Many Opt for Surgery to Lower Breast, Ovarian Cancer Risk
... Women with BRCA
gene mutations often choose preventive measures, study ... 211 women, aged 35 to 45, with BRCA1 or BRCA2
gene mutations, which are known to increase the risk ...
Forty percent of women with BRCA1 and BRCA2
gene mutations had both breasts removed and 45 percent ...
Carnegie Mellon develops innovative method to detect genetic causes of complex diseases
... method showed increased power in detecting
gene variants associated with complex symptoms ... In one test, GFlasso successfully detected a
gene variant already implicated in severe asthma and ... metrics and family history, and that genome-wide
gene expression profiling can identify tens of ...
Abnormal Brain Circuits May Prevent Movement Disorder
... scans who had no disease and no mutations in the
gene for dystonia.
Dr. Eidelberg and his ... that patients and non-patients with the disease
gene have the same underlying functional brain ... approximately 30% of people who carry the mutated
gene called DYT1 will develop the involuntary ...
Genes key to staph disease severity, drug resistance found hitchhiking together
... for disease severity. They also found the
gene for the toxin traveling with a genetic component ... become drug-resistant is through horizontal
gene transfer, whereby resistance genes move from one ... location that encodes the toxin, which was in
gene clusters that control drug resistance, known as ...
UF scientists program blood stem cells to become vision cells
... this is the first report using targeted
gene manipulation to specifically program an adult ... describe how they used a virus carrying a
gene that gently pushed cultured adult stem cells from ... process, scientists were able to bypass the
gene manipulation step entirely and instead use ...
Gene Found for Age-Related Cataract
...
FRIDAY, July 31 (HealthDay News) -- A
gene associated with the formation of age-related ... has been identified by scientists.
The EphA2
gene encodes an enzyme that plays a role in the repair ... proteins in the eye. Expression of the EphA2
gene decreases with age, which means damaged proteins ...
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gene in Medical Technology
Diabetes Gene Raises Odds of Lower Birth Weight
... -- Pediatric researchers have found that a
gene previously shown to be involved in the ... Diabetes .
"It's a bit unusual to find a
gene linked to both prenatal events and to a disease ... of The Children's Hospital of Philadelphia. "This
gene variant carries a double whammy, in raising the ...
Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology
... ZFNs to generate rats with permanent, heritable
gene mutations, paving the way for the development of ... used ZFNs to knock out an inserted reporter
gene and two native rat genes without causing ... This is the first example of successful
gene editing in mammalian embryos using this ...
Mayo Clinic Study Finds Earliest Evidence of Memory Decline in Middle-Aged People at Genetic Risk for Alzheimer's Disease
... at older ages. Each additional copy of this
gene is associated with a higher risk of Alzheimer's ... appears to decline more quickly in APOE e4
gene carriers, and it is this pattern of cognitive ... in cognitively normal carriers of the APOE e4
gene to evaluate promising Alzheimer's prevention ...
Fruitfly Model of a Neuropathic Disease Demonstrates Novel Role for Proteins in the Family of aTyr Pharma's Product Class
... that some CMT patients have mutations in a
gene encoding tyrosyl-tRNA synthetase. While tRNA ... understand how mutations in the tRNA synthetase
gene disrupt the neurological system of a complex ... this fruit fly model, the tyrosyl-tRNA synthetase
gene encodes a distinct function involved in the ...
Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech
... protein (ZFP) technology for therapeutic
gene regulation and modification. By engineering ZFPs ... factors (ZFP TF(TM)) that can control
gene expression and, consequently, cell function. ... sequence-specific ZFP Nucleases (ZFN(TM)) for
gene modification. The most advanced ZFP ...
More Gene Mutations Linked to Autism Risk
... and deletions is thought to interfere with
gene function, which can disrupt the production of ... He added that the team discovered many "private"
gene mutations, those found only in one or a few ... of genetic complexity, in which many different
gene changes may contribute to an autism spectrum ...
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gene in Medical Products
HER2 FISH pharmDx Kit
Description:... assay designed to quantitatively determine HER2
gene amplification in formalin-fixed, paraffin-embedded breast cancer tissue specimens.
gene amplification is determined from the ratio ... of signals from the hybridization of the HER2
gene probe (red signals) and the number of signals ...
Company:DakoCytomation California Inc.
hGH ELISA
Description:... by cells of the anterior pituitary. The hGH
gene contains five exons and is the best characterized of five members of a
gene family. The hGH ELISA is used to quantitatively ... transfected with a plasmid containing
a reporter
gene encoding for hGH. hGH Elisa is standardized, ...
Company:Roche Diagnostics
Gene Cycler Thermal Cycler
Description:... The
gene Cycler unit is an inexpensive personal or mini ... including the researcher's desk.
The
gene Cycler thermal cycler meets the needs of ... expensive laboratory thermal cycler.
The
gene Cycler is an advanced solid-state thermal cycler ...
Company:Bio-Rad Laboratories
Leptin IRMA Test
Description:... with a molecular weight of 16 kDa. Leptin is a protein encoded by the ob
gene and produced by adipocytes [1,2]. Leptin is thought to play a key role in ... Metab. 82. 3281, 1997
Pelleymounter, MA, et al.: Effects of the obese
gene product on body weight regulation in ob/ob mice. Science 269:540-543, ...
Company:Diagnostic Systems Laboratories, Inc.
Leptin ELISA Test
Description:... with a molecular weight of 16 kDa. Leptin is a protein encoded by the ob
gene and produced by adipocytes [1,2]. Leptin is thought to play a key role in ... Metab. 82. 3281, 1997
Pelleymounter, MA, et al.: Effects of the obese
gene product on body weight regulation in ob/ob mice. Science 269:540-543, ...
Company:Diagnostic Systems Laboratories, Inc.
HSV Typing ASR
Description:... ASR contains primers and a FAM-labeled probe targeting the glycoprotein D
gene of HSV Type 1 as well as primers and an Alexa 532-labeled probe designed to detect the glycoprotein G
gene of HSV Type 2. This ASR requires an instrument that can detect FAM, Texas ...
Company:Cepheid
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gene in Medical Definition
Personalized medicine
... about a patient's genotype or level of
gene expression and a patient's clinical data in ... history. The key task is to find genes and
gene variations that play a role in a disease. The ... is to associate the occurrence of a particualr
gene variant with the incidence of a particular ...
Therapeutic gene modulation
... Therapeutic
gene modulation refers the practice of altering the expression of a
gene at one of various stages, with a view to alleviate some form of ailment. It differs from
gene therapy in ...
Thymocyte
... defects introduced into the T cell receptor by
gene rearrangement.
In order to be ... receptor is made up of a series of alternative
gene fragments. In order to create a functional T cell ... enzymes to clip the DNA and bring separate
gene fragments together. The outcome of this process ...
Atransferrinemia
... inherited in an autosomal recessive pattern, meaning two copies of the
gene in each cell are altered.
A case study was done in 1961 on a ... in the United States [2] and identified mutations in the TF
gene as a probable cause of the disorder.
Treatment
Treatment with ...
Autoimmune regulator
... q22.3
The Autoimmune Regulator, abbreviated AIRE , is a human
gene which is expressed in the thymus . It causes transcription of a wide ... candidiasis. [1] AIRE is expressed primarily in the thymus.
A
gene knockout of the murine homolog Aire has created a transgenic mouse ...
Familial isolated vitamin e deficiency
... is a rare autosomal recessive neurodegenerative disease. Symptoms are much like those of Friedreich ataxia and is caused by mutations in the
gene for a-tocopherol transfer protein.
...
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gene in Medical Dictionary
Adenoviruses
... and eye infections . Adenoviruses used in
gene therapy are altered to carry a specific tumor -fighting
gene . adjunct agent In cancer therapy, a drug or ... effects are short-lived. Maintaining
gene expression so it performs its role properly ...
Adenovirus
... and eye infections . Adenovirus es used in
gene therapy are altered to carry a specific tumor -fighting
gene . adjunct agent ... Adenovirus EIA test kit ... effects are short-lived. Maintaining
gene expression so it performs its role properly ...
Alkaptonuria
... Among the genes on chromosome 3 are the HGD
gene for alkaptonuria , the BTD
gene for biotinidase deficiency , the CPOX
gene for hereditary copro porphyria , the MLH1 ...
Autosomal dominant
... dominant Definition: A single, abnormal
gene on one of the autosomal chromosomes (one of ... Autosomal dominant inheritance means that the
gene is located on one of the autosomes ( chromosome ... affected, and "dominant" means that only one
gene is necessary to have the trait. Autosomal ...
Autosomal recessive
... Autosomal recessive inheritance means that the
gene is located on one of the autosomes ( chromosome ... Requires that both parents carry traits for the
gene in order for it to be passed to their offspring. ... who have received two copies of an autosomal
gene , one copy from each parent. The ...
Breast Cancer
... intake of vegetarian diets. Breast cancer
gene BRCA2: See: BRCA2. Common Misspellings: breast canser
gene brca2 Search All of MedicineNet For: search help ... balanced diet s, ... Alterations in the RB1
gene have also been found in other tumor s, ...
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gene in Biological News
Mary had a lot of lambs: Researchers identify way to accelerate sheep breeding
... researchers have discovered an unusual form of a
gene that prompts ewes to breed out of season as well ... caution that it may only be a marker for the
gene actually responsible for the trait.
"Breeding ... the phenotype the physical expression of the
gene in the researchers' flock during a postdoctoral ...
Women often opt to surgically remove their breasts, ovaries to reduce cancer risk
... mutation carriers. BRCA1 and BRCA2 are hereditary
gene mutations that indicate an increased risk for ... are widely used by carriers of BRCA1 and BRCA2
gene mutations to reduce the risk for breast and ovarian cancer.
Evaluated by
gene type, bilateral risk-reducing ...
Abnormal brain circuits may prevent movement disorder
... scans who had no disease and no mutations in the
gene for dystonia.
Dr. Eidelberg and his ... that patients and non-patients with the disease
gene have the same underlying functional brain ... approximately 30% of people who carry the mutated
gene called DYT1 will develop the involuntary ...
Understanding how weeds are resistant to herbicides
... want to spend two years culling to find that
gene every time. This is a way that we can get all of ... it is resistant or not because we know the
gene sequence and we know the mutation and the ... conserved. So if we have the sequence for the PPO
gene in waterhemp you can use that information to get ...
Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
... from retroviruses are useful tools for long-term
gene transfer because they allow stable integration of ... an effective, alternative method for nonviral
gene transfer that avoids the safety concerns ... the "Sleeping Beauty Transposon System for Stable
gene Expression in Mouse Embryonic Stem Cells" from ...
UBC researchers find first-ever 'wanderlust gene' in tiny bony fish
... A
gene previously associated with physical traits is ... from UBC's Dept. of Zoology have found that the
gene may also be contributing to the fish's tendency ... adjusting to their surroundings the first time a
gene associated with this type of behaviour has been ...
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gene in Biological Technology
gene in Biological Products
GenoStat Inducible Expression System from Upstate
Description:... provides tightly regulated control of exogenous
gene expression in mammalian cells and is capable of ... the chimeric bipartite nuclear receptor complex.
gene expression levels are easily manipulated higher ... Expression System provides maximal levels of
gene expression (often reaching fold induction levels ...
Company:Upstate
pPIC9K from Invitrogen
Description:... pPIC3.5K vectors carry the kanamycin resistance
gene that confers resistance to Geneticin Reagent in ... that multiple copies of the kanamycin resistance
gene and the
gene of interest are integrated into the genome (1). ...
Company:Invitrogen
Gene Pulser/E. coli Pulser Cuvette Rack from Bio-Rad
Description:... The expertise that made the original
gene Pulser apparatus and accessory modules the most ... system available has been applied in the
gene Pulser II system, which features unique PulseTrac circuitry. The modular design of the
gene Pulser II system has the dual advantages of using ...
Company:Bio-Rad
* Quick & Easy E. coli Gene Deletion Kit from Gene Bridges GmbH
Description:... with the kit which can be used to replace a
gene on the E.coli chromosome. Red/ET recombination ... cassette for the replacement of the targeted
gene allows the subsequent removal of the selection ... Flp expression plasmids can be purchased from
gene Bridges. Multiple knockouts can be generated ...
Company:Gene Bridges GmbH
Helios Gene Gun Low-Pressure System, 100-120 V from Bio-Rad
Description:... The Helios
gene gun low-pressure system, 100-120 V, is used for ... into cells. The system includes the Helios
gene gun, helium hose assembly, helium regulator, ... prep station, syringe kit, tubing cutter, Helios
gene gun optimization kit, low-pressure regulator, and ...
Company:Bio-Rad
Helios Gene Gun Kit from Bio-Rad
Description:... Includes
gene gun unit, 5 O-rings, 5 barrel liners, 5 white ... cartridge extractor tool, 9 V battery The Helios
gene gun is a convenient, hand-held device that provides rapid and direct
gene transfer into a range of targets in vivo. The ...
Company:Bio-Rad
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gene in Biological Definition
Albinism
... links
Lack of pigmentation
The
gene which results in albinism prevents the body from ... albinism, individuals inherit an "albinism
gene " from both parents. Where an individual receives one albinism
gene and one normal gene, that person will not show ...
Allele
... one of a number of alternative forms of the same
gene occupying a given locus (position) on a chromosome . An example is the
gene for blossom color in many species of flower - a single
gene controls the color of the petals, but there may ...
Allele frequency
... population , or equivalently the richness of its
gene pool . Allele frequency is defined as follows:
Given a) a particular chromosome locus , b) a
gene occupying that locus, c) a population of ...
The frequencies of all the alleles of a given
gene often are graphed together as an allele ...
Apoptosis
... carried out by human papillomaviruses (HPV), a
gene called E6 is expressed in a product that ... (IFN-alpha/beta)induce transcription of the p53
gene , resulting in the increase of p53 protein level ... and ced-4 .
Ron Ellis also identified a
gene with an opposite effect: ced-9 . The product of ...
Barr body
... can be significant if different alleles of a
gene are present on the different chromosomes; in some ... evidence suggests that the maternally inherited
gene may be imprinted .
It is thought that this ... of CpG sites . These changes help inactivate
gene expression on the inactive X-chromosome and to ...
Biodiversity
... and the United States of America.
If the
gene is the fundamental unit of natural selection, ... . They study processes such as mutations,
gene exchanges, and genome dynamics that occur at the ... genetic engineering , people are going through
gene patenting , processes patenting, and a totally ...
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gene in Biological Dictionary
Y chromosome
... including humans. In mammals, it contains the
gene SRY, which triggers testis development, thus ... In mammals, the Y chromosome contains the
gene that triggers embryonic development as a male. ...... In mammals, the Y chromosome contains the
gene that triggers embryonic ... A team of 40 ...
Viral oncogene
... gene. The protein encoded by the human REL
gene is a member of the NF-κB family of transcription factors. The REL
gene is amplified or mutated in several human B-cell ... The official name of this
gene is "v-Ki-ras2 Kirsten rat sarcoma viral ...
Vesicle
... : cytoplasmic membrane-bounded vesicle [14310
gene products] ... GO:0030136 : clathrin-coated vesicle [396
gene products] ... GO:0030659 : cytoplasmic vesicle membrane [391
gene products] ... GO:0030120 : vesicle coat [200 .....
Untranslated RNA
... bushy ... 3'UTR RNA from Alpha-Tropomyosin
gene Suppresses Tumor Activity. ... Expression of ... Regions of mRNAs Play a Role in Regulating
gene Expression. ... JD: The 3' untranslated region ... ... Tumor Suppression by the Prohibitin
gene 3' Untranslated Region RNA in Human Breast ...
Tumor suppressor
... tumor suppressor gene, or antioncogene, is a
gene that protects a cell from one step on the path to cancer. When this
gene is mutated to cause a loss or reduction in its ... suppressor . genes. ... tumor suppressor
gene ( ¦tümər sə′presər jēn ) ( cell and molecular ...
Tubulin
... encode a distinct isoform. ... The ß3- tubulin
gene encodes a divergent isoform expressed in a ... polymerization. ... Zebrafish protein-coding
gene LOC572064. Represented by 26 ESTs from 16 cDNA ... SIMILARITIES ... Norway rat protein-coding
gene Tuba3a. Represented by 47 ESTs from 2 cDNA ...
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