Chemists create 'Superbowl' molecule; May lead to better health
...perbowl" molecule that shows promise for precision drug delivery, according to a recent study in the Journ... for their wide range of potential uses, including drug delivery, chemical synthesis and as models for cell and viral behavior. Until now, these molecules h...DNA Molecules Used To Assemble Nanoparticles
...ient way to produce a wide variety of nanoparticle drug delivery systems, using DNA molecules to bind the particles together. Nanometer-scaled dendrimers can be assembled in many configurations by using attached lengths of single-stranded DNA molecules, which naturally bind to other DNA strands in a high...New push for public health, AIDS spending at African Union summit
...AIDS and anti-HIV efforts included. Controversial drug trials, battles over patents and the fate of millions of orphans are also likely to be discussed at a summit session devoted to the fight against AIDS on the world's poorest continent, home to nearly two-thirds of the 39.4 million people worldwide in...Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
...id." Moreover, it is possible that in the future, drug therapy might be used to "turn down" the mechanism, decreasing cholesterol levels and heart disease risk, explained Spiegelman, who is also a professor of cell biology at Harvard Medical School. Saturated fats are found in fatty cuts of meat, whole-......ical step in correlating the SNP with a disease or drug sensitivity.To do so, Nanosphere scientists employ a two-step process calledClearReadTM technology. This method sandwiches a target DNA SNP segment between two oligonucleotide sequences to greatly increase detection specificity and sensitivity. One s...DNA/RNA Aptamer Microarray - Comprehensive Service from LC Sciences
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...newly identified gene products, growthfactors, and drug candidates is to identify the changes they exert o... an uncharacterizedgene product, growth factor, or drug candidate in complex signal transductioninteractions. Trans-Reporting Systems: Assess Activation of...Optimizing Transfection Conditions for Studying Signal Transduction Pathways
...racterized gene products,extracellular stimuli, or drug candidates. Many different cell lines maybe used, ...y the in vivo effects of new genes, growthfactors, drug candidates, and extracellular stimuli on the activation of c-JunN-terminal kinase 2,3 (JNK), mitoge...Production of Full-Length, Biologically Active MEK1WT and MEK1CA
Useful tools for signal transduction research and drug screening Quinn Lu Chao-Feng Zheng Stratagene ...y useful tools forsignal transduction research and drug screening. Although MEK1 WT canbe expressed in soluble form in E. coli as glutathione-S-transferase...Signal Transduction Reporting Systems Using Cis-Acting Enhancer Elements
...the in vivo effects of a new gene, growthfactor or drug candidate on signaling pathways. The effects of ex...the in vivo effects of a new gene,growth factor or drug candidate. When more specific assessment of a gene productis desired, the PathDetect trans-reporting...Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion Transactivators
...nal transduction pathways are potentialtargets for drug development efforts. Establishing Stable Reporter Cell Lines Fig.1 To create stable reporter cell lines with the PathDetect trans-reporting systems, we tried several approaches. Figure 1 outlines our most successf...New Drug in Diabetic Neuropathy
...rched by Central Arkansas Research, Arkansas. This drug showed a definite reduction of pain compared to placebo. What does this mean for India? Well, my uncle, the neurologist, will be pretty happy....New hope on the Horizon for People Wishing to Quit Smoking
... will be required to determine whether or not this drug will be beneficial and safe for people who wish to quit smoking. Alan I. Leshner, M.D., director of the National Institute on Drug Abuse (NIDA), says, "This research opens up an exciting new avenue of treatment that can help smokers substantially red...Lean Protein Could Be Key to Obesity Drugs
...r diet drugs of the future.British scientists from drug giant SmithKline Beecham and the University of Cambridge have created mice with a human protein known as Uncoupling Protein 3 (UCP3) that increases their metabolism.In what is every dieter's dream, the mice were able to eat more than normal mice but ...A prescription cream for unwanted facial hair
VaniqaT is a prescription drug which was approved by the FDA in the United States... but rather a new topical-use version of the older drug eflornithine (brand name Ornidyl). Vaniqa, like Viagra, is considered to be a "lifestyle drug", a...An experimental drug could make millions of people suffering from smok...had suffered from COPD for more than a decade, the drug appeared to be safer and better at improving breathing and at reducing infections and hospital visit...Vitrasert Sterile Intraviteral Implant
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...nals or for, home and workplace use. Therapeutic drug monitoring measures the serum level of a specific drug relative to its serum therapeutic rangethe concentration range where the drug has been shown to be e...West Nile Virus Screening and Diagnostics Technology Emerges In Step with North American Outbreak
... approved by the FDA under the investigational new drug mechanism (TaqScreen WNV test, Roche Molecular Systems, Inc.; Procleix WNV assay, GenProbe, Inc.). Although screening has substantially reduced the risk of transfusion associated transmission, there have been screening failures because of low levels...Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.
...he most important gene family to govern individual drug responses, CYP (also called cytochrome P450) oxida... 2C9, 2C19, 2D6, 2E1, 3A4) account for over 90% of drug metabolism (but do not appear to account for the selectivity of BiDil). Since a patient can take se...New Quality Control Systems for Every Laboratory Application
...riety of immune, autoimmune, endocrine, lipid, and drug analytes are available. Serum, urine, and CSF controls are available for relevant clinical chemistries. Other materials are designed for QC in coagulation, hematology, infectious disease, or serology labs. These materials often are available in sever...