UMass Medical School receives $300,000 from JDRF and Iacocca Foundation
... of ER stress in islet transplantation Gregory J. Pazour, PhD, associate professor of molecular medicineThe role of the pancreatic beta cell cilium in diabetes Fumihiko Urano, MD, assistant professor of molecular medicineThe role of ER stress in autoimmune diabetes ...UMass Consortium awarded $300,000 from Juvenile Diabetes Research Foundation and Iacocca Foundation
... role of ER stress in islet transplantation Gregory J. Pazour, PhD, associate professor of molecular medicineThe role of the pancreatic beta cell cilium in diabetes Fumihiko Urano, MD, assistant professor of molecular medicineThe role of ER stress in autoimmune diabetes Were excited about this ...Prestigious Wilson Award Goes To Yale Cell Biologist Joel Rosenbaum
... tubules each had a single non-motile “primary” cilium pointing toward the center of the tubule. ... ciliary membrane, or to the complete lack of the cilium due to a defect in the IFT process. ... are maintained in adults by IFT in a piece of the cilium in the adult rod cell. Finally, a complex ...Genetic Cause of Inherited Eye Diseases Identified
... of cilia in single-celled organisms have been studied, this is the first time that a comprehensive description of the proteins of a mammalian cilium used for movement and sensing has been determined. We want to understand how cilia work normally and how their function is disrupted in ...Gene Responsible for Blindness in Infants and Children Identified
... LCA5, as they have similar structures and functions in the retina. Both the CEP290 and LCA5 genes encode proteins with vital functions in the cilium of the photoreceptors, transporting visual proteins to the compartment where vision occurs. When these genes are mutated, which occurs in about 25 to ...Triptolide: A Potential Drug for Polycystic Kidney Disease
... types. Normal kidney tubule cells have a built in switch for regulating their growth — two proteins, PKD1 and PKD2, located on a bristle-like cilium that bends in response to fluid flow across the cell. During kidney development, cells destined to line a kidney tubule grow and divide until the ...'Cellular antennae' on algae give clues to how human cells receive signals
... The team focused on fertilization of the alga, a process that requires a cilium to bind to a molecule on a cilium from a cell of the opposite mating type. They found that when the external ...