Responsiveness in Medical Technology

New Studies Presented at European Society of Anaesthesia Further Validate Masimo PVI(TM) for Noninvasive and Continuous Fluid Monitoring

... continuous measure of patient fluid status and responsiveness were presented this week at the European Society ... and newer more reliable methods to predict fluid responsiveness are also invasive and costly. Multiple recent ... suggest that an accurate prediction of fluid responsiveness can be obtained non-invasively using the PVI."(1) ...

Study Shows Benefits of a High Omega-3 Diet in Older Adults

... Hormones and Metabolic Research. "As we age, hormone secretion and cell responsiveness decrease, possibly due to loss of cell membrane fluidity or alteration of ... inflammatory markers," said Harman. "However, it did not alter endocrine responsiveness after eight weeks." These findings are consistent with other studies ...

Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity

... of the United States of America, in a scientific paper entitled, "Leptin responsiveness Restored by Amylin Agonism in Diet-Induced Obesity: Evidence from ... the PNAS publication provide preclinical and clinical evidence that leptin responsiveness is at least partially restored by amylin agonism. In several independent ...

Sirius Genomics Announces New Collaboration with Assistance Publique-Hopitaux de Paris

... correlations in severe sepsis patients. The agreement focuses on the continued development of Sirius' pharmacogenomic diagnostic intended to assess responsiveness to recombinant human activated Protein C (sold by Eli Lilly and Company under the trademark Xigris (R)) in patients with severe sepsis at high risk ...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

... 2009, Session Time: 2:00PM - 6:00PM. # 8062 Lynch, T. J. et al. "Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib." N. Engl. J. Med. 350, 2129-2139 (2004). Available at: ...

Gene Abnormality Found to Predict Childhood Leukemia Relapse

... disease, another measure of treatment response in ALL. "Measurement of levels of minimal residual disease is widely used to monitor treatment responsiveness and also to alter patients' therapy if they have a very poor response to treatment," said James Downing, M.D., St. Jude scientific director and the ...

FDA Approves LUSEDRA(TM) (fospropofol disodium) Injection for Monitored Anesthesia Care (MAC) Sedation

... was reported in 20/455 (4%) patients treated with LUSEDRA using the standard or modified dosing regimen. Retention of purposeful responsiveness did not prevent patients from becoming hypoxemic following administration of LUSEDRA. -- Respiratory depression -- Apnea was ...

Agendia's MammaPrint(R) Predicts Response to Neoadjuvant Chemotherapy in Breast Cancer

... believe it provides them with invaluable information for patient treatment planning. MammaPrint's ability to accurately determine high risk patient responsiveness to chemotherapy both confirm and speak to the confidence physicians express in this state-of-the-art genomic breast cancer test," commented Dr. ...

St. Jude Identifies Genomic Causes of a Certain Type of Leukemia Relapse

... called B cells mature and proliferate. Importantly, the relapse-related genetic changes only infrequently involved genes directly regulating the responsiveness to anti-cancer drugs. The analysis also indicated that in most cases, the cancer cells responsible for relapse were related to those that ...

Amylin Pharmaceuticals to Present Novel Data on Promising Obesity Pipeline at 2008 Annual Scientific Meeting of The Obesity Society

... Academy of Sciences of the United States of America, demonstrates that, when pramlintide and metreleptin are administered in combination, leptin responsiveness is at least partially restored by amylin agonism. Experiments in diet-induced obese rats co-administrated with amylin and leptin resulted in ...

Accumetrics Announces the Launch and First Patient Enrolled Into the GRAVITAS Trial

... SAN DIEGO, June 16 /PRNewswire/ -- Patient enrollment into the GRAVITAS (Gauging responsiveness With A VerifyNow(R) Assay-Impact On Thrombosis And Safety) trial has begun, officials from Accumetrics announced today. The GRAVITAS trial is ...

Schering-Plough To Initiate Phase III Studies With HCV Protease Inhibitor Boceprevir in Previously Untreated Hepatitis C Patients and Those Who Failed Prior Treatment

... The study is projected to enroll a total of 375 patients. This study will enroll treatment-failure patients who have documented previous interferon responsiveness by achieving at least a 2 log decrease in viral load by week 12 of peginterferon and ribavirin therapy (nonresponders) or who were viral negative at ...

Data Published at ASCO Find Correlation Between ChemoFx(R) Assay and Significantly Improved Overall Survival in Patients With Ovarian Cancer

... tumor response. The analysis found that median OS could be extended as much as 23 to 38 months. "These overall survival data demonstrate that the responsiveness to treatment established by this sensitivity assay in the laboratory setting, may in fact translate into meaningful clinical outcomes for patients," ...

HistoRx and Radiation Therapy Oncology Group Initiate Brain Tumor Biomarker Research Partnership

... develop customized immunohistochemical assays to be used by RTOG in investigating the relationship between specific protein biomarkers and clinical responsiveness in brain tumor patients. HistoRx intends to commercialize assays and reagents developed in the course of the collaboration for clinical use as ...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

... increase in measured change in static beta cell responsiveness compared with metformin alone (20.1, JANUVIA 50 ... increase in measured change in dynamic beta cell responsiveness compared with metformin alone (151.0, JANUVIA 50 ... glucagon concentrations, and increased responsiveness of insulin release to glucose, resulting in ...

IR BioSciences Announces Promising Data from Study of Its Compound Homspera

... in conjunction with GenPhar Inc. indicates Homspera elevates host immune responsiveness above that induced by vaccine alone system. These results are from an ... capabilities, and thus be capable of augmenting host immune system responsiveness to vaccines for diseases such as pandemic avian influenza, ...

Pharmaxis Reports Phase II Results for Aridol in COPD

... of respiratory symptoms and worsening of the patients health.1 Pharmaxis CEO Dr Alan Robertson said: "The finding that airway hyper- responsiveness improved in trial subjects after taking a short course of inhaled steroids is important, and new, and clinically valuable. The presence of ...

Alnylam and Stanford University Scientists Discover New Role for microRNAs (miRNAs) in T Cell Biology and Immunity

... to increase T cell sensitivity to antigens, while inhibiting miR-181a was found to decrease the immune response. miR-181a was found to regulate the responsiveness of the T cell receptor to antigens by the coordinated down-regulation of a set of phosphatase genes. Inhibiting miR-181a function with a selective ...

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

... inhibition resulted in a 2- to 3-fold increase in circulating levels of active GLP-1 and GIP, decreased glucagon concentrations, and increased responsiveness of insulin release to glucose, resulting in higher C-peptide and insulin concentrations. The rise in insulin with the decrease in glucagon ...