Rupture in Medical Technology

Video: The Arizona Heart Institute Announces the Largest Worldwide Experience with Endoluminal Grafting to Treat Thoracic Aortic Aneurysms and Related Pathologies

... the heart, is a serious condition prone to rupture and sudden death. According to the Society for ... less than half of all patients who experience a rupture of a thoracic aortic die before reaching the ... a dissection is present. Symptoms of aortic rupture or dissection can occur suddenly with severe, ...

Patient Receives vProtect(TM) Luminal Shield in First-Ever Vulnerable Plaque Clinical Trial

... deposits in the coronary arteries that do not produce symptoms until they rupture with potentially fatal consequences. There are more than 500,000 sudden ... "Now is the time to take a new approach, to try and prevent the plaque rupture and prevent the acute event, rather than try to repair the damage after ...

Auxilium Pharmaceuticals, Inc. Announces XIAFLEX(TM) Meets Primary Endpoint With Statistical Significance (p<0.001) in CORD I Pivotal Phase III Study for Dupuytren's Contracture

... confirmed tendon ruptures (rate per injection =0.14%), one reported tendon rupture remains unconfirmed (rate per injection = 0.05%), and one pulley ligament ... one occurred in CORD II (a pulley ligament injury) and one tendon rupture occurred in the PK study. "In summary, we believe that based on all ...

vProtect(TM) Luminal Shield Stabilizes Vulnerable Plaque

... The lesion was unremarkable by angiography (37% diameter stenosis); such lesions are usually not treated, even though vulnerable plaques are prone to rupture with potentially fatal consequences. A 3.5 mm vProtect(TM) Luminal Shield was placed in the vessel (reference vessel diameter 2.74 mm), resulting in ...

Schering-Plough's Investigational Oral Thrombin Receptor Antagonist Meets Primary Endpoint in a Newly Published Study

... myocardial infarction (MI), and ischemic stroke, which are the leading causes of death. Platelets are activated at the site of atherosclerotic plaque rupture in arteries and release substances that initiate aggregation and clot formation, and thrombin is the most potent activator of platelets. Drugs that ...

Prescient Medical Achieves Milestones in Clinical Studies of vProtect(TM) Luminal Shield

... has also broken new ground with a study evaluating use of the vProtect(TM) Luminal Shield in non-obstructive "vulnerable plaque" lesions that may rupture and cause acute myocardial infarction. According to Dr. Delgado, "The self-expanding Shield is designed to deploy with less injury to the artery, ...

FDA Grants Market Clearance for the LipiScan(TM) Coronary Imaging System Developed by InfraReDx, Inc. - A Novel Spectroscopy System for the Identification of Lipid Core Containing Plaques of Interest in the Coronary Arteries

... and stenting were major advances, stenting has not been capable of preventing heart attacks due to the difficulty in identifying lesions likely to rupture and cause thrombosis. With the development of the LipiScan Coronary Imaging System, Sanderling is again contributing to a major step forward in ...

Dong-A PharmTech Co., Ltd. Announces Portal Hypertension Clinical Trial With Udenafil

... to the liver). A major complication related to portal hypertension is variceal bleeding, where increased pressure causes veins in the esophagus to rupture and bleed. These episodes are fatal in 30% of patients and reoccurring in 70% of survivors The most common cause of portal hypertension is ...

Prescient Medical, Inc. Acquires New Technology to Detect Inflammation in Coronary Blood Vessels

... Americans over the age of 35 will suffer a coronary event. Of these victims, over one million of them will suffer a heart attack caused by the sudden rupture of soft plaque hidden inside the artery wall. This type of plaque is believed to be the major culprit in up to 80 percent of all heart attacks. ...

New Analysis of METEOR Study Demonstrate Effects of AstraZeneca's CRESTOR(R) (Rosuvastatin Calcium) on Atherosclerosis in Patients With Two or More Risk Factors for Cardiovascular Disease

... the blood supply to the heart, brain, and other vital organs, resulting in symptoms such as angina or transient ischemic attacks. Plaques can also rupture and lead to the formation of a thrombus, which can result in a sudden, complete blockage of blood flow. In the heart, this blockage causes a heart ...

SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients

... myocardial infarction (MI), and ischemic stroke, which are the leading causes of death. Platelets are activated at the site of atherosclerotic plaque rupture in arteries and release substances that initiate aggregation and clot formation, and thrombin is the most potent activator of platelets. Drugs that ...

VIA Pharmaceuticals Presents Data at American Heart Association Meeting Showing VIA-2291 Significantly Reduces Inflammation in Preclinical Model of Atherosclerosis

... pathway in vascular inflammation, we believe VIA-2291 may have the potential to reduce the major adverse cardiac events that occur as a result of the rupture of unstable plaque. We are encouraged that these data support VIA-2291 as a potential, powerful anti-inflammatory compound for the vascular system." ...

Plavix(R) Indications Expanded in Japan to Include Patients with Acute Coronary Syndrome for Whom Percutaneous Coronary Intervention Is Being Planned

... life-threatening events such as heart attacks and ischemic stroke. It is a progressive disease process in which there is an unpredictable and sudden rupture of an atherosclerotic plaque. The rupture, fissure or erosion of these plaques activates platelets in the blood to form a clot (thrombus) and which ...

Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation

... vessels during heart attack or stroke. "Life-threatening cardiovascular events, such as heart attack and stroke, occur when plaque or fatty deposits rupture and trigger the formation of blood clots inside blood vessels," said Stanley Hazen, M.D., Ph.D., Section Head of Preventive Cardiology and ...

REACH Registry Demonstrates That Multiple Arterial Disease Locations Sharply Increase the Risk of Major CV Events in Outpatients With Atherothrombosis

... on a ruptured plaque (atheroma) in the wall of a blood vessel. Plaques consist of fatty acids and cholesterol, calcium and other materials. The rupture of plaques and the subsequent development of a clot can cause partial or complete blockage of an artery in various parts of the body. When a vessel ...

First Study To Show Positive Benefit On Atherosclerosis For People With Early Signs Of Diseased Arteries

... the blood supply to vital organs such as the heart and brain, resulting in symptoms such as angina or transient ischaemic attacks. Plaques can also rupture leading to thrombus formation, which can result in a sudden, complete blockage of blood flow. In the heart, this causes a heart attack, and in the ...

Presentations at American College of Cardiology Meeting Highlight New Opportunities for HDL Therapy

... plaques in the vascular system and, most critically, in the coronary arteries. If left untreated, these plaques are highly vulnerable to rupture and to blood clot formation, which can result in a fatal myocardial infarction (heart attack). Our HDL Therapy platform increases the functionality ...

New England Journal of Medicine Publishes New Data on Gardasil, Merck's Cervical Cancer Vaccine

... section (e.g., failure of labor, malpresentation, cephalopelvic disproportion), premature onset of labor (e.g., threatened abortions, premature rupture of membranes), and pregnancy-related medical problems (e.g., pre-eclampsia, hyperemesis). The proportions of pregnant subjects who ...

Data Published in The Lancet Show Gardasil was 100 Percent Effective in Preventing High-Grade Vulvar and Vaginal Lesions Caused by HPV Types 16 and 18

... section (e.g., failure of labor, malpresentation, cephalopelvic disproportion), premature onset of labor (e.g., threatened abortions, premature rupture of membranes), and pregnancy-related medical problems (e.g., pre-eclampsia, hyperemesis). The proportions of pregnant subjects who ...

Five Days of LEVAQUIN(R) as Effective as 10 Days of Ciprofloxacin in Complicated Urinary Tract Infections and Acute Pyelonephritis

... receiving concomitant corticosteroids, especially the elderly. The quinolone should be discontinued in patients experiencing pain, inflammation, or rupture of a tendon. Some quinolones, including LEVAQUIN, have been associated with prolongation of the QT interval, infrequent cases of arrhythmia, and ...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

... periodicity was observed in the onset of stroke. Striking evidence suggests that the morning surge in blood pressure is crucial in determining the rupture of critically weakened arterial walls and subjects with a large surge in morning blood pressure have a significantly elevated risk of intracerebral ...