Tumors in Medical Technology

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

... the trial. Importantly, in patients with tumors harboring activating KRAS mutations, PFS was ... KRAS tumors, but patients with KRAS mutant tumors were negatively affected when Vectibix was added ... Vectibix should not be used in patients with tumors containing activating KRAS mutations." ...

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

... in 1,776 advanced cancer patients with solid tumors (not including breast and prostate cancer) or ... benefit for advanced cancer patients with solid tumors that have metastasized to the bone, and to ... next year." Bone metastases, the spread of tumors to the bone, are a serious concern for many ...

Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program

... drug that has shown to be active in many solid tumors in human clinical studies. Access has commenced ... drug that has shown to be active in many solid tumors in human clinical studies. Platinum drugs are one ... shown to be active in a wide variety of solid tumors in both preclinical models and in human trials. ...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

... as a single agent treatment for recurrent solid tumors in pediatric patients. This Phase 1 study is now ... prognosis, or proliferation, in several pediatric tumors such as neuroblastoma, glioblastoma, ... with novel agents in patients with advanced brain tumors are expected to commence later this year. Such ...

Ipsogen Reports Incorporation of the Genomic Grade in the 2009 St. Gallen International Consensus Meeting on the Primary Treatment of Early Breast Cancer

... cancer, by resolving 80% of histological grade 2 tumors in genomic grade 1 or 3 of similar long term ... "Treatment decision in a number of ER+ HER2- tumors remains a daily challenge", said Dr Fabrice ... such as the Elston-Ellis score, which classifies tumors into 3 grade categories of growing potential for ...

Neurobiological Technologies' Partner, Celtic Pharma, Announces Results of XERECEPT(R) Phase 3 Clinical Program

... in patients with edema associated with brain tumors and from preclinical studies of XERECEPT in brain ... in Patients with Primary and Metastatic Brain tumors Administration of XERECEPT(R) in Patients ... effects in the treatment of patients with brain tumors is an important goal," said Lawrence Recht, MD, ...

Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

... in relapsed patients with advanced solid tumors demonstrate promising single-agent anti-cancer ... patients with late-stage or metastatic solid tumors who have failed multiple prior treatments are ... patients with a variety of relapsed solid tumors established a dosing schedule of 20 mg/m2 on days ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... benefit in patients with advanced neuroendocrine tumors of the midgut - Early data show that at ... LAR in metastatic neuroendocrine midgut tumors Data from the PROMID study (abstract #4508)* ... effect in patients with metastatic neuroendocrine tumors (NET) of the midgut(1). Sandostatin LAR, ...

BioVex to Report Phase I/II Clinical Trial Results for the Front Line Treatment of Head and Neck Cancer With OncoVEX GM-CSF at the 2009 American Society of Clinical Oncology Meeting

... was detected in injected and adjacent uninjected tumors at a therapeutic dose. Dr Robert ... annually. Patients with locally advanced tumors are best treated with concurrent chemo radiation, ... works by; replicating and spreading within solid tumors (whilst leaving healthy cells unaffected), ...

AUA Guideline: Full Kidney Removal Not Necessary for All Kidney Tumors

... is not the best treatment for most small kidney tumors because it puts patients at risk for chronic ... malignancies, but small, clinically confined tumors are very heterogeneous, and most do not require ... intervention. However, more aggressive or larger tumors (>3 to 4 cm) should be managed in a proactive ...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

... to Reverse the Immune Suppressing Effects of tumors by Changing the Tumor Microenvironment and ... Release and Recruitment of Macrophages to tumors - DENVER and TUSTIN, Calif., April 21 ... and spread and also to reverse the ability of tumors to suppress the body's natural immune response, ...

Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers

... Center. "Additionally, we now believe that PPB tumors arise from an unusual mechanism in which cells ... lung cysts in the early stage to solid lung tumors in later stages. If detected in the earliest ... cells. The researchers indicate that PPB lung tumors probably originate when one or more cells in the ...

Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier

... and being developed for the treatment of solid tumors and hematologic malignancies. Pharmacyclics ... in multiple Phase I clinical trials in solid tumors and hematological malignancies. PCI-24781 is in a ... I clinical study in patients with advanced solid tumors and in a Phase I/II clinical study in patients ...

Freezing Prostate Cancer Does a Man's Body Good

... is as effective as surgery in destroying diseased tumors and can be considered a first-line treatment for ... approach because earlier detection of smaller tumors increases the likelihood that a small tumor can ... and overtreatment in many men with low-risk tumors has led to a concept in the medical community of ...

Freezing Kidney Cancer: Hot Treatment Should Be New Gold Standard for Destroying Small Tumors

... 9 /PRNewswire-USNewswire/ -- Freezing kidney tumors -- using a safe minimally invasive interventional ... first treatment option for all individuals with tumors that are 4 centimeters in size or smaller. And, ... who are diagnosed with kidney cancer have small tumors that are discovered incidentally. "Cryoablation ...

Lexicon Presents Clinical Data on LX1032 for Carcinoid Syndrome at European Neuroendocrine Tumor Society Meeting

... on diagnosis and treatment of neuroendocrine tumors including carcinoid. The meeting brings together ... that is the result of metastatic neuroendocrine tumors that usually originate from the gastrointestinal tract. These tumors secrete large amounts of serotonin, which can ...

New Proton Therapy Equipment Enables More Tumors to be Treated

... Therapy Institute enables physicians to treat tumors that are deeper in the body, tumors that are very large and tumors that are situated closer to vital organs. ...

Breast Cancer Patients May Have a New Treatment Option When Cancer Spreads

... a safer, more convenient treatment for spine tumors LAS VEGAS, Feb. 22 /PRNewswire-USNewswire/ ... also make it possible to treat recurrent spinal tumors in patients who have already received the maximum ... proximity of the spinal cord and nerves, those tumors can lead to serious neurological complications. ...

Access Licenses ProLindac(TM) and MuGard(TM) to JCOM Ltd, an Affiliate of DONG-A Pharmaceuticals in Korea

... shown to be active in a wide variety of solid tumors in both preclinical models and in human trials. ... shown to be active in a wide variety of solid tumors in both preclinical models and in human trials. ... which is activated in the hypoxic zones of solid tumors to kill cancer cells; Alchemix, a ...

EntreMed Presents Initial Clinical Results for ENMD-2076

... a Phase 1 study in patients with refractory solid tumors as well as preclinical data showing significant ... Phase 1 study in patients with refractory solid tumors demonstrated that ENMD-2076 administered orally ... for the clinical evaluation of ENMD-2076 in tumors responsive to platinum compounds, and ...

Chemoembolization Improving as Liver Cancer Treatment

... beads to choke off and kill cancerous liver tumors is becoming more successful, according to ... The most effective way to treat most cancerous tumors is by surgically removing them. However, more ... into the tumor. A month after treatment, tumors in 27 of the patients (51 percent) showed a ...

New Study First to Confirm Sandostatin LAR(R) Depot Controls Tumor Growth in Patients With Rare Gastrointestinal Tumors

... patients with newly diagnosed neuroendocrine tumors (NETs) EAST HANOVER, N.J., Jan. 13 ... in patients with metastatic neuroendocrine tumors (NETs) of the midgut, according to interim data ... and flushing associated with neuroendocrine tumors and now this study demonstrates that Sandostatin ...

Molecular Marker Identifies Normal Stem Cells as Intestinal Tumor Source

... that normal stem cells can act as the source of tumors in mature solid tissues MEMPHIS, Tenn., ... particularly interesting since human intestinal tumors contain Prominin1-expressing cancer stem cells." ... Remnant cancer stem cells might therefore cause tumors to relapse and re-grow following treatment. If we ...

Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology

... the evidence that it is often activated in tumors that are resistant to other forms of anticancer ... as well as glioblastoma. The majority of tumors expressing high levels of pAkt were high-grade, ... with poor prognosis. High pAkt is often seen in tumors that are resistant to conventional cancer ...

Light Sciences Oncology Completes Patient Enrollment in Phase 3 Clinical Trial of Litx as a Treatment for Hepatocellular Carcinoma

... zone" around the LED array. Litx attacks tumors from the inside-out, rather than outside-in, the ... that the production of large apoptotic masses in tumors with light-activated drug therapies, including ... CD8+ T-cells that infiltrate distant, untreated tumors and destroys them. Human trials of Litx have ...

Medarex Announces Initiation of Phase 1b Clinical Development Program with MDX-1106 for the Treatment of Cancer

... dosing of MDX-1106 in adult patients with solid tumors and will also provide a preliminary assessment of ... (1, 3 or 10 mg/kg) in these patients. The tumors to be studied include malignant melanoma, renal ... correlation between increased PD-L1 expression on tumors and a negative survival prognosis in cancer ...

Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium

... death, in cultured human tumor cells and human tumors grown in mice. MLN4924 advanced to clinical ... effects in patients with advanced solid tumors or with hematological malignancies. -- ... Nedd8-activating enzyme, in human xenograft tumors grown in immunocompromised mice -- Lead ...

Young Women Diagnosed with Early-Stage Breast Cancer More Likely to Die than Older Women

... Dr. Margenthaler further explained that the tumors of women under 40 tended to be estrogen- and ... outcomes. That is the case because these tumors do not respond to the antiestrogen therapies now ... have recently begun a study examining some of the tumors removed from their own patients under 40. ...

Eating Walnuts Slows Cancer Growth, Laboratory Study Finds

... fed the mice the walnuts, the growth rate of the tumors they had was dramatically suppressed," Hardman ... of two servings for humans -- came from walnuts. tumors in the walnut-fed group took twice as long to double in size as tumors in the control group, the article reports. The ...

Breast MRI Scan Could Determine Need for Radiation Therapy

... radiation therapy, especially those with smaller tumors and tumors that have not spread to the lymph nodes, he ... it give us traditional anatomic information about tumors but information about the biology of the tumor as ...

RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors

... - 82% of patients with pancreatic neuroendocrine tumors (NET) experienced clinical benefit when treated ... or remained stable. "Pancreatic neuroendocrine tumors cause debilitating symptoms related to hormone ... in patients with pancreatic neuroendocrine tumors who are resistant to chemotherapy." Two Phase ...

Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors

... range of 18 cancer cell lines representing solid tumors (lung, pancreatic, prostate, colon, ... the genesis of many cancers including both solid tumors and hematologic malignancies. Cancer research and ... in Phase I clinical trials in both solid tumors and multiple myeloma. For more information see ...

Bayer and Onyx Begin Enrollment in STORM Trial Studying Nexavar as Adjuvant Therapy for Patients With Liver Cancer

... about 90 percent of the primary malignant liver tumors in adults. Liver cancer is the sixth most common ... resection or local ablation will see their tumors return within three years and 70 percent will see their tumors return within five years.(3) Nexavar's ...

FDA Clears the Pathwork(R) Tissue of Origin Test for Hard-To-Identify Tumors

... to help pinpoint the source of hard-to-identify tumors and is the first test of its kind to receive FDA ... poorly differentiated and undifferentiated tumors that had been identified as one of the 15 tumor ... tissue specimens.(6) "Hard-to-identify tumors are a significant clinical problem," said ...

Halozyme Therapeutics Announces Positive Findings With Pegylated Enzyme in Prostate Cancer Models

... The effects of PEGPH20 were selective to prostate tumors producing hyaluronan (HA), consistent with the ... acting PEGPH20 enzyme candidate against HA-rich tumors in combination with chemotherapy," said Gregory ... and Chief Scientific Officer. "By targeting tumors that overproduce the HA matrix component, PEGPH20 ...

Rosetta Genomics and Collaborators Identify MicroRNAs That Can Accurately Discriminate Between Primary and Metastatic Tumors in the Brain

... Study Demonstrates Differentiation of Primary tumors From Metastases in the Brain ... Differentiating Primary From Metastatic tumors is Critical for Optimal ... primary from metastatic tumors of the brain, have been published online in the ...

Children's Brain Tumor Foundation's Tissue Bank Consortium May Solve Dire Problem in Pediatric Cancer Research

... to speed treatment and cures for pediatric brain tumors and cancer, the Children's Brain Tumor Foundation ... any have sufficient volume of different kinds of tumors to conduct comprehensive research. Without the ... According to Dr. Curran, although pediatric brain tumors can be devastating, their low incidence has ...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Causes Tumor Regression in AML Xenograft Models

... and commercialization of therapies for solid tumors and hematological malignancies, today announced ... Phase 1 clinical trials with SGI-1776 in solid tumors and leukemias later this year. SGI-1776 may ... and commercialization of therapies for solid tumors and hematological malignancies. SuperGen ...

EntreMed Receives New Patent for 2-Methoxyestradiol Analogs

... that certain analogs of 2ME2 can attack tumors on multiple fronts -- directly by ... and by blocking blood vessels that feed tumors (angiogenesis inhibition). U.S. Patent No. ... the '741 patent claims methods for treating tumors with compounds having the claimed structural ...

Research Explains How Advanced Prostate Cancer Becomes Resistant to Androgen-Deprivation Therapy

... what may be the key to understanding how prostate tumors eventually become resistant to ... very low or castrate levels, metastatic prostate tumors are themselves able to maintain significant ... levels were four times higher in metastatic tumors from castrate men (collected immediately after ...