Retinal in Medical Technology

Tiny Cup Attached to Eye Improves Drug Delivery For Retinal Diseases

... for the sustained delivery of medicines for retinal and vitreous diseases, according to a new report ... normal vision. Currently, drugs for most retinal diseases are delivered either through an I.V. ... visits and can lead to vitreous hemorrhage and retinal detachment. Eye drops are also generally ...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

... of the PI3K/Akt/mTOR pathway showing efficacy in retinal scarring caused by retinal detachment - JAMAICA PLAIN, Mass., May 6 ... Photoreceptor Cell Death Following Experimental retinal Detachment", today at the annual meeting of the ...

Fovea Reports Positive Results with Prednisporin(TM) in Persistent Allergic Conjunctivitis

... of ocular diseases, with a special focus on retinal pathologies. Founded in May 2005, Fovea has ... on dry AMD, glaucoma (neuroprotection) and retinal dystrophies as well as clinical programs underway ... allergic conjunctivitis, diabetic macular edema, retinal vein occlusion, and retinitis pigmentosa. To ...

Sirion Therapeutics Announces Clinical Data Presentations at the 2009 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting

... ophthalmic emulsion) 0.05%, fenretinide, and retinal research programs from the Sirion San Diego, CA ... Therapeutics Poster Presentations Featuring retinal Research Accumulation of Toxic retinal Fluorophores in Various ...

Bayer and Regeneron Extend Development Program for VEGF Trap-Eye to Include Central Retinal Vein Occlusion

... of certain eye diseases, to include Central retinal Vein Occlusion (CRVO). The companies plan to ... CRVO is caused by obstruction of the central retinal vein that that leads to a back up of blood and fluid in the retina, resulting in retinal injury and loss of vision. The retina can also ...

Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting

... infarction, angina, pericardial effusion, retinal ischemia, retinal artery or vein thrombosis, blindness, decreased ... tachycardia, retinopathy including macular edema, retinal hemorrhage, cotton wool spots, papilledema, ...

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

... infarction, angina, pericardial effusion, retinal ischemia, retinal artery or vein thrombosis, blindness, decreased ... tachycardia, retinopathy including macular edema, retinal hemorrhage, cotton wool spots, papilledema, ...

Scientists Discover a Role for the Growth Factor TGF-beta in Maintaining Health of Retinal Blood Vessels

... in the retina and that blocking it can cause retinal dysfunction. These findings, published in the ... in understanding the changes that occur in the retinal microvasculature prior to the development of ... treated mice, the team found clear evidence that retinal blood vessels were losing their integrity -- ...

FDA Approves an Expanded Indication for Peginterferon-Based Combination Therapy for Patients With Chronic Hepatitis C

... infarction, angina, pericardial effusion, retinal ischemia, retinal artery or vein thrombosis, blindness, decreased ... tachycardia, retinopathy including macular edema, retinal hemorrhage, cotton wool spots, papilledema, ...

Quark Pharmaceuticals Announces First RNAi Drug Candidate Having a Novel, Proprietary Structure Covered by Quark Intellectual Property

... Effect of Quark's New RNAi Product on Dying retinal Ganglion Cells, a Cause of Blindness in Glaucoma ... activity towards RGCs. It significantly protected retinal neurons against delayed degeneration and reduced ... may be an effective neuroprotective therapy for retinal ganglion cells in acute injuries such as ...

Bayer and Regeneron Dose First Patient in Second Phase 3 Study for VEGF Trap-Eye in Wet Age-Related Macular Degeneration

... and anatomical endpoints, including retinal thickness, a measure of disease activity. The ... has the potential to significantly reduce retinal thickness and improve vision," said Kemal Malik, ... the gain in visual acuity and decrease in retinal thickness achieved at week 12 through week 32 of ...

Gene Therapy Improves Vision in Patients with Congenital Retinal Disease

... innovative treatment for this and possibly other retinal diseases. An international team led by The ... Eye Institute, have been researching inherited retinal degenerations such as Leber congenital amaurosis ... collecting and studying patients with inherited retinal diseases, under the supervision of Francesca ...

Gene Therapy Provides Vision to People who Were Nearly Blind

... reverse blindness in people with a variety of retinal degenerative diseases," says Jean Bennett, ... of Philadelphia (CHOP)-Penn Pediatric Center for retinal Degenerations in Philadelphia. More than 10 ... source of non-governmental funding for retinal degenerative disease research in the world. The ...

NeoVista Presents One Year Data on Novel Wet AMD Therapy at Macula Society

... to the vitrectomy procedure (retinal tear, retinal detachment, subretinal hemorrhage, and vitreous ... been reported to date. Jeffrey S. Heier, MD, a retinal specialist, partner at Ophthalmic Consultants of ... lesion without irreparably damaging the normal retinal vasculature. Utilizing strontium 90, the focused ...

MacuSight(TM) Announces Positive Preliminary Results From Phase 1 Study of Sirolimus in Wet Age-Related Macular Degeneration

... in visual acuity consistent with anatomical retinal changes were observed following a single ... scientific advisory board, managing partner, retinal Consultants of Arizona, Phoenix AZ, ... as demonstrated by a reduction in retinal thickness. These preliminary findings ...

St. Jude Defines Eye Cancer Gene's Role in Retinal Development

... important aspect of this coordination is that retinal thickness be the same, irrespective of eye size. ... smaller than that of the elephant eye, but the retinal thickness in these two species is comparable." ... that N-myc plays a central role in coordinating retinal proliferation with eye growth during ...

Fovea Pharmaceuticals Receives Orphan Drug Designation from EC for RdCVF for the Treatment of Retinitis Pigmentosa

... to improve the survival and the functionality of retinal cone cells that are responsible for ... Classically in affected people, the retinal rod photoreceptors responsible for night vision ... of ocular diseases, with a special focus on retinal pathologies. Created in May 2005, Fovea has a ...

Research Highlights Potential Benefits of Telemedicine in Treating Eye Disease

... over the course of a year who had the recommended retinal examination before the installation of a ... number of patients with diabetes who had a retinal examination in the two years following ... we've dramatically increased the rate of annual retinal evaluations." In the first year, out of 1,257 ...

Ellex 2RT Study Demonstrates Clinical Efficacy in Treatment of Diabetic Macular Edema

... improve and stabilize visual acuity and to reduce retinal edema in patients with diabetic maculopathy and ... 2RT's potential as an early stage therapy for retinal diseases." ABOUT THE CLINICAL TRIAL The ... laser therapy for the treatment of AMD and other retinal diseases. The grant was applied for in order to ...

5-Year Study Published in Diabetologia Demonstrated Long-Term Safety of Lantus(R) Compared to NPH

... open-label study was specifically designed to further characterize the retinal safety profile of Lantus(R) versus NPH in 1024 patients (Lantus(R) once ... study This long-term study was designed to further characterize the retinal safety profile of insulin glargine (glargine) and human neutral protamine ...

NeoVista Unveils 18-month Data on Novel Wet AMD Therapy at Retina Society Meeting

... of adverse events were related to the vitrectomy procedure (retinal tear, retinal detachment, subretinal hemorrhage, and vitreous hemorrhage), rather than ... the peak dose of energy directly to the lesion without damaging the normal retinal vasculature. Utilizing strontium 90, the focused energy is delivered to a ...

Alimera Reports Results From the Three-Month Interim Readout of the Human PK Medidur(TM) FA Study

... similar to an intravitreal injection, a procedure commonly employed by retinal specialists. This three-month interim readout from the PK Study ... dose and the high dose of Iluvien resulted in a significant reduction in retinal thickness as compared to the baseline. From a safety perspective, no ...

ThromboGenics Completes Patient Enrolment in the Phase IIb Trial of Microplasmin in Vitrectomy (MIVI III)

... carried out in the treatment of many back of the eye diseases such as retinal detachment, diabectic vitreous hemorrhage and macular hole. Vitrectomy is ... to this surgery including bleeding, infection, increased eye pressure, retinal detachment, and development of cataracts. As Microplasmin could induce a ...

Enrollment Complete in Pivotal Phase 3 Trial of Medidur(TM) FA for Diabetic Macular Edema

... as this brings us closer to taking Medidur FA, the next generation of retinal drug delivery, to market and to our ultimate goal of delivering treatments ... of diabetic retinopathy, patients can develop DME which involves retinal thickening of the macular area. More than 500,000 people live with DME in ...

MacuSight(TM) Announces Positive Initial Results From Phase 1 Study of Sirolimus in Diabetic Macular Edema

... surgery, department of ophthalmology, University of Arizona, partner at retinal Consultants of Arizona in Phoenix, Arizona, and the study's lead ... (DME) is a serious manifestation of diabetic retinopathy that involves retinal swelling brought on by the leaking of fluid from small blood vessels ...

ThromboGenics' Microplasmin Phase III Program Progressing According to Schedule

... vitreous gel, in the center of the eye, has an abnormally strong adhesion to the retina at the back of the eye. These adhesions can cause vessel and retinal distortion which results in deterioration in the patient's vision. Moreover, vitreomacular adhesion is thought to play a key role in numerous back of ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... and Head of Translational Medicine at Isis Pharmaceuticals. Isis scientists presented new data demonstrating that antisense reduction of retinal binding protein 4 (RBP4) caused significant improvements in insulin sensitivity with associated improvement in cardiac glucose metabolism. These ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... and hemorrhagic/ischemic colitis), pancreatitis, and ophthalmologic disorders (decrease or loss of vision, retinopathy including macular edema and retinal thrombosis/hemorrhages, optic neuritis and papilledema). Adverse reactions reported during post-approval use of PEGASYS therapy, with and ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

... and hemorrhagic/ischemic colitis), pancreatitis, and ophthalmologic disorders (decrease or loss of vision, retinopathy including macular edema and retinal thrombosis/hemorrhages, optic neuritis and papilledema). Adverse reactions reported during post-approval use of PEGASYS therapy, with and without ...

Alimera Sciences' Iluvien(TM) Phase 3 Studies for DME Pass Final DSMB Review Prior to October Readout

... needle, which allows for a self-sealing wound. This insertion is very similar to an intravitreal injection, a procedure commonly employed by retinal specialists. Currently, nearly 24 million people, or 8 percent of the population, in the U.S. have diabetes. Over time, all diabetics are ...

Alimera Reports Favorable Safety and Efficacy Results From the 12-Month Interim Readout of the Human PK Iluvien(TM) Study

... needle, which allows for a self-sealing wound. This insertion is very similar to an intravitreal injection, a procedure commonly employed by retinal specialists. About Alimera Sciences, Inc. Alimera Sciences is a biopharmaceutical company that specializes in the research, development ...

ESBATech's Antibody Fragment Enters Phase Ib/IIa in Ophthalmology

... If poorly controlled, a condition called macular edema can be caused by inflammation, which when becoming chronic, leads to permanent damage to the retinal architecture and loss of visual acuity. About ESBATech's Antibody Fragment Platform Technology ESBATech is the first and only company to ...

Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs

... likely to be limited to immune-privileged sites in the body, such as the use of cells in the central nervous system, or the transplantation of ACT's retinal cells into the eye to prevent blindness. "Producing millions of patient-specific stem cell lines is commercially unviable," stated William M. ...

ThromboGenics Begins Phase III Program With Microplasmin for the Non-surgical Treatment of Back of the Eye Disease

... vitreous gel, in the center of the eye, has an abnormally strong adhesion to the retina at the back of the eye. These adhesions can cause vessel and retinal distortion which results in deterioration in the patient's vision. Moreover, vitreomacular adhesion is thought to play a key role in numerous back of ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... Auditory (high-frequency hearing loss, decreased hearing) and ocular (lens opacities, cataracts, elevations in intraocular pressure and retinal disorders) disturbances have been reported with Exjade therapy in less than 1% of patients in clinical trials. Auditory and ophthalmic testing ...

Schering-Plough Provides Update on Boceprevir Clinical Development and Introduces Potent Next-Generation Oral HCV Protease Inhibitor for Treating Patients With Chronic Hepatitis C

... pulmonary infiltrates, pneumonitis and pneumonia, some resulting in patient deaths), urticaria, angioedema, bronchoconstriction, anaphylaxis, retinal hemorrhages, and cotton wool spots. In the PEGINTRON/REBETOL combination trial, the incidence of serious adverse events was 17% in the ...

Durezol(TM) in the Treatment of Uveitis and Ganciclovir in the Treatment of Herpetic Keratitis: Studies of Treatments for Leading Causes of Blindness to Be Presented

... uveitis can cause debilitating pain and photophobia as well as permanent damage and vision loss due to the development of glaucoma, cataract or retinal edema. Dr. Kaufman's poster, "Data from Trials Evaluating Ganciclovir Ophthalmic Gel, 0.15% and Acyclovir Ophthalmic Ointment, 3% for ...

New Study Shows that PEGASYS(R) Regimen Provides Higher Sustained Virological Response Rates for Hepatitis C Patients

... and hemorrhagic/ischemic colitis), pancreatitis, and ophthalmologic disorders (decrease or loss of vision, retinopathy including macular edema and retinal thrombosis/hemorrhages, optic neuritis and papilledema). Adverse reactions reported during post-approval use of PEGASYS therapy, with and without ...

DSMB Again Supports Continuation of Alimera Sciences' Phase 3 Clinical Trial of Iluvien(TM) for the Treatment of DME

... 25-gauge needle, which allows for a self-sealing wound. This insertion is very similar to an intravitreal injection, a procedure commonly employed by retinal specialists. Currently, nearly 24 million people, or 8 percent of the population, in the U.S. have diabetes. Over time, all diabetics are at risk ...

Encouraging Gene Therapy Results in Genetic Form of Blindness

... the authors reported no vector-related serious adverse events, immune reactions, or systemic toxicity. "Human ocular gene therapy for inherited retinal disease is undergoing a birth experience as early phase trials report efficacy and safety. LCA can now be redefined as a potentially curable eye ...