Suppressor in Medical Technology

Late-Breaking Data Highlighting Research Advances in Several Blood Disorders to Be Presented At the American Society of Hematology Annual Meeting

... of anemia, and the discovery of a new tumor suppressor gene in patients with myeloproliferative ... concerns. TET2 is a Novel Tumor suppressor Gene Inact i vated in Myeloproliferative ... time. This research unveiled a new tumor suppressor gene called TET2 (Ten-Eleven Translocation-2), ...

Data Show SuperGen's MP-470 is Safe in Humans

... in humans (Abstract No. 4083). Entitled, "MP-470, a potent oral Rad51 suppressor is safe and tolerable in first-in-human study," the poster highlights data ... for repair of DNA double strand breaks. "This is the first Rad51 suppressor that has advanced into Phase 1 clinical trials," said Dr. Gregory Berk, ...

Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrine's anti-PS Vascular Targeting Antibodies

... of a Bavituximab Equivalent and an Agent that Re-Activates the Tumor suppressor P53 Inhibited Tumor Growth Synergistically in Preclinical ... PRIMA-1. PRIMA-1 restores the normal function of mutant forms of the tumor suppressor p53, enabling it to induce tumor cell death. The combination therapy ...

Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

... Vidaza reverses the effects of DNA hypermethylation with subsequent tumor suppressor gene re-expression. MGCD0103 exerts its epigenetic effects by acting as an ... HDAC inhibitor. Together, the two act synergistically to induce suppressor gene re-expression and favorably influence the clinical course of cancer. ...

Gene Marker May Improve Odds of Stem Cell Therapies for Disease

... in several genes involved in stem cell self-renewal and DNA repair, including Rb1 and p107 gene expression. However, pRB2/p130, a tumor suppressor gene first identified by Antonio Giordano, Director of the Sbarro Institute for Cancer Research and Molecular Medicine at the College of Science and ...

Data Suggest CEL-SCI's CEL-2000 Vaccine Prevents or Retards Permanent Damage of Rheumatoid Arthritis

... of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). Therefore, it would appear that the L.E.A.P.S.(TM) construct represents a chimeric peptide with bi-functional behavior. About CEL-SCI: ...

Exelixis Reports Positive Clinical Pharmacodynamics Data for PI3K/mTOR Inhibitor XL765 at ASCO

... machinery and hence, cell growth. PI3K is activated in human cancers by elevated receptor tyrosine kinase activity, by deletion of the tumor suppressor PTEN, or by mutation of its catalytic domain. mTOR is activated by growth factors via PI3K and AKT, but is also activated in a PI3K-independent ...

Presentation of Data on Progen's Cancer Epigenetic Targets Platform

... to specifically demethylate histone proteins (demethylates Lysine 4 of histone H3) and plays an important role in the regulation of specific cancer suppressor genes. LSD-1 inhibitors prevent the action of LSD-1, causing increased levels of histone methylation, resulting in the reactivation of the cancer ...

SuperGen to Highlight Oncology Pipeline Data in Multiple Presentations at the AACR Annual Meeting

... and stability Tuesday, 8 a.m. - noon #4083 -- MP-470, a potent oral Rad51 April 15 suppressor is safe and tolerable in first-in-human study Tuesday, 2:25 p.m. - #4974 -- A potent small molecule PIM ...

Pharmion Submits European Marketing Authorization Application (MAA) for Vidaza(R) in Patients with Higher-Risk Myelodysplastic Syndromes (MDS)

... expression and, unlike DNA mutations, may be reversed by targeting the mechanisms involved. The silencing of key cell cycle control genes and tumor suppressor genes through these two mechanisms of epigenetic regulation has been demonstrated in vitro and in vivo in hematological malignancies and in solid ...

MDS Patients on Five-Day Vidaza(R) Dosing Schedules Achieve Transfusion Independence Consistent with Seven-day Schedule

... gene expression and, unlike DNA mutations, may be reversed by targeting the enzymes involved. The silencing of key cell cycle control genes and tumor suppressor genes through these two mechanisms of epigenetic regulation has been demonstrated in vitro and in vivo in hematological malignancies and in solid ...

Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS)

... expression and, unlike DNA mutations, may be reversed by targeting the mechanisms involved. The silencing of key cell cycle control genes and tumor suppressor genes through these two mechanisms of epigenetic regulation has been demonstrated in vitro and in vivo in hematological malignancies and in solid ...

SuperGen to Highlight Oncology Pipeline Data in Multiple Presentations at AACR

... a potent 15 suppressor of Rad51, Poster ... #4028 April suppressor of Rad51, 17 ... silenced tumor suppressor genes Wed., 8 a.m. - 12 p.m. Dual ...

Introgen's Advexin Demonstrates Clinical Benefit in Inherited Cancer

... by inherited mutations in the p53 tumor suppressor gene. This is the first reported treatment of ... after therapy identified restoration of p53 tumor suppressor function including suppression of tumor growth ... of action is targeted to restoring p53 tumor suppressor function that is abnormal in Li-Fraumeni tumors ...

Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference

... Association for Cancer Research. Abnormality of the p53 tumor suppressor is one of the most common and fundamental molecular defects in cancer. ... of the most fundamental and common molecular defects, abnormal p53 tumor suppressor function, associated with cancer initiation, progression and treatment ...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

... potent small molecule inhibitors." Abstract No. 4028 MP470, a potent suppressor of Rad51, improves response to platinum-based anticancer agents Rad51 is ... window. Abstract No. 1540 Hydrochloride salt of MP470, a potent suppressor of Rad51, improves bioavailability and tolerability Results from this ...

Rosetta Genomics and Weizmann Institute Scientists Identify Role of microRNA in Cancer Suppression

... (apoptosis) in the context of the potent tumor suppressor p53. p53 has been widely accepted as a powerful ... tumor suppression mechanism." About p53 Tumor suppressor The p53 protein, also known as tumor protein 53 ... factor that functions as a major tumor suppressor in mammals. p53 has been described as "the ...

Study in Cell by Magen BioSciences Co-Founder David E. Fisher Identifies New Roles in Skin Cancer Prevention for Key Tumor Suppressor Protein

... two new functions for an important protein, p53, in the pigmentation of skin. Fisher's study shows that in addition to its function as a tumor suppressor in other cancers in the body, p53 also plays a key role in prompting the skin to tan in response to ultraviolet light from the sun. By promoting ...

Santaris Pharma presents positive preclinical data on SPC2996 at the American Association for Cancer Research

... in the circulation by fresh cells produced in the bone marrow. This process of programmed cell death is known as apoptosis. Bcl-2 is an apoptosis suppressor protein, i.e. it extends the lifespan of the cell in the presence of normal apoptosis stimuli. The levels of Bcl-2 within the cell are frequently ...

Pro-Pharmaceuticals to Present Abstract at the International Society of Oncodevelopmental Biology and Medicine Conference

... of cancer therapy. The scientific program will present new discoveries in the research of tumor cell biology (carcinogenesis, oncogenes and tumor suppressor genes, metastasis formation/invasion, angiogenesis) as well as clinical applications of tumor markers - established and new ones - for tumor ...

Cytogen Reports Publication Validating the Utility of its Proprietary ProChart Database

... validating the utility of its ProChart(TM) database to help define the function of the WW domain-containing oxidoreductase (WWOX), an important tumor suppressor gene with known involvement in breast, prostate, lung, pancreatic, esophageal, and gastric cancers. The peer-reviewed article was published in the ...

Introgen and Clinical Collaborators to Report New Results with Advanced-Stage Cancer Therapies at Upcoming Medical Meetings

... Center by Elena V. Shashkova, VirRx, Inc. -- Clinical Experience with the mda-7/IL-24 Tumor Suppressor, Abstract # 380: Presentation during "Tumor suppressor and Targeted Gene Therapy" poster session and oral presentation on Friday, June 1, 2007 at 8:45 a.m. at the Washington State Convention Center ...

Pharmion to Present Clinical Data on Commercial and Pipeline Products at 2007 American Society of Clinical Oncology (ASCO) Meeting

... advanced Hodgkin's lymphoma. Furthermore, as we begin to understand the way in which multiple epigenetic mechanisms co-operate to silence key tumor suppressor genes in cancer, we are able to choose epigenetic drugs from within our portfolio to combine and attack these silencing systems simultaneously, ...

Introgen Reports Updated Phase 2 Advexin Data Correlating Improved Survival, Tumor Responses and Predictive p53 Biomarker

... in a wide range of tumor types and clinical settings because it targets one of the most fundamental and common molecular defects, abnormal p53 tumor suppressor function, associated with cancer initiation, progression and treatment resistance. ADVEXIN has demonstrated increased survival and tumor growth ...

Clinical Data Reported on Vidaza in Hematologic Malignancies and Advanced Solid Tumors

... gene expression and, unlike DNA mutations, may be reversed by targeting the enzymes involved. The silencing of key cell cycle control genes and tumor suppressor genes through these two mechanisms of epigenetic regulation have been demonstrated in vitro and in vivo in hematological malignancies and in ...

Santaris Pharma Presents Positive Clinical Data on SPC2996 in Chronic Lymphocytic Leukaemia

... in the circulation by fresh cells produced in the bone marrow. This process of programmed cell death is known as apoptosis. Bcl-2 is an apoptosis suppressor protein, i.e. it extends the lifespan of the cell in the presence of normal apoptosis stimuli. The levels of Bcl-2 within the cell are frequently ...

Lexicon Pharmaceuticals and Fox Chase Publish Findings on Immune Deficiency

... at Lexicon Pharmaceuticals discovered that deletion of the ubiquitously expressed Rpl22 gene resulted in the up-regulation of p53, a key tumor suppressor gene that triggers apoptosis and cell death. Further, it was determined that this up-regulation of p53 was responsible for blocking alpha-beta+ ...