New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease
... the treatment of moderately to severely active
ulcerative colitis, in patients with an inadequate response ... spondylitis (AS), psoriatic arthritis (PsA),
ulcerative colitis (UC), pediatric Crohn's disease (PCD) and ... or young adult males with Crohn's disease or
ulcerative colitis who were taking REMICADE and azathioprine ...
Prometheus Announces New Findings Regarding Patients at Risk for Celiac Disease at DDW
... IBD vs. non-IBD and Crohn's disease vs.
ulcerative colitis than using traditional cutoff value ... It is estimated that Crohn's disease and
ulcerative colitis, the two main types of IBD, together ... The main difference between Crohn's disease and
ulcerative colitis is the location and nature of the ...
PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference
... patients with Crohn's disease and potentially
ulcerative colitis," said Pirow Bekker, M.D., Ph.D., Senior ... that may result in Crohn's disease or
ulcerative colitis - the two principal forms of IBD. In ... prophylactically in models of Crohn's disease and
ulcerative colitis. In addition to the ongoing PROTECT-1 ...
Medarex Announces Primary Endpoint Achieved in MDX-1100 Anti-IP-10 Antibody Phase 2 Trial for Rheumatoid Arthritis
... in a range of inflammatory diseases, including
ulcerative colitis in an ongoing companion Phase 2 study."
... is also being explored as a treatment for
ulcerative colitis (UC). A Phase 2 randomized, double-blind, ... inflammation ascertained by endoscopy.
ulcerative colitis is a chronic inflammatory bowel disease ...
Takeda Initiates Two Phase III Studies with Vedolizumab (MLN0002) in Patients with Inflammatory Bowel Disease
... Studies to Investigate Novel Therapy for
ulcerative Colitis and Crohn's Disease
OSAKA, Japan, ... will study vedolizumab for the treatment of
ulcerative colitis and Crohn's disease, the two main types ... the lives of patients with Crohn's disease and
ulcerative colitis."
Though current IBD treatments have ...
New Findings Show Efficacy of REMICADE(R) Compared With Azathioprine in Treatment of Crohn's Disease According to First-of-its Kind Study
... that the
FDA has approved for the treatment of
ulcerative colitis, a related
inflammatory bowel disease, ... (AS), psoriatic arthritis (PsA),
ulcerative colitis (UC),
pediatric Crohn's disease (PCD) and ... ankylosing spondylitis, psoriatic
arthritis,
ulcerative colitis, pediatric Crohn's disease and ...
Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis
... in
inflammatory bowel disease, including
ulcerative colitis and Crohn's
disease. RDEA119 was shown to ... used for acute and maintenance
treatment of
ulcerative colitis.
"Despite the existing treatments, ... for a new
generation of therapies aimed to treat
ulcerative colitis and Crohn's
disease," said Barry D. ...
New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease
... -- Data from a new analysis of the
Active
ulcerative Colitis Trials (ACT 1 and ACT 2) showed that at ... treatment option for patients with active
ulcerative colitis,
whether recently diagnosed or struggling ... healing, all goals of therapy in the
treatment of
ulcerative colitis."
In the analysis of 728 patients from ...
Analysis of Ulcerative Colitis (UC) Time to Symptom Resolution Data from Pivotal Study of LIALDA(TM) (mesalamine) Presented at DDW
... 302) of Shire plc's
(LSE: SHP, Nasdaq: SHPGY)
ulcerative colitis (UC) drug, LIALDA(TM), will be
presented ... in patients with active, mild to moderate
ulcerative colitis
compared to placebo and these study ... in patients
with active, mild to moderate
ulcerative colitis. Safety and effectiveness
of LIALDA ...
Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis
... that
targets CXCL10 (also known as IP-10), in
ulcerative colitis (UC) and
rheumatoid arthritis (RA). ... Anti-CXCL10 (IP10) Monoclonal Antibody, in
ulcerative Colitis" (Abstract #704) - Oral presentation ... the
treatment of inflammatory diseases such as
ulcerative colitis and
rheumatoid arthritis.
About ...
New Analyses of Long-Term LIALDA(TM) (mesalamine) Data Presented at ACG
... Shire plc's (LSE: SHP, Nasdaq: SHPGY, TSX: SHQ)
ulcerative colitis
(UC) drug LIALDA(TM) (mesalamine) provide ... data on LIALDA in
patients with mild to moderate
ulcerative colitis. These analyses of
LIALDA's 303 trial, a ... Once or Twice Daily LIALDA for Mild vs. Moderate
ulcerative Colitis Poster Presentation: Tuesday, October ...
Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets
... tablets, which are indicated for the treatment of moderately active
ulcerative colitis (UC), a form of inflammatory bowel disease. UC involves ... 79 percent in ASCEND III and 74 percent in ASCEND II. (1,2)
About
ulcerative Colitis (UC)
UC involves inflammation of the lining of the colon and ...
Shire Presented Results of a New Database Analysis on Lialda(R) (Mesalamine) and Other 5-ASAs for Ulcerative Colitis at Digestive Disease Week
... for the induction of remission in patients with active, mild to moderate
ulcerative colitis (UC). Safety and effectiveness of Lialda beyond eight weeks have ... for the induction of remission in patients with active, mild to moderate
ulcerative colitis. Safety and effectiveness of Lialda beyond 8 weeks have not been ...
New Genes Found for Inflammatory Bowel Disease in Children
... which can affect any
part of the gastrointestinal tract, and half have
ulcerative colitis, which
is limited to the large intestine.
IBD that begins in ... to each
patient."
The study team also found an association between
ulcerative colitis and
genes on the major histocompatiblity complex (MHC) on ...
Cerimon Pharmaceuticals Initiates Phase II Study to Evaluate Simulect(R) (Basiliximab) for Noninfectious Uveitis
... a Phase IIb study for patients with moderate-to-severe,
steroid-refractory
ulcerative colitis (UC) in April 2007.
"The initiation of this proof-of-concept ... being assessed as a
treatment for moderate-to-severe, steroid-refractory
ulcerative colitis
(UC). The second program is studying Simulect as a treatment ...
REMICADE-Treated Patients Experienced Rapid and Substantial Improvement in Psoriasis in Critical Regions of Body
... arthritis (RA), ankylosing
spondylitis (AS), psoriatic arthritis (PsA),
ulcerative colitis (UC),
pediatric Crohn's disease (PCD) and psoriasis (PsO). The ... rheumatoid arthritis, ankylosing spondylitis, psoriatic
arthritis,
ulcerative colitis, pediatric Crohn's disease and psoriasis.
The world leader in ...
Study Data Show Asacol(R) (Mesalamine) is Effective in Treating All Extents of Ulcerative Colitis Including Isolated Proctitis
... Findings reinforce the benefits of Asacol for
ulcerative colitis patients
AVENTURA, Fla., Dec. 5 /PRNewswire/ -- Data from two ... in previous trials and the current prescribing information.
About
ulcerative Colitis (UC)
UC involves inflammation of the lining of the colon and ...
Foundation Venture Capital Group Invests in UMDNJ Company Working to Improve Leukemia Treatments
... is also looking at Leukotoxin for use in autoimmune diseases such as psoriasis, rheumatoid arthritis, multiple sclerosis, lupus, Crohn's disease and
ulcerative colitis.
"While there are numerous drug candidates under development for treating various forms of leukemia, Dr. Kachlany's approach to ...
Schering-Plough Highlights R&D Pipeline Progress, Innovation and Breadth of Research Projects
... and autoimmune disorders (under review in EU for rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis, and in Phase III for
ulcerative colitis); Schering-Plough has exclusive marketing rights to golimumab outside the U.S. except in Japan and certain other Asian markets;
...
Schering-Plough Provides Update on Boceprevir Clinical Development and Introduces Potent Next-Generation Oral HCV Protease Inhibitor for Treating Patients With Chronic Hepatitis C
... 1% with PEGINTRON or interferon alpha: Severe decreases in neutrophil or platelet counts, hypothyroidism, hyperglycemia, hypotension, arrhythmia,
ulcerative and hemorrhagic colitis, development or exacerbation of autoimmune disorders including thyroiditis, RA, systemic lupus erythematosus, psoriasis, ...
Boceprevir Phase II Study Showed High Rate of Sustained Response With 28- and 48-Week Regimens in Genotype 1 Treatment-Naive Hepatitis C Patients
... 1% with PEGINTRON or interferon
alpha: Severe decreases in neutrophil or platelet counts, hypothyroidism,
hyperglycemia, hypotension, arrhythmia,
ulcerative and hemorrhagic colitis,
development or exacerbation of autoimmune disorders including thyroiditis,
RA, systemic lupus erythematosus, psoriasis, ...
CIMZIA(R) (Certolizumab Pegol) Provides Long-Term Benefit Without Dose Escalation in Crohn's Disease Patients
... many as half a million Americans. People with Crohn's can
experience an ongoing cycle of flare-up and remission throughout their
lives. Together with
ulcerative colitis, Crohn's disease is an inflammatory
bowel disease (IBD).
About CIMZIA (certolizumab pegol)
CIMZIA is the only PEGylated anti-TNFa (Tumour ...
Ardea Biosciences Presents Preclinical Anti-Inflammatory Data on its Lead MEK Inhibitor, RDEA119, at the ACG 2008 Annual Meeting
... chronic colitic mice. The beneficial effect of RDEA119 exceeded
that of Remicade(R) (infliximab), the current standard-of-care for the
treatment of
ulcerative colitis.
"Blocking the MEK1/2 pathway appears to be a promising strategy for
treating inflammatory disease, for which a significant unmet medical ...
CIMZIA(R) (certolizumab pegol) Reduces Intestinal Lesions and Induces Endoscopic Improvement in Crohn's Patients
... many as half a million Americans. People with Crohn's can
experience an ongoing cycle of flare-up and remission throughout their
lives. Together with
ulcerative colitis, Crohn's disease is an inflammatory
bowel disease (IBD).
About CIMZIA (certolizumab pegol)
CIMZIA is the only PEGylated anti-TNFa (Tumour ...
Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients
... 1% with PEGINTRON or interferon
alpha: Severe decreases in neutrophil or platelet counts, hypothyroidism,
hyperglycemia, hypotension, arrhythmia,
ulcerative and hemorrhagic colitis,
development or exacerbation of autoimmune disorders including thyroiditis,
RA, systemic lupus erythematosus, psoriasis, ...
Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival
... equal to one percent
with PEGINTRON(TM): Severe decreases in neutrophil or platelet counts,
hypothyroidism, hyperglycemia, hypotension, arrhythmia,
ulcerative and
hemorrhagic colitis, development or exacerbation of autoimmune disorders
including thyroiditis, RA, systemic lupus erythematosus, ...
Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City
... represents a breakthrough mechanism of action for inflammatory
disease and is being investigated in separate Phase 2 proof-of-concept
trials for
ulcerative colitis and rheumatoid arthritis. Interim data from
these trials are expected in 2009.
-- MDX-1401 is a fully human antibody that targets CD30, a ...
FDA Advisory Committee Unanimously Recommends Approval of Ustekinumab for Treatment of Moderate to Severe Plaque Psoriasis
... Centocor has already brought innovation to the treatment
of Crohn's disease, rheumatoid arthritis, ankylosing spondylitis, psoriatic
arthritis,
ulcerative colitis, pediatric Crohn's disease and psoriasis.
The world leader in monoclonal antibody production and technology,
Centocor has brought critical ...
ChemoCentryx Completes Enrollment of PROTECT-1, a Phase II/III Clinical Trial of CCR9 Antagonist CCX282-B (Traficet-EN(TM)) in Crohn's Disease
... the digestive tract. The
trafficking of T cells to the small and large intestine causes persistent
inflammation that may result in Crohn's disease or
ulcerative colitis - the
two principal forms of IBD. In preclinical studies, the compound worked
both therapeutically and prophylactically in models of Crohn's ...
Data From Two Phase 3 Studies Show Anti-TNF Golimumab Significantly Improved Signs and Symptoms of Rheumatoid Arthritis
... Centocor has already brought innovation to the treatment
of Crohn's disease, rheumatoid arthritis, ankylosing spondylitis, psoriatic
arthritis,
ulcerative colitis, pediatric Crohn's disease and psoriasis.
The world leader in monoclonal antibody production and technology,
Centocor has brought critical ...
Schering-Plough To Initiate Phase III Studies With HCV Protease Inhibitor Boceprevir in Previously Untreated Hepatitis C Patients and Those Who Failed Prior Treatment
... 1% with PEGINTRON or interferon
alpha: Severe decreases in neutrophil or platelet counts, hypothyroidism,
hyperglycemia, hypotension, arrhythmia,
ulcerative and hemorrhagic colitis,
development or exacerbation of autoimmune disorders including thyroiditis,
RA, systemic lupus erythematosus, psoriasis, ...
Safety and Efficacy Results Presented From Largest Prospective Controlled Clinical Study of Ulcerative Colitis
... g/day also demonstrated efficacy in secondary endpoints:
clinical remission, rectal bleeding, stool frequency and sigmoidoscopy
improvement.
About
ulcerative Colitis (UC)
UC involves inflammation of the lining of the colon and rectum. It
varies in clinical severity with patients having mild, moderate or ...
Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Hepatitis C Data Presentations at Digestive Disease Week (DDW) Annual Meeting
... 1% with PEGINTRON or interferon
alpha: Severe decreases in neutrophil or platelet counts, hypothyroidism,
hyperglycemia, hypotension, arrhythmia,
ulcerative and hemorrhagic colitis,
development or exacerbation of autoimmune disorders including thyroiditis,
RA, systemic lupus erythematosus, psoriasis, ...
Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL
... 1% with PEGINTRON or interferon
alpha: Severe decreases in neutrophil or platelet counts, hypothyroidism,
hyperglycemia, hypotension, arrhythmia,
ulcerative and hemorrhagic colitis,
development or exacerbation of autoimmune disorders including thyroiditis,
RA, systemic lupus erythematosus, psoriasis, ...
Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL)
... 1% with PEGINTRON or interferon
alpha: Severe decreases in neutrophil or platelet counts, hypothyroidism,
hyperglycemia, hypotension, arrhythmia,
ulcerative and hemorrhagic colitis,
development or exacerbation of autoimmune disorders including thyroiditis,
RA, systemic lupus erythematosus, psoriasis, ...
Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Data Presentations at European Association for the Study of the Liver (EASL) Annual Meeting
... 1% with PEGINTRON or interferon
alpha: Severe decreases in neutrophil or platelet counts, hypothyroidism,
hyperglycemia, hypotension, arrhythmia,
ulcerative and hemorrhagic colitis,
development or exacerbation of autoimmune disorders including thyroiditis,
RA, systemic lupus erythematosus, psoriasis, ...
Shire Strives to Increase Adherence Among Chronic Kidney Disease Stage 5 Patients
... accumulate in the GI tract, liver and bone in animals, the clinical significance in humans is unknown.
-- Patients with acute peptic ulcer,
ulcerative colitis, Crohn's disease, or bowel obstruction were not included in FOSRENOL clinical studies. Caution should be used in patients with ...
Pegintron(TM) Plus Weight-Based Rebetol(R) Resulted in Higher SVR Than Flat Dosing; Low Relapse Rates in Patients With Chronic Hepatitis C
... 1% with PEGINTRON or interferon
alpha: Severe decreases in neutrophil or platelet counts, hypothyroidism,
hyperglycemia, hypotension, arrhythmia,
ulcerative and hemorrhagic colitis,
development or exacerbation of autoimmune disorders including thyroiditis,
RA, systemic lupus erythematosus, psoriasis, ...
Florastor(R) Receives ConsumerLab.com Certification
... to be effective in helping to
manage intestinal issues ranging from acute diarrhea to chronic
inflammatory conditions (such as Crohn's disease or
ulcerative colitis).
Florastor has also been clinically proven to be particularly effective in
combating antibiotic-associated diarrhea, since, unlike ...
Ustekinumab (CNTO 1275) Phase 3 Data Show Long-Term Improvement Of Chronic Plaque Psoriasis
... Centocor has already brought innovation to the treatment
of Crohn's disease, rheumatoid arthritis, ankylosing spondylitis, psoriatic
arthritis,
ulcerative colitis, pediatric Crohn's disease and psoriasis.
The world leader in monoclonal antibody production and technology,
Centocor has brought critical ...