Small in Medical Technology

Cognition Therapeutics Closes Series A Financing to Advance Drug Candidates for Alzheimer's Disease

... drug discovery company developing small molecule disease-modifying treatments for ... Ph.D., J.D. "Our combination of novel, small molecule drug candidates and ... is a leader in the discovery and development of small molecule therapeutics targeting the toxic ...

Music & Medicine: Unique Collaboration Combines Performing Arts and Science

... and her body sways in time to the prelude. Her small hands glide over the keyboard gracefully, ... help prevent pianists -- especially those with small hands -- from developing pain caused by playing ... pain, with lack of flexibility and small hand span as contributors. This Joint ...

Vantia Therapeutics' Lead Candidate VA106483 Demonstrates Positive Anti-diuretic Effect in Phase IIa Trial in Nocturia

... pharmaceutical company developing novel, small molecule drugs targeting large, underserved ... than US$500 million. VA106483 is a novel small molecule drug candidate that exerts its ... and has been developed by Vantia based on its small molecule drug development expertise and is the ...

Transave Receives $2.2 Million Cystic Fibrosis Foundation Award for Development of ARIKACE(TM)

... endogenous to the lung that are formulated into small (0.3 micron), neutral liposomes that enable ... delivered through nebulization, which enables the small aerosol droplet size (1 to 5 microns) to ... time. Combined with its silent mode of operation, small size (it fits in the palm of the hand), light ...

CeNeRx BioPharma Obtains Rights to Novel Drug Candidate for Prevention and Treatment of Neurodegeneration Disorders

... disorders. The drug candidate, CXB909, is a small molecule, orally active agent that enhances the ... Officer of CeNeRx. "In preclinical studies, our small molecule agent CXB909 has been shown to increase ... company's CNS pipeline also includes CXB909, a small molecule, orally active agent for the prevention ...

Two-Year Data Show Patients Receiving SIMPONI(TM) (golimumab) Experienced Sustained Improvement in Signs and Symptoms of Psoriatic Arthritis and Ankylosing Spondylitis

... (one patient), colon cancer (one patient) and small cell lung cancer (one patient) in patients ... patients), prostate cancer (one patient), and small cell lung cancer (one patient) in patients ... climbing accident (SIMPONI 50 mg) and one due to small cell lung cancer (SIMPONI 100 mg). About ...

SCAI Statement on the BARI 2D Trial (Bypass Angioplasty Revascularization Investigation With Diabetes Trial) Presented at the American Diabetes Association (ADA) Annual Scientific Sessions and Published in The New England Journal of Medicine

... Since the BARI-2D study enrolled a very small subset of CAD patients with diabetes, SCAI looks ... the patients studied in BARI-2D faced only a small risk of death or heart attack to begin with, it ... are highly selected and represent only a very small slice of diabetes and heart disease patients. ...

PARI Pharma Reports Successful Phase Ib Clinical Results for Inhaled Liposomal Cyclosporine A and Gains FDA Orphan Drug Designation for the Prevention and Treatment of Bronchiolitis Obliterans

... a devastating, incurable disease of the small airways affecting approximately 60,000 patients ... perforated membrane that includes thousands of small holes that produce the aerosol mist. Compared to ... time. Combined with its silent mode of operation, small size (it fits in the palm of your hand), light ...

PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference

... dose (QD) of Traficet-EN in patients with small bowel and/or colonic Crohn's disease was ... Traficet-EN(TM) (CCX282-B) Traficet-EN is a small molecule, orally-available drug that is ... tract. The trafficking of T cells to the small and large intestine causes persistent ...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

... TRU-016 is the Company's proprietary anti-CD37 small Modular ImmunoPharmaceutical (SMIP(TM)) product ... 3017: A Phase 1 Trial of TRU-016, An Anti-CD37 small Modular ImmunoPharmaceutical (SMIP(TM)), in ... (#16007) of TRU-016 for the treatment of CLL and small lymphocytic leukemia (SLL). The objectives of the ...

Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer

... rarely cured with available treatments. Only a small proportion of people (<2%) live more than two ... contrast, no treatment response was observed in a small group of patients without the BRAF mutation, and ... discovery and development of novel small molecule pharmaceuticals to treat human disease. ...

Spirus Medical Announces Complete Examinations of the Small Intestine by Physicians Using Endo-Ease(TM)

... have performed complete examinations of the small intestine, or pan-endoscopy. Spirus is ... through June 4. Complete examination of the small intestine has been elusive in regular practice ... through the long, tortuous path in the body. The small intestine is about 20 to 23 feet long and other ...

Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support

... small Molecule Stem Cell Modulator Administered in Dual ... treated in a Phase 1b clinical trial of FT1050, a small molecule Stem Cell Modulator (SCM) designed to ... "The mission of Fate Therapeutics is to develop small molecules and biologics that modulate adult stem ...

Ascenta Therapeutics Announces Multiple Presentations on AT-101 at 2009 ASCO Annual Meeting

... (T) in patients with relapsed or refractory small cell lung cancer (SCLC) after prior platinum ... May 30, 8:00 a.m.-12:00 p.m. Min P, et al. small molecule pan-bcl-2 inhibitor AT-101 induces ... with advanced solid tumors and extensive-stage small cell lung cancer (ES-SCLC). Abstract #e13502; ...

PARI Pharma's Nebulized DSCG Shows Results Similar to Inhaled Steroids in Asthma Studies Presented at ATS

... with IsoCrom administered via a customized small droplet Investigational eFlow Nebulizer System ... II trial, treatment with IsoCrom inhaled via a small droplet (MMAD ~ 3.3 microns) Investigational ... in asthma. This requires delivery of DSCG via small droplets to the target site in the lungs and can ...

Poniard Pharmaceuticals Reports First Quarter 2009 Financial Results and Provides a Corporate Update

... of picoplatin for the second-line treatment of small cell lung cancer, along with the independent Data ... market potential for multiple indications beyond small cell lung cancer." Recent Clinical and Corporate Developments small Cell Lung Cancer In March, Poniard ...

Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia

... of D-3263, Dendreon's orally bioavailable small molecule, which targets TRPM8 (a transmembrane ... and in pathology. Dendreon has synthesized small molecule agonists including D3263 that activate ... Dendreon is also developing an orally-available small molecule that targets TRPM8 that could be ...

Dendreon Initiates Phase 1 Clinical Trial of Small Molecule Targeting TRPM8 in Cancer

... with advanced cancer. D3263 is Dendreon's lead small molecule drug candidate designed to target TRPM8 ... and in pathology. Dendreon has synthesized small molecule agonists including D3263 that activate ... Dendreon also is developing an orally-available small molecule that targets TRPM8 that could be ...

Cylene to Present Advances in its Oral Inhibitor of CK2 at AACR Annual Meeting

... be presenting new data on recent advances of its small molecule anticancer agents during a symposium and ... Sunday, April 19, 2009: 8:00 AM CX-4945, a small molecule inhibitor of CK2, inhibits angiogenesis ... of CX-4945 a selective orally bioavailable small molecule inhibitor of protein kinase CK2: Phase ...

Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update

... Relapse) clinical trial for the treatment of small cell lung cancer, presenting data from our ... Relapse) trial as a second-line treatment for small cell lung cancer (SCLC); ... intravenous picoplatin include a Phase 3 trial in small cell lung cancer and Phase 2 trials in metastatic ...

DURECT Reports Positive Phase IIb Data from TRANSDU(TM)-Sufentanil Clinical Program

... available opioid patches. We anticipate that the small size of our sufentanil patch (potentially as small as 1/5th the size of currently marketed ... convenience, compliance, efficacy and safety for small molecule and biologic drugs. For more ...

Freezing Kidney Cancer: Hot Treatment Should Be New Gold Standard for Destroying Small Tumors

... More Than 75 Percent of Patients Diagnosed Have small Renal Cell Tumors; Safe Interventional Radiology ... who are diagnosed with kidney cancer have small tumors that are discovered incidentally. ... is especially significant for individuals with small tumors, since more than 75 percent of patients ...

Nektar Announces Positive Results from Phase 2 Study of Oral NKTR-118 in Patients with Opioid-Induced Constipation (OIC)

... Oral NKTR-118 combines Nektar's advanced small molecule polymer conjugate technology platform ... an important potential advance for many other small molecule therapies. "NKTR-118 demonstrates ... conjugate technology can potentially create new small molecule drugs with optimal physicochemical and ...

Boston Scientific Submits Final Modules to FDA for Approval of Second-Generation Small Vessel and Long Lesion Stents

... Atom Stent, which is the Company's first approved small stent and the only DES currently approved by the FDA to treat small vessels. The TAXUS Liberte Long Stent is ... data from the global, multi-center TAXUS ATLAS small Vessel (SV) and Long Lesion (LL) studies, ...

Wrist Access Safer, Easier for Many Patients Undergoing Minimally Invasive Treatment of Blocked Heart Arteries

... the arteries, an interventional physician makes a small incision in the groin at the top of the leg and ... then inflated to open up the artery, and often a small cage-like tube called a stent is left behind to ... for all patients, including those who have very small or twisted arteries or are extremely thin, said ...

Studies Examine Quality of Care for Hospitalized Sickle Cell Disease Patients and Effective Methods for Detecting Risk of Stroke in Children With This Disorder

... settings and showed that hospitals that treat a small number of patients with sickle cell disease have ... to reduce morality at hospitals that treat a small number of patients with sickle cell disease. The ... all organs due to vaso-occlusion (the blockage of small vessels by sickled cells). One of these severe ...

S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis

... of this condition. SB1518 is a small molecule JAK2-selective kinase inhibitor which ... S*BIO's target-driven approach to innovative small molecule therapies for cancer is built on a ... and clinical development of novel targeted small molecule drugs for the treatment of cancer with ...

Exercise Helps Prevent Age-Related Brain Changes in Older Adults

... cerebral blood flow and a greater number of small blood vessels in the brain, according to findings ... showed that the inactive group exhibited fewer small blood vessels in the brain, along with more ... the brain. "The active adults had more small blood vessels and improved cerebral blood flow," ...

Poniard Pharmaceuticals Announces Management Changes and Focus on Development and Commercialization of Picoplatin

... of picoplatin in the treatment of small cell lung cancer, currently targeted for 2010. ... our ongoing Phase 3 registration trial in small cell lung cancer is on track, with the potential ... intravenous picoplatin include a Phase 3 trial in small cell lung cancer and Phase 2 trials in metastatic ...

ASGE and The Pancreatic Cancer Action Network Partner to Raise Awareness About Pancreatic Cancer

... can block the flow of these substances into the small intestine. This can cause the skin and eyes to ... (ERCP). During this test a small camera (scope) is used to inject a dye into the ... juices. It also allows doctors to insert a small tube (stent) if needed to relieve a blockage. ...

Alba Therapeutics Announces Enrollment of Its First European Patient in Global Phase IIb Study of Larazotide Acetate for Treatment of Active Celiac Disease

... This then causes damage to the villi in the small intestine and can lead to total villous atrophy ... such as osteoporosis, refractory sprue, small intestinal cancer, and lymphoma. Celiac disease ... of tight junctions in epithelial cells lining the small intestine. In celiac disease, gluten crosses the ...

Paratek Reports Positive Phase 2 Clinical Data on its New Antibiotic PTK 0796 in Late Breaker Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy

... program, Paratek has also identified small molecules that inhibit bacteria-specific ... synthesis effort to produce novel and diverse small molecules, with the goal of ... and FSMA to develop tetracycline-derived small molecule drugs for a range of uses, including ...

Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium

... tumor growth and survival. It is a first-in-class small molecule inhibitor of NAE. Both clinical ... Takeda." MLN4924 MLN4924 is a first-in-class small molecule inhibitor of NAE, a new target ... and efficacy relationship of MLN4924, a novel small molecule inhibitor of Nedd8-activating ...

Perceptive Informatics Improves Clinical Trial Management With Enhanced TrialWorks(R) Solution

... System (CTMS) designed specifically for small and mid-size companies. The enhanced 2.1 version ... the world. "To meet the unique needs of small and mid-size biopharmaceutical companies ... system, which is built to meet specific needs of small and mid-size biopharmaceutical companies and ...

Paratek to Present Clinical Data in Late Breaker Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy

... program, Paratek has also identified small molecules that inhibit bacteria-specific ... synthesis effort to produce novel and diverse small molecules, with the goal of ... and FSMA to develop tetracycline-derived small molecule drugs for broad-spectrum use in treating ...

Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent

... from the TAXUS ATLAS Workhorse, Direct Stenting, small Vessel and Long Lesion trials were presented at ... data showed significantly reduced restenosis in small vessels and positive results in direct stenting ... pre-dilatation," said Dr. Turco. TAXUS Atlas small Vessel and Long Lesion Two-year data from the ...

Boston Scientific to Release Broad Range of Clinical Trial Data on the Performance of TAXUS(R) Coronary Stent Systems at TCT 2008

... Direct Stenting trials and two-year ATLAS data on small vessels and long lesions (TAXUS Liberte Stent). ... ET) -- TAXUS ATLAS Workhorse, Direct Stenting, small Vessel and Long Lesion studies. Three-year data ... In addition, two-year data from the TAXUS ATLAS small Vessel and Long Lesion studies will be presented ...

Alba Therapeutics Presents New Data for Larazotide Acetate at the 2008 American College of Gastroenterology Annual Scientific Meeting

... which triggers an inflammatory reaction in the small intestine. This then causes damage to the villi in the small intestine and can lead to total villous atrophy ... such as osteoporosis, refractory sprue, small intestinal cancer, and lymphoma. The only current ...

S*BIO Initiates U.S. Phase I Clinical Trials of Oral JAK2 Inhibitor SB1518 for the Treatment of Hematological Malignancies

... overall safety profile of SB1518. SB1518 is a small molecule JAK2-selective kinase inhibitor which ... target-driven approach to developing innovative small molecule therapies for cancer is built on ... and clinical development of novel targeted small molecule drugs for the treatment of cancer with ...

ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options

... of testing is not as effective in diagnosing small polyps. CT colonography is one of several ... It has been suggested that patients with small polyps may be followed by CT colonography at ... tested and it is important to recognize that even small polyps can infrequently harbor early or advanced ...