at HIS4 were detected ... ... of aberrant segregation associated with meiotic recombination at HIS4. ... Failure to repair the mismatch will result in a post meiotic segregation ...

Euploidy

... > ... What do you mean by euploidy ? What is abortion euploidy ? ... Modern Genetic Analysis was written for instructors and students ... aberrant Euploidy Organisms with multiples of the basic chromosome set are called euploid. ... A series of studies has helped to shed light on when ...

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Other Contents
(Date:8/22/2014)... (PRWEB) August 22, 2014 Japantown Dental ... a new teeth whitening technique. Air polishing is a ... appointments. , Dark teeth can be caused by a ... external stains and internal stains. External stains include coffee, ... be caused by certain medications, such as tetracycline, and ...
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(Date:8/22/2014)... New Orleans, LA The LSU Health New ... Advanced Education Nursing Traineeship grant to increase access ... disadvantaged, underserved and under-represented groups, as well as ... the US Department of Health and Human Services ... will serve as the grant,s project director., The ...
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Breaking Medicine News(10 mins):Health News:Japantown Dental Introduces Air Polishing 2Health News:Toyota Indiana Adding 300 Jobs to Build More Highlanders 2Health News:Millennium Treatment Group Has a New Website 2Health News:Mi40x: Review Exposes Ben Pakulski’s Guide to Packing on Lean Muscle Fast 2
(Date:8/22/2014)... Bethesda, MD FASEB MARC (Maximizing Access to Research ... the FASEB Grant Writing Seminar & Practical Exercises Workshop ... in Bethesda, Maryland from August 25-26, 2014. These ... postdoctorates and research scientists from underrepresented groups in the ... This year MARC conferred 11 awards totaling $20,350. ...
(Date:8/22/2014)... important discoveries in basic and clinical research and ... into a complex offensive spanning multiple fronts. , ... lab could help find new and more selective ... that targets a specific enzyme overexpressed in certain ... from brain tumours. , Chemistry professor Christopher Cairo ...
(Date:8/22/2014)... study of captive black rhino reproduction in Europe ... of breeding programmes. , Researchers from Chester Zoo, ... Liverpool carried out a six-year study which encompassed ... Dr Katie Edwards led the research as part ... She says: "Although some black rhinoceros breed well ...
Breaking Biology News(10 mins):New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3Hormone analysis helps identify horny rhinos 2
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