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surrogate at Biology News

Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth

...yrene, a known potent mutagen and carcinogen, as a surrogate for total PAH exposure. Cruise emissions, cold engine emissions and intersection emissions were used to estimate total traffic PAH emissions. In addition, meteorological information was used in a geographic dispersion model to determine PAH exposure...

Microarrays as phenotype

...der of genes in a particular genome -- acting as a surrogate measure of cell physiology, said researchers at Ba...pes to determine the order of genes and are a good surrogate measure of cell status," said Dr. Gad Shaulsky, associate professor of molecular and human genetics ...

Russian 'surrogate' alcohols are a killer

...esearchers have now analyzed the contents of these surrogate alcohol products, finding either high alcohol cont..." For the current study, researchers analyzed the surrogate products being consumed, dividing them into three broad groups: "samogon" (home-produced spirits, al...

Phenolic compounds may explain Mediterranean diet benefits

...ta suggest that endothelial dysfunction could be a surrogate end point for prediction of cardiovascular risk, but we need more information on the utility of the different methods to evaluate endothelial dysfunction," Dr. Pérez Jiménez said. Robert F. Wilson, M.D., from the University of Minnesota in Minneapol...

Researchers use mass spectrometry to detect norovirus particles

...y separated, purified and concentrated a norovirus surrogate from a clinical sample within a few hours. Nanospray mass spectrometry was used to demonstrate the feasibility of detecting norovirus particles in the purified concentrates. Human norovirus is responsible for an estimated 23 million cases of gastroi...

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surrogate at Biology Products
surrogate at Biology Technology

Principles and applications of electrical cell fusion

...ult. The fusion product is implanted into a surrogate mother and is then carried through the full gestation period. Cloning mammals from embryonic cells was carried out as long ago as the late 1980s [6 -10] and aroused little public interest at the time. ...

Principles and applications of electrical cell fusion

...ult. The fusion product is implanted into a surrogate mother and is then carried through the full gestation period. Cloning mammals from embryonic cells was carried out as long ago as the late 1980s [6 -10] and aroused little public interest at the time. ...

SNPs Powerful Tools for Association Studies

...s location can help focus the search for possible surrogate or causative SNPs in candidate gene or candidate region association studies. However, most SNPs are neutral functionally; only a small minority directly affect gene function by altering protein coding or regulatory element sequences. Becaus...

FDA programs encourage and expedite drug development and approval

...ct based on substantial evidence of an effect on a surrogate endpoint reasonably likely to predict clinical benefit, such as evidence of how patients feel, function, or appear during well-controlled clinical trials. The FDA requires post-approval studies to verify the clinical benefit, and also can impose res...

Machine like me

...ence is. Part of the technologist role is to play surrogate machine, to encounter the messy, analog real world, understand it at least a little bit, and then place that understanding in progressively more structured languages until the actual machines can do something productive with it. The danger in this ro...

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surrogate at Biology Definition

Infertility

... take place inside the woman's body. Use of a surrogate mother to carry the child. Ethics There are many ethical issues associated with infertility and its treatment. High-cost treatments are out of financial reach for some couples. Health insurance and infertility treatment. The status of embr...

Cloning

... this provided hope that similar techniques (using surrogate mothers of another species) might be used to clone extinct species; in anticipation of this possibility, the last bucardo, a Spanish mountain goat, was frozen immediately after it died (from illness after birth). Researchers are also considering clo...
surrogate at Biology Dictionary

Stem cell

...ected into blastocyst s, which are implanted into surrogate mothers. Full article >>> Germline stem cell s reside in the anteriormost region of the germarium, immediately under the terminal filament (Fig. 1A). Full article >>> B cell A type of lymph ocyte derived from bone ...

Polygenic disorders

...nformative short tandem repeat polymorphism as a surrogate for a less-informative gene and to explore complex, multifactorial, or polygenic disorders . Full article >>>...

Blastocyst

...ected into blastocyst s, which are implanted into surrogate mothers. Another method, useful in organ isms such as drosophila , is to induce mutation s in a large population and then screen the progeny for the desired mutation . Full article >>> Egg , 2- cell , 8- cell , and blastocyst...
surrogate at Medicine News

FDA Approves Remodulin for Pulmonary Hypertension

... for marketing clearance based on an effect// on a surrogate endpoint, provided well-controlled postmarketing studies are conducted. United Therapeutics received an approvable letter for Remodulin earlier this year after the FDA's Cardiovascular and Renal Drugs Advisory Committee voted 6-3 in August 2001 to ...

Steroid Treatment after head injury may be fatal

...void trusting in underpowered clinical trials with surrogate rather than clinical endpoints, and transferring evidence from one disease to another."...

SNUPPY – Woo Suk Hwang reveals World’s first dog cloe

...d adult male Afghan, and transferred them into 123 surrogate mothers. Just three pregnancies resulted: one misc...t, the embryos were implanted into the uterus of a surrogate mother, which was a labrador dog. The team used DNA fingerprinting to confirm that Snuppy was geneti...

Researchers Bring New Insight To Asthma And SABA Fills

...ta-agonist (SABA) prescriptions could be used as a surrogate marker for asthma morbidity of steroid and non-steroid users//. Using claims data for recipients covered by Illinois Medicaid, with a diagnosis of asthma from fiscal year 1996 through June 1998, researchers from Chicago, IL, obtained the claims for ...

A first for India - IVF baby born of surrogacy

India's first surrogate in vitro fertilization (IVF) baby of a single pare...VF technology and transferred to the uterus of the surrogate mother. IMA president Sudipto Roy said he could comment on legal matters, "but from medical point ...

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surrogate at Medicine Products
surrogate at Medicine Technology

NovaDel Announces Positive Data from Two Studies Comparing Zolpidem Oral Spray to Ambien Tablets

...STmeasurements are a scientifically, well accepted surrogate forsedation and a significant reduction in DSST score may indicateearlier onset of therapeutic action for these drugs." NovaDel's findings from its pharmacodynamic study using DSSTyielded the following results for healthy volunteers in the NVD003stu...

Positive Results for Second-Generation Taxus Liberte Coronary Stent System Highlighted in Journal of American College of Cardiology

... Express2(TM) Stent system mayrepresent a clinical surrogate for the improved deliverability andconformability of the TAXUS Liberte Stent as compared to the TAXUSExpress Stent. TAXUS ATLAS is a global, multi-center single arm trial comparingthe TAXUS Liberte paclitaxel-eluting stent system to a case-matchedco...

Lilly Studies Try to Shed Light on Impact of Race on Lung Cancer Treatment

...ess of ALIMTA insecond-line NSCLC was based on the surrogate endpoint, responserate. There are no controlled trials demonstrating a clinicalbenefit, such as a favorable survival effect or improvement ofdisease-related symptoms. Important Safety Information Myelosuppression is usually the dose-limiting toxici...

Enzo Biochem Individualized Oral Immune Regulation Therapy May Be Effective Approach to Treating Crohn's Disease

... (IBDQ), and investigationof a number of potential surrogate biomarkers. Rates of remissionand response nearly doubled for evaluable subjects treated withAlequel(TM) compared to placebo, although, due to the size of thestudies, the differences were not yet statistically significant.Enzo is currently enrolling ...

New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard Therapy in Treatment of Hypertension

...heart and kidney). PRA is an independentand direct surrogate marker for several cardio-renal diseases, suchas myocardial infarction and chronic renal disease. Renininhibitors lower PRA whereas most current leading anti-hypertensivedrug classes such as ACE-Is and ARBs increase PRA levels. Speedel in-licensed S...

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surrogate at Medicine Definition

Surrogate markers

...rged into Surrogate endpoint . ( Discuss ) A surrogate marker (or surrogate end point ) is term used in medical research for a change to the human body that is believe to be ...
surrogate at Medicine Dictionary

Surrogate

...ection . Full article >>> Indirect surrogate s. Disease -free survival. Progression-free survi...rm bank is inserted directly into the woman or a surrogate mother may be attempted. Full article >>> A durable power of attorney for health car...

Sperm

...rm bank is inserted directly into the woman or a surrogate mother may be attempted. Full article >>> But when this person makes eggs or sperm there are several possibilities. The normal chromosomes 21 and 14 may be passed on, resulting in a normal baby. Full article >>> Do ...

Insemination

...rm bank is inserted directly into the woman or a surrogate mother may be attempted. Full article >>> Intrauterine insemination (using a small catheter to put washed sperm inside your partner's uterus at the time of ovulation ) In-vitro fertilization (incubating eggs and sperm t...
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(Date:9/4/2008)...-FirstCall/ -- ULURU Inc. (Amex:,ULU) today announ...Weisel,Partners Healthcare Conference at 3:15 p.m....out ULURU Inc.:, ULURU Inc. is an emerging specia...ent of a portfolio of wound management, plastic su...nd consumers improved clinical,outcomes through co...
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(Date:9/3/2008)...exas University of Texas Medical Branch at Galves...link in the process by which the Ebola Zaire virus...o treat the deadly disease produced by the virus. ...gic fever in its victims and inflicts mortality ra...ine or antiviral therapy has been developed agains...
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