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Definitive Outcomes of Radiofrequency Ablation for Barrett's Esophagus Using the HALO Ablation System Reported at the Digestive Disease Week Meeting for Gastroenterologists and Esophageal Surgeons

... after 2 years, compares favorably with endoscopic resection for advanced disease, and reduces the risk for ... that were randomized to receive either endoscopic resection or radiofrequency ablation with the HALO ablation ... complete eradication rates (95-100%), endoscopic resection was associated with a significantly higher risk ...

Early Esophageal Cancer and Pre-Cancer Eliminated With Non-Surgical Treatment Combination

... and pre-cancerous dysplasia using endoscopic resection followed by ablation therapy with the HALO ... cancer and/or advanced dysplasia, used endoscopic resection to remove focal abnormal areas, then ... with this non-surgical approach using endoscopic resection and ablation," said Amsterdam Medical Centre ...

Progen Announces Commencement of Global Phase 3 Study for PI-88 in Post- Resection Liver Cancer

... carcinoma, HCC) following curative resection with the first patient having been ... the efficacy and safety of PI-88 in the post resection liver cancer setting. The trial will recruit ... surgery and five-year survival following resection is less than 50%. Dr. James Garner, Progen's ...

Progen Provides Update on Phase 3 Clinical Program for PI-88 in Liver Cancer

... data from a randomized phase II trial in the post resection liver cancer setting was presented at the ... The phase 3 study investigating PI-88 as a post- resection treatment for hepatocellular carcinoma (HCC, primary liver cancer) following curative resection is a double-blinded, placebo-controlled study, ...

Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients

... for the treatment of patients with colorectal cancer (CRC) after complete resection of liver metastases. The trial has three arms comparing single agent ... their disease. The only chance of long-term survival comes with curative resection of hepatic metastasis by liver surgery with reported five and 10 year ...

Oncolytics Biotech Inc. Announces Start of Patient Enrolment in Translational Clinical Trial Investigating REOLYSIN(R) in Patients with Metastatic Colorectal Cancer

... in patients with metastatic colorectal cancer prior to surgical resection of liver metastases. The principal investigator is Professor Alan Melcher ... proven colorectal cancer, planned for potentially curative surgical resection of liver metastases. Up to 20 patients will receive one cycle of treatment ...

Huntington Hospital Surgeon Performs First Single Port Resection on Colorectal Cancer Patient in CA

... of the Huntington Hospital Cancer Center, performed the first single-port resection on a colorectal cancer patient in California last week. In a typical resection there are three ports involved in a minimally invasive procedure, or one ...

Multi-Centre European Clinical Trial Shows Advanced Dysplasia and Early Cancer of Esophagus Cured With Combined Endoscopic Resection and Radiofrequency Ablation With HALO Ablation System

... esophagus, dysplasia and early cancer, were staged with endoscopic mucosal resection and then treated with the endoscopic radiofrequency ablation using the ... in using the HALO Ablation System in conjunction with endoscopic resection to cure patients with advanced dysplasia or early cancer of the ...

Radioactive Seed Therapy Shows Significant Reduction in Lung Cancer Recurrence

... complications or other co-morbidities. In these cases, sublobar wedge resection is a more tolerable approach, but one that carries a much higher chance of ... appear that those odds may be improved considerably by combining sublobar resection with intraoperative mesh brachytherapy," said Robert Keenan, M.D., ...

Bradmer reports progression free survival data from previous Phase II glioblastoma multiforme trials

... markets. The current standard of care for GBM patients is surgical resection followed by radiation and temozolomide. GBM tumors typically have ... surgery. The Neuradiab(TM) therapy is delivered directly into the surgical resection cavity in a separate procedure after the initial surgery. Neuradiab(TM) ...

Data Confirm Avastin(R) Helps Patients With Metastatic Colorectal Cancer Live Even Longer

... considered inoperable. The data showed: - The overall success rate of resection surgery in patients with metastatic CRC reached an impressive 79% in the ... - Patients who received Avastin plus chemotherapy and underwent complete resection of their tumor had almost double the chance of surviving at 2 years ...

Eisai's Commitment to Oncology Demonstrated by Clinical Data to be Presented at ASCO Annual Meeting

... wound healing and brain edema. Communication between the surgical resection cavity and the ventricular system should be avoided to prevent the wafers ... the head may demonstrate enhancement in the brain tissue surrounding the resection cavity after implantation of Gliadel. This enhancement may represent edema ...

IDM Pharma Announces Phase 3 Mifamurtide (L-MTP-PE) Study Demonstrating Improved Survival Published in the Journal of Clinical Oncology

... cisplatin, doxorubicin, and methotrexate and underwent definitive surgical resection of primary tumor. Patients were randomly assigned to receive or not to ... since the mid-1980s. The standard treatment for osteosarcoma is tumor resection with combination chemotherapy before and after surgery. About IDM ...

Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM)

... the bladder that has not yet spread into the deeper muscle layer. This form of bladder cancer is treated predominantly by urologists using surgical resection and intravesical infusion therapy. Urocidin is an intravesical infusion therapy, administered via trans-urethral catheter into the bladder. ...

ThermoGenesis Announces National Institute of Health Grant

... blood processing disposable, used to prepare fibrin sealants from plasma in about an hour. The CryoSeal FS System is approved in the U.S. for liver resection surgeries. The CryoSeal FS System has received the CE-Mark which allows sales of the product throughout the European community. Asahi Medical is ...

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

... being developed under a collaboration with Merck Serono. Adecatumomab is in a phase 2 clinical trial in colorectal carcinoma patients after complete resection of liver metastases, and a phase 1b clinical trial evaluating adecatumumab in combination with docetaxel for the treatment of patients with ...

Micromet Presents Update on Blinatumomab's Response Rate and Duration in a Phase 1 Study in Non-Hodgkin's Lymphoma Patients

... being developed under a collaboration with Merck Serono. Adecatumomab is in a phase 2 clinical trial in colorectal carcinoma patients after complete resection of liver metastases, and a phase 1b clinical trial evaluating adecatumumab in combination with docetaxel for the treatment of patients with ...

Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer

... of radiation. Twenty-three eligible patients were enrolled at the time of abstract submission. Five of the first 11 patients (45%) who underwent resection had a pathologic complete response. A prophylactic feeding tube was not routinely used. Grade 3-4 toxicity in the first 15 patients included ...

Glivec(R) is the First Adjuvant Treatment Approved in the UK to Delay Return of Gastrointestinal Cancer After Surgery

... Last accessed 7 May 2009 2. DeMatteo, R. et al. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. The Lancet. Online publication 19/03/09. ...

ThermoGenesis Announces MXP Involvement in New Regenerative Medicine Initiatives

... processing disposable, is used to prepare fibrin sealants from plasma in about an hour. The CryoSeal FS System is approved in the U.S. for liver resection surgeries. The CryoSeal FS System has received the CE-Mark which allows sales of the product throughout the European community. Asahi Medical is the ...

Micromet Key Events for 2009

... Merck-Serono is expected to start a randomized, controlled, multicenter phase 2 clinical trial in relapsed colorectal cancer patients after complete resection of liver metastasis in Q1 2009; -- Blinatumomab, a CD19-targeting BiTE antibody in development with MedImmune, is expected to start an ...

Rexin-G Controls Tumor Growth and Improves Survival in Chemotherapy-Resistant Soft Tissue Sarcoma and Osteosarcoma: Phase I/II & Confirmatory Phase II Studies

... greater than seven months; that is, after failing standard chemotherapies. Two patients are disease-free greater than 6 months after surgical resection of residual tumors and Rexin-G given as both neoadjuvant and adjuvant monotherapy. These studies indicate that (i) intravenous Rexin-G is safe and ...

NCI Funded Clinical Trial to Study Treatment of Breast Cancer Using Cryoablation

... Chicago. Both the pilot study and pending ACOSOG clinical trial share the common clinical protocol elements of cryoablation followed by MRI, surgical resection of the tumor and subsequent pathological evaluation. "Cryoablation has been used effectively for years to treat a number of medical conditions, ...

Micromet Presents Data at ESMO 2008 on Anti-EpCAM Antibody Adecatumumab (MT201) in Combination with Chemotherapy

... Micromet is also in the process of setting up a randomized phase 2 clinical trial in patients suffering from colorectal cancer (CRC) after complete resection of first liver metastases. (1) First results from a Phase 1b study of the anti-EpCAM antibody adecatumumab (MT201) in combination with docetaxel in ...

Bayer and Onyx Begin Enrollment in STORM Trial Studying Nexavar as Adjuvant Therapy for Patients With Liver Cancer

... the United States.(1,2) Currently there are no adjuvant treatments with proven benefit in HCC and half of the patients who have undergone surgical resection or local ablation will see their tumors return within three years and 70 percent will see their tumors return within five years.(3) Nexavar's ...

Rosetta Genomics and M. D. Anderson to Develop a MicroRNA-based Diagnostic Test to Identify Risk of Recurrence of Lung Cancer

... risk of disease recurrence in lung cancer patients who have undergone curative resection. Current treatment for lung cancer includes surgical resection which may be followed by adjuvant therapy. While patients with high risk of recurrence may benefit from adjuvant therapy, those with low risk ...

BioVex Reports Positive Phase II Clinical Trial Results of OncoVEX GM-CSF in Metastatic Melanoma at the 2008 American Society of Clinical Oncology Meeting

... is 120,000 and median survival for Stage IV disease is six months. Treatment of melanoma depends on the stage of the disease, with surgical resection being effective in less severe, non-metastatic forms of the disease. However, survival rates for later Stage III and IV patients are poor, reflecting ...

New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma

... have led to a Phase III safety and efficacy trial in MAGE-A3-positive NSCLC patients (stage IB, II and IIIA) who have undergone complete surgical resection (MAGRIT; MAGE-A3 Adjuvant Non-Small Cell LunG CanceR ImmunoTherapy). At this year's ASCO, GSK also presented data regarding the use of the genetic ...

Perioperative Eloxatin(R)-Based Regimen Significantly Reduced the Risk of Relapse Versus Surgery Alone in Eligible Colorectal Cancer Patients with Initially Resectable Liver Metastases

... 36.2%) versus surgery alone (Hazard Ratio (HR) of 0.77; Confidence Interval (CI): 0.60-1.00; p=0.041). Among patients who were also able to undergo resection of the liver metastases, post-entry (n=303), perioperative FOLFOX4 significantly improved PFS by 9.2% (from 33.2% to 42.4%) compared with surgery ...

NPS Reports Successful GATTEX(TM) Extension Study

... highly disabling condition that impairs quality of life and can lead to serious life-threatening complications. SBS typically arises after extensive resection of the small bowel. There are an estimated 10,000 to 15,000 SBS patients in North America who are PN-dependent, the cost of which can exceed $100,000 ...

Anti-Cancer Drug CYT997 Update

... in combination with two other approved anti-cancer agents. GBM is an aggressive brain tumor commonly treated with radiotherapy, surgical resection and chemotherapy. Unfortunately, many patients relapse and subsequently have very poor prognoses. Experimental therapies which attack GBM blood ...

Inclusion of Six-Year Overall Survival Data in the Eloxatin(R) (oxaliplatin injection) Prescribing Information Granted FDA Priority Review

... regimen for their Stage III colon cancer patients." In the MOSAIC trial, Stage III colon cancer patients treated after complete surgical resection of the tumor with Eloxatin in combination with infusional 5-FU/LV had a significant reduction (20%) in the risk of dying after a median of six years ...

IDM Pharma Announces Non-Binding Opinion of the European Committee for Medicinal Products for Human Use (CHMP) that Mifamurtide (L-MTP-PE) Provides a Possible Clinical Benefit in Survival

... Group, the survival of children with osteosarcoma has remained at 60-65 percent since the mid-1980s. The standard treatment for osteosarcoma is tumor resection with combination chemotherapy before and after surgery. About IDM Pharma IDM Pharma is focused on the development of innovative cancer ...

Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases

... blood vessels) and metastasis (the spread of cancer to other sites) -- critical to the growth and progression of cancer. In a Phase 2 trial in post- resection liver cancer, 160mg of PI-88 demonstrated a 25% improvement in the primary endpoint of disease-free rate at 48 weeks and 78% improvement in secondary ...

IDM Pharma Announces Updated Phase 3 Mifamurtide (L-MTP-PE) Data Confirms Statistically Superior Overall Survival in Osteosarcoma Patients

... Group, the survival of children with osteosarcoma has remained at 60-65 percent since the mid-1980s. The standard treatment for osteosarcoma is tumor resection with combination chemotherapy before and after surgery. About IDM Pharma IDM Pharma is focused on the development of innovative cancer ...

Avastin Achieves Impressive Rate of Curative Surgery in Patients with Advanced Colorectal Cancer

... as first line treatment and were assessed for their suitability for potentially curative surgery during the course of the treatment. "The complete resection of metastatic lesions is the only option for cure in patients with metastatic colorectal cancer. Therefore these results represent a major step ...

The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved Progression Free Survival When Given Before and After Surgery in Patients With Resectable Liver Metastases From Colorectal Cancer

... by 27% (HR=0.73, p=0.025) among patients for whom resection was successful. When evaluating results among all ... who were not able to undergo liver metastases resection or were ineligible, FOLFOX4 did not significantly ... showed that FOLFOX4 given before resection did not prevent patients' ability to undergo ...

Molecular Target of Bradmer's Neuradiab Further Validated by Independent Findings

... markets. The current standard of care for GBM patients is surgical resection followed by radiation and temozolomide. GBM tumors typically have ... surgery. The Neuradiab therapy is delivered directly into the surgical resection cavity in a separate procedure after the initial surgery. Neuradiab ...

Progen's Phase 2 Liver Cancer Trial Exceeds Efficacy Objective

... "These Phase 2 data clearly support the conclusion that PI-88 has the potential to extend the disease-free survival time of patients with post- resection liver cancer, who have few if any treatment options and a high likelihood of disease recurrence," said Professor Pei-Jer Chen, Director of the ...
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Breaking Biology News(10 mins):For children with pacemakers, 'self-competence' affects quality of life 2New diagnostic test to distinguish psoriasis from eczema 2
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