Species in Medical Technology

Is Obesity an Oral Bacterial Disease?

... difference of seven of the 40 bacterial species measured was greater than 2 percent in the saliva ... identified by the presence of a single bacterial species ( Selenomonas noxia ) at levels greater than 1.05 ... women. It seems likely that these bacterial species could serve as biological indicators of a ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... Robust and Sustained Glucosuria in Multiple species and is Safe and Well-Tolerated," Dr. Sanjay ... in glucose excretion in the urine in multiple species including monkeys Secondary improvements ... of metabolic targets in a variety of animal species that reduced mRNA target levels in specific ...

AdvanDx Submits Yeast Traffic Light PNA FISH(TM) for FDA 510(k) Clearance for Detection of Candida species in Positive Blood Cultures

... Light PNA FISH(TM) for detection of Candida yeast species from positive blood cultures. Yeast Traffic ... a bloodstream infection caused by Candida species is one of the most serious hospital acquired ... While identification of the infecting Candida species is used to guide effective antifungal therapy, ...

Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs

... Our group and others have successfully used eggs to clone closely-related species (for instance, we cloned two endangered species - the guar and banteng using cow eggs). Rabbit eggs have also been used ...

DEP to Complete Aerial Mosquito Treatments to Stem West Nile Virus in Southeastern Counties

... recommendation threshold or have a significant population of mosquito species that could become infected. Weather permitting, residents in the ... Urdaneta, the Pennsylvania state epidemiologist. Certain mosquito species carry the West Nile virus, which, when transmitted to people, can cause ...

Isis Highlights Robust Drug Portfolio for Diabetes and Obesity at ADA Conference

... Lowered SGLT2 mRNA levels in the kidney by approximately 80% in all species tested, with doses as low as 1-2 mg/kg/week with no effect on SGLT1, ... of antisense drugs against eight promising new targets in a variety of species and models, including diabetic animals. Results of the studies showed that ...

Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells

... until now and the development of our ZFN technology, genomes of other species such as humans and plants could not be efficiently modified in a site ... the specific and targeted modification of any genome of potentially any species and may enable the development not only of potential therapeutics but also ...

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... modified animal models of human disease. ZFN technology will make the generation of such animals faster and will create new opportunities in species other than mice. "Until now, rat geneticists lacked a viable technique for 'knocking out,' or mutating, specific genes to understand their ...

Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA

... 5-HIAA, is a biomarker used in the diagnosis of the condition. In preclinical studies, LX1032 reduced peripheral serotonin in several different species without affecting serotonin levels in the brain. In Phase 1 clinical studies, LX1032 reduced serotonin levels and urinary 5-HIAA in healthy ...

Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets

... J. Timothy Greenamyre, MD, PhD, University of Pittsburgh Validation of Nox1/Rac1, a novel molecular source of reactive oxygen species in the nigrostriatal pathway, as a target for Parkinson ' s disease therapy Yoon-Seong Kim, MD, PhD, Weill Medical College of Cornell ...

Alimera Sciences Announces Presentation of Data From the 12-Month Interim Readout of the Human PK Iluvien(TM) Study at ARVO 2009 Annual Meeting

... into an exclusive worldwide agreement with Emory University to explore oxidative stress management -- specifically the reduction of reactive oxygen species (ROS) -- as a treatment strategy for ophthalmic diseases. Under this agreement, Alimera has acquired options to exclusive, worldwide licenses for two ...

AdvanDx Launches Fast, 90 Minutes Protocol for All CE-IVD Marked PNA FISH(R) Tests in Europe

... requiring only a fluorescence microscope to get started Identification of staphylococci, enterococci, Gram-Negative bacteria and Candida species directly from positive blood cultures Fast and actionable results for 95-99% of all patients with bloodstream infections and positive blood ...

ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients

... rats, observed only in the 1000 mg/kg dose group, being a marginal decrease in the rate of weight gain. Anadys previously reported NOAELs in both species after 28 days of 1000 mg/kg, the highest dose tested in that study. The dosing portion of the 26-week study in rats is now complete, while the ...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

... as 0.1 microgram/kilogram were sufficient to prevent tumor growth from mutated human colorectal cancer cells. Studies in a relevant non-human primate species suggest that active serum levels of the cetuximab-based BiTE antibody are tolerated. "The data show that our BiTE technology can overcome ...

Alimera Sciences' Iluvien(TM) Phase 3 Studies for DME Pass Final DSMB Review Prior to October Readout

... into an exclusive worldwide agreement with Emory University to explore oxidative stress management -- specifically the reduction of reactive oxygen species (ROS) -- as a treatment strategy for ophthalmic diseases. Under this agreement, Alimera has acquired options to exclusive, worldwide licenses for ...

Alimera Reports Favorable Safety and Efficacy Results From the 12-Month Interim Readout of the Human PK Iluvien(TM) Study

... into an exclusive worldwide agreement with Emory University to explore oxidative stress management -- specifically the reduction of reactive oxygen species (ROS) -- as a treatment strategy for ophthalmic diseases. Under this agreement, Alimera has acquired options to exclusive, worldwide licenses for two ...

Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)

... offers several other pharmacological advantages." "Neurotoxicity observed in AD is believed to be related to the toxicity from reactive oxygen species produced in the brain by beta-amyloid protein bound primarily to copper ions," commented Professor Kelvin Davies Chairman of the Company's Scientific ...

Scientists Discover Why Teeth Form in a Single Row

... part of the National Institutes of Health. "Beyond medical applications, our results suggest that diversity in the number of tooth rows across species may be due to evolutionary changes in the control of the BMP4/Msx1 pathway," Jiang said. "In mammals, Osr2 suppresses this pathway to restrict teeth ...

Nanoemulsion Kills Highly Resistant Bacteria Found in Patients With Cystic Fibrosis

... of death in persons with cystic fibrosis, and there are simply no effective therapies for patients infected with Burkholderia and other bacterial species that are resistant to all known antibiotics," said John LiPuma, M.D., professor and associate chair for research in the department of pediatrics at ...

Study Shows Leconotide, an Investigative Calcium Channel Blocker, Has Potential as a Selective, Efficacious, Non-Opioid Pain Treatment

... into and out of the cell. Some are specialized for the flow of chemical ions such as sodium, potassium and calcium. The amount of ions of each species passing through those channels controls many functions of the cell such as force of contraction of a muscle cell in the heart or blood vessels or ...

Synvista Therapeutics Announces First Dosing of SYI-2074 in Clinical Trial for Psoriasis

... varies inversely with levels of GPx activity (i.e., higher levels of oxidized lipids promote the creation of oxygen free radicals and reactive oxygen species (ROS), such as H2O2, which can promote inflammation). As noted above, a topical form of our GPx mimetic SYI-2074 is being developed for ...

Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA

... and - Resistant Enterococci and Staphylcocci -- F1-2061: TR-700, a Novel Oxazolidinone, Tested Against Linezolid-Resistant Gram-Positive species with Well-Characterized Resistance Mechanisms -- F1-2062: In Vitro Pharmacodynamics of TR-700, the Active Moiety of Prodrug TR-701, a ...

Alimera Reports Results From the Six-Month Interim Readout of the Human PK Iluvien(TM) Study

... into an exclusive worldwide agreement with Emory University to explore oxidative stress management -- specifically the reduction of reactive oxygen species (ROS) -- as a treatment strategy for ophthalmic diseases. Under this agreement, Alimera has acquired options to exclusive, worldwide licenses for two ...

DSMB Again Supports Continuation of Alimera Sciences' Phase 3 Clinical Trial of Iluvien(TM) for the Treatment of DME

... into an exclusive worldwide agreement with Emory University to explore oxidative stress management -- specifically the reduction of reactive oxygen species (ROS) -- as a treatment strategy for ophthalmic diseases. Under this agreement, Alimera has acquired options to exclusive, worldwide licenses for two ...

Rapid Test for Pathogens Developed By K-State Researchers Could Be Used to Detect Diseases Used By Bioterrorists

... genetic sequences that set each pathogen apart. So far they can detect as many as 557 genes, making it possible for them to screen for 40 different species of bacteria, 1,200 serotypes of Salmonella, five common serotypes of E. coli, and resistance to the 45 most common antibiotics used to treat human ...

Positive Mosquito Count for West Nile Virus Lead DEP, Southeastern PA Counties to Ramp up Treatment Activities

... with truck-mounted equipment, which dispenses Biomist 3 + 15, a permethrin insecticide product, at a rate of 0.75 ounces per acre. Certain mosquito species carry the West Nile virus, which, when transmitted to people, can cause West Nile encephalitis, an infection that can result in an inflammation of ...

New Research Provides Evidence that Tea May Improve Attention and Focus, Keep Brain Cells Healthy, & Influence Genetics in Cancer

... high flavonoid content, the importance of tea's polyphenolic flavonoids in supporting healthy brain cells appears to go beyond the simple oxygen species scavenging, involving pleiotropic effects on numerous biological pathways to help keep human brain cells from dying and even help repair them when ...

Study Shows Use of AdvanDx's PNA FISH(TM) Test was Associated with an 82% Reduction in Intensive Care Unit Mortality Rates from Staphylococcus aureus Bloodstream Infections

... easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. The unique properties of the non-charged, peptide backbone of PNA probes enable the use of ...

Bad News to Bad Bugs: Northern Antibiotics Develops Novel Polymyxins With Reduced Toxicity

... them. Plasmid-mediated carbapenemases, probably transferred from Klebsiella pneumoniae, have now been found in E. coli, the clinically most important species of Gram-negative enteric bacteria. Also plasmid-mediated methylases that cause resistance to all aminoglycosides have been encountered. Finally and ...

Alimera Reports Results From the Three-Month Interim Readout of the Human PK Medidur(TM) FA Study

... into an exclusive worldwide agreement with Emory University to explore oxidative stress management -- specifically the reduction of reactive oxygen species (ROS) -- as a treatment strategy for ophthalmic diseases. Under this agreement, Alimera has the exclusive option to license compounds, which are ...

Proof of Concept Study in Second Species Demonstrates Increase in Absorption of Oral B12 Using Emisphere Technology

... studies using dogs further demonstrate that its proprietary eligen(R) technology enhances the absorption of oral B12. These data confirm in a second species Emisphere's earlier-reported proof of concept studies conducted in rats. "These additional animal studies are an important milestone in our plans ...

Bionovo Announces Publication of the Paper Detailing the Mechanism of Action of Its Cancer Drug BZL101

... Shtivelman, Ph.D., Director of Cancer Research at Bionovo. "This selective cell killing is based on strong induction by BZL101 of reactive oxygen species (ROS) in tumor cells. The ROS cause extensive DNA damage in tumor cells but not in normal cells, which then leads to the inhibition of glycolysis ...

DSMB Again Supports Continuation of the Phase III Clinical Trial of Medidur(TM) FA for the Treatment of DME

... into an exclusive worldwide agreement with Emory University to explore oxidative stress management -- specifically the reduction of reactive oxygen species (ROS) -- as a treatment for ophthalmic diseases. The agreement gives Alimera the exclusive option to license compounds which are NADPH (nicotinamide ...

FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008

... then undergoes a unique non-enzymatic conversion as it passes through the gut and into systemic circulation, which limits the exposure of the active species to unwanted targets, such as DPP 8 and 9. Such "soft drug" properties of ARI-2243 confer functional selectivity and are believed to contribute to a ...

Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results

... milestones that represent the successful application of Sangamo's ZFP technology to the generation of specific traits in two major crop species -- maize and canola. -- Sangamo closed a registered direct offering to institutional investors. In July, Sangamo sold an aggregate of ...

BioCryst Updates Peramivir Clinical Development Plan

... A viruses of H5N1 subtype are circulating among birds worldwide. The virus is considered extremely contagious in fowl. It is believed that all species of birds are susceptible to avian influenza, but domestic poultry, including chickens and turkeys, are among the more susceptible to the highly ...

St. Jude Defines Eye Cancer Gene's Role in Retinal Development

... of eye size. For example, the mouse eye is about 5,000 times smaller than that of the elephant eye, but the retinal thickness in these two species is comparable." Working with mice, the researchers found that a gene called N-myc coordinates the growth of the retina and other eye structures ...

Neptune Industries Reports Favorable Phase II Trial Results on Ento- Protein(TM)

... the pivotal milestone in developing a viable dietary protein alternative in the $7 billion dollar market for fishmeal. Phase I selected four species of suitable insects based upon a myriad of key production and nutritional parameters. The industry has been focused on vegetable-based alternatives, ...

Stem Cell Breakthrough Advances Science Without 'Ethical Landmines,' Says Cardinal

... it does not clone or destroy human embryos, does not harm or exploit women for their eggs, and does not blur the line between human beings and other species through desperate efforts to make human embryos using animal eggs. Ian Wilmut, head of the team that cloned 'Dolly' the sheep, now says he is ...

Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week

... of mammoths. The method for obtaining ancient DNA, as described in today's paper, uses hair shafts and not live cells. Hair from many extinct species is available in museum collections around the world. The new protocol, along with 454 Sequencing, opens the door to sequence many ancient species. ...