regulator

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

...GLP-1) levels, another hormone that is animportant regulator of blood sugar levels. This aspect of themechanism of action of metformin used in combination with JANUVIAwas previously unknown. GLP-1 acts, in part, by enhancingpancreatic beta cell insulin production and secretion. JANUVIA is a selective, once-d...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

...alled renin-angiotensin system (RAS), an important regulator ofblood pressure. Angiotensin II causes blood vessels tonarrow, resulting in increased blood pressure. In a phase IIa clinicaltrial, vaccination with CYT006-AngQb has been shown to reduce bloodpressure by induction of antibodies that bind angiotensin...

Karo Bio Announces Sucessfule Phase II Results of KB2115

...nction. The thyroid hormone receptor (TR) is a key regulator ofmetabolic pathways and holds the promise of a new target for thetreatment of dyslipidemia. KB2115 is an innovative and first inclass liver selective agonist for the TR. Unlike the naturalthyroid hormones, KB2115 is a liver selective TR agonist that...

Elixir Pharmaceuticals Presents Additional Preclinical Data Demonstrating the Potential of Ghrelin Antagonism to Regulate Metabolism, Body Weight and Glycemic Control

...hways regulating aging. Ghrelin is a key metabolic regulator that is known to stimulateappetite and food consumption and is believed to play a key role inmetabolism and energy storage. Ghrelin is a naturally occurringhormone secreted by the stomach, which acts primarily at the levelof the hypothalamus in the b...

Pieris Demonstrates Potent Anti-Tumor Activity of a VEGF-Specific Anticalin in Preclinical Studies

...indications. PRS-050 targets VEGF, a key positive regulator of angiogenesisimportant in several diseases including cancer and neovascular eyedisorders. PRS-050 exhibits a favorable binding and functional invitro activity profile in direct comparison to all currentlyapproved VEGF antagonists. Strong reduction ...

Emisphere Technologies, Inc. Reports Clinical Data on Oral Delivery of GLP-1 and PYY

...a meal. It is believed that PYY may be animportant regulator of food intake. About Diabetes According to statistics provided by the World HealthOrganization and the American Diabetes Association, approximately177 million people worldwide are afflicted by diabetes, withapproximately 18 million of those afflic...