A gene's first 'kiss' sets off that affair known as puberty
...searchers looked to the nonhuman primate, the only animal with a reproductive system in common with the human's. The onset of puberty becomes official when gonadotropin-releasing hormone (GnRH) is secreted and sets off a chain reaction of chemical messages. Inside the hypothalamus, nerve cells release GnRH...Wisconsin scientists grow critical nerve cells
... humans. "We cannot simply translate studies from animal to humans," says Zhang. The next step, Li says, will be to test if the newly generated neurons can communicate with other cells when transplanted into a living animal. The team will first test the neurons in chicken embryos. While the new results a...It's not all genetic: Common epigenetic problem doubles cancer risk in mice
...ouble IGF2 and the APC mutation should be a useful animal model to evaluate the impact of colon cancer prevention strategies, including dietary interventions and targeted drugs. ...Fox Chase Cancer Center scientists identify immune-system mutation
...turally occurring defect in Fox Chase's laboratory animal facility in 1997. Known as "helper deficient" or H... affects humans. In addition to providing a unique animal model to study the SCID syndrome, SCID mice have become a highly valuable tool for studying the immu...Current human embryonic stem cell lines contaminated UCSD/Salk team finds
...wn or derived from laboratory culturesthat contain animal sources of the non-human Neu5Gc molecule. Alltradi...sthat have never been exposed to Neu5Gc-containing animal products ofany kind," the researchers said in the Nature Medicine paper, notingthat none of the sugg...Mouse Dopaminergic Neuron Differentiation Kit, 2nd Generation from R&D Systems
...bstantia nigra results in Parkinsons disease. Both animal models and clinical trials have suggested that cell replacement therapies may be effective in treating Parkinsons disease. This approach is limited, however, by the availability of a rich, effective source of neural precursors for DA neuron generatio...AccuSampler Large Animal from DiLab, Inc.
Large animal systems need to be able to handle larger sample vo... time, and the computer can be located outside the animal room to minimize disruption of physiological parameters during sampling. By selecting variable with...Smarter Fermentation System Controller for One Vessel from Major Science
...ation : cultivation of microorganisms and human or animal cells...Automatic Cuff Inflation Pump from IITC Life Science
...20-NW cuff pump is a dedicated cuff pump for small animal noninvasive blood pressure testing. This cuff pump replaces manual inflation and can be used for all IITCs indirect blood pressure test systems for mouse and rat; from single up to multi-channel systems are available. The IITC Model 20-NW cuff pump h...ForagingDesigned to reward the animal for foraging behavior.The Spatial Behavior line is...6 moving animals. Software automatically extracts animal positions and records them, but also allows video replay of all or machine-selected events. There a...New Kit Generates Exceptionally Pure Total RNA for RT-PCR
...l RNA with undetectable levels of DNA from animal tissues and cultured cells. 2 Eliminate DNA Contamination Fig.1 In Figure 1 , PCR analysis was performed to demonstrate the absence of DNA contamination in RNA isolated from different quantities ...Innovative Tissue Array Technology for High-Throughput Screening of Gene Expression
... survey, in which all tissues and cell types in an animal species are screened. Traditional sections for whole-animal surveys require approximately 25 to 40 histological slides for complete screening. With each slide requiring preparation and processing that includes staining, labeli...New Protocols for Isolating High- Molecular-Weight Genomic DNA
...bacteriophage lambda and can be retrieved from the animal by subjecting thegenomic DNA to the specialized in vitro lambda Transpack packagingextract.** ,4 Because the shuttle vector is nearly 50-kb long and ispresent in multiple copies within the genome of the animal, efficient packagingis contingent on ...Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons*
...ptide vasopressin. As previously demonstrated with animal models, 2,5 hNT neuronal vasopressin synthesis res...le the humanaging brain more closely than previous animal models. Our results show thatthese neurons respond to various sex steroids and to varying concentrat...Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer
...ed tissues. Tissue specificity isalso a feature of animal model systems. For example, when male mice are exposedto the flame retardant tris(2,3-dibromopropyl)phosphate (TDBP), they contractkidney tumors, and the alkylating agent dimethylnitrosamine predominantlyproduces liver, kidney, and lung tumors. Sex c...Endangered species may be successfully cloned in another animal's womb
...me have found a way for the survival of endangered animal species of the world. In a major breakthrough a ...feat has managed to clone cells from an endangered animal (Asian Gaur) and successfully impregnated an Iowa cow with the clone. The scientific journal Cloni......Branch at Galveston, has shown her study using the animal model that Vitamin E may prevent bone loss after menopause as effectively as estrogen. In this study it is shown that female rats that had their ovaries removed and treated with vitamin E had much higher bone densities after eight weeks than the rat...... and mood changes. Homocysteine is a byproduct of animal protein which is broken down in the bloodstream by B comlex vitamins and folate. Elevated levels of this chemical caused damage to the cells lining the walls of the arteries which contributes to its thickening leading to a block. The study showed th...West Nile Virus Screening and Diagnostics Technology Emerges In Step with North American Outbreak
...ross North America. As of January, 2005, avian or animal infections have been reported from 47 states and Puerto Rico, and human infections have been reported in 40 states. By October, 2004, ArboNET had received reports of WNV infection in 58 mosquito species and 284 bird species and had recorded 6690 case...Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
...EGFR, HER1, c-ErbB-1). In vitro assays and in vivo animal studieshave shown that binding of ERBITUX to the EGFR blocksphosphorylation and activation of receptor-associated kinases,resulting in inhibition of cell growth, induction of apoptosis, anddecreased matrix metalloproteinase and vascular endothelial g...New Information on the Potential of Plasmin Shared at ISTH Congress
...- Preliminary data utilizing a clinically-relevant animal modelfor human ischemic stroke will help guide clinical protocoldevelopment in this area. 4. Importance of Fibrin Binding for Therapeutic Efficacy ofDirect Thrombolytics (Abstract # P-S-383): -- Valery Novokhatny, Ph.D., Research Fellow, TalecrisB......o essentially 100%,validates similar findings from animal models," said Richard C.Yocum, MD, Vice President of Clinical Development and MedicalAffairs at Halozyme. "We have shown previously in two differentanimal species and with three different representative largemolecules that rHuPH20 locally co-injected......mercializestherapeutic proteins through transgenic animal technology.ATryn(R), GTC's recombinant form of human antithrombin, is approvedby the European Commission for use in patients with hereditaryantithrombin deficiency undergoing surgical procedures. This wasthe first approval anywhere in the world of a ...