vessels

Bench-Top Centrifuges--Basic Tools for the Small Lab

... allows the centrifugation of conical cell culture vessels at up to 10,000 x g, while a high-performance 24-place microliter rotor rapidly accelerates 1.5 or 2 ml tubes to a maximum RCF of 21,885 x g. Both rotors are autoclavable to 121C. Process control is via the EASYcontrol II panel, which displays all op...

New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility

...ed to inhibit clot formation in venous andarterial vessels to prevent potential acute or chroniccomplications of venous or arterial thrombosis. As with allanticoagulants, the most frequently reported side effect withLovenox(R) is bleeding. Clinical indications for Lovenox(R) mayvary from one country to anoth...

Insmed Inc. Welcomes Studies Linking IGFBP-3 to Prevention of Blindness in Premature Infants

...ear. ROP impedesthe development of the small blood vessels in the back of the eye,leading to blindness in severe cases. A Phase I clinical studyinvestigating IPLEX(TM) as a treatment for ROP is underway at theUniversity of Goteborg, in collaboration with scientists at theHarvard Medical School. Ten patients ...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

...ator ofblood pressure. Angiotensin II causes blood vessels tonarrow, resulting in increased blood pressure. I... to its receptors and subsequentnarrowing of blood vessels should be decreased. The RAS has alreadybeen successfully targeted by three major classes ofantihype...

NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans

... on, orexpressed, at high levels only in the blood vessels that feedtumors in mice and humans. These genes, a... a tumor's blood supply without affectingthe blood vessels of healthy tissues, overcoming one of the majorconcerns of current anticancer therapies targeted at ...

Treating Heart Disease Risk Factors May Slow Alzheimer's Disease Progression

...result ofatherosclerosis. Atherosclerosis in blood vessels in the brainreduces oxygen supply to the brain and could cause a stroke or avery mild stroke known as a transient ischemic attack (TIA). Rosebud O. Roberts, MB, ChB, and colleagues at the Mayo Clinicin Rochester, Minn., investigated whether people w...

Pivotal Phase III Trial Showed Promacta (eltrombopag olamine) Raised Platelet Counts and Reduced Bleeding in Patients With Chronic ITP

...ar.(2)People with ITP often bleed from small blood vessels causingbruises, nosebleeds, bleeding from the gums during dental work orother bleeding that is difficult to stop. The predicted five- yearmortality rates for ITP patients with persistent low plateletcounts range from 2.2% for patients younger than 40...

Clinical Results From EntreMed's Panzem NCD and Taxol Breast Cancer Study Presented at ASCO

...-1 alpha) causednear-complete destruction of tumor vessels and significantlyimproved radio-sensitivity in radiation resistant breast tumors.The inhibition of HIF-1alpha was thought to have the same orsimilar impact on chemotherapy-resistant tumors. HIF-1alpha isover-expressed in more than 70% of human tumors...

Merck at ASCO 2007: Spectrum of Studies Reinforces Promise of Erbitux for Colorectal and Head and Neck Cancer Patients

...iotherapyand to inhibit the formation of new blood vessels inside tumors,which appears to lead to an overall suppression of tumorgrowth. The most commonly reported side effect with Erbitux is anacne-like skin rash that seems to be correlated with a goodresponse to therapy. In approximately 5% of patients,hy...

XYOTAX More Cost Effective With Fewer Side Effects Than Gemcitabine or Vinorelbine in Treating Non-Small Cell Lung Cancer

...e chemotherapyand its associated toxicities. Blood vessels in tumor tissue,unlike blood vessels in normal tissue, are porous to molecules likepolyglutamate. Once inside the tumor cell, enzymes met...

Phase 2 Results for EntreMed's Panzem NCD Brain Cancer Study Presented at ASCO

...ction (MOA) andblocks the development of new blood vessels that feed tumor cells.Panzem's MOAs include apopto...mor cells, and caninterrupt the formation of blood vessels that nourish tumor cellsand sustain tumor growth. To view the poster presentation of this Phase 2 t...

GSK'S Pazopanib Shows Positive Results in Patients with Advanced Renal Cell Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma

...ess. Angiogenesis, whichis the growth of new blood vessels in the body, plays a criticalrole in the growth and spread of tumors. (1,2) Renal cell carcinoma study (Abstract 5031) (3) This ongoing Phase II randomized discontinuation study isevaluating patients with advanced or metastatic RCC who have notrece...

Investigational Drug Cediranib (AZD2171) Shows Promise in Patients With Recurrent Glioblastoma (GBM)

...river ofangiogenesis -- the formation of new blood vessels that tumors needto grow and spread. Cediranib is currently in Phase II/IIIdevelopment for advanced non-small cell lung cancer (NSCLC) andadvanced colorectal cancer (CRC) -- as well as being investigatedas part of a wide-ranging signal search program ...

New Study Suggests Better Patient Outcomes with CYPHER Sirolimus-Eluting Coronary Stent than with Taxus Stent in Real-World Clinical Settings

...ded a 20 percent relative reductionof TLR in large vessels (2.4 percent versus 3.0 percent in arterieswith a ...in smallvessels (2.9 percent versus 4.8 percent in vessels less than 2.8 mmin diameter; p=0.046) compared to the Taxus Stent. In the United States, the CYPHER...

Biothera's Imprime PGG Enhanced Effectiveness of Avastin in Cancer Study

...nhibit angiogenesis, the process bywhich new blood vessels develop and carry vital nutrients to atumor. Avastin is approved, in combination with intravenous5-fluorouracil-based (5-FU) chemotherapy, for first- or second-linetreatment of patients with metastatic carcinoma of the colon orrectum and in combinati...

EntreMed's Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models

...malmodels by preventing the formation of new blood vessels andinducing regression of formed vessels at well-tolerated doses.Orally-administered ENMD-981693 induced tumor regression withminimal toxicit...

Peregrine Pharmaceuticals Reports Positive Top-Line Results in Bavituximab Combination Therapy Trial in Advanced Cancer Patients

...sed on the outside ofthe cells that line the blood vessels of tumors, creating aspecific target for anti-cancer treatments. Bavituximab iscurrently in clinical trials in the U.S. for the treatment of solidtumors and as a treatment for chronic hepatitis C infection inpatients co-infected with HIV. Clinical da...

Abbott Announces Continued Positive Results with Xience V Everolimus Eluting Coronary Stent in Spirit Clinical Trials

...en shown toreduce tissue proliferation in coronary vessels following stentimplantation, and one of the world's most popular metallicplatforms -- the MULTI-LINK VISION Coronary Stent System. XIENCE V is designed, studied and manufactured by AbbottVascular. Abbott supplies a private-labeled version of XIENCE ...

Medtronic Announces Positive Nine-Month Results for Endeavor Resolute Next Generation Drug-Eluting Stent at EuroPCR

...esions that aredifficult to treat, including small vessels and long lesions, andthese results are extremely promising. Zotarolimus continues to bea very potent drug in preventing restenosis while the new BioLinxpolymer appears to be delivering the drug as intended." Endeavor Resolute leverages the strengths...

Gilead Announces Presentation of Long-Term Data for Ambrisentan, a Potential Treatment for Patients With Pulmonary Arterial Hypertension

... disease characterized by constriction ofthe blood vessels in the lungs leading to high pulmonary arterialpressures. These high pressures make it difficult for the heart topump blood through the lungs to be oxygenated. Patients with PAHsuffer from shortness of breath as the heart struggles to pumpagainst the...

Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage 2 Patients Compared With Amlodipine + Benazepril

...yblocking the angiotensin II receptor on the blood vessels andantagonizing the release of the hormone which causes salt retentionand increased blood volume. BENICAR HCT combines BENICAR with thediuretic hydrochlorothiazide. BENICAR and BENICAR HCT are indicated for the treatment ofhypertension. They may be ...

VEGF Trap-Eye Phase 2 Wet AMD Results Reported at ARVO Annual Meeting

...se normal role is to triggerformation of new blood vessels (angiogenesis) to support the growthof the body's ...withthe abnormal growth and fragility of new blood vessels in the eye,which lead to the development of wet AMD. The VEGF Trap-Eye is afully human, soluble VEGF...

Early Results of the CellCept Spare the Nephron Study Examine Kidney Function

...pairment of kidney function and damage to theblood vessels and filtering capacity of the kidneys.(1)(2) The STNtrials are being conducted at more than 35 transplant centers inthe United States and Canada and use CellCept and otherimmunosuppressants in combinations that reduce or eliminate the useof steroids ...

Researchers Urge Caution in Using ESAs for Cancer-Related Anemia

...ythropoietin in the endothelial cells lining blood vessels andpossibly in tumor cells as well. Because of their geneticallymodified characteristics, ESAs may have stronger effects on thesereceptors than natural erythropoietin does. If so, then it ispossible that ESAs may promote abnormal formation of new blo...

Evidence of Nanoparticles Found in Plaque-Filled Arteries

...n, D.C., on April 29. Calcium deposits clog blood vessels and damage major organs,such as the heart. But the molecular mechanisms that kick-startthis process, called pathologic calcification, haven't beenexplained. The study's author, Maria Kraemer, a Mayo Graduate Schoolstudent in Rochester, Minn., and co...

Peregrine Pharmaceuticals Highlights Significant Advances in the Company's Clinical and Preclinical Cancer Programs Presented This Week at the AACR Annual Meeting

...rily expressed on the surface of tumor blood vessels enables bavituximab-like antibodies to also ...ntended to affect only the established blood vessels that are essential for the survival and growth of tumors. Researchers reported on their progr...

The Lancet Publishes PREVAIL Study Results Showing Lovenox Superiority Over Unfractionated Heparin for Reducing the Risk of Venous ThromboEmbolism in Patients With Acute Ischemic Stroke

...sed to inhibit clot formation invenous or arterial vessels to avoid potential acute or chroniccomplications of venous or arterial thrombosis such as pulmonaryembolism, myocardial infarction or death of cardiovascular origin.As with all anticoagulants, the most frequently reported sideeffect for enoxaparin is...

Spectrum Pharmaceuticals Announces Data From Three Oncology Programs Presented at the American Association of Cancer Research Annual Meeting

...ning the bloodvessels, to selectively dilate blood vessels in the tumor,resulting in a transient increase in ...s to date. Tumors get their blood supply fromblood vessels that are different from normal blood vessels and lackthe surrounding smooth muscle cells -and associ...

Data Presented at AACR Meeting Shows Peregrine's Immunocytokine Fusion Proteins Reduce Growth of B-Cell Lymphoma Tumors by 85% in Preclinical Studies

...eins incorporatingantibodies that target the blood vessels of tumors are newpreclinical candidates under Pere...s were capable ofselectively targeting tumor blood vessels and displayed potentanti-cancer effects in a number of tumor models without causing anyobservable to...

Data Presented at AACR Meeting Show Peregrine's Bavituximab Equivalent Can Generate Curative Immune Responses as Part of a Vaccine-Like Regimen in Preclinical Models of Aggressive Brain Cancer

...sed on theoutside of the cells that line the blood vessels of tumors. Oncebound to tumor blood vessels, bavituximab alerts the body's immunesystem to attack the tumor's blood supply, stopping the flow ofoxygen and nutrients to the tumor cells and resulting in tumor celldeath. PS is also thought to play a rol...

Data Presented at AACR Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Growth of Both Hormone-Dependent and Hormone-Independent Prostate Cancer by Up to 94 Percent in Preclinical Studies

...sed on the outside ofthe cells that line the blood vessels of tumors, thus creating aspecific target for anti-cancer treatments. Once bound to the tumorblood vessels, bavituximab alerts the body's immune system toattack the tumor's blood supply, stopping the flow of oxygen andnutrients to the tumor cells and...

Data Presented at AACR Meeting Shows Peregrine's Selective Anti-VEGF Antibodies are as Effective as Avastin(R) in Preclinical Cancer Models

...ant of the development and maintenanceof the blood vessels needed by tumors to survive and grow. It isthought to work by binding to and activating two receptors that areexpressed on endothelial and other types of cells. The series ofstudies reported today tested the hypothesis that selectivelyinhibiting VEGF...

Data supporting three Antisoma programmes presented at AACR

...e vascular disruptingagent which targets the blood vessels that nourish tumours. Thedrug was discovered by Pr...fibronectin, a proteinassociated with tumour blood vessels in a wide range of cancers.AS1409 is designed to be a targeted therapy that delivers IL12specificall...

Abbott Researchers Focus on New Cutting-Edge Approaches in the Fight Against Cancer

...al uniquecharacteristics -- they require new blood vessels to deliver oxygenand nutrients (angiogenesis), they grow uncontrollably(proliferation), they travel throughout the body (metastasis), andthey escape programmed cell death, a natural process by which thebody rids itself of damaged or unwanted cells (a...

CytImmune To Present At ASCO Phase I Clinical Trial of CYT-6091 to be Presented on June 3, 2007

...s able to exit the blood streamthrough leaky blood vessels and sequester in and around tumor siteswith TNF binding to available receptors in this area. Preclinicalstudies indicate that CYT-6091 is then able to actively andpassively target tumors, potentially delivering more drug to thesite of disease with re...

Presentations at American College of Cardiology Meeting Highlight New Opportunities for HDL Therapy

...se atherosclerosis, asystemic disease of the blood vessels caused by the build-up ofcholesterol-filled plaques in the vascular system and, mostcritically, in the coronary arteries. Regression of such plaquesmay have a major impact on reducing the risk of acute coronaryevents. The Company's Viral Immunotherap...

Pieris Demonstrates Potent Anti-Tumor Activity of a VEGF-Specific Anticalin in Preclinical Studies

...S-050 Angiogenesis - the development of new blood vessels frompre-existing vasculature - plays an important role in severaldiseases. Although various pro- and anti-angiogenic factors havebeen identified, Vascular Endothelial Growth Factor (VEGF) has beenimplicated as the key angiogenic factor in cancer and ...

Interferon Beta DNA Treatment Delivered with Ichor Technology Reduces Atherosclerosis Progression in Mice

...e-damaging inflammation thatcharacterize the blood vessels of these mice with atherosclerosis,"said Marc S. Penn, M.D., Ph.D., principal investigator fromCleveland Clinic. While preliminary, these results broaden the support for the useof the electroporation-based TriGrid as an enabling platformtechnology t...

Positive Interim Phase 2 Data Reported for VEGF Trap-Eye in Age-Related Macular Degeneration

...se normal role is to triggerformation of new blood vessels (angiogenesis) to support the growthof the body's ...withthe abnormal growth and fragility of new blood vessels in the eye,which lead to the development of wet AMD. The VEGF Trap-Eye is afully human, soluble VEGF...

Abbott's Xience V Everolimus Eluting Coronary Stent Superior to Taxus Stent in Spirit III U.S. Pivotal Clinical Trial

...hown toreduce tissue proliferation in the coronary vessels following stentimplantation, and is based upon the highly deliverable and provenMULTI-LINK VISION coronary stent platform. XIENCE V was launched in Europe and Asia Pacific in 2006. XIENCEV is currently an investigational device in the United States ...

Antisoma plc (UK) - Second lung cancer trial adds to positive data on AS1404

...e vasculardisrupting agent which targets the blood vessels that nourishtumours. The drug was discovered by Professors Bruce Baguley andWilliam Denny and their teams at the Auckland Cancer SocietyResearch Centre, University of Auckland, New Zealand. It wasin-licensed by Antisoma from Cancer Research Ventures ...

Data From Adherex's European Phase Ib/II Trial of ADH-1 to be Presented at International Symposium on Targeted Anticancer Therapies

...resent on certain tumorcells and established blood vessels that feed solid tumors. STS, adrug from our specialty pharmaceuticals pipeline, protects againstthe disabling hearing loss that can often result from treatmentwith platinum-based chemotherapy drugs. With a diversifiedportfolio of unique preclinical a...