Signal in Medical Technology

European Union's CHMP Issues Positive Opinion on Sugammadex

... trial program including the results from the signal and AURORA clinical trials. The signal trial involved adult patients undergoing surgery. ... the current standard of care in reversal. signal clinical findings demonstrate that the median ...

St. Jude Study Shows How T Cell's Machinery Dials Down Autoimmunity

... and that the ITAMs were there for signal amplification. The second possibility is that ... a relatively small defect in the efficiency of signal transduction through the T cell receptor ... need a very big reduction in T cell receptor signal strength to have a defect in negative ...

Sugammadex Trials Demonstrate Rapid Recovery from Profound Neuromuscular Blockade During General Anesthesia

... to neostigmine in the Phase III pivotal signal trial.(1) In a second trial, named Spectrum, ... trial results were presented on October 14. The signal trial compared the efficacy and safety of ... from succinylcholine-induced blockade. "The signal trial results are clinically significant ...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

... oral, anticancer agent that modulates Akt and several other important signal transduction pathways. Keryx is currently in the process of finalizing ... tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are ...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

... effects to the retina. This suggests that inhibiting the PI3K/Akt/mTor signal transduction pathway by Palomid 529 may be neuroprotective to ... complexes, one of which, TORC1, regulates cell growth by acting on the signal transduction protein S6K, while the other, TORC2, regulates cell survival ...

Astrocytes Help Separate Man From Mouse

... but we are finding striking differences in the astrocytes. Our astrocytes signal faster, and they're bigger and more complex. This has big implications for ... team noted additional differences: Astrocytes in people signal five times as fast as those in mice and rats. Human astrocytes are ...

PTC Therapeutics Completes Enrollment of Pivotal Trial in Muscular Dystrophy

... mutation genetic disorders. Nonsense mutations create a premature stop signal in the mRNA causing the ribosome to terminate translation before a ... to continue translation of the mRNA, by overriding the premature stop signal leading to the formation of a functioning protein. Ataluren is a ...

Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology

... oral anti-cancer agent that modulates Akt and a number of other key signal transduction pathways, including the JNK and MAPK pathways, all of which ... tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are ...

Technique for Rapidly Reprogramming Adult Cells Into Stem Cells Published in PLoS Biology

... (1) Promotion of Reprogramming to Ground State Pluripotency by signal Induction. Silva, J. et al. (2008) PLoS Biol 6(10): e253 ... (1) Promotion of Reprogramming to Ground State Pluripotency by signal Induction. Silva, J. et al. (2008) PLoS Biol 6(10): e253 ...

BRIDION(R) (sugammadex) Injection - First and Only Selective Relaxant Binding Agent - Approved in European Union

... including data from the SIGNAL, AURORA and SPECTRUM clinical trials. The signal trial involved adult patients undergoing surgery. Rocuronium was ... or neostigmine plus glycopyrrolate, a current reversal regimen. In the signal trial, the median time to reversal of muscle relaxation to a train-of-four ...

Nonin Medical Inc. Announces Entry Into the Cerebral Oximeter Market

... physiological monitoring with specific focus on highly effective signal processing and the advancement of innovative pulse oximeter products. With ... effective, yet simple solutions. Our newly developed sensor and patented signal processing technology is designed to deliver on these objectives." The ...

Brain Stem Cells Can Be Awakened, Say Schepens Scientists

... the team discovered that astrocytes in the hippocampus were sending one signal to the stem cells and that those from the rest of the brain were sending a different signal to stem cells. In the second (PNAS) study, the team went on to discover ...

St. Jude Finds 'Dancing' Hair Cells Are Key to Humans' Acute Hearing

... only passive detectors, the so-called "outer hair cells" amplify the sound signal as it transforms into an electrical signal that travels to the brain's ... the outer hair cells. The somatic motility theory proposes that the sound signal is amplified by an amplifier protein, called prestin, embedded in the ...

Keryx Biopharmaceuticals, Inc. Announces Phase 1 and Phase 2 Data on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Multiple Myeloma at 49th Annual Meeting of American Society of Hematology

... to inhibit or otherwise modify signaling through a number of different signal transduction pathways including Akt, MAPK, and JNK. Akt isoforms have been ... body associated with tumor survival and growth, and a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are ...

Phase 1 & 2 Data of Perifosine (KRX-0401) in Patients with Advanced Renal Cell Carcinoma Presented Today at the 25th Annual Chemotherapy Foundation Symposium

... to inhibit or otherwise modify signaling through a number of different signal transduction pathways including Akt, MAPK, and JNK. Akt isoforms have been ... body associated with tumor survival and growth, and a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are ...

Keryx Biopharmaceuticals, Inc. Announces Positive Preliminary Phase 2 Data on KRX-0401 in Patients with Chemo-Insensitive Rare Sarcoma

... oral anticancer agent that modulates AKT and a number of other key signal transduction pathways, including the MAPK and JNK pathways all of which ... body associated with tumor survival and growth, and a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are ...

Signalife Completes Testing of Modules for Holter and Intra-Cardiac Monitor

... on the monitoring and detection of disease through continuous biomedical signal monitoring. Signalife uses its patented signal technology to design and develop medical devices that simplify and reduce ...

Swissmedic Grants Debiopharm Marketing Authorisation for Moapar(R), a New Therapeutic Avenue for the Treatment of Sexual Deviations

... of treatment of sexual deviations with Moapar(R)," said Rolland-Yves Mauvernay, President and Founder of Debiopharm Group. "This is an important signal for us, as we move closer to providing an alternative treatment for this controversial disorder. It's a small market, but we feel that it's our ...

Swissmedic Grants Debiopharm Marketing Authorisation for Moapar(R), a New Therapeutic Avenue for the Treatment of Sexual Deviations

... of treatment of sexual deviations with Moapar(R)," said Rolland-Yves Mauvernay, President and Founder of Debiopharm Group. "This is an important signal for us, as we move closer to providing an alternative treatment for this controversial disorder. It's a small market, but we feel that it's our ...

Cytokine PharmaSciences Initiates Phase I Study of Oral Anti-Inflammatory Agent, CPSI-2364

... over time." CPSI-2364 is a chemically-modified form of the synthetic guanylhydrozone, semapimod. Semapimod has been shown to inhibit the signal transduction pathways that lead to the production of nitric oxide and important pro-inflammatory cytokines, including TNF-alpha, IL-1, IL-6, and ....

deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia

... than 300,000 SNPs in a total of 17,000 patients and controls from England, Finland, Germany, Iceland, Italy and Scotland. The 1500 SNPs with the best signal were then analyzed in 11,000 patients and controls from the International Schizophrenia Consortium (ISC) and the European-American portion of the ...

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

... the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which constitute novel therapeutic modalities for the treatment of major cardiovascular disorders. Cordex has a ...

Value of Genetic Testing for Preventing Blood Clots Unproven, According to New AHRQ Study

... The authors also reviewed the evidence for the accuracy of the testing methods used to identify the FVL and prothrombin G20210A mutations, which can signal continued risk of blood clots. The evidence shows that tests for identifying the mutations have excellent analytic validity and that nearly all ...

New Studies Presented at European Society of Anaesthesia Further Validate Masimo PVI(TM) for Noninvasive and Continuous Fluid Monitoring

... may be required under the applicable securities laws. Contact: Dana Banks Masimo Corporation 949-297-7348 Masimo, SET, signal Extraction Technology, Improving Outcomes and Reducing Cost of Care by Taking Noninvasive Monitoring to New Sites and Applications, Rainbow, SpHb, ...

Two New Clinical Studies Show That Limited Exposure to Blood Transfusion Significantly Increases Morbidity and Mortality After Surgery

... required under the applicable securities laws. Media Contact: Dana Banks, Masimo Corporation 949-297-7348 Masimo, SET, signal Extraction Technology, Improving Outcomes and Reducing Cost of Care by Taking Noninvasive Monitoring to New Sites and Applications, Rainbow, SpHb, ...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell ...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell ...

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

... the PI3K/PTEN pathway. About PI3 Kinase Phosphatidylinositol 3 kinases (PI3K) are involved in one of the major pathways of intracellular signal transduction and are important in controlling cell growth/angiogenesis, differentiation, proliferation and survival/apoptosis. Dysregulation of the ...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

... anti-cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell ...

VA Studies Advanced Prosthetic Arm

... his mouth and drink. "Learning to use the controls is not difficult," he said, due in part to a sensor in the artificial hand that sends a vibration signal that tells how strong the grip is. A stronger grip causes more vibration. VA prosthetics research also includes vision and hearing aids, ...

Kinex Pharmaceuticals To Present at ASCO 2009 Annual Meeting

... The Company has utilized its platform technologies to identify highly selective inhibitors of therapeutically relevant targets that are involved in signal transduction and cell cycle control. CONTACT: Lyn Dyster, Vice President, Research Operations of Kinex Pharmaceuticals, +1-716-881-8984 ...

Stand Up To Cancer Awards $73.6 Million for Novel, Groundbreaking Cancer Research

... of Southern California ; "Targeting the PI3K Pathway in Women's Cancers" / Leader: Lewis C. Cantley, Ph.D., Chief of the Division of signal Transduction at Beth Israel Deaconess Medical Center; Co-Leaders: Charles L. Sawyers, M.D., Director of the Human Oncology and Pathogenesis Program ...

New NIH-Funded Study Shows Masimo Rainbow SET(R) May Help Clinicians Assess Oxygenation in Children With Sickle Cell Disease

... required under the applicable securities laws. Media Contact: Dana Banks, Masimo Corporation 949-297-7348 Masimo, SET, signal Extraction Technology, Improving Outcomes and Reducing Cost of Care by Taking Noninvasive Monitoring to New Sites and Applications, Rainbow, SpHb, ...

Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting

... the PI3K/PTEN pathway. About PI3 Kinase Phosphatidylinositol 3 kinases (PI3K) are involved in one of the major pathways of intracellular signal transduction and are important in controlling cell growth/angiogenesis, differentiation, proliferation and survival/apoptosis. Dysregulation of the ...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

... various solid tumors and hematological cancers. The current focus of research includes compounds in three areas: angiogenesis inhibition, signal transduction inhibition and cell-cycle kinase inhibition. BIBW 2992 entered Phase IIb/III clinical development in NSCLC earlier in 2008 and was ...

Glivec(R) is the First Adjuvant Treatment Approved in the UK to Delay Return of Gastrointestinal Cancer After Surgery

... can mutate and become over active.(5) The normal role of KIT is to provide the 'signal' to cells in the body to grow and divide: this signal is not given continuously but can be turned 'on' and 'off' to limit cell division and growth. However, in people with GIST, a mutation in the DNA ...

Arcion Therapeutics' Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy

... of the underlying biology of neuropathic pain." Previously published research has shown that in neuropathic pain conditions such as PDN, the signal that triggers pain actually arises at the level of the skin. The data reported today for ARC-4558 provide further rationale for applying therapies ...

Medizone International, Inc. (MZEI.PK): Trials of the AsepticSure Hospital Sterilization System Have Begun

... our equipment and protocols are fully effective at eliminating the bacteria being tested, as we anticipate, the results will constitute a powerful signal to the health care community that a safe and inexpensive solution will soon be available to effectively address a problem which last year resulted in ...

EPSScentral Responds to Pandemic Alert

... mitigation measures in the face of WHO's phase 5 classification of the Influenza A crisis. According to the WHO, phase 5 ... is a strong signal that a pandemic is imminent and that the time to ... mitigation measures is short." (Logo: ...

Abbott's Market-Leading XIENCE V(R) Shows Increasing Clinical Advantages Over TAXUS(R) Express2(TM)/TAXUS(R) Liberte(TM) Between Two and Three Years

... Boston Scientific as part of a distribution agreement between the two companies. Everolimus, developed by Novartis Pharma AG, is a proliferation signal inhibitor, or mTOR inhibitor, licensed to Abbott by Novartis for use on its drug eluting stents. Everolimus has been shown to inhibit in-stent ...