substitution

Neurogen Proprietary Insomnia Compound Data for Two Studies Presented at Associated Professional Sleep Societies Annual Meeting

...phy (amethod of quantifying balance), digit symbol substitution test(DSST), electroencephalogram beta frequency band (EBFB), andpsychomotor vigilance testing (PVT). In the primary analysis, NG2-73 had a statistically significanteffect on sedation compared with placebo, and as measured by theObserver and the Subj...

IMPAX Presents at Movement Disorder Society's 11th International Congress of Parkinson's Disease and Movement Disorders

...s to assess motor fluctuations. Inthis population, substitution with IPX054 maintains CD/LD efficacyand provides ease of administration which may offer improvedtreatment compliance. About The Movement Disorder Society The Movement Disorder Society (MDS) gathers thousands of thefield's clinicians, researchers, t...

Caelyx Delays Time to Disease Progression as Maintenance Therapy in Patients with Metastatic Breast Cancer

...patientswith impaired hepatic function. Accidental substitution of DOXILfor doxorubicin HCl has resulted in severe side effects. DO NOT SUBSTITUTE. Use of DOXILshould be limited to physicians experienced in the use of cancerchemotherapeutic agents. The most common side effectsreported with DOXIL therapy included...

NovaDel Announces Positive Data from Two Studies Comparing Zolpidem Oral Spray to Ambien Tablets

...dem oral spray studies performed thedigital symbol substitution test (DSST). According to Dr. Tom Roth,Director of Sleep Medicine at Henry Ford Hospital in Detroit, "DSSTmeasurements are a scientifically, well accepted surrogate forsedation and a significant reduction in DSST score may indicateearlier onset of th...

Evotec AG (DE) - Evotec Reports Positive Proof-of-Concept Top-Line Results with ...

...ly a small decremental effect on the digitalsymbol substitution test (DSST) assessed at nine hours post dosing.Initial analysis showed that EVT 201 did not impair slow wave sleepunlike many benzodiazepine full agonists. The study thereforedemonstrated EVT 201 has robust effects on both sleep onset andsleep mainte...

Evotec Reports Positive Proof-of-Concept Top-Line Results with Insomnia Drug Candidate EVT 201

...ly a small decremental effect on the digitalsymbol substitution test (DSST) assessed at nine hours post dosing.Initial analysis showed that EVT 201 did not impair slow wave sleepunlike many benzodiazepine full agonists. The study thereforedemonstrated EVT 201 has robust effects on both sleep onset andsleep mainte...

Auxilium Announces New Data That Show Total Testosterone Blood Levels Increase Significantly Following Switch from AndroGel(R) to Testim(R)

...patients who couldbe evaluated for the efficacy of substitution to the alternatebrand of therapy due to an initial...d in 76 percent of men who underwent a brand substitution following an initial inadequate response. About Hypogonadism Low testosterone ("Low T"), or hypogo...

InterMune Presents Research on ITMN-191 in Hepatitis C at EASL Annual Meeting

...trations of ITMN-191. Aswas seen in previous work, substitution at position 168 of NS3appears to be fundamental to resistance but alone is not sufficientfor HCV replicon persistence at all ITMN-191 concentrationsachieved in the liver of animal species following oral dosing. Thissuggests that the genetic barrier t...