Proteins in Medical Technology

Video: New Dove(R) Body Washes with NutriumMoisture(TM) Restore Skin's Natural Moisture

... body wash. Current body washes actually damage proteins and lipids in the skin's outer layer, often ... clinically proven to preserve both skin's natural proteins and lipids while significantly reducing dryness ... dual approach to healthy skin by preserving both proteins and lipids during cleansing which is critical ...

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... failure and cancer. ZFNs are engineered proteins that induce double strand breaks at specific ... the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. ... enable the engineering of a class of DNA-binding proteins known as zinc finger ...

Cognition Therapeutics Closes Series A Financing to Advance Drug Candidates for Alzheimer's Disease

... or prevent Alzheimer's disease by targeting the proteins that cause the earliest stages of this disease". ... small molecule therapeutics targeting the toxic proteins that cause the cognitive decline associated with ... degenerative diseases of the human brain. Toxic proteins play a crucial role in a large class of diseases, ...

SAFC Biosciences(R) and Vivalis Collaborate to Optimize Cell Culture Media for Vaccines Production

... manufacturing of viral vaccines and recombinant proteins for human and veterinary use. This cell line has ... development of production systems for recombinant proteins and monoclonal antibodies. VIVALIS licenses its EB66 cell line for the production of recombinant proteins to biotechnology and pharmaceutical companies. ...

Intercell Starts a Phase I Clinical Trial for a New Streptococcus pneumoniae Vaccine

... vaccine consisting of three conserved surface proteins from Streptococcus pneumoniae . Two of these proteins were discovered using Intercell's proprietary ... vaccine candidate is composed of highly conserved proteins of Streptococcus pneumoniae that have the ...

Sangamo BioSciences Announces Presentations at Two Upcoming Investor Conferences

... the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a ...

Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer

... treatment is by increasing the expression of proteins that inhibit apoptosis (programmed cell death). The most recognized group of such proteins are the antiapoptotic members of the Bcl-2 ... and Mcl-1. Overexpression of Bcl-2 family proteins in human tumor specimens has been reported by ...

Scientists Unmask Genetic Markers Associated With Psoriasis

... association with psoriasis. As a result, four proteins produced from the altered DNA code now can be ... psoriasis genes (IL12B and IL23R) encode proteins that bind to IL23A protein. Variations in the ... The team also found that genetic signals for proteins activated by TNF-alpha, a key signaling molecule ...

Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP

... expected increase in the half-life of therapeutic proteins between these species. Based on the results of ... the CTP technology for use with all therapeutic proteins except for the four endocrine hormones licensed ... versions of already approved therapeutic proteins that currently generate billions of dollars in ...

Synvista Therapeutics Announces Published Data Demonstrating Elevation of Carboxymethyl-Lysine (CML) Is Associated with Decline in Renal Function and Arterial Stiffness in Older Adults

... damage is caused by the attachment of glucose to proteins in a process called glycation. When the glucose-modified proteins go through further oxidation, the resulting ... Glycation End Product (A.G.E.). These damaged proteins are often dysfunctional, inflammatory and ...

Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives

... the research and development of novel DNA-binding proteins for therapeutic gene regulation and ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a ...

Aiming at Multiple Alzheimer's Proteins May be Key to Success

... been split on the relative effect of these two proteins on the disease process. Further, many scientists ... probably true for tau. If we could control both proteins in the same patient, we might get a synergistic ... for single molecules that will bind to both proteins and possibly other Alzheimer's-related proteins ...

Burcon announces GRAS status for Puratein(R) & Supertein(TM)

... expected to participate with soy, dairy and egg proteins in the multi-billion dollar global ... bars, among many others. Nutritionally, the proteins are equally exciting with unique amino ... Puratein(R) and Supertein(TM) canola proteins are considered GRAS from today's date for the ...

St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins

... stitches all-important molecular adjustments onto proteins contorts itself to regulate its own function ... new insight into how the cell's vast array of proteins would instantly be reduced to a confusion of lethally malfunctioning molecules without a system for proteins to "accessorize" in order to regulate their ...

Modigene Platform Validated in Independent Phase III Trial of CTP Technology

... the Duration of Action of Therapeutic proteins - NES-ZIONA, Israel, July 10 ... the duration of action of other therapeutic proteins and peptides. Schering-Plough licensed the CTP ... to the CTP technology for use with all other proteins and peptides. Modigene is currently applying the ...

Pressure Cycling Technology (PCT) Results in a Higher Yield of Proteins and in the Extraction of Proteins Not Previously Identified in Cancer, Stroke, and IVF Studies

... only greater protein yield, but the extraction of proteins not previously identified in these types of ... Using PCT and ProteoSolve-LRS, we identified two proteins in IVF growth media only seen in competent embryos. These proteins may prove to be biomarkers that can enhance ...

Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells

... the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a ...

Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting

... the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a ...

Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs

... the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a ...

Seven Presentations by Two Independent Research Groups Highlight Advantages of Pressure Cycling Technology (PCT) at Scientific Symposia in Philadelphia, Boston, and New York City

... was used by Dr. Pevsner and colleagues to extract proteins from colon tissue samples prior to analysis. Dr. Pevsner reported that new and additional proteins were extracted with PCT when compared to ... to reduce the time required for preparing these proteins with trypsin for further analysis from 12 hours ...

Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR

... essential protein that exports key regulatory proteins ("cargo" proteins) from the nucleus to the cytoplasm. Many cargo proteins that depend on CRM1 for nuclear export, such as ... (cell death). Accumulation of these CRM1 cargo proteins in the nucleus, by blocking nuclear export, ...

EntreMed Presents MKC-1 and ENMD-1198 Preclinical Data at AACR Annual Meeting

... levels of the oncogenic transcription factor proteins HIF-1alpha, pSTAT3, and pNFkappaB. Treatment with ... with the relative lack of inhibition of oncogenic proteins observed in 1A9-1198R cells, suggests interaction ... may be important for the modulation of oncogenic proteins by ENMD-1198. In summary, data demonstrate that ...

Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting

... the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a ...

Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' Cell Lines

... the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a ...

Novel PCT Method Unveiled by Pressure BioSciences, Inc. and Collaborators at the Harvard School of Public Health

... extract DNA, RNA, and lipids together with proteins from the same initial sample. We believe that ... currently available methods in the extraction of proteins from lipid-rich samples; that nucleic acids, ... and less problematic way; that proteins may be extracted by the PCT method that may not ...

Vermillion's Biomarkers Prove Beneficial in Identifying Women With Ovarian Cancer and Detecting Early-Stage Disease

... Another study found that calgranulin A and B, two proteins commonly found in malignant ovarian cysts, may be ... ovarian cyst fluids and identify the underlying proteins that could serve as potentially useful biomarkers ... ovarian tumors were examined. The calgranulin proteins were increased in malignant ovarian cyst fluids ...

Bionomics Achieves US$1 Million Milestone Payment from Genmab

... pre-clinical testing on the first of eight proteins licensed to US $2.6 billion Danish antibody ... the exclusive worldwide rights to eight proteins identified and characterised by Bionomics using ... angiogenesis platform. Antibodies to these proteins have potential as treatments for cancer and other ...

Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results

... the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a ...

Baxter Announces Recombinant Factor IX Development Program For Hemophilia B

... to develop recombinant Factor IX proteins to treat hemophilia B. Baxter will develop both ... plans to develop recombinant Factor IX proteins to treat hemophilia B, including unmodified recombinant Factor IX proteins and using Nektar's PEGylation technology to ...

Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy

... the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. ... the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize ...

The Pittsburgh Life Sciences Greenhouse Relocates Therapeutics Company to Pittsburgh

... small molecule therapeutics targeting the toxic proteins that cause the cognitive decline associated with ... platform. "Our approach is to target the toxic proteins that build up in the brains of elderly ... degenerative diseases of the human brain. Toxic proteins play a crucial role in a large class of disease ...

Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells

... are the dominant class of naturally occurring proteins known as transcription factors and are found in ... the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. ... enable the engineering of a class of DNA-binding proteins known as zinc finger ...

First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs

... HSP90 proteins. As ligand-regulated chaperones -- proteins that help other cellular proteins achieve their ... in cellular regulation and recognition. The HSP90 proteins have been the subject of increasing international ... are more similar to those found in the GRP94 proteins than to the more widely studied HSP90 proteins. ...

AngioGenex Files Patent on First Small Molecule Id-Inhibitors for the Treatment of Cancer

... patent establishes the 'drugability' of the Id proteins as targets allowing the Company to move forward ... be orally active." Further, "inhibition of the Id proteins by these small molecules is unlikely to cause ... diagnostic that detects low levels of the Id proteins in serum. This diagnostic was developed ...

Strategic Diagnostics Launches Initial Oncology-Targeted Antibody Reagent Catalog

... the three dimensional conformation of target proteins through synthetic immunogens have resulted in ... and the ability to stain disease-associated proteins across thousands of clinical biopsy samples. More ... the ability to differentiate highly conserved proteins in cell sorting assays, the ability to react with ...

Promising Data from Paratek Pharmaceuticals' MAR Inhibitor Program Presented in 'Late Breaker' Session at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

... Adaptation Response (MAR) inhibitor program. MAR proteins in bacteria serve as the "master switch" ... preclinical studies in 2009." About the MAR proteins MAR proteins such as ExsA and its homologues in other ...

Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion

... (MPD) to detect the presence of misfolded proteins in brain, serum and plasma. Study results ... specific test for the detection misfolded prion proteins that may be useful in both preclinical and ... are several challenges to detecting misfolded proteins in the blood. The coexistence of a large amount ...

Fruitfly Model of a Neuropathic Disease Demonstrates Novel Role for Proteins in the Family of aTyr Pharma's Product Class

... new area of biology: novel signaling functions for naturally occurring proteins resected from ancient proteins such as tRNA synthetases. This work in Drosophila illustrates a ...

Neuroscience Researcher Has Positive Message for International Alzheimer's Awareness Week, July 6 - 12: 'Even Though World Economy is Declining, Alzheimer's Research is Advancing'

... "Humans are born able to manufacture their own calcium-binding proteins but we gradually stop producing them at about age 40, and that's when our ... says Underwood. "Those with Alzheimer's apparently stop producing these proteins at a faster rate so their cognitive impairment occurs with greater ...

Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy

... node metastasis. Dr. Nahleh said that increased identification of proteins in these aggressive forms of breast cancer is needed to develop better ... of EZH-2 represents just the first step in the mission to find more proteins that cause deadly breast cancer tumors and assess them for possible ...