proliferation

Rapid Whole Blood Testing for Infectious Mononucleosis Antibodies

...nt atypical lymphocytes. In keeping with the rapid proliferation of point-of-care diagnostic kits and devices, several products have now been CLIA-waived by the Centers for Disease Control and Prevention (CDC). At present, 13 biomedical manufacturers produce 17 distinct test kit products that have gained CLIA wai...

Monitoring Options Expand for Therapeutic Agents and Drugs of Abuse

In keeping with the recent proliferation of rapid, easy-to-use diagnostic tests, many assays and collection products have entered the marketplace to help clinicians assess dosage appropriateness of therapeutic drugs and to screen for the presence of drugs of abuse. Some of these products re...

Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop

...fight infection anddisease), are overproduced. The proliferation of these abnormalplasma cells, known as myeloma cells, causes decreased productionof normal red and white blood cells, and of normal disease-fightingantibodies, as well as the growth of tumors that spread to multiplesites - hence the term multiple my...

Antisense Pharma: Promising Phase IIb Results of Targeted Therapy with AP 12009 in Recurrent Anaplastic Astrocytoma

...ression. Immunosuppression,invasion and migration, proliferation and angiogenesis aresimultaneously promoted in a variety of malignant tumors.Thismultiple impact on cancer cells is inhibited by AP 12009 (3,4). General Background on High-Grade Glioma Anaplastic astrocytomaand glioblastoma are the two most common f...

Barrier Therapeutics Announces Liarozole Phase 2/3 Study Results in Lamellar Ichthyosis

..., acne and photo-damage, which result fromabnormal proliferation and differentiation of skin cells. Liarozole was placed on clinical hold by the FDA in 2006 and noclinical studies in humans may be initiated in the U.S. until theFDA's concerns are addressed. Based on feedback from EMEA webelieve it is highly likel...

Avalon Updates the AVN944 Phase I Hematologic Malignancies Trial

...tudies of AVN944 indicate that AVN944inhibited the proliferation of lymphoid and myeloid cells, theprincipal cells involved in the most common types of humanleukemias. In a single-dose, dose-escalation Phase I clinical trialof AVN944 conducted in the United Kingdom in healthy volunteers,AVN944: (1) was well tolera...

Research Indicates Geron's Human Embryonic Stem Cell-Based Therapeutic for Spinal Cord Injury Evades Direct Attack by the Human Immune System

...ow levels of T cellproliferation. Allogenic T cell proliferation is a standard measureof immune recognition of fore...asgamma interferon or TNF alpha, allogeneic T cell proliferation wasnot induced. In addition, GRNOPC1 cells were not lysed by natural killercells, the "innate" arm ...

Pivotal Phase III Trial Showed Promacta (eltrombopag olamine) Raised Platelet Counts and Reduced Bleeding in Patients With Chronic ITP

...nicalresearch and clinical trials to stimulate the proliferation anddifferentiation of megakaryocytes, the bone marrow cells that giverise to blood platelets, and thus can be considered a plateletgrowth factor.(4) The safety profile will be further examined inongoing clinical trials. PROMACTA was discovered as a r...

Phase I Results for ImClone Pipeline Anti-IGF-1R Monoclonal Antibody IMC-A12 Presented at ASCO

... believed to play importantroles in the growth and proliferation of tumors or tumorvasculature. Specific targets include insulin-like growth factor-1receptor (IGF-1R), vascular endothelial growth factor receptor-1(VEGFR-1), VEGFR-2, VEGFR-3, platelet-derived growth factorreceptor alpha (PDGFR(alpha)), FMS-like tyr...

Clinical Data Reported on Vidaza in Hematologic Malignancies and Advanced Solid Tumors

...nt and maintenance of tumor vasculature,and in the proliferation of some tumor cells. It inhibits FGFR1,FGFR3, RET, VEGFR2, and PDGFR. The compound is also a potentinhibitor of FLT3, an important driver of leukemia cellproliferation in some patients with acute myelogenous leukemia(AML). XL999 exhibited potent acti...

Abbott Announces Continued Positive Results with Xience V Everolimus Eluting Coronary Stent in Spirit Clinical Trials

...s everolimus, which has been shown toreduce tissue proliferation in coronary vessels following stentimplantation, and one of the world's most popular metallicplatforms -- the MULTI-LINK VISION Coronary Stent System. XIENCE V is designed, studied and manufactured by AbbottVascular. Abbott supplies a private-labele...

Data to be presented at AAN Meeting -Study results of drug candidate for MS

... thatregulate a variety of functions, such as cell proliferation andmigration. (Muellershausen et al) A second study, also conducted in cell culture, demonstratedthat FTY720 improved the survival and increased the number ofimmature and mature oligodendrocytes - cells that help form myelinin the CNS. Stimulation o...

Preclinical Studies Identify Novel Approach for Enhancing the Anticancer Activity of Introgen's INGN 241

... analyses demonstrated that INGN 241inhibited cell proliferation in cells with activated NF-kB, andthat this effect was enhanced with inhibition of NF-kB. INGN 241activity also was enhanced in animal models of lung tumorsengineered to inhibit NF-kB activation. The studies also identifiedtwo other proteins, MEKK1 a...

EntreMed Presents Preclinical Data for MKC-1 in Hematological Cancers

...se signaling pathways arestrongly linked to cancer proliferation and survival. Additionally, MKC-1 showed enhanced activity with cytosinearabinoside (Ara-C) in combination studies in vitro when addedeither simultaneously or sequentially in an AML cell line. MKC-1,therefore, induces apoptosis in hematopoietic cell...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

...romolaractivity against the Axl enzyme and in cell proliferation assays.Lead optimization toward the identification...an either treatmentalone in the inhibition of cell proliferation and phosphorylationof Akt in EGF and PDGF pathways. Moreover, in combination withTarceva, MP470 inhi...

ImClone Systems Showcases Extensive Research and Development Program at the AACR Annual Meeting

... believed to playimportant roles in the growth and proliferation of tumors or tumorvasculature. Specific targets include insulin-like growth factor-1receptor (IGF-1R), vascular endothelial growth factor receptor-1(VEGFR-1), VEGFR-2, VEGFR-3, platelet-derived growth factorreceptor alpha (PDGFR(alpha)), FMS-like tyr...

Alnylam Announces Advancement of a New RNAi Therapeutic Development Program for the Treatment of Liver Cancer

... rodent model;and -- Halting of human cancer cell proliferation in vitro when KSPwas silenced by a target-specific siRNA. Alnylam's RNAi therapeutic, ALN-VSP01, is comprised of two smallinterfering RNAs, or siRNAs, the molecules that mediate RNAi. EachsiRNA targets a distinct and well-validated gene in the growt...

terna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles

...f PI3K and functional cellularassays of tumor cell proliferation have been performed. Inaddition, physicochemical and initial ADMET data were collected.Several derivatives are currently undergoing first pharmacokineticin vivo studies. About terna Zentaris Inc. terna Zentaris Inc. is aglobal, pure play biopha...

Biomira Selects PX-866 as Clinical Development Candidate and Presents Promising Preclinical Data at AACR

..., and cervical cancers, where itleads to increased proliferation and inhibition of apoptosis(programmed cell death). In preclinical studies, PX-866 has beenshown to induce prolonged inhibition of tumor PI3 kinase signalingfollowing both oral and intravenous administration. The compoundalso has been shown to have g...

EntreMed Presents Multi-Mechanism Antitumor Data for ENMD-1420 in Preclinical Models

...olymerized in microtubules,and prevent cancer cell proliferation by interfering with themicrotubule dynamics required for cell division. This interferenceblocks the cell cycle sequence, leading to cell death(apoptosis). About EntreMed EntreMed, Inc. is a clinical-stage pharmaceutical companydeveloping therapeuti...

Sunesis Presents Data Supporting SNS-032's Potential Anticancer Activity in Multiple Myeloma at the American Association for Cancer Research Meeting

...iting CDKs 2, 7 and 9 targets both unregulatedcell proliferation and the microenvironment associated withmultiple m...ing these CDKs, SNS-032 may halt both aberrantcell proliferation and induce apoptosis. About Sunesis' Oncology Programs Sunesis has built a rich portfolio of produ...

Ascenta Therapeutics Highlights Multiple Data Presentations at Upcoming AACR Annual Meeting

...ousapoptosis pathways to shut down cell growth and proliferation incancer cells. For additional information on Ascenta Therapeutics, please visitthe company's website at www.ascenta.com. Contact Ascenta Therapeutics, Inc. Mark Benedyk PhD Vice President, Business Development 858-436-1200 <a target="_blank" ...

ANA380 Exhibits Activity In Vitro Against Multiple Clinically Relevant Hepatitis B Virus Mutants

... strand of RNA. ANA380 isbelieved to inhibit viral proliferation by interrupting thereplicating machinery of the virus. Hepatitis B Virus HBV is a significant global health problem that can cause bothacute and chronic viral infections. According to the WHO, of the 2billion people who have been infected with HBV,...

Callisto Pharmaceuticals Announces Publication of Research Article on Atiprimod Preclinical Studies in Mantle Cell Lymphoma

...r Center, focuses onAtiprimod's ability to inhibit proliferation of mantle celllymphoma (MCL) cells in vitro and to inhibit growth of MCL tumorsin tumor-bearing mice. The animal data demonstrated that Atiprimodsignificantly inhibited tumor growth in vivo and prolonged survivalof tumor-bearing mice. Atiprimod was s...

Rigel Provides Clinical Update of R788 Phase 2 Trials in ITP, Rheumatoid Arthritis and Lymphoma

... by anover- expression of B-cell receptors and the proliferation ofB-cells. Research has shown that R788 effectively interrupts thegrowth of B-cells and signaling proteins that contribute to thesurvival of these tumors. The open label clinical trial is expected to enroll a total ofapproximately 60 patients at 10 ...

Avalon Pharmaceuticals to Present at the American Association for Cancer Research 2007 Annual Meeting

...tudies of AVN944 indicate that AVN944inhibited the proliferation of lymphoid and myeloid cells, theprincipal cells involved in the most common types of humanleukemias. In a single-dose, dose- escalation phase I clinicaltrial of AVN944 conducted in the United Kingdom in healthyvolunteers, AVN944: (1) was well toler...

Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice

...rcent decrease). This was correlated withdecreased proliferation of tumor cells and inhibition of mTOR. Our studies provide an exciting link between exposure to animportant tobacco carcinogen, NNK, and mTOR, said Phillip A.Dennis, M.D., Ph.D., head, Signal Transduction Section of NCI'sCenter for Cancer Research. ...

Emisphere Technologies, Inc. Reports Clinical Data on Oral Delivery of GLP-1 and PYY

...ne stimulates insulin secretion, promotesbeta cell proliferation and neogenesis, and inhibits glucagonsecretion. However, GLP-1 receptors are also expressed outside theislets, increasing the likelihood that GLP-1 also plays a role inother organs. These functions are mainly the inhibition of gastricemptying, gastri...

Abbott's Xience V Everolimus Eluting Coronary Stent Superior to Taxus Stent in Spirit III U.S. Pivotal Clinical Trial

...s everolimus, which has been shown toreduce tissue proliferation in the coronary vessels following stentimplantation, and is based upon the highly deliverable and provenMULTI-LINK VISION coronary stent platform. XIENCE V was launched in Europe and Asia Pacific in 2006. XIENCEV is currently an investigational devi...