stiffness in Medical Technology

Prospective Clinical Advantages of Trabecular Metal(TM) Technology Highlighted in Comparative Study

... the Indiana Research Foundation describes the low stiffness and osteoconductive properties of Zimmer's ... confirmed initial assumptions that the low stiffness properties of this porous metal --similar to ... directly compare bone-remodeling effects of a low stiffness porous metal construct to more rigid traditional ...

Study Shows Pine Bark Naturally Reduces Knee Osteoarthritis

... rate the pain level, and obtain measures of joint stiffness and to what extent the arthritis affects ... The overall score, summarizing pain, stiffness and daily activities, improved statistical ... explains the success in lowering joint pain and stiffness for arthritic joints," said Rohdewald. "After ...

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... three million people in Europe. Signs and symptoms of RA include pain, stiffness and motion restriction in multiple joints. Because RA is a progressive ... of skin psoriasis and psoriasis nail involvement. Symptoms may include stiffness and tenderness of the joints and surrounding tissue and reduced range of ...

Two-Year Data Show Patients Receiving SIMPONI(TM) (golimumab) Experienced Sustained Improvement in Signs and Symptoms of Psoriatic Arthritis and Ankylosing Spondylitis

... 20 percent improvement from baseline in both total back pain and morning stiffness measures were switched to either SIMPONI 50 mg (previously receiving ... of skin psoriasis and psoriasis nail involvement. Symptoms may include stiffness and tenderness of the joints and surrounding tissue and reduced range of ...

Siemens Introduces New Standard of Care for Breast Ultrasound

... information by interrogating the mechanical strain properties or stiffness of tissue, which may be correlated with pathology. "Virtual ... first and only application to provide a numerical value related to tissue stiffness at a precise anatomical location. The application is highly promising in ...

New Analysis Shows Efficacy of SIMPONI(TM) (golimumab) in Anti-TNF Experienced Rheumatoid Arthritis Patients

... affects approximately 1.3 million people in the United States and more than three million people in Europe. Signs and symptoms of RA include pain, stiffness and motion restriction in multiple joints. Because RA is a progressive disease, it can cause permanent joint deformity and severe disability if not ...

Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

... characterized by inflammation of the membrane lining in the joints. This inflammation causes a loss of joint shape and function, resulting in pain, stiffness and swelling, ultimately leading to irreversible joint destruction and disability. Characteristics of RA include redness, swelling, pain and movement ...

Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients

... characterized by inflammation of the membrane lining in the joints. This inflammation causes a loss of joint shape and function, resulting in pain, stiffness and swelling, ultimately leading to irreversible joint destruction and disability. Characteristics of RA include redness, swelling, pain and movement ...

When to Have That Joint Replacement?

... replaced with an artificial one, made of a combination of plastic, metal, and/or ceramic. The most common reasons for this surgery are pain and stiffness that limit normal activities such as walking and bending and that cannot be satisfactorily treated with medications or other therapies. Therefore, ...

American Academy Of Orthopaedic Surgeons 2009 Annual Meeting 'Highlights and Hot Topics'

... "Remarkable" Drug Shows Success in Hard-To-Treat Patients Patients who undergo hip replacement surgery often complain of stiffness and occasionally suffer severe muscle spasms, limiting surgical recovery and lowering post-surgical quality-of-life. Physical therapy alone does not ...

Cymbalta(R) Significantly Reduced Osteoarthritis Knee Pain in New Study

... of this disorder, impacting the lives of approximately 10 million Americans.(2) In addition to pain, other symptoms of osteoarthritis include aching, stiffness and limited range of motion of the joint.(3) Duloxetine is being studied to manage the pain associated with this disorder. Methods In ...

Synvista Therapeutics Announces Published Data Demonstrating Elevation of Carboxymethyl-Lysine (CML) Is Associated with Decline in Renal Function and Arterial Stiffness in Older Adults

... advanced glycation end product (A.G.E.) called carboxymethyl-lysine (CML) in older adults is associated with a decline in renal function and arterial stiffness in older adults. Kits developed through a license to Synvista's technology were used in these studies. Synvista is validating this clinical ...

Roche and FDA Agree on Pathway Towards U.S. Approval of ACTEMRA(R) (tocilizumab)

... characterized by inflammation of the membrane lining in the joints. This inflammation causes a loss of joint shape and function, resulting in pain, stiffness and swelling, ultimately leading to irreversible joint destruction and disability. Characteristics of RA include redness, swelling, pain and ...

Schering-Plough Reports Preladenant Meets Primary Endpoint in Phase II Dose-Finding Trial for Parkinson's Disease

... to be caused by a loss of nerve cells in the midbrain. The resulting symptoms include tremor, abnormal gait and posture, loss of balance, muscle stiffness and slowness of movements. These symptoms often severely compromise a patient's ability to lead a normal life. All currently available treatment ...

APTA Supports Surgeon General's 'Call to Action' to Prevent Deep Vein Thrombosis and Pulmonary Embolism

... captain has turned off the "Fasten Seat Belt" sign. "Performing these exercises will keep the leg muscles from contracting and will help relieve stiffness during the flight. The exercises also will help prevent fluid build-up in the legs, and stretching the back and the muscles around the torso will ...

Pediatric Researchers Find Possible 'Master Switch' Gene in Juvenile Arthritis

... have JIA, of which about 1,500 children are seen at Children's Hospital. JIA is the inflammation of the lining tissues of a joint and often causes stiffness and pain. While there is no cure for JIA, medicines and physical therapy can help maintain movement and reduce swelling and pain. Researchers have ...

Patients Taking Cymbalta(R) Reported Reduced Pain Severity of Osteoarthritis of the Knee in New Study

... of this disorder, impacting the lives of approximately 10 million Americans.(2) Other symptoms of osteoarthritis in addition to pain include aching, stiffness and limited range of motion of the joint.(3) Additional Study Highlights: - Compared with patients receiving placebo, patients receiving ...

New Global Survey Exposes Considerable Burden of Fibromyalgia Including Potential Economic Impact

... common, chronic widespread pain conditions and affects between 16 and 40 million people worldwide. Fibromyalgia is usually accompanied by poor sleep, stiffness and fatigue along with other co-morbidities. Fibromyalgia is more prevalent in women, who account for 87 percent of diagnosed cases; however, men can ...

Alpharma Presents Data Addressing Abuse Liability Features, Safety and Efficacy on ALO-01 (EMBEDA(TM)) (morphine sulfate extended-release with sequestered naltrexone hydrochloride) at the American Pain Society Annual Scientific Session

... Pain Inventory (BPI); and pre- and post-treatment scores using the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index of pain, stiffness and function. Plasma levels were evaluated for morphine sulfate and naltrexone pre-dose and at specified intervals up to 12 hours post-dose on days ...

U.S. Food and Drug Administration Approves ORENCIA(R) (abatacept) for the Treatment of Moderate-to-Severe Polyarticular Juvenile Idiopathic Arthritis (JIA) in Patients Six Years and Older

... disease in children, and it is an important cause of short-term and long-term disability(3). It is an autoimmune disease that causes chronic pain, stiffness and swelling of the joints(4), which may ultimately lead to joint damage and deformities(5). The disease usually begins before the age of 16(6). ...

Rigel Announces Initiation of Phase 1 Clinical Trial of R348 for Rheumatoid Arthritis, Psoriasis and Other Immune Disorders

... worldwide, and is a lifelong skin disease. About 10-30% of patients with psoriasis also develop psoriatic arthritis, which causes pain, swelling and stiffness of the joints. These diseases are mediated by activated T-cells, which rely on JAK3 signaling. Current treatments for these diseases include ...

Synvista Therapeutics Announces Initiation of Phase 2 Study With Alagebrium for Chronic Heart Failure

... are proteins formed by oxidative or non-oxidative reactions. AGEs cause the formation of collagen cross-links, which result in increased myocardial stiffness whereby the stiff ventricle fails to relax adequately between beats and allow blood to fill the chamber. As a result, blood volume backs up into the ...

Milnacipran Demonstrated Significant Improvement in Pain and the Core Symptoms of Fibromyalgia Syndrome, Data Show

... outside of the U.S. by Pierre Fabre Medicament. About Fibromyalgia FMS is a chronic and debilitating condition characterized by widespread pain and stiffness throughout the body, accompanied by severe fatigue, insomnia and mood symptoms. According to the American College of Rheumatology, FMS is estimated ...

New Anti-TNF Golimumab Significantly Reduced Signs and Symptoms of Ankylosing Spondylitis According to Phase 3 Study Findings

... with 15 percent of patients receiving placebo (P < 0.001). The BASDAI measures important markers of disease activity, including pain, morning stiffness and joint swelling. "When treating this potentially progressive and debilitating disease, we attempt to reduce pain and other symptoms so that ...

Feeling Anxious or Distracted? New Research Shows a Cup of Tea Could Help

... artery and arterial stiffness. "Our studies have found that tea flavonoids improved endothelium-dependent vasorelaxation and decrease arterial stiffness in study participants, thereby suggesting that tea consumption may have favorable effects on cardiovascular disease." These new developments in ...

ORENCIA(R) (abatacept) Supplemental Biologics License Application for Juvenile Idiopathic Arthritis Accepted by FDA for Filing and Review

... Idiopathic Arthritis JIA -- also commonly known as juvenile rheumatoid arthritis (JRA) -- is a chronic, autoimmune disease, causing chronic pain, stiffness and swelling of the joints, which may ultimately lead to joint damage and deformities. The disease usually begins before the age of 16 and may affect ...

Lyrica Significantly Reduced Pain and Helped Patients Manage the Symptoms of Fibromyalgia, Data Show

... pain conditions and is thought to result from neurological changes in how patients perceive pain. Fibromyalgia is usually accompanied by poor sleep, stiffness and fatigue. The pain of fibromyalgia can hamper a patient's ability to work and often results in increased medical costs and disability. There are ...

Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Positive Results of Phase III Study for Milnacipran as a Treatment for Fibromyalgia Syndrome

... its licensor, Cypress Biosciences, Inc. About Fibromyalgia (FMS) FMS is a chronic and debilitating condition characterized by widespread pain and stiffness throughout the body, accompanied by severe fatigue, insomnia and mood symptoms. According to the of Rheumatology, FMS is estimated to affect over six ...

New Data Confirms Significant Improvement of Disease Signs and Symptoms in Patients with Rheumatoid Arthritis

... of multiple joints and fatigue as well as the possibility of osteoporosis, anaemia, and lung, skin and liver effects. This inflammation causes pain, stiffness and swelling, resulting in loss of joint function due to destruction of the bone and cartilage, often leading to progressive disability. Further, ...

Enbrel Safety Data for up to Eight Years in Patients with Juvenile Rheumatoid Arthritis Being Presented at EULAR

... in Barcelona, Spain. Approximately 50,000 children in the United States have JRA. Symptoms of JRA include fatigue, joint pain and stiffness following sleep or inactivity, fever and associated muscle weakness. There are differing presentations of the signs and symptoms of JRA and there is ...

Actemra (tocilizumab) Significantly Improves Symptoms of Rheumatoid Arthritis Compared to a Current Standard of Care

... characterized by inflammation of the membrane lining in joints. This inflammation causes a loss of joint shape and function, resulting in pain, stiffness and swelling, ultimately leading to irreversible joint destruction and disability. RA affects more than 21 million people worldwide with ...

Remicade Two Year Data in Ankylosing Spondylitis Show Improvement in Spinal Mobility and Spinal Inflammation

... States or every 6-8 weeks in the European Union. AS is a progressive rheumatic disease that leads to inflammation of the back, resulting in pain, stiffness and reduced mobility, which in advanced cases can result in fusion of the vertebrae of the spine ('ankylosis'). Data collected from 279 patients with ...

Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis

... characterized by inflammation of the membrane lining in the joints. This inflammation causes a loss of joint shape and function, resulting in pain, stiffness and swelling, ultimately leading to irreversible joint destruction and disability. Characteristics of RA include redness, swelling, pain, and ...