Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
...yrene, a known potent mutagen and carcinogen, as a surrogate for total PAH exposure. Cruise emissions, cold engine emissions and intersection emissions were used to estimate total traffic PAH emissions. In addition, meteorological information was used in a geographic dispersion model to determine PAH exposure......der of genes in a particular genome -- acting as a surrogate measure of cell physiology, said researchers at Ba...pes to determine the order of genes and are a good surrogate measure of cell status," said Dr. Gad Shaulsky, associate professor of molecular and human genetics ...Russian 'surrogate' alcohols are a killer
...esearchers have now analyzed the contents of these surrogate alcohol products, finding either high alcohol cont..." For the current study, researchers analyzed the surrogate products being consumed, dividing them into three broad groups: "samogon" (home-produced spirits, al...Phenolic compounds may explain Mediterranean diet benefits
...ta suggest that endothelial dysfunction could be a surrogate end point for prediction of cardiovascular risk, but we need more information on the utility of the different methods to evaluate endothelial dysfunction," Dr. Pérez Jiménez said. Robert F. Wilson, M.D., from the University of Minnesota in Minneapol...Researchers use mass spectrometry to detect norovirus particles
...y separated, purified and concentrated a norovirus surrogate from a clinical sample within a few hours. Nanospray mass spectrometry was used to demonstrate the feasibility of detecting norovirus particles in the purified concentrates. Human norovirus is responsible for an estimated 23 million cases of gastroi...Principles and applications of electrical cell fusion
...ult. The fusion product is implanted into a surrogate mother and is then carried through the full gestation period. Cloning mammals from embryonic cells was carried out as long ago as the late 1980s [6 -10] and aroused little public interest at the time. ...Principles and applications of electrical cell fusion
...ult. The fusion product is implanted into a surrogate mother and is then carried through the full gestation period. Cloning mammals from embryonic cells was carried out as long ago as the late 1980s [6 -10] and aroused little public interest at the time. ...SNPs Powerful Tools for Association Studies
...s location can help focus the search for possible surrogate or causative SNPs in candidate gene or candidate region association studies. However, most SNPs are neutral functionally; only a small minority directly affect gene function by altering protein coding or regulatory element sequences. Becaus...FDA programs encourage and expedite drug development and approval
...ct based on substantial evidence of an effect on a surrogate endpoint reasonably likely to predict clinical benefit, such as evidence of how patients feel, function, or appear during well-controlled clinical trials. The FDA requires post-approval studies to verify the clinical benefit, and also can impose res......ence is. Part of the technologist role is to play surrogate machine, to encounter the messy, analog real world, understand it at least a little bit, and then place that understanding in progressively more structured languages until the actual machines can do something productive with it. The danger in this ro...FDA Approves Remodulin for Pulmonary Hypertension
... for marketing clearance based on an effect// on a surrogate endpoint, provided well-controlled postmarketing studies are conducted. United Therapeutics received an approvable letter for Remodulin earlier this year after the FDA's Cardiovascular and Renal Drugs Advisory Committee voted 6-3 in August 2001 to ...Steroid Treatment after head injury may be fatal
...void trusting in underpowered clinical trials with surrogate rather than clinical endpoints, and transferring evidence from one disease to another."...SNUPPY – Woo Suk Hwang reveals World’s first dog cloe
...d adult male Afghan, and transferred them into 123 surrogate mothers. Just three pregnancies resulted: one misc...t, the embryos were implanted into the uterus of a surrogate mother, which was a labrador dog. The team used DNA fingerprinting to confirm that Snuppy was geneti...Researchers Bring New Insight To Asthma And SABA Fills
...ta-agonist (SABA) prescriptions could be used as a surrogate marker for asthma morbidity of steroid and non-steroid users//. Using claims data for recipients covered by Illinois Medicaid, with a diagnosis of asthma from fiscal year 1996 through June 1998, researchers from Chicago, IL, obtained the claims for ...India's first surrogate in vitro fertilization (IVF) baby of a single pare...VF technology and transferred to the uterus of the surrogate mother. IMA president Sudipto Roy said he could comment on legal matters, "but from medical point ...NovaDel Announces Positive Data from Two Studies Comparing Zolpidem Oral Spray to Ambien Tablets
...STmeasurements are a scientifically, well accepted surrogate forsedation and a significant reduction in DSST score may indicateearlier onset of therapeutic action for these drugs." NovaDel's findings from its pharmacodynamic study using DSSTyielded the following results for healthy volunteers in the NVD003stu...... Express2(TM) Stent system mayrepresent a clinical surrogate for the improved deliverability andconformability of the TAXUS Liberte Stent as compared to the TAXUSExpress Stent. TAXUS ATLAS is a global, multi-center single arm trial comparingthe TAXUS Liberte paclitaxel-eluting stent system to a case-matchedco...Lilly Studies Try to Shed Light on Impact of Race on Lung Cancer Treatment
...ess of ALIMTA insecond-line NSCLC was based on the surrogate endpoint, responserate. There are no controlled trials demonstrating a clinicalbenefit, such as a favorable survival effect or improvement ofdisease-related symptoms. Important Safety Information Myelosuppression is usually the dose-limiting toxici...... (IBDQ), and investigationof a number of potential surrogate biomarkers. Rates of remissionand response nearly doubled for evaluable subjects treated withAlequel(TM) compared to placebo, although, due to the size of thestudies, the differences were not yet statistically significant.Enzo is currently enrolling ......heart and kidney). PRA is an independentand direct surrogate marker for several cardio-renal diseases, suchas myocardial infarction and chronic renal disease. Renininhibitors lower PRA whereas most current leading anti-hypertensivedrug classes such as ACE-Is and ARBs increase PRA levels. Speedel in-licensed S...