Sequences in Medical Technology

J. Craig Venter, Ph.D. Receives Double Helix Medal from Cold Spring Harbor Laboratory

... along with Dr. James D. Watson for making each of their individual genome sequences available for scientific use on the Internet and for promoting awareness ... of genetics upon human health. Dr. Venter and his teams have published the sequences of more than 50 genomes, and through the Sorcerer II Expedition have more ...

Karolinska Institute to Test Vical's Vaxfectin(R) Adjuvant with Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control

... packaged. The DNA prime vaccine component contains only the specific gene sequences in a plasmid DNA ring, and cannot reconstitute into an infectious virus. ... (the virus that causes cowpox) to shuttle the same non-infectious gene sequences into the body. The boost vaccine component was developed by the NIH and ...

Vical Advances RapidResponse(TM) DNA Vaccine Platform Under $6 Million Grant from NIH

... called a linear expression cassette (LEC), which includes only those DNA sequences essential for eliciting immune responses. The bacterial fermentation ... produces a closed loop of DNA, called a plasmid, which includes DNA sequences required by the bacteria in the manufacturing process. Vical holds patents ...

Thermo Fisher Scientific Advances Gene-Silencing Technology for Life Sciences Research

... we can now effectively deliver stably expressed gene silencing sequences into a broad range of cell types, including those that are difficult to ... added Jardine. "Alternative technologies frequently produce shRNA sequences that are ineffective at silencing the targeted genes, while causing high ...

Researchers Identify Virus Possibly Responsible for Declining Honeybee Population Using 454 Sequencing Technology from Roche

... foreign organisms living in and among the bees were identified by reading sequences of DNA isolated from the bee colonies. The study, entitled "A metagenomic ... between any infectious agent and CCD; nonetheless, the prevalence of IAPV sequences in CCD operations, as well as the temporal and geographic overlap of CCD ...

Multiple NIH Phase 2 HIV Vaccine Trials Using Vical's Technology Produce Encouraging Results

... the genes are packaged. The pDNA component contains only the specific gene sequences in a pDNA ring, and cannot reconstitute into an infectious virus. The ... adenoviral vector to shuttle the same non-infectious gene sequences into the body. The pDNA vaccine used in the trials was developed by VRC ...

Replikins LLC Finds West Nile Virus Replikin Count Has Reached Its Highest Recorded Value

... by Replikins LLC of the most currently available West Nile virus protein sequences world wide listed on PubMed indicates that the Replikin Count(TM) has ... In Replikins's Early Warning/Rapid Responset(TM) Service, virus protein sequences of threatening viruses, as soon as available, are analyzed within hours ...

Cepheid Receives Grant to Develop Ten-Color Real-Time PCR Detection Technology for Use in the GeneXpert(R) System

... for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect, and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed samples. Modular in design, the GeneXpert System has a variety of configurations to meet the ...

Siemens Corporate Research Develops RAPID2 System for Fast Discovery of Discriminative Pathogen Signatures

... from the outset." SCR used its new system recently to quickly discover a DNA barcode for detecting the H1N1 Flu after they received the genomic sequences of the virus isolated from infected patients from the National Institute of Health (NIH). In addition to applications related to ...

Mutant Genes in High-Risk Childhood Leukemias Identified

... triggering the uncontrolled proliferation of white blood cells that is seen in leukemia." Thus, the researchers began to analyze the genetic sequences of many kinases known to be components of the proliferation machinery of white blood cells. The team analyzed the leukemic cells from 187 patients ...

Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin

... for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed samples. Modular in design, the GeneXpert System has a variety of configurations to meet the ...

Adlyfe Strikes Translational Medicine Partnership With Wyeth Pharmaceuticals for Alzheimer's Biomarker Assay

... is based on the synthesis of small peptides, or Pronucleon(TM) peptides, that are amino acid sequence matched to target amyloids of interest. Ligand sequences are selected based on regions of the target protein known to undergo conformational changes (structural changes in shape) associated with amyloid ...

Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs

... DNA methylation/demethylation of the donor DNA occurs in a species-specific way, and that the eggs might lack the ability to demethylate repetitive sequences from other species. While cleavage division relies on maternal factors in the egg, further development requires activation of the embryonic genome to ...

Research Teams at J. Craig Venter Institute and Ludwig Institute for Cancer Research Uncover New Chromosomal Alterations in Cancer Using Transcriptome Sequencing Approach

... line. The team began by generating more than half a million 454 reads of cDNA sequences. After extensive data mining, the team uncovered 496 sequences that indicate chromosomal translocations. Of these 496, the team characterized 208 as inter-chromosomal abnormalities and 210 were intra-chromosomal ...

A Milestone in Cancer Genetics: deCODE Discovers First Common Genetic Variants Affecting the Risk of Many Types of Cancer

... and prostate. Rs 2736089 is located in the gene encoding the human telomerase reverse transcriptase (TERT), which directs the addition of repeat DNA sequences to the ends of chromosomes. Importantly, the risk of these different cancers conferred by these two SNPs appears to be independent. ...

Vical Pandemic Influenza Vaccines Achieve T-Cell Responses and Cross-Clade Reactivity in Humans

... but could elicit T-cell responses against H5 as well. Vical's trivalent vaccine contains the H5 plasmid plus separate plasmids encoding consensus sequences of two highly conserved influenza virus proteins: nucleoprotein (NP) and ion channel protein (M2). The trivalent vaccine was designed to elicit a ...

Cepheid Molecular Diagnostic Test for Positive Blood Culture Bottles Categorized 'Moderate Complexity' by FDA

... for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed samples. Modular in design, the GeneXpert System has a variety of configurations to meet the ...

Cepheid Announces CE IVD Release of First On-Demand Test for van A/van B Genes Most Associated With Hospital-Acquired VRE Infection

... for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed samples. Modular in design, the GeneXpert System has a variety of configurations to meet the ...

Rapid Test for Pathogens Developed By K-State Researchers Could Be Used to Detect Diseases Used By Bioterrorists

... further it can spread." Narayanan and Peterson have analyzed DNA of hundreds of pathogens and synthesized DNA probes for the specific genetic sequences that set each pathogen apart. So far they can detect as many as 557 genes, making it possible for them to screen for 40 different species of ...

Karolinska Institutet to Test Vical's Vaxfectin(R) Adjuvant With Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control

... at different times. The two vaccine components differ in how the genes are packaged. The DNA prime vaccine component contains only the specific gene sequences in a plasmid DNA ring, and cannot reconstitute into an infectious virus. The HIV DNA vaccine was developed by the SMI and the Karolinska Institutet ...

febit and TGen Collaborate to Study New DNA Capture Method

... Microarray Technology. febit's HybSelect(TM) Technology enables selective DNA capture and elution, an extremely efficient method to preselect sequences for Next-Generation Sequencers. HybSelect is based on febit's proven Geniom Technology and uses arrays within microfludic biochips for the ...

Cepheid GeneXpert(R) System and Xpert(TM) MRSA Selected for up to 11 Victoria, Australia Hospitals in Rollout of 'Start Clean' Strategy

... for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed samples. Modular in design, the GeneXpert System has a variety of configurations to meet the ...

Vical Announces Breakthrough for Pandemic Influenza DNA Vaccines With Preliminary Human Data

... but could elicit T-cell responses against H5 as well. Vical's trivalent vaccine contains the H5 plasmid plus separate plasmids encoding consensus sequences of two highly conserved influenza virus proteins: nucleoprotein (NP) and ion channel protein (M2). The trivalent vaccine is designed to elicit a ...

FDA Files Application To Convert ONTAK(R) (Denileukin Diftitox) to Full Approval for Use in Cutaneous T-Cell Lymphoma (CTCL)

... confirm a clinical benefit of the biologic agent. About ONTAK ONTAK is a genetically engineered fusion toxin protein consisting of the amino acid sequences for the enzymatically-active portion of diphtheria toxin fused to the sequence of human interleukin-2, resulting in a molecule that is cytotoxic for ...

Isis Highlights Robust Drug Portfolio for Diabetes and Obesity at ADA Conference

... first antisense drug for a kidney target, ISIS 388626 is also unique due to its 12 nucleotide length rather than the more typical 18 - 21 nucleotide sequences that comprise Isis' other drugs. This attribute simplifies manufacturing and has the potential to substantially reduce related expenses. The short ...

Pharmasset Announces Clevudine and R7128 Presentations at HEP-DART

... active inhibitor of the hepatitis C virus NS5B polymerase currently in clinical development. Proprietary and public database containing HCV NS5B sequences representing six HCV genotypes were analyzed for the presence of the S282T substitution. S282T results in a small loss in the antiviral activity of ...

Cepheid Launches New GeneXpert(R) Tests in Europe for Simultaneous, Rapid Detection of Staphylococcus Aureus and Methicillin Resistant Staphylococcus Aureus

... for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed samples. Modular in design, the GeneXpert System has a variety of configurations to meet the ...

Xenomics Announces Issuance of a US Patent That Covers Use of Transrenal Nucleic Acid Technology for Infectious Disease Diagnostics and Monitoring

... a developer of next-generation medical DNA diagnostic technologies, announced today issuance of its US patent "Methods for detection of nucleic acid sequences in urine," RE39,920 that covers use of its proprietary transrenal nucleic acid technology in the area of infectious disease diagnostics and ...

Dynavax Presents New Analysis of TOLAMBA(TM) Data at ACAAI Meeting

... that alter immune system responses in highly specific ways. Our TLR9 agonists are based on immunostimulatory sequences, or ISS, which are short DNA sequences that enhance the ability of the immune system to fight disease and control chronic inflammation. Our product candidates include: HEPLISAV(TM), a ...

Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells

... Biotech Unit. "This work demonstrates the specificity and efficiency with which Sangamo's ZFN technology platform can be used to correct and add DNA sequences into the genomes of living cells and is further proof of its power and broad applicability. The ZFN technology has potential applications in the ...

Dynavax Begins TOLAMBA(TM) Environmental Exposure Chamber Study

... that alter immune system responses in highly specific ways. Our TLR9 agonists are based on immunostimulatory sequences, or ISS, which are short DNA sequences that enhance the ability of the immune system to fight disease and control chronic inflammation. Our product candidates include: HEPLISAV, a ...

One Shot of Gene Therapy Spreads Through Brain in Animal Study

... blood-brain barrier very well," said Dr. Wolfe. Therefore, some strategies for treating these diseases have focused on gene therapy-delivering DNA sequences that can enter cells and produce the needed enzyme. Researchers have also sought to deliver gene therapy directly to the brain rather than to the ...

Dynavax's HEPLISAV(TM) Hepatitis B Vaccine Maintains Full Immunogenicity at 50 Weeks in Phase 3 Trial

... that alter immune system responses in highly specific ways. Our TLR9 agonists are based on immunostimulatory sequences, or ISS, which are short DNA sequences that enhance the ability of the immune system to fight disease and control chronic inflammation. Our product candidates include: HEPLISAV, a ...

Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion

... is based on the synthesis of small peptide, or Pronucleon(TM) ligands, that are amino acid sequence matched to target amyloids of interest. Ligand sequences are selected based on regions of the target protein known to undergo conformational changes (structural changes in shape) associated with amyloid ...

Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza

... both pDNA vaccines and conventional protein-based vaccines." Vical's vaccine contains three individual DNA plasmids encoding consensus sequences of two highly-conserved influenza virus proteins -- nucleoprotein (NP) and ion channel protein (M2) -- plus a hemagglutinin (HA) surface protein from ...

Testing for Human Papillomavirus

... Until recently, Digenes exclusive rights to many of the high-risk HPV sequences have limited commercialization of diagnostic HPV tests, but the availability of HPV sequences has broadened. Ventana Medical Systems (Tucson) offers Inform HPV, an ...

CytoGenix Announces Successful Testing of synDNA Vaccine for Avian Influenza Virus

... and cleaner than production using traditional fermentation methods and has developed a novel expression vector that enables production of ssDNA sequences inside the cell. CytoGenix currently holds 11 granted patents and about 36 international or US pending patent applications claiming methods and ...

Vion Presents Data on Cloretazine (VNP40101M) at the 100th Annual Meeting of the American Association of Cancer Research (AACR)

... be presented on Tuesday, April 17 from 1 to 5 p.m. These preliminary in vitro studies were designed to assess the effects of various sequences of administration of Cloretazine(R) and anthracyclines on cell survival and provide direction as to which combinations to further evaluate in ...

Researchers Identify New Genetic Risk Factors for Type 2 Diabetes

... One intriguing association is located in a region of chromosome 11 not known to contain any genes. Researchers speculate that the variant sequences may regulate the activity of genes located elsewhere in the genome, but more work is needed to determine the exact relationships to pathways involved ...