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Sequential in Medical Technology
... (CRT), a treatment paradigm defined as sequential therapy, compared to upfront CRT alone, ... and patients who received CRT alone.
The sequential therapy of adding IC to CRT improved ... in 61.5% of the patients treated with the sequential strategy (IC+CRT) compared to 44.5% of those ...
... today announced interim findings from a study of sequential treatment of plaque psoriasis using Clobex (R) ... and efficacy of these products when used in a sequential regimen. In this study, Clobex Spray was used in ... scores. The interim results indicate that sequential treatment of plaque psoriasis with Clobex Spray ...
... presented at the meeting were results from the sequential Treatment Analysis (STA) of BIG 1-98 that support ... tamoxifen. The study investigators conclude that sequential treatment does not improve disease-free survival ... the second cohort (solely contributing to the sequential Treatment Analysis) began enrolling patients to ...
... the results of a Phase I Feasibility Study of sequential targeted gene delivery -- using Rexin-G followed ... and therapeutic potential of this sequential regimen, in an effort to achieve a personalized ... for a personalized cancer vaccination using this sequential gene transfer approach is now a realistic goal. ...
... versus AL-08 with celecoxib, using group sequential design and a natural history control group for a ... planned to enroll up to 120 patients, in sequential pools of 60. Our ability to halt the trial early ... targeted enrollment of up to 120 patients in sequential pools of 60 to evaluate the ...
... compared to allopurinol alone (p=0.0012). The study also compared a sequential combination of the two agents (Elitek for three days followed by ... alone, which showed a reduction in plasma uric acid levels for the sequential combination versus allopurinol alone (p=0.06). Tumor lysis ...
... placed gene-based therapy for heart failure within reach and yielded valuable insights for the entire field of study." The Phase 1 open-label, sequential dose escalation, multi-center phase of the trial was designed to investigate safety and biological effects of restoring SERCA2a enzyme activity in ...
... the role of anti-PS antibodies in mediating tumor cell cytotoxicity and the tumor microenvironment, showing that the anti-PS antibody induced a sequential release of cytokines and beta-chemokines and stimulated enhanced macrophage recruitment to tumors. Furthermore, the researchers showed that in ...
... of three oral loading doses of TRA (10mg, 20mg or 40mg) or placebo in a 3:1 ratio of active drug to placebo. The loading doses were increased in a sequential fashion based on a blinded review by a Safety Review Committee. Those patients who subsequently underwent PCI (n=573) were randomized to one of ...
... heart function in more patients." CUPID, which is funded by Celladon, is a Phase 1/2 trial. The Phase 1 portion reported today is an open-label, sequential dose escalation study. The Phase 2 portion is a randomized, double-blind, placebo-controlled, parallel-group, dose ranging trial that compares the ...
... of patients with advanced, metastatic solid tumors refractory to standard therapy. Patients receive treatment at one of five dose levels in a sequential dose-escalating design; the first cohort has now been treated safely. Once the maximum tolerated dose is defined, an additional three to six patients ...
... Inc. (CTI) (Nasdaq and MTA: CTIC) markets Zevalin in the United States. "In a high risk, elderly patient population with significant comorbidities, sequential R-CHOP followed by radioimmunotherapy resulted in excellent complete response and overall and progression-free survival rates," concluded Hamlin. ...
... rights to Zevalin in December, 2007. The objective of the study was to determine the tolerability and efficacy of Zevalin consolidation following sequential fludarabine and mitoxantrone therapy without rituximab in first-line treatment of follicular NHL. "This study underscores the potential use of ...
... discontinued the study. Given the potent antiviral activity and favorable preliminary safety demonstrated at 800 mg once-daily, we will explore sequential cohorts of 400 mg once-daily followed by 200 mg once-daily. "We are pleased with the safety profile and potency observed with the 800 mg dose of ...
... patients as compared to treatment with standard irinotecan in combination with cetuximab. The colorectal study is comprised of two sequential stages. The Phase 2a is an open-label, dose-finding trial in multiple solid tumor types that are refractory to standard curative or palliative ...
... The first patients have been enrolled and have undergone initial treatment steps in preparation for receiving DCVax(R)-L. The trial involves two sequential studies, and comprises an innovative combination of multiple treatment modalities. DCVax(R)-L forms the cornerstone of the treatment regimen, and ...
... were randomized into three Albuferon treatment groups (900 mcg every two weeks, 1200 mcg every two weeks, and 1200 mcg every four weeks, followed by sequential escalation to 1500 mcg every two weeks, and 1800 mcg every two weeks). A total of 115 patients participated. All patients received weight-based oral ...
... (HR: 0.73; p=0.02). Treatment with TPF in the TAX 323 study resulted in a 27% reduction in the risk of death. "TAX 324 study results show that sequential therapy starting with a Taxotere-based chemotherapy regimen significantly increases survival in patients who are suffering from this particularly ...
... poster session, is a double-blind, randomized, placebo-controlled, single-group assignment safety study with seven subjects per group enrolled in sequential dose groups of healthy overweight or obese adult male and female volunteers who have a body mass index (BMI) of 27-40. Five subjects in each dosing ...
... dose based on the previous weekly dose of epoetin. In contrast to previous studies in which dialysis patients were converted from IV epoetin using sequential increases in dosing intervals, most patients in MAXIMA were converted directly from a predominantly three-times-a-week regimen of epoetin (87 percent ...
... It is feasible to administer gemcitabine at lower doses than 1,000mg/meter squared with concurrent radiotherapy with predictable toxicity (see SPC). sequential radiotherapy (given >7 days apart): Enhanced toxicity has not occurred when gemcitabine was started after the resolution of acute radiation effects ...
... males, between the ages of 18 and 55, were enrolled in the double-blind, placebo-controlled trial conducted at one center in Belgium. In a series of sequential dosing cohorts, subjects received a single oral dose of either 10, 20, 30 or 35 mg of NGX267 once-daily for four consecutive days. NGX267 was well ...
... study of 536 patients in 15 countries designed to evaluate the safety and efficacy of a TAXUS paclitaxel-eluting coronary stent, in which two sequential cohorts of patients with standard risk, de novo coronary artery lesions were treated with different dose formulations. Boston Scientific is a ...
... placebo-controlled trial which included safety and pharmacokinetic (PK) data from 20 treated subjects and eight vehicle controls in four sequential dose groups. According to Dr. DelConte, PK profiles from the study thus far show a predictable pattern with minimal subject-to-subject variability ...
... through a 'stressor' effect due to decreased levels of R2 target expression, may potentially apply to other GTI-2040 combinations as well. This new sequential dose strategy will be an important consideration to maximize efficacy in the GTI-2040 clinical program. The second presentation titled, "siRNAs ...
... the p-Erk pathway. A randomized Phase 2 trial is currently investigating the clinical benefit of satraplatin and erlotinib, administered in a sequential schedule, for elderly patients with advanced non- small cell lung cancer (NSCLC). Abstract #3118 -- SPI (IRL) -1620 Increases the Efficacy ...
... 5 mg twice daily plus picoplatin or docetaxel 75 mg/m2 every three weeks plus prednisone 5 mg twice daily plus picoplatin. Picoplatin was given to sequential cohorts of subjects at 60, 80, 100 and 120 mg/m2 with docetaxel 60 mg/m2 and at 100 and 120 mg/m2 with docetaxel 75 mg/m2. To date, 26 patients ...
... in this tumor type as well. Geron expects to initiate both trials in the coming months." Background Geron's ongoing Phase I/II trial is a sequential cohort, dose escalation study to determine the safety and tolerability of GRN163L administered intravenously on a weekly basis to patients with ...
... today announced interim findings from a study of sequential treatment of plaque psoriasis using Clobex (R) ... and efficacy of these products when used in a sequential regimen. In this study, Clobex Spray was used in ... scores. The interim results indicate that sequential treatment of plaque psoriasis with Clobex Spray ...
... presented at the meeting were results from the sequential Treatment Analysis (STA) of BIG 1-98 that support ... tamoxifen. The study investigators conclude that sequential treatment does not improve disease-free survival ... the second cohort (solely contributing to the sequential Treatment Analysis) began enrolling patients to ...
... the results of a Phase I Feasibility Study of sequential targeted gene delivery -- using Rexin-G followed ... and therapeutic potential of this sequential regimen, in an effort to achieve a personalized ... for a personalized cancer vaccination using this sequential gene transfer approach is now a realistic goal. ...
... versus AL-08 with celecoxib, using group sequential design and a natural history control group for a ... planned to enroll up to 120 patients, in sequential pools of 60. Our ability to halt the trial early ... targeted enrollment of up to 120 patients in sequential pools of 60 to evaluate the ...
... compared to allopurinol alone (p=0.0012). The study also compared a sequential combination of the two agents (Elitek for three days followed by ... alone, which showed a reduction in plasma uric acid levels for the sequential combination versus allopurinol alone (p=0.06). Tumor lysis ...
Research Identifies Need for Improved Understanding of Sickle Cell Disease in Adulthood
... on transfusion and improvement of neuropsychological function. -- sequential deferiprone-deferoxamine superior to deferiprone monotherapy, the current ... heart failure. This trial evaluated deferiprone monotherapy compared with sequential treatment with deferiprone for four days followed by deferoxamine for ...... placed gene-based therapy for heart failure within reach and yielded valuable insights for the entire field of study." The Phase 1 open-label, sequential dose escalation, multi-center phase of the trial was designed to investigate safety and biological effects of restoring SERCA2a enzyme activity in ...
... the role of anti-PS antibodies in mediating tumor cell cytotoxicity and the tumor microenvironment, showing that the anti-PS antibody induced a sequential release of cytokines and beta-chemokines and stimulated enhanced macrophage recruitment to tumors. Furthermore, the researchers showed that in ...
Cynosure Announces Presentation of Favorable Results from Post-Marketing Studies of Smartlipo MPX
... - Technological Innovation for Facial Rejuvenation," Richard Gentile, Northeastern Ohio University , Youngstown, Ohio "A Nd:YAG Laser with sequential Emission of 1320nm and 1440nm Wavelengths with CAP Technology is Effective in Neck Rejuvenation," Adriana Ribe, Natalie Ribe, Institut Natalie Ribe, ...... of three oral loading doses of TRA (10mg, 20mg or 40mg) or placebo in a 3:1 ratio of active drug to placebo. The loading doses were increased in a sequential fashion based on a blinded review by a Safety Review Committee. Those patients who subsequently underwent PCI (n=573) were randomized to one of ...
... heart function in more patients." CUPID, which is funded by Celladon, is a Phase 1/2 trial. The Phase 1 portion reported today is an open-label, sequential dose escalation study. The Phase 2 portion is a randomized, double-blind, placebo-controlled, parallel-group, dose ranging trial that compares the ...
... of patients with advanced, metastatic solid tumors refractory to standard therapy. Patients receive treatment at one of five dose levels in a sequential dose-escalating design; the first cohort has now been treated safely. Once the maximum tolerated dose is defined, an additional three to six patients ...
New CyberKnife Technologies Demonstrate Dramatic Reduction in Treatment Times
... the next generation CyberKnife System achieved a considerable reduction in treatment times. Using the latest advancement in treatment planning, sequential Optimization enabled treatment plans to be developed in as little as 15 minutes. With the new 800 monitor unit/minute linear accelerator treatment ...... Inc. (CTI) (Nasdaq and MTA: CTIC) markets Zevalin in the United States. "In a high risk, elderly patient population with significant comorbidities, sequential R-CHOP followed by radioimmunotherapy resulted in excellent complete response and overall and progression-free survival rates," concluded Hamlin. ...
DATATRAK International Reports First Quarter Results for 2008
... out, the trend should be progressively upward." Green Continued, "Based partially on our first quarter 2008 revenues, which represented our first sequential quarterly revenue increase in quite some time (going from $1.8 million in the fourth quarter of 2007 to $2.1 million during the first quarter of this ...... rights to Zevalin in December, 2007. The objective of the study was to determine the tolerability and efficacy of Zevalin consolidation following sequential fludarabine and mitoxantrone therapy without rituximab in first-line treatment of follicular NHL. "This study underscores the potential use of ...
... discontinued the study. Given the potent antiviral activity and favorable preliminary safety demonstrated at 800 mg once-daily, we will explore sequential cohorts of 400 mg once-daily followed by 200 mg once-daily. "We are pleased with the safety profile and potency observed with the 800 mg dose of ...
... patients as compared to treatment with standard irinotecan in combination with cetuximab. The colorectal study is comprised of two sequential stages. The Phase 2a is an open-label, dose-finding trial in multiple solid tumor types that are refractory to standard curative or palliative ...
... The first patients have been enrolled and have undergone initial treatment steps in preparation for receiving DCVax(R)-L. The trial involves two sequential studies, and comprises an innovative combination of multiple treatment modalities. DCVax(R)-L forms the cornerstone of the treatment regimen, and ...
... were randomized into three Albuferon treatment groups (900 mcg every two weeks, 1200 mcg every two weeks, and 1200 mcg every four weeks, followed by sequential escalation to 1500 mcg every two weeks, and 1800 mcg every two weeks). A total of 115 patients participated. All patients received weight-based oral ...
... (HR: 0.73; p=0.02). Treatment with TPF in the TAX 323 study resulted in a 27% reduction in the risk of death. "TAX 324 study results show that sequential therapy starting with a Taxotere-based chemotherapy regimen significantly increases survival in patients who are suffering from this particularly ...
... poster session, is a double-blind, randomized, placebo-controlled, single-group assignment safety study with seven subjects per group enrolled in sequential dose groups of healthy overweight or obese adult male and female volunteers who have a body mass index (BMI) of 27-40. Five subjects in each dosing ...
... dose based on the previous weekly dose of epoetin. In contrast to previous studies in which dialysis patients were converted from IV epoetin using sequential increases in dosing intervals, most patients in MAXIMA were converted directly from a predominantly three-times-a-week regimen of epoetin (87 percent ...
MedImmune Announces Phase 2 Safety Data for Anti-RSV Antibody and National RSV Surveillance Results
... of motavizumab, an investigational anti-RSV MAb, in young children with a history of prematurity who received two sequential seasons of the antibody. RSV Surveillance: Retrospective and Current Data on the Variance in Season Onsets and Offsets (Poster ...... It is feasible to administer gemcitabine at lower doses than 1,000mg/meter squared with concurrent radiotherapy with predictable toxicity (see SPC). sequential radiotherapy (given >7 days apart): Enhanced toxicity has not occurred when gemcitabine was started after the resolution of acute radiation effects ...
Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers
... was to explore the effect of food on the pharmacokinetics of R7128. Single oral doses of R7128 were administered to 46 healthy volunteers in five sequential dose groups (500 mg, 1500 mg, 4500 mg, 6000 mg, and 9000 mg) and one food effect group (1500 mg). There were 8 subjects per sequential dose group (6 ...... males, between the ages of 18 and 55, were enrolled in the double-blind, placebo-controlled trial conducted at one center in Belgium. In a series of sequential dosing cohorts, subjects received a single oral dose of either 10, 20, 30 or 35 mg of NGX267 once-daily for four consecutive days. NGX267 was well ...
... study of 536 patients in 15 countries designed to evaluate the safety and efficacy of a TAXUS paclitaxel-eluting coronary stent, in which two sequential cohorts of patients with standard risk, de novo coronary artery lesions were treated with different dose formulations. Boston Scientific is a ...
Boston Scientific Announces Schedule for European Society of Cardiology Congress 2007
... II is a randomized, double-blind, controlled study of the safety and efficacy of the TAXUS Paclitaxel-Eluting Coronary Stent, in which two sequential cohorts of patients with standard risk, de novo coronary artery lesions were treated with different dose formulations versus a bare-metal ...... placebo-controlled trial which included safety and pharmacokinetic (PK) data from 20 treated subjects and eight vehicle controls in four sequential dose groups. According to Dr. DelConte, PK profiles from the study thus far show a predictable pattern with minimal subject-to-subject variability ...
CSL Therapy That Mimics “Good” Cholesterol May Reduce Plaque Volume in Coronary Arteries
... but the 40mg/kg dose was safe and generally well tolerated. CSL confirmed that the results were based on data from 145 patients who had 2 sequential IVUS procedures. The main findings were that there was a reduction in coronary plaque volume after infusions of CSL-111 of 3.4 percent and after ...... through a 'stressor' effect due to decreased levels of R2 target expression, may potentially apply to other GTI-2040 combinations as well. This new sequential dose strategy will be an important consideration to maximize efficacy in the GTI-2040 clinical program. The second presentation titled, "siRNAs ...
... the p-Erk pathway. A randomized Phase 2 trial is currently investigating the clinical benefit of satraplatin and erlotinib, administered in a sequential schedule, for elderly patients with advanced non- small cell lung cancer (NSCLC). Abstract #3118 -- SPI (IRL) -1620 Increases the Efficacy ...
... 5 mg twice daily plus picoplatin or docetaxel 75 mg/m2 every three weeks plus prednisone 5 mg twice daily plus picoplatin. Picoplatin was given to sequential cohorts of subjects at 60, 80, 100 and 120 mg/m2 with docetaxel 60 mg/m2 and at 100 and 120 mg/m2 with docetaxel 75 mg/m2. To date, 26 patients ...
Study Shows Advantages of Complete Phase Ib Trial Over Separate Phase I Trials
... is feasible. The initial experience has suggested that this approach is safe and highly efficient with several potential advantages over multiple sequential combination phase Ib studies. "Our US Oncology research team is confident that the methodology described in our poster will significantly shorten ...Clinical Results From EntreMed's Panzem NCD and Taxol Breast Cancer Study Presented at ASCO
... there was one complete response (CR), one partial response (PR), and one patient with a 30% reduction in tumor volume. Patients also underwent sequential biopsies of their tumors to evaluate biomarkers of hypoxia and angiogenesis. Paclitaxel causes an increase in tumor HIF-1alpha expression, which is ...Prana Biotechnology Presents New Key Findings on PBT2
... animals freely interacting with their environment. Sampling from the brains of genetically-engineered AD mouse models which have received single or sequential oral doses of PBT2, it was found that the drug exerts its inhibitory effects upon the target molecule, Abeta, rapidly and reproducibly without ...... in this tumor type as well. Geron expects to initiate both trials in the coming months." Background Geron's ongoing Phase I/II trial is a sequential cohort, dose escalation study to determine the safety and tolerability of GRN163L administered intravenously on a weekly basis to patients with ...
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(Date:12/3/2009)...A team of scientists from the U.S. Department of E...ard University, and the Indian Institute of Scienc...ules locate the genetic information in DNA that is...sses. The research, published in the December 1, 2...ogy , confirms that many proteins responsible for ...
(Date:12/2/2009)...HIA Cigarette smoking and alcohol consumption bef...ts the patient,s future risk of death, according t...how a similar effect among those who continued the... survivors are counseled to quit smoking; despite ...ontinued to smoke even after their cancer diagnosi...
(Date:12/2/2009)...TTE, Ind. ╤ A Smoky Mountain forest,s woodla... a role in how forest understories recover from lo... Despite heavy logging in portions of the forest ...plants on the secondary forest floor was similar t...rdue assistant professor of forestry and natural r...
Breaking Biology News(10 mins):Grooving down the helix 2Grooving down the helix 3Head and neck cancer survivors who use alcohol and cigarettes have increased death risk 2Study finds logging effects vary based on a forest's history, climate 2CenterWatch Celebrates 15 Year Milestone as Leading Information Provider for the Clinical Trials Industry 55529 1CenterWatch Celebrates 15 Year Milestone as Leading Information Provider for the Clinical Trials Industry 55529 2Tennis Legend John McEnroe Tells Men to Get Serious About Prostate Cancer 55525 1Tennis Legend John McEnroe Tells Men to Get Serious About Prostate Cancer 55525 2Tennis Legend John McEnroe Tells Men to Get Serious About Prostate Cancer 55525 3Tennis Legend John McEnroe Tells Men to Get Serious About Prostate Cancer 55525 4Tennis Legend John McEnroe Tells Men to Get Serious About Prostate Cancer 55525 5Panel assesses evidence for the collection and use of family health history information 55523 1Panel assesses evidence for the collection and use of family health history information 55523 2Panel assesses evidence for the collection and use of family health history information 55523 3(Date:12/4/2009)...FirstCall/ -- PD-Rx Pharmaceuticals, Inc. (Pink Sh...for the first quarter ended September 30, 2009, a ...ating income and net income for the quarter were $...ease over the same period last year. ,, Results...les. This trend is expected to continue throughou...
(Date:12/4/2009)...The National Cancer Institute has awarded a $55.4 ... Cancer Research Center to become the nation,s sol...ct Center. ,, The move will create 60 new jobs ...e of its current CIS workforce - once the consolid...ed for March 15, 2010. The Seattle CIS center will...
(Date:12/4/2009)...e (BUSM) researchers at the Slone Epidemiology Cen...ry products have a reduced incidence of uterine le...ack Women,s Health Study, appears in the current i... Uterine fibroids are benign tumors of the uterus...k women than white women. They are the primary ind...
(Date:12/4/2009)...guage patient education leaflets support Joint Com...uage access in healthcare organizations. , ...009 -- Lexi-Comp, Inc., a provider of clinical inf...on materials for healthcare institutions, understa...een the health care professional and the patient w...
(Date:12/4/2009)... Author and Political Analyst Leslie Sanchez proud...Providence Hospital’s “Adopt-a-Family ... $5000 in cash and toy donations for the charity a...match the donation. Toys will be distributed to fa...tal. , Washington, DC (P...
Breaking Medicine News(10 mins):Health News:PD-Rx Pharmaceuticals, Inc. Reports 1st Quarter Earnings 2Health News:Hutchinson Center Wins $55.4 Million Contract to Become Sole Operator of the NCI Cancer Information Service 2Health News:Researchers find increased dairy intake reduces risk of uterine fibroids in black women 2Health News:Lexi-Comp Focused on Improving Patient Communication in Healthcare Institutions Treating Diverse Patient Populations 2Health News:Lexi-Comp Focused on Improving Patient Communication in Healthcare Institutions Treating Diverse Patient Populations 3Health News:Bobby Berk Home and Leslie Sanchez Announce 1st Annual Toy Drive for DC's Neediest Families 2[0] PD-Rx Pharmaceuticals, Inc. Reports 1st Quarter Earnings[0] Hutchinson Center Wins $55.4 Million Contract to Become Sole Operator of the NCI Cancer Information Service[0] Researchers find increased dairy intake reduces risk of uterine fibroids in black women[0] Lexi-Comp Focused on Improving Patient Communication in Healthcare Institutions Treating Diverse Patient Populations [0] Bobby Berk Home and Leslie Sanchez Announce 1st Annual Toy Drive for DC's Neediest Families
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