substrate

West Nile Virus Screening and Diagnostics Technology Emerges In Step with North American Outbreak

...ated with horseradish peroxidase (HRP), and enzyme substrate plus chromogen. Absorbance is measured at 450 nm.... of HRP-conjugated goat anti-human IgG, and enzyme substrate plus chromogen. Absorbance is measured at 450 nm. There are 3 wash steps and the total incubation ...

The Past, Present and Future of HLA Typing

...s such as horseradish peroxidase. The appropriate substrate can be added to produce a fluorometric (or colorimetric) readout without the problems associated with radioactivity. Variations of the technique have also risen; for example, it is possible to construct PCR primers pre labeled with biotin, and then...

New Point-of-Care Methods to Measure Coronary and Cerebrovascular Risk

...o skin cholesterol. The second contains an enzyme substrate that allows readout with a spectrophotometer. The test can be performed in minutes. PREVU(x) is marketed by McNeil Consumer Healthcare and approved for use in North America and Europe. The manufacturer has also announced plans for a quantitative ...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

...nvolves active tubular secretion. Sitagliptin is a substrate forhuman organic anion transporter-3 (hOAT-3), whi...ort has not been established. Sitagliptin is alsoa substrate of p-glycoprotein, which may also be involved in mediatingthe renal elimination of sitagliptin. Howe...

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

...nvolves active tubular secretion. Sitagliptin is a substrate forhuman organic anion transporter-3 (hOAT-3), whi...ort has not been established. Sitagliptin is alsoa substrate of p-glycoprotein, which may also be involved in mediatingthe renal elimination of sitagliptin. Howe...

Positive Statistical Analysis from Synthetic Blood's Oxycyte Traumatic Brain Injury Trial Indicates Achievement of Primary Endpoint

... in the field ofoxygen therapeutics and continuous substrate monitoring. TheCompany has under development a blood substitute, a liquidventilation product and an implantable glucose sensor. Theseproducts are based upon core technologies that include biomedicalapplications for perfluorocarbons, and medical and i...

terna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles

...inthis promising therapeutic approach. Cellular substrate phosphorylationstudies targeting the inhibition of PI3K and functional cellularassays of tumor cell proliferation have been performed. Inaddition, physicochemical and initial ADMET data were collected.Several derivatives are currently undergoing firs...

AEterna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles

... inthis promising therapeutic approach." Cellular substrate phosphorylation studies targeting theinhibition of PI3K and functional cellular assays of tumor cellproliferation have been performed. In addition, physicochemical andinitial ADMET data were collected. Several derivatives arecurrently undergoing firs...

Amicus Therapeutics Presents Data From Preclinical and Phase 1 Studies of Amigal for Fabry Disease

...duction of globotriaosylceramide (GL-3), the lipid substrate thataccumulates in Fabry disease, after oral administration of apharmacological chaperone. These data were not available at thetime of abstract submission but will be included in thepresentation at the meeting. Amigal is designed to selectively bind...