Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
...s not only raise LDL levels in the bloodstream but lower high-density lipoproteins (HDL, or "good" cholesterol) and may have even stronger adverse effects than do saturated fats. The researchers report that when activated by harmful fats, PGC-1beta alters liver metabolism through a cascade of biochemical ...Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
... had not. They found that DNA repair capacity was lower in breast cancer patients than in the control subjects. Deficient DNA repair capacity was associated with a twofold increase in the risk of breast cancer. In addition, when the data were stratified into quartiles of DNA repair capacity, the risk of b...Spleen may be source of versatile stem cells
...s the kind of payback that can come fromstudies of lower animals like newts and sponges. Combining theknowledge of Hox11's role in those animals with what we'd found aboutislet cell regeneration in mice helped us find this previously unknownexample of normal, controlled Hox11 expression in an adult mammal....Novel antiviral technology inhibits RSV infection in mice
...and after infection with RSV, showed significantly lower levels ofvirus in the lung and less airway inflammation and hyper-reactivitythan untreated mice....Male circumcision reduces risk of HIV transmission from women to men
...oursewas on the order of one in 1000 or less, much lower than theprobability of one in 160 found in this study. Taken with the authors'evidence that female-to-male infection rates may be more than two-foldgreater for uncircumcised men, this new information may help usunderstand why the virus is spreading r...Applied Biosystems 2720 Thermal Cycler from Applied Biosystems
...tem 9700 -- but in a more compact package and at a lower price. And of course, it provides the same reliability and performance that customers around the world have come to expect from Applied Biosystems thermal cyclers. Small Footprint Saves Valuable Lab Space The 2720 thermal cyclers exceptionally sma...DSQ II Single Quadrupole GC/MS from Thermo Scientific
...ended linear range, and advanced fast scanning for lower levels of detection. With continued product enhancements in ion source and detector technologies, the new DSQ II is ideal for routine GC/MS analysis across a wide range of applications including environmental, food safety, forensic chemistry and toxi...PR Competitor Assay Green from Invitrogen
...rmation of a Fluormone/PR complex will result in a lower polarization value. The shift in polarization in the presence of test compounds is used to determine the relative affinity of test compounds for PR. Contents: The Progesterone Receptor Competitor Assay Kits contain partially purified PR protein, Fl...RapidVUE® Particle Shape and Size Analyzer from Beckman Coulter
...eshold is chosen between "0" and "256". All pixels lower in value (darker) than the threshold are considered to belong to a particle. The image is scanned from top to bottom, identifying dark segments on each line, and associating them with the segments on the previous line. Features: Ease of Use - Intui...PolarScreen Progesterone Receptor Competitor Assay Kit, Far Red from Molecular Probes (Invitrogen)
...f a Fluormone/PR-LBD (GST) complex, resulting in a lower polarization value. The shift in polarization in the presence of test compounds is used to determine the relative affinity of test compounds for PR-LBD (GST) (Figure 1, Table 1). The PolarScreen Progesterone Receptor Competitor Assay Kits contain pa...A Positive Selection Assay for Mutation Analysis in Big Blue Animals
...or lysogenization. Mutations in the cIIregion that lower the levels of cII protein result in a decreased ability oflambda to lysogenize. When grown under conditions that favor lysogeny, lambdaprophages carrying such mutations ( l cII )survive only by entering the lytic pathway of development, forming pla...New Mammalian Two-Hybrid System Detects Protein-Protein Interactions
...modification or externalstimulation not present in lower eukaryotes. Protein-protein interactions in mammalian cells are the basis of virtuallyevery cellular process, such as DNA replication, transcription, translation,splicing, secretion, cell cycle control, signal transductions, and intermediatemetaboli...Highest Transfection Efficiency of an Endotoxin-Sensitive Mammalian Cell Line
...xchange-purified plasmid DNA were nearly 800 times lower than magneticbead-purified DNA and three times lower than DNA purified by cesium chloridedensity gradient centrifugation. The StrataPrep-purified plasmid...Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits
... hybrids to easily dissociate at a significantly lower temperature than exact complementary hybrids. 2 This thermal instability of mismatched hybrids increases the specificity of molecular beacons, thus enabling them to distinguish targets that differ by a few or only a s...Highest Possible Transformation Efficiencies for High-Throughput Applications
...2.7 kb); efficiencies for ligated DNA were lower as expected. With the advent of the Hte phenotype, transformation efficiencies for ligated DNA increased 25-fold. This phenotype allows competent cells to better accept ligated or larger DNA plasmids, which are known to transf...Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
...earchers began testing the first drugs designed to lower elevated cholesterol levels, she found that a lot of people taking the drugs were dying of causes unrelated to cardiovascular system. Another researcher added that, "A lot of them seemed to be smashing their cars into bridges and doing all sorts of ...Lean Protein Could Be Key to Obesity Drugs
...fects from the increased UCP3. They had 70 percent lower cholesterol levels than normal mice and seemed to be using their insulin more efficiently."That is important to us because the majority of obese patients go on to develop Type 2 diabetes," Clapham said....More to Garlic than warding of Dracula
...t disease. Several studies suggest that garlic may lower total cholesterol, LDL ("bad") cholesterol and blo...dies have demonstrated a link between garlic and a lower risk for heart disease....Developmental, neurologic problems common in extremely preterm infants
...re assessed for neurologic function Based on their lower scores on the Mental and Psychomotor Development Indexes compared with a population mean, 19% were classified as severely disabled, while 11% were classified as having "other disability." In addition, 10% of the children had severe neuromotor disabil...More Accurate "PROSTATE CANCER" Test can save Unnecessary Biopsies
...he people who do have cancer. Free" PSA levels are lower in men with cancer than in those without. The test catches 95 percent of cancers while sparing men without the disease painful, expensive biopsies"....Lambert Chalazion Forceps - Large
Round solid lower plate. Open upper plate with inside diameter 15 mm. Serrated handle with locking thumb screw and polished finish. Most popular size or model....Lambert Chalazion Forceps - Small
Round solid 10 mm wide lower plate. Open upper plate with inside diameter 8 mm. Serrated handle with locking thumb screw and polished finish. Most popular size or model....Oval solid 17 mm wide lower plate. Open upper plate with inside dimensions 12 mm x 14 mm. Serrated handle with locking thumb screw and polished finish. Most popular size or model....Oval solid 16 mm wide lower plate. Open upper plate with inside dimensions 12 mm x 14 mm. Serrated handle with locking thumb screw and polished finish....Solid lower plate with outside width 28 mm. Open upper plate. Serrated handle with locking thumb screw and polished finish. Right....New Advances in Gastric Diagnostics: Smaller is Better
... attached to the esophageal wall at 5 cm above the lower esophageal sphincter, using a proprietary endoscopic delivery system. Normally patients are unaware of the capsule, although some may feel a mild sensation in the esophagus or chest while eating. Data on pH levels can be collected without any interfe...Digital vs. Analog Mammography
... from dense parenchyma to skin. Because there is a lower level of intrinsic noise, a lower dose of x-ray may be used than is currently used in conventional mammography with no loss in accurac...Fast, Accurate Influenza A/B Antigen Detection
...ash, nasopharyngeal aspirate, nasopharyngeal swab, lower nasal swab, throat swab and bronchoalveolar lavage... in particular, the sensitivity of rapid tests are lower than for viral culture and vary by test. Because of the lower sensitivity of the rapid tests, physic...Rapid Flu Tests May Prove Especially Helpful This Season
...ash, nasopharyngeal aspirate, nasopharyngeal swab, lower nasal swab, throat swab and bronchoalveolar lavage. Test results time is 15 minutes. Thermo Electron Corp., Waltham, Mass., produces the FLU OIA test, a high-performance assay for the undifferentiated diagnosis of Influenza A and B. in just over 15 m......re accurate and more comprehensive devices at even lower costs....