BARACLUDE(R) (entecavir) Data Continue to Demonstrate Low Incidence of Resistance Through Five Years of Treatment in Nucleoside-naive Chronic Hepatitis B Patients
... Through five years
of treatment, the cumulative
probability of developing mutations in the
virus that confer ... with lamivudine failed, the cumulative
probability of genotypic
BARACLUDE resistance was 51 percent ... studies over time is low, with a cumulative
probability of genotypic BARACLUDE resistance of 1.2 percent ...
National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness
... line.
"These preclinical data provide important further insights into the specific bio-marker (tumor glutathione levels) that increases the
probability of achieving improved anti-tumor effectiveness by careful selection of patients who are most likely to benefit, and is consistent with our focus on ...
Landmark Study for GSK's Cervical Cancer Vaccine Published in The Lancet
... (CIN), graded as CIN 1, 2 and 3 refers to pre-cancerous cells found on the surface of the cervix. The higher the grading number, the higher the
probability the abnormal cells will become cancer cells. CIN 1, 2 and 3 refers to mild, moderate or severe cell changes respectively. CIN 2+ is the surrogate ...
IBM and EU Partners Create a Better Way to Fight AIDS Virus
... combinations for any given HIV genetic variant. EuResist is a powerful online system that helps doctors choose the treatment with the highest
probability of halting virus replication and impairing evolution of drug resistance.
Although there have been tremendous leaps and bounds in the management ...
Optimer Pharmaceuticals Presents Results From Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection
... minimal disruption to the normal intestinal flora. This may facilitate the return of the normal physiological conditions in the colon and reduce the
probability of CDI recurrence.
About Optimer Pharmaceuticals
Optimer Pharmaceuticals, Inc. is a biopharmaceutical company focused on discovering, ...
China Sky One Medical, Inc. Achieves Significant Breakthrough in Research for Sudden Cardiac Death (SCD) Early Examination Kit
... Yang concluded that the existence of MicroRNA-1 in human blood is a useful predictor of SCD, and higher concentrations of MicroRNA-1 means a higher
probability of SCD. The discovery was published in the Journal of Nature-Medicine. In late 2008, Prof. Yang received the national patent for this discovery.
...
Investigational Genetic Test May Help Address Common Problems in Prostate Cancer Diagnosis
... Key AUA Studies
Results from selected PCA3 studies presented at the AUA meeting showed that:
PCA3 scores are correlated with the
probability of a positive initial prostate biopsy in men with elevated serum PSA levels. In addition, PCA3 scores were higher in men whose prostate tumors had ...
Optimer Pharmaceuticals Receives Production Patent for Lead Product Candidate Fidaxomicin
... minimal disruption to the normal intestinal flora. This may facilitate the return of the normal physiological conditions in the colon and reduce the
probability of CDI recurrence.
About Optimer Pharmaceuticals
Optimer Pharmaceuticals, Inc. is a biopharmaceutical company focused on discovering, ...
Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology
... treatment. While the underlying cause for the development of prostate cancer is still unknown, factors such as age, race, and lifestyle affect the
probability of developing the disease. Of these, age is the strongest risk factor, and as life spans continue to increase, more men are surviving to an age at ...
Transgenomic and Power3 Medical Complete Agreement for Exclusive License of Neurodegenerative Biomarker Test
... was developed by Power3 Medical to monitor the concentration of a panel of blood serum protein biomarkers, using biostatistical analysis to assign a
probability score reflecting the likelihood a patient may have a neurodegenerative disease. The test is an objective tool that helps clinicians distinguish ...
Research Explores the Effects of Stem Cell Source and Patient Age on Stem Cell Transplantation Outcomes
... patient by comparing their human leukocyte antigens (HLAs). Current estimates from the National Marrow Donor Program donor registry suggest that the
probability of finding a matched unrelated adult donor is relatively low (51 percent for Caucasians, 30 percent for Hispanics, 20 percent for Asians, and 17 ...
Studies Examine Quality of Care for Hospitalized Sickle Cell Disease Patients and Effective Methods for Detecting Risk of Stroke in Children With This Disorder
... was eight years for patients receiving hydroxyurea and five years for those who did not receive hydroxyurea.
The study found that the
probability of 10-year survival was 91 percent for the patients treated with hydroxyurea compared with 70 percent for the conventionally treated patients. ...
Breakthrough Mapping of Alzheimer's Genome Helps ID Four New Suspect Genes
... all of it
directly into research.
Cure Alzheimer's Fund(TM) is a 501c3 public charity established to fund
targeted research with the highest
probability of slowing, stopping or
reversing Alzheimer's disease. For more information, please visit
http://www.curealzfund.org .
Contact: David Roscow
...
The Children's Hospital of Philadelphia Announces New Regional Participant in The National Children's Study
... be conducted in 105 previously designated
study locations across the U.S., that together are representative of the
nation's population. A national
probability sample was used to select the
counties in the study, which took into account factors including race and
ethnicity, income, education level, number of ...
Cell Therapeutics Announces that the European Organization for Research and Treatment of Cancer Completes Enrollment in Phase II Clinical Trial of Brostallicin as First Line Therapy for Advanced or Metastatic Soft Tissue Sarcoma
... cells' vulnerabilities (weak spots) and where the drugs
are the strongest. With these data, investigators can target those patients
with the highest
probability of benefiting from a particular drug. By
treating only the patients with the genetic characteristics known to react
well to the drug, scientists may ...
Dendreon Expects Interim Data Analysis for Phase 3 PROVENGE IMPACT Trial in October
... therapy to the many prostate cancer patients who
currently have few appealing treatment options. While the final analysis of
the trial has a higher
probability of success, the interim analysis
provides us with the potential to accelerate our BLA amendment for
PROVENGE," said Mitchell H. Gold, president and ...
Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City
... and market
research to maximize efficiency, increase productivity, augment the quality
of our antibody drug development efforts and increase the
probability of
success for product candidates.
"We have a world-class antibody drug development platform which allows
us to enrich our pipeline with ...
CherryPharm First All-Natural Food to Improve Sleep
... decreased the time it took to fall
asleep (Sleep Latency) and decreased the time spent awake after falling
asleep (Wake After Sleep Onset). With
probability or "P" values of .047 and
.011 respectively, these results are statistically significant. Modest
trends, although not statistically significant, were ...
NicOx Completes Patient Enrollment in Third Naproxcinod Pivotal Phase 3 Study
... a lower rate of positive efficacy
results than knee studies. Nevertheless, we believe the stringent criteria
applied to the 303 study give us a good
probability of achieving a positive
result on the primary endpoint."
Trial design and endpoints of the 303 study
The 303 study is a 13-week, double-blind, ...
Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events
... SNPs was significantly associated with response to ziprasidone
The combination of six markers defined several groups of patients with
different
probability of response to iloperidone. Twenty-seven percent of
patients carried at least five of the most favorable genotypes and
constituted a group of ...
New Gene Discovery Suggests Which Patients CTI's Brostallicin May Benefit
... cells' vulnerabilities (weak spots) and where the drugs
are the strongest. With these data, investigators can target those patients
with the highest
probability of benefiting from a particular drug. By
treating only the patients with the genetic characteristics known to react
well to the drug, scientists may ...
EnVivo Pharmaceuticals Announces Initiation of Clinical Safety and Biomarker Study of Alpha-7 Nicotinic Agonist, EVP-6124, in Patients with Schizophrenia
... cognitive benefits in learning and memory and
we believe we understand the dosing range in which to expect efficacy. This
significantly enhances the
probability of success of the upcoming biomarker
and Phase II studies."
About Electrophysiological Biomarkers in Schizophrenia Patients
Patients with ...
Landmark ONTARGET(TM) Trial Demonstrates Micardis(R) is Equally Effective as Ramipril, with Fewer Discontinuations, in a Broad High-Risk Cardiovascular Population
... in 1,423 patients (16.7 percent) receiving telmisartan
versus 1,412 patients (16.5 percent) receiving ramipril.(1) The relative
risk (ratio of the
probability of the event occurring in the telmisartan
group versus the ramipril group) was 1.01, with a 95 percent CI of 0.94 -
1.09.
Telmisartan is now the ...
Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells
... sickle cell anemia," said
Dr. Ataga. "As noted in the paper, a Phase III study of senicapoc in SCD
patients was recently terminated due to the low
probability of achieving a
reduction in crisis rate, the primary endpoint of that study. Clearly,
further work is necessary to understand how the reduction in ...
Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH
... from the National Kidney Foundation;
CKD was severe in 21 percent of patients. The analysis of patient data
prior to study entry showed that the
probability of progression of this
overall untreated population of PNH patients to a major clinical kidney
event, including severe renal damage, renal ...
BiPar Genomic Biomarker Data Demonstrate Overexpression of PARP-1 Gene in Multiple Cancer Types
... in San Francisco. "These results allow us to focus our clinical development plan for
BSI-201 by targeting tumors types that have the greatest
probability of
clinical success," said BiPar Executive Vice President Barry Sherman, M.D. BiPar researchers used the Gene Logic Inc. BioExpress(R) ...
Studies Showing Significant Survival Improvement with Taxotere(R)-based Regimens in the Induction Treatment of Patients with Locally Advanced Head and Neck Cancer are Published in the Same Issue of the New England Journal of Medicine
... risk of death that was 30% lower (HR 0.70;
p=0.006). This represents a more than three year absolute improvement in
median overall survival. The
probability to survive three years was 62% in
the Taxotere arm compared to 48% in the standard arm (p=0.0058). Overall, the incidence of grade 3/4 toxicity was ...
Surgeons Develop Innovative Life-Saving Treatments to Correct Massive Bleeding in Trauma Patients
... survival and unexpected death in this
study were defined by the Trauma Related Injury Severity Score (TRISS)
Methodology, which determines the
probability of survival on the basis of
the severity of injury, the patient's condition on admission to the
hospital, and age.
The protocol also decreased the ...
Taxotere(R) (docetaxel) Granted FDA Approval to Treat Locally Advanced Head and Neck Cancer Prior to Chemoradiotherapy and Surgery
... vs. 30.1 months for patients
receiving PF only, representing a more than three year improvement in
median OS for patients treated with TPF. The
probability to survive three
years was 62% in the TPF arm compared to 48% in the PF arm. "The TAX 324 trial found that the addition of Taxotere to ...
AspenBio Pharma Reports Strong Results with Appendicitis Triage Blood Test from Large Multiple Hospital Study
... with a CT scan resulted in a specificity of 99% (95% CI = 97%
to 99.9%). So when AppyScore and CT both are positive, there is an
extremely high
probability the patient truly has appendicitis. Dr. John Bealer, a Denver based pediatric surgeon, consultant to
AspenBio, and co-inventor of the test noted, ...
Nabi Biopharmaceuticals Announces Continued Positive NicVAX Phase 2b Data at Nine Months
... Schedule 2 (five injections over six months) -- Most effective dose selected: 400 micrograms -- Threshold antibody level identified and
probability of abstinence vs. antibody levels calculated: -- Attainment of the antibody threshold at Target Quit Date determines chronic ...
Survey Reveals Significant Public Lack of Diabetes Awareness
... propensity to be online.
With a pure
probability sample of 2,436 one could say with a
ninety-five percent
probability that the overall results would have
a sampling ... account. This online
survey is not based on a
probability sample and therefore no
theoretical sampling ...
Eighty-one Percent of U.S. Adults say that Birth Control Pills and
Procedures Should Be Covered by Health Insurance
... of
these words should be avoided.
With pure
probability samples, with 100 percent response rates, it
is possible to calculate the
probability that the sampling error
(but not other sources of error) is not greater than some number.
With pure
probability samples of 2,402 one could say with a
ninety-five ...
Flu Vaccine Used Last Winter Seems to Have Been Less Effective Than
Vaccines Used in Previous Years
... use of
these words should be avoided.
With pure
probability samples, with 100 percent response rates,
it is possible to calculate the
probability that the sampling error
(but not other sources of ... is not greater than some number.
With a pure
probability sample of 2,563 adults one could say with ...
New Survey Finds Troubling Data on American Asthma Sufferers
... propensity to be online.
With a pure
probability sample of 1,105, one could say with a 95
percent
probability that the overall results would have a ... account. This online survey is
not based on a
probability sample and therefore no theoretical
sampling ...
Hypertension Education Foundation Survey Results Announced At
American Society For Hypertension Annual Meeting Suggests Improved
Control Of High Blood Pressure, But Misconceptions Still Exist
... to be online.
With a pure
probability sample of 1,245 adults, one could say
with a ninety-five percent
probability that the overall results
have a sampling error of ... account.
This online survey is not based on a
probability sample and
therefore no theoretical sampling ...
New Poll Shows Men, Women Incorrectly Blame Symptoms of Low
Testosterone on Normal Aging
... are nationally
representative.
With a pure
probability sample of 2,008 one could say with a 95
percent
probability that the overall results would have a ... points. This online survey is not based
on a
probability sample and therefore no theoretical sampling ...
Survey: Migraine Patients Taking Potentially Addictive Barbiturate
or Opioid Medications Not Approved by FDA as Migraine Treatments
... would have a sampling error of +/- 4.4
percentage points. With a pure
probability sample of 201 one could
say with a ninety-five percent
probability that the overall results
would have a sampling error of +/- 6.9 percentage ...
La Jolla Pharmaceutical Announces Positive Interim Antibody Results
From Riquent Lupus Phase 3 Trial
... as in our previous studies. We believe
that the greater reductions in antibodies to dsDNA observed with
these higher doses of Riquent imply a greater
probability of
obtaining positive clinical results from the Phase 3 trial."
"These data definitely show an increased biological effect. This
will improve ...