Digital vs. Analog Mammography
...r detection and diagnostic capabilities at a lower radiation level.2 One reason for the improved detection is that digital mammography can distinguish more shades of gray than film mammography. The capability to acquire images in near-real time and to process them, i.e., to vary brightness and contrast levels,...Appendicitis: Evolving Tools to Diagnose a Classic Disease
...ppendicitis. Unfavorable aspects of CT remain the radiation dose and need for contrast. Another option is ultr...fe of approximately 6 hours, and the safety of the radiation dose is well established. A special camera used in nuclear medicine suites can detect the radiolabe...Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
... rectum. ERBITUX (Cetuximab), in combination with radiation therapy, isindicated for the treatment of locally ...us cell carcinoma of the head andneck treated with radiation therapy and ERBITUX as compared to noneof 212 patients treated with radiation therapy alone. Fatal e...Protox Announces Positive Clinical Data from Prostate Cancer Study
...ith localized, recurrent prostate cancerfollowing radiation failure. The trial results indicate thatPRX302 is ...evels of PSA (prostatespecific antigen) following radiation treatment. Using a well-established, image-guided technique, PRX302 was administereddirectly into t...Molecular Target of Bradmer's Neuradiab Further Validated by Independent Findings
...m of brain cancer. Neuradiab deliverstumor-killing radiation specifically to residual brain tumor cellsafter su... forGBM patients is surgical resection followed by radiation andtemozolomide. GBM tumors typically have infiltrating edges that arevery difficult to completely r...RTA 402 Shown to Protect Animals Against Toxicities of Standard Cancer Treatments
...wing thatwhen RTA 402 is given in combination with radiation therapy to ratsbearing human lung cancer tumors, the drug protected non-canceroustissue from radiation damage while simultaneously enhancing theanti-tumor effect of the radiation treatment. The senior au......y sensitizes myelomacells to the lethal effects of radiation from QUADRAMET, resultingin prolonged survival, re...venconcurrently with chemotherapy or external beam radiation therapyunless the clinical benefits outweigh the risks. Blood countsshould be monitored weekly for a......ng the bone marrow of patientsundergoing intensive radiation therapy for blood cancers." "This recent announcement by Researchers at the University ofPittsburgh School of Medicine that hematopoietic, or blood formingstem cells, can be isolated from fat, or adipose tissue, could havea major impact on the accept...... for use of Xcytrin in combination withwhole brain radiation therapy for treatment of brain metastasesfrom NSCL...leagent or in combination with chemotherapy and/or radiation inmultiple cancer types. A New Drug Application for use of Xcytrin incombination with WBRT for treat......at 45-65 years.Current therapies comprise surgery, radiation and/or chemotherapy.Despite recent advances the prognosis for these patients is stillpoor, with 94% dying within two years of initial diagnosis. About Antisense Pharma GmbH Antisense Pharma is abiopharmaceutical company located in Regensburg, German...... study of Efaproxyn (efaproxiral) plus whole brain radiation therapy (WBRT) in womenwith brain metastases origi...rs is an essential element for the effectivenessof radiation therapy. About ENRICH ENRICH was a randomized, open-label, multi-center Phase 3 studydesigned to e......profile,which we believe allows us to increase the radiation dosage neededto achieve more effective results. The 45 mCi/m(2) cumulative doselevel is more than two-fold higher than the maximum allowable doseof 32 mCi for ibritumomab tiuxetan, or 18.5 mCi/m(2) based on abody area of 1.73 m(2) for a standard pers...Clinical Results From EntreMed's Panzem NCD and Taxol Breast Cancer Study Presented at ASCO
...els and significantlyimproved radio-sensitivity in radiation resistant breast tumors.The inhibition of HIF-1alpha was thought to have the same orsimilar impact on chemotherapy-resistant tumors. HIF-1alpha isover-expressed in more than 70% of human tumors and HIF-1alphaover-expression correlates with tumor aggr...Extensive Clinical Data on Erbitux Presented at the 2007 ASCO Annual Meeting
...ity in IgG2 monoclonalantibodies. -- Erbitux plus radiation is currently a standard of care forpatients with l...ented. ERBITUX incombination with chemotherapy and radiation is being furtherevaluated in an ongoing Phase III trial conducted by the RadiationTherapy Oncology G...Immunomedics Reports Initial Clinical Results With Hpam4 For Pancreatic Cancer Therapy
...showed acceptable distribution within the body and radiation dosageto the pancreas. 90Y-hPAM4 was administrated at 15 mCi/m(2), 20mCi/m(2) or 25 mCi/m(2). One patient, enrolled into the clinicaltrial at this site, showed shrinkage of a liver lesion. Two patients, from other study sites, have also had reported......ntherapy for GBM using temozolomide, external beam radiation (EBRT),and Gliadel Wafers" About Aloxi(R) Injection Aloxi is approved for the prevention of acute nausea andvomiting associated with initial and repeat courses of moderatelyand highly emetogenic cancer chemotherapy and for the prevention ofdelayed ...Study Shows Advantages of Complete Phase Ib Trial Over Separate Phase I Trials
...physicians operating in 433locations, including 90 radiation oncology facilities in 38states. CONTACT: Kimberly Rutherford of US Oncology, Inc.,+1-832-601-6193,; or Elizabeth Vocke, +1-813-775-6206,, for USOncology, Inc. <a target="_blank" href="mailto:Kimberly.Rutherford@usoncology.com">Kimberly.Ruth......ed Gliadel implantation, followed bytreatment with radiation and concurrent temozolomide plusrotational chemoth...ntherapy for GBM using temozolomide, external beam radiation (EBRT),and Gliadel Wafers" About Aloxi(R) Injection Aloxi is approved for the prevention of acute ...... and secondary malignancy rates for adjuvant radiation therapy versus observation in stage I testicular s...physicians operating in 433locations, including 90 radiation oncology facilities in 38states. CONTACT: Kimberly Rutherford of US Oncology, +1-832-601-6193,,or E...Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
...oke, traumatic brain injury, Parkinson'sdisease or radiation damage. The findings, to be published in the June 4 advance onlineversion of the Proceedings of the National Academy of Sciences,could eventually make it possible to track human stem cells thatare transplanted into the brains of patients. Gary Stei...Oncolytics Biotech Inc. Announces Positive Clinical Data from U.S. Phase I REOLYSIN Trial
...f the human reovirus, alone and incombination with radiation or chemotherapy. For further informationabout Oncolytics, please visit <a target="_blank" href="http://www.oncolyticsbiotech.com/">www.oncolyticsbiotech.com This press release contains forward-looking statements, withinthe meaning of Sectio......allowing the delivery of a predetermined amount of radiation toeach patient. The BEXXAR Therapeutic Regimen has been studied for more than 15years. It was originally approved by the FDA based on amulticenter, single-arm, clinical trial in 40 patients who hadreceived a median of four prior chemotherapies and w...Investigational Drug Cediranib (AZD2171) Shows Promise in Patients With Recurrent Glioblastoma (GBM)
...erapeutic techniques such as chemotherapydrugs and radiation therapy," said Dr. Batchelor. "The prognosis for recurrent glioblastoma patients is poor,"commented AstraZeneca's Dr. Nick Botwood, Global Medical Directorfor cediranib. "These are promising Phase II results anddiscussions are ongoing with Dr. Tracy......ting the effects of satraplatin incombination with radiation therapy, in combination with othercancer therapies and in a number of cancer types are underway orplanned. About Pharmion Pharmion is a biopharmaceutical company focused on acquiring,developing and commercializing innovative products for thetreatme......fter surgicalresection of their tumor and adjuvant radiation andchemotherapy. The median overall survival for ...ns following pancreaticcancer surgery and adjuvant radiation and chemotherapy. Inaddition, we are also looking forward to the results of a thirdongoing Phase 2 t...Updated Overall Survival Data From Pivotal Herceptin Adjuvant Studies in HER2-Positive Breast Cancer
...ave had initialtreatment - surgery with or without radiation therapy - with thegoal of reducing the risk of cancer recurrence and/or theoccurrence of metastatic disease. These two randomized, controlled Phase III studies evaluatedfour cycles of doxorubicin and cyclophosphamide followed bypaclitaxel, either ev......irectly and increasethe effectiveness of companion radiation treatments. Research hasalso shown promising results from the use of hyperthermia therapyin combination with chemotherapy, and for tumor reduction prior tosurgery. For further information visit BSD Medical's website at<a target="_blank" href="htt......ting the effects of satraplatin incombination with radiation therapy, in combination with othercancer therapies and in a number of cancer types are underway orplanned. About Pharmion Pharmion is a biopharmaceutical company focused on acquiring,developing and commercializing innovative products for thetreatme...New Data for Cytogen's QUADRAMET Reported at Annual ASCO Meeting
...venconcurrently with chemotherapy or external beam radiation therapyunless the clinical benefits outweigh the risks. Blood countsshould be monitored weekly for at least 8 weeks, or until recoveryof adequate bone marrow function. Non-hematologic adverse eventsthat occurred in 5% or more of patients and greater ...OXiGENE Abstracts Published in ASCO Program
...uding cytotoxicdrugs, anti-angiogenesis drugs, and radiation therapy. Therationale for combining ZYBRESTAT with other therapeutic modalitiesstems from the hypothesis that agents with different andpotentially complimentary mechanisms of action and with anon-overlapping toxicity profile may achieve synergistic a...Lilly Studies Try to Shed Light on Impact of Race on Lung Cancer Treatment
... administration of GEMZAR withtherapeutic doses of radiation has not yet been determined in alltumor types. GEMZAR has radiosensitizing activity and radiationrecall reactions have been reported. It is not known whether GEMZAR or its metabolites are excretedin human milk. The effectiveness of GEMZAR in pediat......andomized trials,Xcytrin combined with whole brain radiation therapy (WBRT) has beenshown to prolong time to ne...leagent or in combination with chemotherapy and/or radiation inmultiple cancer types. A New Drug Application for use of Xcytrin incombination with WBRT for treat......imilar synergies withother chemotherapies and with radiation treatment. Dr. Chada added, "These preclinical da...N 241 in combination withstandard chemotherapy and radiation regimens and we are planningfuture clinical trials based on these results." About INGN 241 INGN 24......f the human reovirus, alone and incombination with radiation or chemotherapy. For further informationabout Oncolytics, please visit <a target="_blank" href="http://www.oncolyticsbiotech.com/">www.oncolyticsbiotech.com . This press release contains forward-looking statements, withinthe meaning of Sec...OncoGenex and Isis Announce OGX-011 Data to be Presented at ASCO
...ncluding hormone ablationtherapy, chemotherapy and radiation therapy. Preclinical studieshave shown that inhibition of clusterin can disable the tumorcell's adaptive defences, render the tumor cells susceptible toattack with a variety of cancer therapies, including chemotherapy,and facilitate tumor cell death.......afin gadolinium (MGd) combined with whole brain radiation therapy prolongs time to neurologic progression in...leagent or in combination with chemotherapy and/or radiation inmultiple cancer types. More information about the company, itstechnology, and products can be foun......ting the effects of satraplatin incombination with radiation therapy, in combination with othercancer therapies and in a number of cancer types are underway orplanned. About Pharmion Pharmion is a biopharmaceutical company focused on acquiring,developing and commercializing innovative products for thetreatme...Allos Therapeutics' PDX Granted Orphan Medicinal Product Designation by the European Commission
...ge clinical development: EFAPROXYN(efaproxiral), a radiation sensitizer currently under evaluation ina pivotal Phase 3 trial in women with brain metastases originatingfrom breast cancer, and PDX (pralatrexate), a novel antifolatecurrently under evaluation in a pivotal Phase 2 trial in patientswith relapsed or ......eII clinical trial study combined chemotherapy and radiation plusAvastin. There have been two confirmed serious adverse events of TEfistula (one fatal) reported in the first 29 patients enrolled inthis study. A third, fatal event (upper aerodigestive tract hemorrhage anddeath of unknown cause), was also repor...Pacgen Announces Positive Results from Phase I/II Trial of Novel Antifungal Drug
...ated with antibiotics orsteroids, chemotherapy, or radiation therapy to the head and neck,and those with cellular immune deficiency states, such as HIV andAIDS. Patients with xerostomia and those treated with inhaledcorticosteroids for asthma or rhinitis are also at risk.Oropharyngeal candidiasis infection can...Quest PharmaTech's Prostate Cancer Program Update
...ancer cells, including those that are resistant to radiation andchemotherapy. Quest's innovative Photodynamic Therapy (PDT) prostate cancertreatment system utilizes our patented Sonolight Technology, ourproprietary and potent Hypocrellin based photosensitizer, SL052,with a novel intra-arterial drug delivery s......r novel therapeuticagents, including chemotherapy, radiation and proteosomeinhibitors. Both HGS-ETR1 and HGS-ETR2 are currently beingevaluated in clinical trials in a variety of human tumors. In a separate poster presentation, results were reported from apreclinical study, which demonstrated that low concentr......and in a Phase 3 clinicaltrial in combination with radiation therapy in solid tumors. Themda-7 gene is the active component of INGN 241 and was discoveredin the laboratory of Dr. Paul B. Fisher, professor of clinicalpathology at Columbia University. Introgen holds an exclusiveworldwide sublicense to the Columb......l Sclerosis (ALS),protection of healthy cells from radiation therapy, Parkinson'sdisease, stroke and neurofibromatosis, among other indications. TheCompany is currently in the process of planning and securing thefinancial resources to support a phase 2 study to test the efficacyof AEOL 10150 in humans. About ......ells in micewith prostate tumor cells treated with radiation therapy. The studyalso showed that the compound di...interfere with the tumordestruction effects of the radiation therapy. Researchers reported a statistically significant decrease intumor growth in animals that re......e whether administration of SPI (IRL)-1620prior to radiation enhances the efficacy of radiotherapy. SPI (IRL)-...om 1 to 9nmol/kg via tail vein 15 minutes prior to radiation administration.Tumor diameter was measured twice a week for a total of 70days. Results Control ani...Aranesp ``145 Study'' Shows No Difference in Survival in Patients with Small-Cell Lung Cancer
...tients withadvanced head and neck cancer receiving radiation therapy whenadministered to target a hemoglobin of...malignant diseasereceiving neither chemotherapy or radiation therapy. ESAs are notindicated for this population. Patients receiving ESAs pre-operatively for red...ImClone Systems Showcases Extensive Research and Development Program at the AACR Annual Meeting
...anticancereffects with ERBITUX in combination with radiation in non-smallcell lung cancer cells and in combination with HDAC or Srcinhibition in colon cancer cells. (#3111 Brooks et al. TargetingEGFR signaling to enhance response of non-small cell lung cancercells to radiation; #683 LaBonte et al. The effects ......in combinationwith chemotherapeutic agents or with radiation therapy," said Dr.Barry Wenig, Head of Otolaryngology - Head and Neck Cancer atEvanston Northwestern Healthcare Centre. "These data offer excitingpossibilities for the use of Proxinium(TM) not solely as a localimmunotherapy, but more importantly as a......le agent or in combination withchemotherapy and/or radiation in multiple cancer types. Moreinformation about the company, its technology, and products can befound at <a target="_blank" href="http://www.pharmacyclics.com/">www.pharmacyclics.com .Pharmacyclics(R), Xcytrin(R) and the "pentadentate" logo(R......f the human reovirus, alone and incombination with radiation or chemotherapy. For further informationabout Oncolytics, please visit <a target="_blank" href="http://www.oncolyticsbiotech.com/">www.oncolyticsbiotech.com . This press release contains forward-looking statements, withinthe meaning of Secti......ncluding hormone ablationtherapy, chemotherapy and radiation therapy. Preclinical studieshave shown that inhibition of clusterin can disable the tumorcell's adaptive defences, render the tumor cells susceptible toattack with a variety of cancer therapies, including chemotherapy,and facilitate tumor cell death.......a) delivered in an adenovector, incombination with radiation therapy, showed key effects on stromaltissues and blood vessels, both of which are critical components ofhuman solid tumors. These results support the potential of broadactivity in many tumor types. "These results demonstrate two key findings, a pot...... rectum. ERBITUX (Cetuximab), in combination with radiation therapy, isindicated for the treatment of locally ...us cell carcinoma of the head andneck treated with radiation therapy and ERBITUX as compared to noneof 212 patients treated with radiation therapy alone. Fatal e......tients withadvanced head and neck cancer receiving radiation therapy whenadministered to target a hemoglobin of...alignant diseasereceiving neither chemotherapy nor radiation therapy. ESAs are notindicated for this population. (See WARNINGS: Increased Mortality and/or Tumor...Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference
...and in a Phase 3 clinicaltrial in combination with radiation therapy in solid tumors. Themda-7 gene is the active component of INGN 241 and was discoveredin the laboratory of Dr. Paul B. Fisher, professor of clinicalpathology at Columbia University. Introgen holds an exclusiveworldwide sublicense to the Columb......s and developsnovel therapeutic agents for cancer, radiation protection andhematological disorders. Currently, the Company is conductingclinical trials at major centers in the USA and abroad. The novelchemical library platform is permitting identification of non-ATPcompetitive kinase inhibitors directed at val......ditional cancer treatmentssuch as chemotherapy and radiation therapy. Oncophage has beengranted fast track and orphan drug designations from the US Foodand Drug Administration (FDA) in both metastatic melanoma and renalcell carcinoma. Study Findings The investigator-sponsored Phase 1/2 study is designed toev...Abbott Researchers Focus on New Cutting-Edge Approaches in the Fight Against Cancer
...re found to enhance the effects ofchemotherapy and radiation used to treat other types of cancer,such as non-sm...heeffectiveness of common cancer therapies such as radiation andalkylating agents. ABT-888 has entered a Phase 0 trial for patients with refractorysolid tumors ...Nuvelo Announces Publication of NU206 Study Results in Gastroenterology
...ted growth and repair of thesetissues in models of radiation treatment or chemotherapy, as wellas in animal models of inflammatory bowel disease and short bowelsyndrome. A publication in the August 2005 issue of Sciencedescribed results from studies in animal models of mucositis, whereNU206 was shown to dimini...