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situ in Medical Technology

American College of Cardiology and Center of Excellence for Simulation Research of Western Michigan University (CESR) Partner for in situ Simulation to Improve Team Communication and Door-to-Balloon (D2B) Time

... simulation technology to advance patient care. In situ simulation has improved safety in commercial ... United Airlines, has been a leader in adapting in situ simulation technology to healthcare models. Dr. ... shoring up safety and improving performance. In situ simulation offers a unique opportunity for ...

BSGI Posts Higher Sensitivity than Mammography or MRI for the Detection of Ductal Carcinoma In Situ

... for the detection of Ductal Carcinoma In situ (DCIS) than mammography or MRI and can reliably ... issue," said Dr. Brem. DCIS Ductal Carcinoma In situ (DCIS), the most common type of ... . Detection of Ductal Carcinoma In situ with Mammography, Breast Specific Gamma Imaging, ...

Protein Tomography(TM) Reveals Molecular Mode of Action of Humax-EGFr Published in PNAS

... possible to study the molecular mode of action of individual molecules in situ and in vitro. The unique biological information obtained can also be used ... on April 21, 2008 About Sidec Sidec studies molecular interactions in situ and in vitro using its proprietary technology Protein Tomography(TM). ...

Quest Diagnostics Introduces ClariSure(TM) Test for Identifying Chromosome Abnormalities Associated With 85 Developmental Disorders in Children

... A positive result may be confirmed using a licensed fluorescence in situ hybridization (FISH) methodology. The company expects to provide test ... patients who have already had extensive cytogenetic and/or fluorescence in situ hybridization testing.(2) CGH microarray technologies are also more ...

Indevus Receives Approvable Letter From FDA for VALSTAR(R) for Bladder Cancer Therapy

... FDA for therapy of bacillus Calmette-Guerin (BCG)-refractory carcinoma in situ (CIS) of the urinary bladder. VALSTAR was removed from the market in 2002 ... is indicated for intravesical therapy of BCG-refractory carcinoma in situ (CIS) of the urinary bladder in patients for whom immediate cystectomy ...

Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State

... with dozens of disorders, including Down, cri du chat, DiGeorge and Williams syndromes. A positive result may be confirmed using a fluorescence in situ hybridization (FISH) methodology. aCGH technologies compare and contrast a specimen's DNA to the DNA of a healthy individual to identify, at a ...

Breast Cancer Clinical Results Show Test Can Differentiate Normal, Early and Later Stage Cancers

... that "GOS reactivity as measured by adjusted chroma values are significantly different between normal patients, those with Ductal Carcenoma In situ and those with invasive cancer" and that "these results warrant further investigation". "We are extremely pleased that the data was supportive of ...

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

... CLL patients (73 male, 65 female, with a median age of 64 years) stratified according to cytogenetic markers that were identified by fluorescent in situ hybridization (FISH) testing. The median number of two prior therapies in this group was two (range, 0 - 10), and of the patients who received prior ...

New Mammography Technology Effective in Detecting Breast Cancer

... Of 189 malignant lesions imaged, PEM detected 176 for an overall sensitivity rate of 93 percent. Fifteen percent were ductal carcinoma in situ (DCIS), a noninvasive cancer confined to the ducts of the breast; 85 percent were invasive cancer. PEM successfully detected cancer in 100 ...

Ipsogen Launches a New Test to Determine Tumor HER2 Status and Guide Herceptin(R) Prescription in Breast Cancer

... tested for HER2 with 2 main complementary technologies: immunohistochemistry (IHC) which identifies HER2 protein expressed in the tumor cells and in situ hybridization (ISH), which quantifies HER2 DNA copy number in the cell chromosomes. Some RT-PCR assays, that quantify the amount of HER2 mRNA, have ...

The First Direct Structural Evidence of SV2A has Been Revealed Thanks to Protein Tomography(TM), and Published in BBRC

... Again Provided Structural Proof of a Drug Target Function. A Study Performed by Sidec and UCB, Characterizes the Target of Anti-Epileptic Drug in situ Where Two Major Conformations Have Been Identified STOCKHOLM, September 9 /PRNewswire/ -- Sidec AB has together with ...

Genomic Health Announces Data Supporting Use of Oncotype DX(R) to Accurately Assess HER2 Gene Expression in Breast Cancer Patients

... for HER2 gene expression, as measured by the company's Oncotype DX(R) breast cancer assay, has a high degree of concordance with both fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) testing. HER2 is an important marker for therapeutic decision-making for patients with breast ...

Study Shows Use of AdvanDx's PNA FISH(TM) Test was Associated with an 82% Reduction in Intensive Care Unit Mortality Rates from Staphylococcus aureus Bloodstream Infections

... and appropriate therapy and save patient lives. About PNA FISH(TM) PNA FISH is an easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. ...

AdvanDx Submits Yeast Traffic Light PNA FISH(TM) for FDA 510(k) Clearance for Detection of Candida species in Positive Blood Cultures

... and appropriate therapy and save patient lives. About PNA FISH(TM) PNA FISH is an easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in bacteria and yeast. PNA ...

TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)

... by Reximmune-C to recruit the body's immune cells into the same tumor compartments, thereby prompting recognition of the tumor neoantigens in situ and inducing long-lasting anti-tumor immunity. The purpose of the Phase I study was to evaluate the overall safety/toxicity and therapeutic ...

XTENT Announces Positive Six-Month CUSTOM III Trial Data Presented at EuroPCR Meeting

... percent, and the neointimal hyperplasia (NIH) volume was 3.8 percent. "The CUSTOM III results are very promising and demonstrate the safety of in situ customization for treatment of simple and complex lesions. The IVUS and angiographic results confirm the efficacy of the Custom NX stent, and the ...

Karmanos Researchers Study the Impact of Galectin-3 on Breast Cancer Disparity in Caucasian and Asian Women

... at more than 40,000 this year alone. It's estimated that in 2007 there were 178,480 new cases of invasive breast cancer and another 62,000 of in situ breast cancer, and Caucasian women are far more prone to develop breast cancer than Asian women, for reasons unknown. Although the mutations in ...

ALS Therapy Development Institute Signs Collaboration Agreement with the Allen Institute for Brain Science

... Development Institute (ALS TDI) today announced it has entered into an agreement with the Allen Institute for Brain Science in Seattle, Wash. for in situ hybridization (ISH) services using diseased tissues from a preclinical animal model of amyotrophic lateral sclerosis -- ALS, or Lou Gehrig's disease. ...

Cardium and Tissue Repair Company's Excellarate Candidate for Healing Diabetic Wounds Gains Media Focus in Multiple Regions Across U.S.

... the immobilized vector and gene and then transiently express the encoded therapeutic protein. Compared with topical applications of proteins, this in situ expression method significantly prolongs the local availability of therapeutic protein to the cells involved in tissue repair. TRC's GAM technology ...

Three Year Analysis of Treatment Efficacy, Cosmesis, and Toxicity Support use of the Hologic Mammosite Radiation Therapy System

... 2002 and July 2004. Of the total, 87 percent of the patients had invasive breast cancer and 13 percent had been diagnosed with ductal carcinoma in situ (DCIS). The authors presented a subset analysis of the first 400 cases enrolled in the study with a median follow-up of 37.5 months. The ...

Abbott's m2000(TM) Molecular Diagnostic Instrument and RealTime HIV-1 Test Win Chicago Innovation Award

... information to help them predict if a particular type of cancer treatment may be effective for an individual patient. PathVysion fluorescence in situ hybridization (FISH) technology measures the number of copies of the HER-2 gene at the DNA level. Using fluorescent colors and a microscope, ...

Researchers Develop New Procedure to Screen All 46 Human Chromosomes to Identify Abnormalities in Embryos

... the most commonly used technology for chromosomal analysis of embryos (sometimes termed preimplantation genetic diagnosis or PGD), is florescent in situ hybridization (FISH). This technique assesses fewer than half of the 23 chromosome pairs found in the human karyotype and has a suboptimal error ....

American Fertility Association Calls for Expanded Research to Advance New Technology to Screen Embryos for Genetic Abnormalities

... the most commonly used technology for chromosomal analysis of embryos (sometimes termed preimplantation genetic diagnosis or PGD), is florescent in situ hybridization (FISH). This technique assesses fewer than half of the 23 chromosome pairs found in the human karyotype and has a suboptimal error ....

New England Journal of Medicine Publishes New Data on Gardasil, Merck's Cervical Cancer Vaccine

... neoplasia (CIN) grade 3 and adenocarcinoma in situ (AIS)), cervical pre-cancers ... (and its precursor lesion adenocarcinoma in situ (AIS)). HPV also causes approximately 35-50% of ... lesions: -- Cervical adenocarcinoma in situ (AIS) -- Cervical intraepithelial ...

Data Published in The Lancet Show Gardasil was 100 Percent Effective in Preventing High-Grade Vulvar and Vaginal Lesions Caused by HPV Types 16 and 18

... neoplasia (CIN) grade 3 and adenocarcinoma in situ (AIS)), cervical pre-cancers ... (and its precursor lesion adenocarcinoma in situ (AIS)). HPV also causes approximately 35-50% of ... lesions: -- Cervical adenocarcinoma in situ (AIS) -- Cervical intraepithelial ...

One-Third of Patients Discontinue Common Breast Cancer Therapy

... cancer, ductal carcinoma in situ (DCIS), and reduction in breast cancer incidence in high risk women. WARNING - For Women with Ductal Carcinoma in situ (DCIS) and Women at High Risk for Breast Cancer: Serious and life-threatening events associated with tamoxifen in the risk reduction setting (women ...

Immunicon Will Exhibit CellCapture CTC Mouse/Rat Kit and EasyCount System for Automated Cell Counting at AACR

... development services for its CellTracks(R) System rare cell technology, including biomarker assays for protein markers or fluorescence in situ hybridization (FISH) targets and new assay kit development for analysis of other rare cells. Immunicon's clinical trial testing services include ...

Novel Human Tissue Transgenic Cancer Model May Offer Significant Advance Toward Accurately Modeling Human Cancer

... Depending on the combination of transgenes employed, the reconstituted human breast tissue developed into preneoplastic lesions (Carcinoma In situ or CIS) or to invasive adenocarcinomas. Importantly, despite using the same set of genetic alterations, significant variation in tumor phenotype was ...

Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy

... PATHWAY (Ventana Medical Systems). The Ventana PATHWAY offers an integrated system of IHC plus a reflex FISH assay (see below). Fluorescent in situ hybridization (FISH) involves the hybridization of specific DNA probes, which are visible on a fluorescent microscope. FISH is compatible with all ...

Testing for Human Papillomavirus

... Systems (Tucson) offers Inform HPV, an analyte specific reagent assay that can be performed on both tissue specimens and LBPTs. The assay is an in situ hybridization test performed on histology or LBPT slides that are incubated with fluorescein-tagged DNA probes and counterstained. Microscopic ...

Genetic Analysis Systems Enter the Clinical Mainstream

... for its Aneuvysion assay, the only FDA cleared product to test for prenatal aneuploidy. Vysis offers an expansive line of DNA FISH (fluorescence in situ hybridization) probes for evaluation of chromosome anomalies in preimplantation, prenatal and postnatal genetic testing and research. The ...
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