Monitoring Patient Glucose Levels: New Advances in software make it easier
...urposes and encourages diabetic clients to discuss therapy with their physicians first. TheraSenses Freestyle Co-Pilot is another program that allows patients with Internet Explorer web browsers to upload their glucose monitor readings and insulin dosage levels to a secure server and web site in the U.S. It...Point of Care Strep Tests Speed Treatment, Lower Costs
...tococcus has often caused physicians to administer therapy without first knowing the etiological agent. Alter...ADT has improved the appropriateness of antibiotic therapy and allowed earlier laboratory, evidence-based treatment of group A -hemolytic streptococcal pharyng...New Assays to Detect Disseminated Fungal Infections
...cians have been forced to start empiric antifungal therapy in response to any unexplained fever or shock in susceptible patients. It is not uncommon for a disseminated Aspergillus infection to be discovered only at autopsy. Fortunately, a number of new assays offer solutions to these problems. Fungitell,...Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.
... Together, these advances will make tailored drug therapy a reality, and patients will benefit from more consistent phamacodynamics with fewer side effects....Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
...develop early detection methods and more effective therapy have made important progress. This is particularl.... Herceptin has thus earned a place as first-line therapy for qualified patients. FDA-approved kits use one of three methods to quantify Her-2/neu overexpress...Near-Patient Testing: The Advantages of C-Reactive Protein in Hematological Testing
... antibiotic treatment, or withdrawal of antibiotic therapy if required. Conversely an observed drop in CRP levels and a rise in white blood cells (WBC) can allow an earlier patient discharge. The combination of CRP and CBC analyses can therefore improve the follow-up of aplasia patients who may have other h...Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
... of the head and neck for whomprior platinum-based therapy has failed. ERBITUX is indicated for the treatmen...rcinoma of the head andneck treated with radiation therapy and ERBITUX as compared to noneof 212 patients treated with radiation therapy alone. Fatal eventsocc...Positive Aggrastat Results Featured in the Journal of the American College of Cardiology
...hrombolyticagents has not been established. During therapy with AGGRASTATR,patients should be monitored for potential bleeding. When bleedingcannot be controlled with pressure, infusion of AGGRASTATR andheparin should be discontinued. About Medicure Inc. Medicure is a biopharmaceutical company focused on ......ining trough levels above 1 IU/dL withprophylactic therapy may decrease the number of bleeding episodes,parti...e with severe hemophiliausing standard prophylaxis therapy vary according to age groups.For both adolescents and adults, joint bleeds were more likely tooccur ......und, 105 patientswere treated once by photodynamic therapy with one of threedifferent ALA concentrations or placebo. Primary endpoint of theclinical trial was the percentage of the complete remission ofactinic lesions. Since strong pain often occurs during photodynamictherapy with competitor products, the ap...BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
...Inc. BioSante is developing a pipeline of hormone therapy products totreat both men and women. These hormone therapy products are gelformulations for transdermal administration that deliverbio-identical estradiol and ...... sixcycles. Patients are evaluated for response to therapy every twocycles and evaluated every two months fol...rscans (MUGA), is evaluated prior to initiation of therapy and thenat the completion of every two cycles of therapy. Thus far, routineprophylactic administrati...Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
...pite these changesreturning to baseline during off therapy periods they precludeexploration of higher doses of OE. "Unfortunately, the study results were disappointing butdefinitive," said Douglas Abel, president and chief executiveofficer of Manhattan Pharmaceuticals. "With all our developmentprograms, M......integrating device design, biopharma, gene andcell therapy and biotech to enhance patient safety and improveclinical outcomes. Cook won the prestigious Medical DeviceManufacturer of the Year for 2006 from Medical Device andDiagnostic Industry magazine. For more information, visitwww.cookmedical.com. "Safe H......cancer-specific expression that it can be used for therapy andperhaps for imaging," notes senior author Mien-.... "This looks like a promising approach to gene therapy forpancreatic cancer and we are working to bring it to a clinicaltrial," says James Abbruzzese, M.D.......atments of steroids and immunosuppressants. The AP therapy wasadministered through a duodenal drip at a dose ...-related withdrawals werereported. AP is a unique therapy for ulcerative colitis based on thedephosphorylation and detoxification of a group of bacterialendot...Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
...who havefailed treatment with androgen deprivation therapy and failedtreatment with first line docetaxel-base...signal of clinicalactivity in second line hormonal therapy patients, but it also forthe first time demonstrates that CB7630 is capable of impactingtime to prog...MediGene Announces Cancer-Fighting Virus Shows Promise in Early Clinical Trial
...o patients whohad failed first-line therapy. Viral therapy was followed by twocycles of second-line chemotherapy using FDA-approved agents fortreatment of colorectal cancer. Results: Dose escalation to 1x10e8pfu NV1020 was performed without dose-limiting toxicities, andmaximum tolerated dose was not reached.......ents with stage IIIb or IV NSCLC tocisplatin-based therapy by determining levels of the biomarkerERCC-1 mRNA ...were separated by levels of ERCC-1.Cisplatin-based therapy (docetaxel/cisplatin) was assigned topatients with low levels of ERCC-1, while non cisplatin-basedth...... has been one of the cornerstones ofantiretroviral therapy for more than a decade. However, NNRTIresistance l...an 5,000 copies/mL, were on a stableantiretroviral therapy regimen, and had evidence of at least oneNNRTI-resistance-associated mutation, either at screening o......t-experienced adult patients. The use ofPREZISTA/r therapy in this broader range of treatment-experiencedpatients has not been approved by the FDA. These results will besubmitted to the FDA as part of the post-marketing commitment tosupport the traditional approval of PREZISTA. PREZISTA, co-administered wit...... articlehighlights a very promising new biological therapy for advancedcoronary artery disease (CAD) patients, FGF-1, from CardioVascularBioTherapeutics Inc. (CVBT). BusinessWeek cites The Bruckner Group's (BGI) study presentingthe preliminary value proposition for FGF-1 use in advancedcoronary artery diseas......f breast cancer in women takinghormone replacement therapy that included a progestin. In the past, anti-progestins such as Proellex have beenpostulated to be of potential benefit in the treatment of breastcancer. Unfortunately, most of the drugs in the class havesignificant anti-glucocorticoid activity wh...Rosetta Genomics and Weizmann Institute Scientists Identify Role of microRNA in Cancer Suppression
... (miR-34a) to be used as a drug candidatein cancer therapy to increase programmed cell-death (apoptosis) inthe context of the potent tumor suppressor p53. p53 has been widely accepted as a powerful tumor inhibitor thatcan prevent or slow the spread of cancer cells by facilitatingapoptosis. In this study, ac...Genzyme Announces Results of Clinical Trial of Hylastan
...lify OA painmanagement, reduce the overall cost of therapy and advance atreatment option that may expand the benefits ofviscosupplementation to a broader number of patients. Genzyme's development program also includes Synvisc-One(TM), aninvestigational combined-dose regimen of Synvisc(R) (hylan G-F 20)provi...Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
...estroy tumors like tiny homing missiles. This gene therapy approach is a novel way to attack smalltumor metastases that evade current detection techniques andtreatments, the researchers conclude in the July 1 issue of CancerResearch, a journal of the American Association for CancerResearch. “These fa...Ablynx Announces Interim Results of First Nanobody Phase I Study of ALX-0081 (ANTI-VWF)
...potential to set a new standard in anti-thrombotic therapy based onits immediate onset of action, its high potency and significantlyimproved safety compared to the currently marketed therapies in theform of significantly reduced bleeding complications. Ablynx hasdemonstrated a large therapeutic window for AL...Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections
...mpound knownas CSA-13 shows promise as a potential therapy to treat multidrugresistant Pseudomonas aeuroginos...ts of their ability to breathe. "The conventional therapy used to treat Pseudomonas infectionsin cystic fibrosis patients is Tobramycin but there are anincrea......Phase III clinical trial evaluating aVELCADE based therapy in newly diagnosed multiple myeloma (MM)patients. As induction therapy prior to stem cell transplantation(SCT), the VELCADE based therapy produced a high complete remissio...Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme
...neurotransmitterdopamine in the brain. Replacement therapy using L-DOPA, theprecursor of dopamine, is the main treatment for Parkinson'sdisease. However, L-DOPA is quickly metabolised in the gut andliver allowing only a small proportion (approximately one per cent)to reach the brain. Therefore, L-DOPA is for...RTA 402 Shown to Protect Animals Against Toxicities of Standard Cancer Treatments
...hen RTA 402 is given in combination with radiation therapy to ratsbearing human lung cancer tumors, the drug ...e. RTA 402 is anovel, orally administered targeted therapy that inhibits thetranscriptional activity of NF-kB and STAT3. Correlative studiespresented at MASSC ......py, chemotherapy, endocrinetherapy, and especially therapy with some of the newerbiologicals. The effects of perifosine on Akt are of particular interestbecause of 1) the importance of this pathway in the development ofmost cancers; 2) the evidence that it is often activated in tumorsthat are resistant to o......e cause oftheir wheezing. Synagis is a biologic therapy known as a monoclonal antibodyadministered monthly...sure. If a severehypersensitivity reaction occurs, therapy with Synagis should bepermanently discontinued. If milder hypersensitivity reactionoccurs, caution s......after firstrelapse. Risks associated with VELCADE therapy include new or worseningperipheral neuropathy, hypotension observed throughout therapy,cardiac and pulmonary disorders, gastrointestinal adverse events,thrombocytopenia, neutropenia and tumor lysis syndrome. Women ofchildbearing potential should avoi......or patients, and assuch, VELCADE will be a leading therapy in this diseasesetting." Frontline VMP in Elderly...dy evaluated efficacy and safety of VMPcombination therapy in untreated MM patients aged 65 years or olderwith a median age of 75 years. The study included 54 ...CombinatoRx Product Candidate CRx-150 Shows Activity on DAS28 and Pain, but Not CRP
...evaluating the effectiveness of CRx-150 plus DMARD therapy comparedto placebo plus DMARD in a 2:1 ratio in su...enrolled in this study. Patients had to be onDMARD therapy (such as methotrexate or sulfasalazine) for at least3 months and be on a stable dose of DMARD therap......herefore provide a significant advance in clinical therapy ofmyeloma. About Cytogen Cytogen is a specialty ...M) (tamoxifen citrate) is the first liquidhormonal therapy approved in the U.S. for the treatment of breastcancer in adjuvant and metastatic settings. The Comp...Speedel Reports Successful SPP635 Phase IIa Trial in Hypertension
...ininhibitors are currently being investigated as a therapy that mayprovide benefits over current therapies to reduce blood pressure,decrease salt retention and may protect end organs such as thekidney, heart and brain. About Speedel Speedel is a public biopharmaceutical company that seeks to createvalue fo......ncouraging and show the potential of aregenerative therapy in diabetes," said Sherwyn Schwartz, MD, anoted di...l for manymonths post-treatment following a 4-week therapy is unprecedentedin type 2 diabetes. The improvements in HbA1c correlated withchanges in multiple oth...Opexa Advances Monocyte Derived Islet Technology to Proof of Principle in stz-induced NOD/SCID Mice
... monocyte-derived islets, as beta-cell replacement therapy fordiabetes mellitus. The first presentation was m...or advance in the development of a cellreplacement therapy for the treatment of diabetes." "These presentations by Dr. Winnier demonstrate significantadvancem......nt response in patients after 24 weeksof induction therapy with 185 patients in the MMF arm and 185 inthe IVC... least 50 mIU/mLwithin one week prior to beginning therapy even where there hasbeen a history of infertility, unless due to hysterectomy. Women ofchildbearing ......ursor to osteoporosis. The lack of safe, efficient therapy forosteopenia beyond lifestyle changes with calcium and vitamin Dleaves many patients and physicians with a lack of options. Fosteum, the first prescription product developed to safely meetthe nutritional requirements of patients with osteopenia and......e marrow of patientsundergoing intensive radiation therapy for blood cancers." "This recent announcement by R...opment, tissue engineering, cell culturing, genome therapy anddrug delivery systems to become a leading source for stem cellresearch technology and innovation.......f Xcytrin in combination withwhole brain radiation therapy for treatment of brain metastasesfrom NSCLC was filed with the U.S. Food and Drug Administration inApril 2007. About Non-Small Cell Lung Cancer The American Cancer Society estimates that there will be morethan 213,000 new cases of lung cancer in th......Scientific Sessions showed that initialcombination therapy with Januvia(TM) (sitagliptin) and metformindemons...use of JANUVIA and metformin as initialcombination therapy led to improvement in markers of beta cellfunction in patients with type 2 diabetes (0533-P; Study #......e,which may result in premature discontinuation of therapy and limitthe physician's ability to use this activ...ts who might benefit fromlonger-term anthracycline therapy than can be administered withcurrently approved agents. Details of the Preclinical Studies The stu...... treated with Levemir® once-daily, as anadd-on therapy to any other glucose-lowering regimens, or asrepla...her adverse events commonlyassociated with insulin therapy may include injection sitereactions (on average 3-4 percent of patients in clinical trials)such as l......tudied and the most prescribedcholesterol-lowering therapy in the world, with nearly 139 millionpatient-years of experience. Lipitor is supported by an extensiveclinical trial program involving more than 400 ongoing andcompleted trials with more than 80,000 patients. Important Safety Information Lipitor is......broken down in the body and thus notpractical as a therapy for type 2 diabetes. GLP-1 is released fromthe gas...reas such as haemostasismanagement, growth hormone therapy and hormone replacement therapy.Novo Nordisk manufactures and markets pharmaceutical products andser......e be calculatedin all patients prior to initiating therapy with Viread and asclinically appropriate during therapy. Coadministration of Vireadand didanosine should be undertaken with caution. Patients shouldbe monitored closely for didanosine-associated adverse events, anddidanosine should be discontinued if......y T-cells for the treatment ofHIV/AIDS and a novel therapy for the treatment of glioblastoma --were reviewed and unanimously approved by the National Institutesof Health Recombinant DNA Advisory Committee (RAC) earlier thisweek. Sangamo filed applications for both programs with the RACearlier this year, and ......izziness, and fatigue. Participants on a combined therapy of metformin and sulfonylureawith a baseline HbA1c greater than or equal to 7.5, indicatingsuboptimal glycemic control (mean baseline HbA1c of 8.3), weresubjected to a pre-specified secondary analysis focused onCycloset(TM)'s ability to reduce HbA1c ......ime. BYETTA is indicated for use as an adjunctive therapy for peoplewith type 2 diabetes who are not achievi...llingtheir blood sugar levels. BYETTA is an add-on therapy for peoplecurrently using metformin, a sulfonylurea, or a thiazolidinedione.BYETTA provides sustaine......uring treatment with JANUMET. Initial combination therapy with JANUVIA and metforminsignificantly improved b...cent with metformin 1000mg twice daily). "Initial therapy with one agent is often unsuccessful at gettingpatients to blood sugar goals. Many patients may requ...... FHCRC. Shelly Heimfeld, director of the cellular therapy laboratory atthe Fred Hutchinson Cancer Research Center, commented: "We wereimpressed by how much better the CryoStor patented mediaformulations improved the post-preservation recovery of CD34+ andcolony-forming cells. We will continue our evaluation...Positive Clinical Results for DG041 Lead Product Development Highlights at deCODE R&D Event
...s potential as a next-generationoral anti-platelet therapy -- an effective means of preventingarterial thromb...g a potentially major new approach toanti-platelet therapy - one that acts specifically to preventarterial thrombi, targets a pathway not addressed by existing......could provide a safe, effective and well-tolerated therapy whenused alone or in combination with other anti-diabetic therapies,"said Alan J. Garber, MD, Ph.D, Professor of Medicine, Biochemistryand Molecular Biology, and Molecular and Cellular Biology at theBaylor College of Medicine in Houston, Texas. "The ......her adverse events commonly associated withinsulin therapy may include injection site reactions (on average3-...reas such as haemostasismanagement, growth hormone therapy and hormone replacement therapy.Novo Nordisk manufactures and markets pharmaceutical products andser......e be calculatedin all patients prior to initiating therapy with Viread and asclinically appropriate during therapy. Coadministration of Vireadand didanosine should be undertaken with caution. Patients shouldbe monitored closely for didanosine-associated adverse events, anddidanosine should be discontinued if......linide calciumhydrate) monotherapy, or combination therapy with metformin, tomanage glucose surges before and after meals. The data werepublished in the Abstract Book for the American DiabetesAssociation 67th Annual Scientific Sessions in Chicago, Illinois.Glufast is an insulin secretagogue that lowers postp...