Analysis of Edoxaban Phase II Data Provides Insight Into Reduced Bleeding Events Seen in Once-Daily Dosing
... today at the XXII International Society on
thrombosis and Haemostasis Congress in Boston. Edoxaban is ... established by the International Society on
thrombosis and Haemostasis(3), the most sensitive scale of ... products in non-surgical patients. Journal of
thrombosis and Haemostasis 2005;3: 692-694.
...
ThromboGenics and BioInvent Start Recruitment of Second 100 Patient Cohort in Phase II DVT Prophylaxis Study With TB-402
... being developed for the prevention of deep vein
thrombosis (DVT) following
orthopaedic surgery. The decision ... the XXII
Congress of the International Society on
thrombosis and Haemostasis (ISTH) on
July 15, 2009 in ... this product candidate."
About Deep Vein
thrombosis (DVT)
DVT is caused when a blood clot ...
Isis and Collaborators Present New Research at the ATVB Annual Conference
... data were presented during the Arteriosclerosis,
thrombosis and Vascular Biology's (ATVB) Annual Conference. ... drug candidate for development from our new
thrombosis effort. It is another example of the power of ... Factor XI as the optimal target to inhibit
thrombosis without causing bleeding. In addition to Factor ...
Abbott's Market-Leading XIENCE V(R) Shows Increasing Clinical Advantages Over TAXUS(R) Express2(TM)/TAXUS(R) Liberte(TM) Between Two and Three Years
... for TAXUS, p-value=0.092)*.
No stent
thrombosis between two and three years with XIENCE V, and a low rate of stent
thrombosis from zero to three years, per Academic Research ... (ARC) definition of definite/probable stent
thrombosis (0.9 percent for XIENCE V and 2.8 percent for ...
March 2009 Mayo Clinic Health Letter Highlights Knee Repair Surgery, Anxiety Disorder and Preventing Blood Clots
... flights aren't the only risk factor for deep vein
thrombosis (DVT), the medical term for blood clots in the ...
For most healthy adults, deep vein
thrombosis is extremely rare. Every year, about 350,000 ... are used to diagnose DVT. Treatment for deep vein
thrombosis seeks to prevent the clot from becoming bigger ...
Circulation Publishes Pivotal Two-Year Results On XIENCE V(TM) Drug Eluting Stent
... p-value=0.07)*.
-- Low rates of stent
thrombosis (blood clotting within the treated area)
per the ... (ARC) definition of definite/probable
stent
thrombosis (1.3 percent for XIENCE V vs. 1.7 percent for ... percent for TAXUS).
The ARC definitions of stent
thrombosis were developed to eliminate
variability in the ...
Portola Pharmaceuticals Initiates Phase II Trial of Novel IV and Oral Anti-Platelet Drug in Non-Urgent Percutaneous Coronary Intervention
... an
important anti-platelet therapy in treating
thrombosis patients in both the
acute and chronic settings." ... receptor on
platelets has been proven to prevent
thrombosis and subsequent heart attacks.
Portola believes ... ischemic events, and elective PCI.
About
thrombosis
Thrombosis, or the development of harmful ...
Research Highlights New Approaches to Prevent Blood Clots in Several High-Risk Patient Populations Including Largest Study Ever to Examine Use of Blood-Thinning Medication in Patients With Cancer
... arterial thromboembolic events (i.e., deep-vein
thrombosis of the lower and upper limbs, visceral and ... i n the Treat m ent of Deep-Venous
thrombosis (EQUINOX Study): Safety, Efficacy, and ... patients with symptomatic and confirmed deep-vein
thrombosis were randomized to receive weekly subcutaneous ...
Portola Announces Data Showing Its Anti-Platelet Drug Inhibits Platelets in Clopidogrel (Plavix(R)) Non-Responders
... receptor on platelets has been proven to prevent
thrombosis and
subsequent heart attacks. Portola believes ... of Cardiovascular Research at the
Center for
thrombosis Research at Sinai Hospital, Baltimore, MD. ... achieved the
predefined endpoint. Inhibition of
thrombosis was highly significant in
these non-responder ...
Abbott's XIENCE V(TM) Drug Eluting Stent Outperforms TAXUS(R) in Key Efficacy and Safety Endpoints Out to Two Years
... TAXUS, p-value=0.03)*.
-- Low rates of stent
thrombosis between one and two years, defined as
very late ... (ARC)
definition of definite/probable stent
thrombosis (0.5 percent for XIENCE V
and 0.8 percent for TAXUS). The ARC definitions of stent
thrombosis were
developed to eliminate variability in the ...
Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent
... The adjusted rate of ARC
definite/probable stent
thrombosis at three years for the TAXUS Liberte
Stent group ... adjusted rate of ARC
definite/probable stent
thrombosis for the direct stent group at 0.3
percent, as ... of 46 percent. ARC definite/probable total
stent
thrombosis at two years was 0.8 percent for the TAXUS ...
APTA Supports Surgeon General's 'Call to Action' to Prevent Deep Vein Thrombosis and Pulmonary Embolism
... MPH to reduce the number of
cases of deep vein
thrombosis and pulmonary embolism in the United States.
... Pulmonary Section, blood clots, called deep vein
thrombosis (DVT), can
occur after periods of being immobile, ... and prevention of symptomless deep-vein
thrombosis in long-haul
flights: a randomised trial. Lancet. ...
Surgeon General's 'Call to Action' to Prevent DVT/PE Praised by NATT as Turning Point
... -- The National
Alliance for
thrombosis and Thrombophilia (NATT) praised Acting ... to Action" (CTA) to prevent deep vein
thrombosis (DVT) and pulmonary
embolism (PE).
RADM Galson ... NC
In the past year, CDC has designated
thrombosis as a priority,
increasing surveillance of DVT/PE ...
TAXUS OLYMPIA Registry Shows Excellent Outcomes for High-Risk Patients Treated With Second-Generation TAXUS(R) Liberte(R) Stent
... re-intervention (TLR) (2.5%). The definite
stent
thrombosis rate was 0.8 percent after one year, which is ... stent-related composite cardiac events
and stent
thrombosis were 4.3 percent and 0.9 percent respectively. ... "The low
occurrence of cardiac events and stent
thrombosis is noteworthy, especially
given the high degree ...
Prasugrel Head-to-Head Study Showed Reduced Cardiovascular Events in Diabetes Patients by 30 Percent Compared with Clopidogrel
... reduced
risk of heart attack and stent
thrombosis compared with clopidogrel among ... was also a
significantly lower rate of stent
thrombosis among diabetes patients
treated with prasugrel, ... in a 48 percent relative risk reduction
in stent
thrombosis compared with clopidogrel (3.6 percent vs. 2.0 ...
Arena Pharmaceuticals Announces Positive Phase 1b Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis
... peripheral conditions related to arterial
thrombosis with a novel
mechanism that may provide ... novel mechanism of
action.
About Thrombosis
thrombosis is the formation of a clot, or thrombus, inside a ... and efficacy of APD791; the role of
serotonin in
thrombosis and in increasing cardiovascular risk; how ...
Thrombosis Guidelines Emphasize Difficult Choices for Pregnant Women
... the prevention and management of
thrombosis in key patient
populations and reinforce ... on the challenges in preventing and treating
thrombosis in
pregnant women and children, and on managing ... are used to prevent and treat
thrombosis or blood clotting that
arises in arteries, veins, ...
XIENCE(TM) V Drug Eluting Stent from Abbott Outperforms Market-Leading Stent in Reducing Major Adverse Cardiac Events at Two Years
... Long-Term Clinical Outcomes, Lower Rates of Stent
thrombosis than Patients Treated ... lower observed rates of late and very late stent
thrombosis in
XIENCE V-treated patients, especially in those ... for TAXUS, p-value=0.07)*. -- Low rates of stent
thrombosis between one and two years, defined as very ...
TRITON-TIMI 38 Stent Analysis Favors Prasugrel
... since the stenting
procedure, or the way stent
thrombosis is defined.
The results of the TRITON-TIMI 38 ... Overall,
prasugrel reduced both early stent
thrombosis -- within 30 days of stenting
-- when compared ... hazard
ratio 0.41, p<0.001) -- and late stent
thrombosis -- more than 30 days
after stenting (0.49 percent ...
Study Finds Repeated Episodes of Stent Thrombosis Common
... Treating stent
thrombosis with another stent hikes the risk of repeat blood ... attack or even death. A single incident of stent
thrombosis is bad
enough, but a new study suggests that one ... total of 437 consecutive patients who had stent
thrombosis confirmed by
angiography between January 2004 and ...
Study Results Show Investigational Drug, Prasugrel, Cuts Risk of Stent-Related Clots by More than Half Versus Clopidogrel
... both BMS and DES at the time of enrollment. Stent
thrombosis was a
pre-defined secondary endpoint in the ... reduced the relative risk of coronary stent
thrombosis (a new
clot at the implanted stent site) over ... research consortium (ARC)
definition of stent
thrombosis was used - definite/confirmed stent
thrombosis, ...
Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH
... Continued to Be Associated with
Reductions in
thrombosis and Improvements in Fatigue, Quality of Life, and ... was
associated with sustained reduction in
thrombosis and improvements in
fatigue, overall quality of ... in
Transfusion Requirements, Fatigue and
thrombosis with Eculizumab Treatment
in Paroxysmal Nocturnal ...
Addition of INTEGRILIN(R) (Eptifibatide) to Bivalirudin Plus Standard of Care Inhibits Platelet Aggregation in Patients Undergoing Elective Coronary Stenting
... (NYSE: SGP ) and The Sinai Center for
thrombosis Research at
Sinai Hospital of Baltimore today ... Paul Gurbel, MD, Director of The Sinai
Center for
thrombosis Research, Sinai Hospital of Baltimore; ... Blood work
was processed at The Sinai Center for
thrombosis Research and the
University of Oklahoma Health ...
Positive Five-Year Safety Data for TAXUS(R) Stent Reported in Boston Scientific Trial
... rates of death,
myocardial infarction, and stent
thrombosis across a broad cross section of
patients and lesions and with no new cases of stent
thrombosis between
years four and five," said Gregg W. ... the TAXUS
IV trial reported no cases of stent
thrombosis between years four and five
for the TAXUS Stent ...
Abbott's XIENCE(TM) V Everolimus Eluting Coronary Stent Shows Continued Superiority to TAXUS Stent in Reducing Major Adverse Cardiac Events in SPIRIT III Clinical Trial
... a difference in either acute (30 day) or late
thrombosis rates between XIENCE V and TAXUS out to one year. ... a statistical difference between rates of
stent
thrombosis for XIENCE V or TAXUS out to one year in the SPIRIT III
trial. Rates of late stent
thrombosis at one year per protocol were 0.3
percent for ...
Four Analyses of Three-Year Clinical Data Suggest CYPHER(R) Sirolimus-Eluting Coronary Stent May Provide Alternative to Surgery for Patients with Multivessel Disease
... analysis
reported the overall incidence of stent
thrombosis in the data set using
the Academic Research ... and definite/probable/possible stent
thrombosis rates for
the CYPHER(R) Stent at three years were ... 5.3 percent and 6.4
percent, respectively. Stent
thrombosis comparisons between the CYPHER(R)
Stent and the ...
Two-Year Outcomes From Large Head-to-Head Clinical Trial Indicate Similar Safety Profile in Diabetic Patients for Cypher(R) Sirolimus-Eluting Coronary Stent and Taxus Stent
... the REALITY Trial
investigators reported a stent
thrombosis rate for the Taxus Stent that was
significantly ... the difference between the
protocol-defined stent
thrombosis rate for each drug-eluting stent in the
diabetic ... death, Q-wave myocardial
infarction and stent
thrombosis favoring the CYPHER(R) Stent were also seen
in ...
Five-Year Data From Taxus II Clinical Trial Highlights Safety and Efficacy of Taxus(R) Stent Compared to Bare-Metal Stent
... the bare-metal control
experienced one stent
thrombosis during this same period. This marks the
third consecutive year of TAXUS II follow-up with no stent
thrombosis seen
in the TAXUS stent patient group. The ... data regarding late and
very late stent
thrombosis out to five years," said Prof. Sigmund ...
Cypher(R) Sirolimus-Eluting Coronary Stent Demonstrates Sustained Clinical Benefits Compared to Bare Metal Stents in Five-Year Randomized Clinical Trial With No Differences in Long-Term Safety
... difference between their rates of stent
thrombosis (blood
clots). "The five-year results of the ... a significant difference in
the rates of stent
thrombosis between the CYPHER(R) Stent and the bare
metal ... were used,
the rates of acute and subacute stent
thrombosis were 0.0 percent for the
bare metal stent and 1.1 ...
PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials
... that Soliris substantially
reduced the risk of
thrombosis in a diverse population of PNH ... the course of the disease.(3,4,5,6) An initial
thrombosis increases
the relative risk of death by five- to ... hemolysis in all treated
patients and reduced
thrombosis by 92 percent, with three events during
Soliris ...
Value of Genetic Testing for Preventing Blood Clots Unproven, According to New AHRQ Study
... a history of blood clots helps to prevent a condition known as deep-vein
thrombosis or to improve other clinical outcomes.
The report, a summary of which ...
As many as 600,000 Americans each year may have deep-vein
thrombosis -- blood clots that form in the legs or pelvis. The condition occurs most ...
Long Term Data Presented at EuroPCR 2009 from Randomized Study Attest to Durability of Results of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) Compared to Drug-Eluting Stents
... Taxus(R) Liberte stent in high risk of restenosis patients. However, the
thrombosis rate for Taxus treated patients increased from one to two years from 4.2% ... at 658 days in a patient who had previously presented with a subacute
thrombosis and who was on dual antiplatelet therapy at the time of both thromboses. ...
Boston Scientific Welcomes Publication of HORIZONS AMI Trial Results in New England Journal of Medicine
... or its components, including death, repeat heart attack, stroke or stent
thrombosis at one year.
"The HORIZONS AMI trial provided outcomes data showing ... individual rates of death, repeat heart attack, stroke and stent
thrombosis between the two groups through 12 months of follow-up, which persisted ...
New Study Suggests Rx Estrogen Delivery Through the Skin May Show Safety Benefits as Opposed to Oral Delivery
... blood. Platelets serve a central role in forming pathological arterial
thrombosis that causes myocardial infarction and stroke. The study's authors further ... to identify postmenopausal women with an increased risk of arterial
thrombosis or clotting before even starting estrogen therapy is an important goal to ...
Abbott Advances Its Revolutionary Fully Bioabsorbable Drug Eluting Stent With Initiation of Next Phase of Clinical Trial
... that the device was absorbed. In addition, there were no cases of
thrombosis (blood clot formation) out to two years of follow-up, and no new major ... Key endpoints of the study include assessments of safety - MACE and stent
thrombosis rates - at 30 days; six, nine, 12 and 18 months; and two years, with ...
The Lancet Publishes Two-Year Results of Abbott's Fully Bioabsorbable Drug Eluting Stent
... the following key results:
A zero percent rate of stent
thrombosis (blood clot formation) for all patients out to two years of follow up.
... Key endpoints of the study include assessments of safety - MACE and stent
thrombosis rates - at 30 days, six, nine and 18 months, and one and two years, with ...
Schering-Plough's Investigational Oral Thrombin Receptor Antagonist Meets Primary Endpoint in a Newly Published Study
... option," said Richard Becker, MD, director of the Duke Cardiovascular
thrombosis Center and lead author of the study. "TRA appears to work in a novel way ... which demonstrate the potential to address unmet medical needs.
thrombosis may result in partial or complete blockage of arteries in the heart, brain ...
New Phase II Data Show Safety of Once-Daily Oral Factor Xa Inhibitor, DU-176b, Comparable to Warfarin in Patients With Non-Valvular Atrial Fibrillation
... evaluated using guidelines established by
the International Society on
thrombosis and Haemostasis(1), the most sensitive
scale of those currently used in ... of antihemostatic medicinal products in non-surgical patients.
Journal of
thrombosis and Haemostasis 2005;3: 692-694.
2. Jorgensen, H.S., Nakayama, ...
Interim Analysis of 12-Month Data from e-HEALING Registry Shows Good Safety and Efficacy in Real-World Use of OrbusNeich's Genous(TM) Bio-engineered R stent(TM)
... were a target lesion revascularization (TLR) rate of 5%, a
subacute
thrombosis (SAT) rate of 0.4%, a late stent
thrombosis (LST) rate
of 0.3%, and a major adverse cardiac events (MACE) rate of ....
12-Month ATLANTA Trial Data Show Sustained Benefit of Catania(TM) Stent in Treatment of De Novo Coronary Lesions
... follow-up data from the ATLANTA Trial. The results include zero
percent
thrombosis in patients discontinuing dual anti-platelet therapy
after only 30 days.
... FIM patient population, the
results showed zero (0.0) percent stent
thrombosis (Academic Research
Consortium, or ARC-defined), death, myocardial ...