tubulin

DNA Recombination and Repair—A New Twist to RecA Function

... intracellular cargo along fibers made of actin or tubulin proteins. The ATP-dependent assembly of actin or tubulin fibers itself can work as a motor: for instance, the march of white blood cells toward pathogens is ...

The making and breaking of microtubules

...evel the forms taken by transitional structures of tubulin (the protein from which microtubules are formed) d... these peculiar structures show how the binding to tubulin of the nucleotide guanosine triphosphate, GTP, controls activity at the growing end of the microtubu...

Snapin: A protein with therapy potential for autism

...to the protein snapin. When snapin binds to cypin, tubulin is crowded out, so fewer dendrites assemble and more branching occurs. When researchers overexpressed snapin in hippocampal neurons in the lab, the number of primary dendrites growing out of the cell body decreased, but many more secondary dendrites...

Sea coral's trick helps scientists tag proteins

... the cytoskeleton of the cell, including actin and tubulin filaments and found the expected patterns of intracellular protein distribution. Dendra belongs to a small family of green-to-red PAFPs. The first protein in this family, Kaede--which is Japanese for maple leaf--was discovered by Japanese researche...

Insects that produce males from unfertilized eggs reveal a surprising cellular feat

...abeled antibodies that recognize and bind to gamma tubulin and other centrosomal proteins, they demonstrated the presence of these proteins in accessory nuclei and showed that the accessory nuclei appear to give rise to centrosomes. Accessory nuclei bud off from the membrane of the nucleus, the cellular st...

More>>

tubulin at Biology Products

Mouse Anti-Tubulin IV, beta Monoclonal Antibody, Unconjugated, Clone ONS.1A6 from Sigma-Aldrich

...#946;-tubulin isotype IV. No reactivity with other tubulin isotypes is observed. ascites fluid synthetic peptide corresponding to the C-terminal sequence of β-tubulin isotype IV, conjugated to BSA ....

tubulin at Biology Technology

Assessing Gene Function with siRNA Libraries

...g of multiple markers, including tubulin to reveal microtubule distribution. This approach revealed one kinase siRNA that triggered a prometaphase-like arrest state (nearly 16% mitotic index, or ~7-fold higher than normal) wherein spindl...

tubulin at Biology Definition

Tubulin

...it hydrolyzes GTP into GDP. The GDP-bound form of tubulin will disassemble from the tip of a microtubule, th...lutionarily related to tubulin. Delta and epsilon tubulin have been found to localize at centrioles and may play a role in forming the mitotic spindle during ...

Cytoskeleton

...ts which, in turn, are polymers of alpha and beta tubulin . They have a very dynamic behaviour, binding GTP for polymerization, they are organized by the centrosome . They play key roles in: Intracellular transport (asociated with dyneins and kinesins they transport organelles like mitochondria...

Colchicine

...] . It inhibits the cytoskeleton by binding to tubulin , one of the main constituents of microtubules . Apart from inhibiting mitosis , a process heavily dependent on cytoskeletal changes, it also inhibits neutrophil motility and activity, leading to a net anti-inflammatory effect. Colchicine as...

tubulin at Biology Dictionary

Tubulin

...re assembled from dimer s of α- and β- tubulin . Each of these subunits has three domain s. γ- tubulin is important in the nucleation and polar orientation of microtubule. Full article >>> ...

Mitotic spindle

...icrotubules . Microtubules are synthesized from tubulin monomers in the cytoplasm and grow out from each centrosome . The chromosomes become shorter and more compact. Full article >>> A specialized region on the centromere that links each sister chromatid to the mitotic spindle ...

Microtubules

...ts which, in turn, are polymers of alpha and beta tubulin . Full article >>> Microtubules a...k are built by the assembly of dimer s of alpha tubulin and beta tubulin . Full article >>> Microtubules act as tracts along which organ...

Marker

... we observed a strong reduction in acetylated a- tubulin immunoreactivity (a marker of stable microtubu...uction of the in situ hybridization signal for tubulin m RNA . Full article >>> Gusella and his research team, who used RFLP s to identify...

Mammals

...... Full article >>> The different tubulin isoforms seem, however, to be functionally equivalent. G- tubulin is localize d in the centrosome and is involved in nucleation of microtubule assembly during the...

More>>

tubulin at Medicine News

Hope For Patients With Prostate Cancer

...d to other treatments. Taxotere works by stopping tubulin -- a protein that helps cancer cells divide and grow. The drug Taxotere in combination with prednisone was found to extend the lifespan of patients by about 2.5 months.Side effects of the drug combination include nausea, hair loss, bone marrow suppre...

Erroneous Laboratory Operation May Lead To a Cancer Drug

...section of cell cytoskeleton called tubulin. While tubulin is involved in building the cell arrangement, PPAR-gamma breaks it down. This indirectly indicates that the gamma compound could actually counter the effect of tumor cells to chemotherapy. Schaefer also intends to pursue this study further and cond...

tubulin at Medicine Products

No data found

Search tubulin medicine products at Google

Search tubulin medicine products at Yahoo

Search tubulin medicine products at Msn

tubulin at Medicine Technology

Study Shows Advantages of Complete Phase Ib Trial Over Separate Phase I Trials

...e new agent issynergistic with an anthracycline, a tubulin interactive agent, anantimetabolite, or an angiogenesis inhibitor of an antibody toepidermal growth factor receptor, EGFR) patients with advancedcancer are treated with the combination deemed most likely to be ofhelp, with a choice of anthracycline +...

EntreMed Presents Preclinical Data for MKC-1 in Hematological Cancers

...inding to multiple intracellular targets,including tubulin and the importin-beta proteins. The importin-betaf...s inPhase 2 studies for cancer. ENMD-1198, a novel tubulin bindingagent, is also in Phase 1 studies in advanced cancers. EntreMed'sgoal is to develop and comme...

EntreMed Presents Multi-Mechanism Results for ENMD-1198 at AACR Annual Meeting

...s inPhase 2 studies for cancer. ENMD-1198, a novel tubulin bindingagent, is also in Phase 1 studies in advanced cancers. EntreMed'sgoal is to develop and commercialize new compounds based on theCompany's expertise in angiogenesis, cell cycle regulation andinflammation -- processes vital to the treatment of c...

EntreMed Presents Multi-Mechanism Antitumor Data for ENMD-1420 in Preclinical Models

...ls. Previous studiesshowed that ENMD-1420 inhibits tubulin polymerization and TNF-alphaproduction, contributi..., stated, "We continue to make good progresson our tubulin inhibitor program. The results of these studies willhelp us to further identify a lead molecule for ...

ZIOPHARM Presents Unique Mechanism Data for Indibulin at AACR

... to peripheralneuropathy. While indibulin binds to tubulin in general, it doesnot bind to neuronal specific tubulin and does not disrupt normalaxonal microtubules in vitro, likely accounting for the differencewith re...

More>>