Relapse in Medical Technology

Video: FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia

... for schizophrenia, the symptoms and the risk of relapse (an exacerbation of symptoms) can be managed in ... with schizophrenia experience at least one relapse within five years of diagnosis(2), and the risk for relapse in patients can substantially increase as a ...

Acute Lymphoblastic Leukemia, the Most Common Childhood Cancer, Is Curable Without Preventive Cranial Radiation

... use, and only patients at highest risk for relapse have received cranial radiation. Now, St. ... identified many important risk factors for CNS relapse and optimized chemotherapy treatment, leading to ... Worth, Texas, between 2000 and 2007. The risk of relapse was determined by measurement of residual ...

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

... to explore potential of Afinitor to prevent relapse in patients with the most common type of ... However, NHL patients have a high risk of relapse after initial therapy and no treatments are ... for a Phase III study of Afinitor to prevent relapse in patients with diffuse large B-cell lymphoma, ...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

... (RLAT) significantly delayed the time to relapse compared to placebo in patients with Bipolar I ... placebo group. The primary endpoint was time to relapse of any mood episode (depression, mania, or mixed). Time to relapse was significantly longer in patients receiving ...

Two-Year Phase III Data Presented at AAN 61st Annual Meeting Show Positive Outcome of Cladribine Tablets in Patients With Multiple Sclerosis

... Endpoint met With a Significant Reduction in relapse Rate - Secondary Endpoints met Including MRI ... a 58% relative reduction in annualized relapse rates with respect to placebo (0.14 versus 0.33 ... a 55% relative reduction in annualized relapse rates with respect to placebo (0.15 versus 0.33; ...

Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting

... the primary endpoint of the study. relapse rates between these two arms also were not ... duration or a reduced PEGINTRON dose on SVR and relapse rates among treatment-naive G2/3 patients in an ... (129/228). Neither co-primary endpoint was met. relapse rates were lower with 24 weeks compared to 16 ...

Gene Abnormality Found to Predict Childhood Leukemia Relapse

... in a gene that predict a high likelihood of relapse in children with acute lymphoblastic leukemia ... only 30 percent of children who experience a relapse of ALL will survive five years. Determining the risk of relapse faced by an individual patient would help ...

St. Jude Identifies Genomic Causes of a Certain Type of Leukemia Relapse

... the majority of acute lymphoblastic leukemia relapse cases arise from a cell already present at the ... offers a pathway to designing treatments for ALL relapse in children and, ultimately, in adults. ... more than 80 percent of ALL cases are cured, relapse is a significant problem, with only 30 percent of ...

European CHMP Issues Positive Opinion on Cymbalta for the Treatment of Generalised Anxiety Disorder

... double-blind placebo-controlled studies and a relapse prevention study -- involving more than 2,000 ... significantly decreased the likelihood of relapse in those patients who initially responded ... (7) Davidson JRT, et al. Duloxetine treatment for relapse prevention in adults with generalized anxiety ...

Patients Treated with Risperidone Long-Acting Injection had a Significantly Longer Time to Relapse Compared to Quetiapine in International Clinical Study

... their medication treatment, which can result in a relapse of symptoms (1,2). Today, data from a new ... had a significantly longer time to relapse (3) compared to patients treated with an oral ... Furthermore, over the 24-month treatment period, relapse occurred in 16.5 percent of patients treated with ...

Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL)

... treatment milestones and significantly lower relapse rates after the end of treatment than Pegasys and ... 81 vs. 83 vs. 74 percent, respectively).(5) -- relapse after the end of treatment was lower for patients ... (23%) group. Additional Safety Information relapse of drug addiction/overdose has occurred in ...

Vermillion and the Ohio State University Report That Novel Diagnostic Test May Help Predict Risk for Relapse of TTP, A Serious Blood Disorder

... from prophylactic treatment to help prevent relapse of this serious blood disorder. TTP is caused by ... based upon their increased risk for relapse of this devastating blood disorder." The study ... be used to help screen for the risk of relapse in patients with TTP. About the Study ...

FTY720, a novel oral therapy in development for MS, shows sustained benefits for the majority of patients after three years of treatment

... 36-month data also showed an average annualized relapse rate of 0.20, equivalent to one relapse in five years, while 89% of patients were free of ... trial showed that FTY720 reduced relapse rates by more than 50% compared to placebo. ...

Clinical Studies of OvaRex in Advanced Ovarian Cancer Fail to Meet Primary Endpoint

... potential of OvaRex to extend the time to disease relapse among patients who had successfully completed ... respond to surgery and chemotherapy, the relapse rate is high and once relapse occurs, there is no known curative therapy. ...

FDA Approves Cymbalta(R) for Maintenance Treatment of Major Depressive Disorder

... experienced a statistically longer time to relapse of depression than did patients on placebo. relapse was defined as an increase of two or more points ... DG, et al. 2006. Duloxetine in the prevention of relapse of major depressive disorder: double-blind ...

SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia

... in the placebo group (p<0.0001). Differences in relapse rate between active treatment and placebo were ... evidence for reducing the risk of relapse when these patients are treated with SEROQUEL ... was the time from randomization to psychiatric relapse (hospitalization for worsening schizophrenia, ...

New Analyses of Long-Term LIALDA(TM) (mesalamine) Data Presented at ACG

... Irrespective of Patient's Previous relapse History Poster Presentation: Sunday, October 14, ... study 303 was done to understand the effect of relapse history in patients with mild-to-moderate ... therapy. A total of 438 patients with complete relapse records at baseline (prior to enrolling in either ...

Glivec(R) is the First Adjuvant Treatment Approved in the UK to Delay Return of Gastrointestinal Cancer After Surgery

... if left untreated after surgery, almost 50% of all patients suffer a relapse within two years and recurrent tumours are often more aggressive and more ... Glivec is now licensed to be used to treat patients at significant risk of relapse following the removal of their tumour following approval from the European ...

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

... was associated with increased viral breakthrough during treatment, higher relapse rates after the end of treatment and lower SVR, strongly indicating that ... suicidal ideation, severe depression; psychosis, aggressive reaction, relapse of drug addiction/overdose; nerve palsy (facial, oculomotor); ...

Research Explores the Effects of Stem Cell Source and Patient Age on Stem Cell Transplantation Outcomes

... chronic graft-versus-host disease (36-53 percent at two years). Rates of relapse were similar across all age groups (29-30 percent at three years). ... and overall survival at one year and for transplant-related mortality and relapse at two years. Patients' general health and degree of tissue-type match ...

Schering-Plough Unveils Top-Line Study Results for SAPHRIS(TM) (asenapine) Demonstrating Efficacy in Long-Term Schizophrenia Relapse Prevention

... SAPHRIS(TM) (asenapine) demonstrating efficacy and safety in preventing relapse of schizophrenia. In this trial, asenapine was statistically ... asenapine (5 or 10 mg BID) compared to placebo in the prevention of relapse in patients with schizophrenia. A total of 700 patients entered the ...

Study Shows Pine Bark Naturally Reduces Knee Osteoarthritis

... after treatment with Pycnogenol is terminated and the results show that no relapse occurred after two weeks. Pycnogenol acts as potent anti-inflammatory and ... for individuals. This is the first study that investigated whether a relapse of symptoms occurs after taking Pycnogenol is stopped. The results show a ...

Sequential R-CHOP and Ibritumomab Tiuxetan (Zevalin(R)) Regimen Produces Impressive Survival Rates in High Risk Elderly Patients With Untreated Aggressive Diffuse Large B-cell Lymphoma

... is an important unmet need since the outcome is poor for patients who relapse with this disease and who cannot tolerate intensive salvage therapy and ... of elderly patients with high risk diffuse large B-cell lymphoma (DLBCL) relapse after treatment with R-CHOP. Treatment options for patients who are ...

New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma

... it may be possible to identify patients that present a high or low risk of relapse after surgery. A gene signature similar to that observed in melanoma was ... of the predictive gene signature, a 43% reduction in the relative risk of relapse was observed(3). (Data on file). Based on these encouraging data in ...

Discovering How Video Games Can Motivate Healthy Behaviors: More than $2 Million Awarded to 12 Research Teams Across U.S.

... of Central Florida, College of Medicine (Orlando, FL) - Practicing relapse Prevention in Artificial-Reality Environments: [PREPARE]: A Game-Based ... to practice skills that can help them prevent real-world relapses. The relapse prevention games are embedded as mini-games within an extensive ...

Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Hepatitis C Data Presentations at Digestive Disease Week (DDW) Annual Meeting

... 8:00 a.m. - 5:00 p.m., Sails Pavilion. Sustained Virologic Response and relapse Rates with Peginterferon Alfa-2b Plus Ribavirin in Clinical Trials Are ... compared to the flat-dosing (23%) group. Additional Safety Information relapse of drug addiction/overdose has occurred in patients on PEGINTRON therapy. ...

Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events

... iloperidone was statistically non- inferior to haloperidol in time to relapse (89.8 days with iloperidone vs. 101.8 days with haloperidol; p=0.764). Additionally, the three trials found similar relapse rates and improvements in CGI-C(5) and PANSS-T scores. Iloperidone's ...

Pegintron(TM) Plus Weight-Based Rebetol(R) Resulted in Higher SVR Than Flat Dosing; Low Relapse Rates in Patients With Chronic Hepatitis C

... REBETOL, the previously labeled dose. Importantly, the study reported low relapse rates consistent with other PEGINTRON studies.(3,4) "PEGINTRON and ... 34% of those receiving INTRON A/REBETOL. Additional Safety Information relapse of drug addiction/overdose has occurred in patients on PEGINTRON therapy. ...

Perioperative Eloxatin(R)-Based Regimen Significantly Reduced the Risk of Relapse Versus Surgery Alone in Eligible Colorectal Cancer Patients with Initially Resectable Liver Metastases

... (HR=0.73 (CI: 0.55-0.97, p=0.025)). "Seventy-five percent of patients relapse after liver metastases have been surgically removed. We found that the investigational use of perioperative FOLFOX4 reduces the risk of relapse by one fourth over surgery alone," said principal investigator Professor ...

Roche responds to announcement of 'IDEAL' hepatitis C trial results

... treatment is critical to achieving success and preventing treatment relapse in hepatitis C," said Douglas Dieterich, M.D., Professor of Medicine in ... a full dose of ribavirin has shown an important ability to reduce relapse following the end of treatment. "PEGASYS quickly became the market ...

'Brain Signature' for Cigarette Cravings Identified

... memory, and reward. "The craving assessments used in our study predict relapse in smoking cessation treatment," said Lerman. "If validated in larger ... MRI may aid in the identification of smokers at increased risk for relapse who may require more intensive therapy." This research was funded by ...

Nabi Biopharmaceuticals Announces Successful Completion of NicVAX(R) Phase 2b Trial; Drug Shows Statistically Significant Rates of Smoking Cessation and Continuous Long-Term Smoking Abstinence at 12 Months

... believes NicVAX(R) also could be effective in preventing smoking relapse. relapse is a significant challenge facing smokers and, with currently-available smoking cessation therapies, relapse rates can be as high as 90% in the first year after a smoker quits. ...

Schering-Plough Highlights PEGINTRON(TM) Clinical Data Presentations at the American Association for the Study of Liver Diseases (AASLD) 2007 Annual Meeting

... virologic response (SVR) rates across patient weights and consistently low relapse rates in a "real-life" treatment setting. Investigators also will present ... 34% of those receiving INTRON A/REBETOL. Additional Safety Information relapse of drug addiction/overdose has occurred in patients on PEGINTRON therapy. ...

Top-Line Efficacy Data Presented from Phase 2 Trial of Alemtuzumab in Multiple Sclerosis

... alemtuzumab experienced at least a 73 percent reduction in the risk for relapse after three years of follow up when compared to patients treated with ... with interferon beta-1a using two primary endpoints: the rate of relapse of MS symptoms, and the time to Sustained Accumulation of Disability over ...

Genzyme and Bayer Schering Pharma AG, Germany Announce Start of Phase 3 Program with Alemtuzumab for Treatment of Multiple Sclerosis

... to begin soon and will enroll patients who have continued to experience relapse episodes while on currently available disease-modifying therapies. ... the time to sustained accumulation of disability, and the annualized relapse rate. Alemtuzumab will be dosed at 12 mg/day for five days by daily IV ...

European Union's CHMP Issues Positive Opinion on PEGINTRON(TM) Combination Therapy for Retreating Hepatitis C Patients Who Failed Previous Therapy

... with confidence." In the study, failure to prior therapy was defined as relapse or non- response to one or more courses of interferon alpha plus ... 34% of those receiving INTRON A/REBETOL. Additional Safety Information relapse of drug addiction/overdose has occurred in patients on PEGINTRON therapy. ...

Replidyne's Investigational Antibacterial Agent REP3123 Prevents Sporulation in Clostridium difficile

... into the environment, thereby potentially reducing outbreak and relapse rates. These results will be presented on Thursday, September 20, 2007 ... tackles the main challenges associated with treating CDAD: high rates of relapse and new outbreaks," stated Kenneth J. Collins, Replidyne's President & ....

Nabi Biopharmaceuticals Announces Continued Positive NicVAX Phase 2b Data at Nine Months

... believes NicVAX also could be effective in preventing smoking relapse. relapse is a significant challenge facing smokers and, with currently-available smoking cessation therapies, relapse rates can be as high as 90% in the first year after a smoker quits. ...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

... resulted in an overall decline in mortality and increased survival, approximately half of all children with malignant solid tumors will experience relapse and, of these children, less than 10% will achieve long-term survival after standard multimodal therapy. About Keryx Biopharmaceuticals, ...

Scottsdale Facility to Be First in U.S. to Showcase True REST Technology

... heavy drinking, and in treating a variety of other behavioral and mental health disorders. A University of Arizona study examined chamber REST as a relapse prevention technique for substance abusers enrolled in traditional outpatient treatment programs. At the end of four years of follow-up, 43 percent ...