R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent
... dose group.
The mean increase in blood
pressure from baseline at 3 months, using a last ... patients in the 100 mg bid dose group had blood
pressure medication adjusted or in some cases initiated ... For those patients who had their dose of blood
pressure medications adjusted or initiated, their ...
FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent
... to need multiple drugs to achieve their blood
pressure goals. Tekturna HCT is a single-pill combination ... (HCTZ), one of the most commonly-used high blood
pressure medications.
The FDA approval of ... of Tekturna and HCTZ offered greater blood
pressure reductions than either drug alone.
"Up ...
Rigel's R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial
... dose groups.
The mean increase in blood
pressure from baseline at 6 months, using a last ... 100 mg bid dose groups, respectively, had blood
pressure medication adjusted or in some cases initiated ... with 7% of the placebo patients. The blood
pressure was successfully reduced in these patients, and ...
Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years: DURATION-1 Interim Long-Term Data Presented at ADA 2009
... Improvements in Systolic Blood
pressure and Triglycerides Also Observed
NEW ORLEANS, ... loss, as well as improvements in systolic blood
pressure and triglycerides, through two years of treatment ... was a significant reduction in systolic blood
pressure (SBP).
"These two-year DURATION-1 data ...
Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results
... May 8 /PRNewswire/ -- Blinded one-year blood
pressure (BP) reduction data from the ongoing landmark ... the secondary objective was to measure cuff blood
pressure (BP).
The double-blinded one-year data ... physicians.
"It is essential to manage blood
pressure very aggressively in diabetics because their ...
New Data Shows Blood Pressure Reduction Therapy with BENICAR(R) and BENICAR HCT(R) Effectively Reduces Blood Pressure in Elderly Patients to Target Blood Pressure
... reduction in 24-hour ambulatory systolic blood
pressure (SBP) of 25.7 mm Hg among patients with an ... also saw their 24-hour ambulatory diastolic blood
pressure (DBP) drop a mean of 12.3 mm Hg. The BeniSILVER ... was designed to investigate the safety and blood
pressure (BP)-lowering efficacy of BENICAR and BENICAR HCT ...
New Data Shows AZOR(R) (amlodipine and olmesartan medoxomil) Significantly Improves 24-Hour Ambulatory Blood Pressure
... from the AZ OR(R) T rial E valuating Blood
pressure Reductions and C ontrol ( AZTEC ) demonstrated ... 24-hour ambulatory reductions in systolic blood
pressure (SBP) of 21.4 mm Hg and diastolic blood
pressure (DBP) of 12.7 mm Hg. In addition, 71 percent of ...
February 2009 Mayo Clinic Women's HealthSource Highlights Diabetes and Heart Disease, Going Vegetarian and Tinnitus
... twice a year.
Blood pressure: High blood
pressure is a common partner to diabetes. For people with ... has shown that most adults with high blood
pressure and diabetes require multiple drug therapies to reach blood
pressure goals.
The bottom line: Risks and ...
NicOx' Naproxcinod Shows Robust Blood Pressure Results in Phase 3 Pooled Analysis
... Both naproxcinod doses showed a similar blood
pressure profile to
placebo, in contrast to naproxen which ... lead to the onset
of new episodes of high blood
pressure or worsening of pre-existing
hypertension. Both ... of previous studies and show a
similar blood
pressure profile to placebo in a large population ...
Third Pivotal Phase 3 Study for NicOx' Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results
... (GI) adverse event rate and a similar blood
pressure profile
to placebo. Naproxcinod is the most ... hip OA, in addition to providing reassuring blood
pressure and safety
data," said Thomas J. Schnitzer, MD, ... blood pressure
profile
The blood
pressure data for naproxcinod 750 mg bid were consistent ...
NicOx Announces Favorable Blood Pressure Data for Naproxcinod in a Large ABPM Study
... results from a
118 patient Ambulatory Blood
pressure Monitoring (ABPM) trial (the 111
study), which compared the 24-hour blood
pressure profile of escalating
doses of naproxcinod and ... was the mean 24-hour
ambulatory systolic blood
pressure (SBP) measured by ABPM over the whole
study ...
Durezol(TM) in the Treatment of Uveitis and Ganciclovir in the Treatment of Herpetic Keratitis: Studies of Treatments for Leading Causes of Blindness to Be Presented
... experienced criterion increases in
intraocular
pressure (defined as a
pressure of greater than or equal to 21
mmHg and a change ... cornea. It is
important to monitor intraocular
pressure when using ophthalmic steroids.
The use of ...
Grapes May Aid a Bunch of Heart Risk Factors, U-M Animal Study Finds
... Research shows that grape intake lowered blood
pressure and signs of
heart muscle damage, and improved ... -- Could eating
grapes help fight high blood
pressure related to a salty diet? And could
grapes calm ... from a research breed
that develops high blood
pressure when fed a salty diet.
In all, after 18 weeks, ...
Sirion Therapeutics Announces Positive Pivotal Uveitis Data for Durezol(TM)
... experienced criterion increases in
intraocular
pressure (defined as a
pressure of greater than or equal to 21
mmHg and a change ... cornea. It is
important to monitor intraocular
pressure when using ophthalmic steroids.
The use of ...
Video: Sirion Therapeutics Launches Durezol for Postoperative Ocular Inflammation and Pain
... increase in intraocular pressure, defined
as a
pressure of greater than or equal to 21 mmHg and a change ... reduced inflammation and pain. Mean intraocular
pressure for
all study groups remained within the normal ... cornea. It is
important to monitor intraocular
pressure when using ophthalmic steroids.
The use of ...
NicOx Announces Second Naproxcinod Pivotal Phase 3 Study (302) Meets Efficacy Primary Endpoints and Supports Non-Detrimental Blood Pressure Effect
... naproxcinod's non-detrimental effect on blood
pressure and
are consistent with those observed in the 301 ... A post hoc pooled analysis of the blood
pressure data from the 301 and
302 studies showed a ... A pre-specified analysis of the
pooled blood
pressure data from the three phase 3 studies will be ...
Novo Nordisk New Data From a Phase 3 Study Confirms Clinical Benefits of Once-Daily Liraglutide in the Management of Type 2 Diabetes
... glucose lowering
(HbA1c), weight loss, blood
pressure reduction and improvements in
beta-cell ... to a statistically
significant decrease in blood
pressure as seen in three of the other
LEAD(TM) studies: ... while also consistently lowering weight and
blood
pressure and enhancing beta-cell function."
About the ...
New Implant Device Remotely Monitors Heart Failure Patients at Northwestern Memorial's Bluhm Cardiovascular Institute
... A
pressure sensor that is permanently implanted into the ... first researchers using a new wireless
pressure sensor technology
that allows them to track the pulmonary artery
pressure of the subjects
while these subjects remain at ...
August 2008 Mayo Clinic Women's HealthSource Highlights Avoiding Blood Pressure Increase at Menopause, Healthful Benefits of Dark Chocolate and Scheduling a Colorectal Exam
... extension 9751.
Ways to Avoid Blood
pressure Increase at Menopause
Five steps to lower blood ... have a blood pressure
advantage.
Women's blood
pressure starts out lower than men's, but the ... Women's HealthSource offers
insights on blood
pressure changes in women and steps to avoid high ...
NicOx Announces Top-Line Results From Naproxcinod 52-Week 301 Safety Extension
... the results showed that the patients' mean blood
pressure was
stable for 52 weeks following the completion ... naproxcinod does not increase blood
pressure over time. Naproxcinod is
NicOx' lead ... naproxcinod. Standardized controlled
office blood
pressure measurements (OBPM) were performed at each ...
NicOx Completes Enrollment of Two Ambulatory Blood Pressure Measurement (ABPM) Studies for Naproxcinod in Hypertensive OA Patients
... These trials are designed to assess the
blood
pressure profile of naproxcinod, in comparison to ibuprofen and
naproxen, using the Ambulatory Blood
pressure Monitoring (ABPM) technique.
Results of both ... 2007. They will also complement the Office
Blood
pressure Measurements (OBPMs) being collected in each of ...
Pressure Cycling Technology (PCT) Results in a Higher Yield of Proteins and in the Extraction of Proteins Not Previously Identified in Cancer, Stroke, and IVF Studies
... These are very exciting results."
About
pressure BioSciences, Inc.
pressure BioSciences, Inc. (PBI) is a publicly traded ... of a novel, enabling technology called
pressure Cycling
Technology (PCT). PCT uses cycles of ...
Pressure BioSciences, Inc. Announces $850,000 NIH SBIR Phase II Award for the Development of a New PCT-dependent System for Improved Biomarker Discovery, Diagnostics, and Drug Discovery
... and tissues using the Company's patented
pressure cycling technology
("PCT"). The Grant is for a ... and related diseases."
About
pressure BioSciences, Inc.
pressure BioSciences, Inc. (PBI) is a publicly traded ...
Blood Pressure Lowering Effect of Hypertension Treatment Device Further Validated in New Studies
... five posters focus on RESPeRATE's effect on blood
pressure as
measured by 24-hour ambulatory blood
pressure monitoring. Three of the
posters also present new ... of obtaining
vascular risk parameters from blood
pressure measurements. The fifth poster
demonstrates the ...
New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering
... Stage 1
hypertension, independent of the blood
pressure lowering effects of these
agents.(1)
In the ... is defined by the JNC 7 as systolic blood
pressure (SBP) of
140-159 mm Hg or diastolic blood
pressure (DBP) of 90-99 mm Hg.(21)
VIOS Study Results
...
NicOx Announces Blood Pressure Analysis From 301 Phase 3 Study for Naproxcinod at EULAR
... announced an additional analysis
of the blood
pressure data from the 301 phase 3 study, showing ... as naproxen, have the
tendency to raise blood
pressure to an extent that may increase the rate ... efficacy
endpoints (p<0.001). Patients' blood
pressure was also measured in the
study, with a well ...
New Study Linking 'High Normal' Blood Pressure to Significant Cardiovascular Risk
... as having "high normal" systolic blood
pressure through
traditional cuff blood
pressure measurement may be at serious
cardiovascular ... SphygmoCor(R) is a
non-invasive central blood
pressure assessment technology that has been
used by ...
NicOx Completes Patient Enrollment in Third Naproxcinod Pivotal Phase 3 Study
... information on naproxcinod's blood
pressure profile in comparison
to another ... are known to have the tendency to
elevate blood
pressure to an extent that may increase the rate of ... patients are undergoing standardized
blood
pressure measurements at each visit to the clinical center ...
Seven Presentations by Two Independent Research Groups Highlight Advantages of Pressure Cycling Technology (PCT) at Scientific Symposia in Philadelphia, Boston, and New York City
... the advantages of the Company's patented
pressure cycling
technology (PCT) at three different ... and enhanced analysis of samples.
About
pressure BioSciences, Inc.
pressure BioSciences, Inc. (PBI) is a publicly traded ...
Pharmacopeia's First-in-Class Investigational Therapy PS433540 Achieves Statistically Significant Reductions in Blood Pressure in Hypertensive Patients
... Novel Approach to Blood
pressure Management
NEW ORLEANS, May 16 ... (DARA), showed statistically significant
blood
pressure reductions in a Phase 2a study in patients with ... in mean 24-hour diastolic ambulatory blood
pressure as well as
seated blood pressure. In this ...
Azor(TM) Reduces Blood Pressure in Difficult to Treat Special Populations
... Blood
pressure reductions demonstrated in Blacks, ... with high BMI)(3) or require lower blood
pressure to achieve
control (those with diabetes).(4)
...
ABOUT THE ANALYSES
RACE/ETHNICITY:
Blood
pressure control in patients with hypertension ...
New Data Shows 45 Percent of Patients with Stage 1 Hypertension Reached Normotension with BENICAR(R) and BENICAR HCT(R)
... 1 hypertension were
able to reach a goal blood
pressure (BP) of BENICAR HCT ... Detection,
Evaluation and Treatment of High Blood
pressure (JNC 7) defines this level
as normotension.
The ... were able to reach the <
140/90 mm Hg blood
pressure goal recommended by the JNC 7 (placebo: ...
Microwave Treatments for Enlarged Prostate Cause Blood Pressure Surges
... prostates experience significant
surges in blood
pressure that could raise their risk of a heart attack ... found that 42
percent experienced systolic blood
pressure surges of more than 30 mm Hg,
while 5 percent had ... paper. "Anecdotal reports of
adverse blood
pressure events during and after transurethral ...
Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients
... combinations of
commonly used high blood
pressure medicines in reduction of cardiovascular ... therapies in this study and exceptional blood
pressure control rates were ... trial demonstrate that high-risk, high
blood
pressure patients treated with Lotrel(R) (amlodipine ...
Landmark ONTARGET(TM) Trial Demonstrates Micardis(R) is Equally Effective as Ramipril, with Fewer Discontinuations, in a Broad High-Risk Cardiovascular Population
... patients with normal blood
pressure or controlled high blood
pressure, and resulted ... risk reduction benefits beyond lowering blood
pressure in this
high-risk population;(1) these benefits ... cardiovascular patients
with normal blood
pressure or controlled high ...
Use of PressureWire(R) Yields a More Accurate Assessment of Translesion Pressure Gradients in Peripheral Vasculature, Two New Studies Report
... gradients when compared to catheter-derived
pressure gradient
(CPG) measurements, according to a paper ... Entitled "Physiologic Evaluation of Translesion
pressure Gradients in
Peripheral Arteries: Comparison of ... Using this low profile PressureWire for arterial
pressure measurement
yields a more accurate assessment of ...
Novel PCT Method Unveiled by Pressure BioSciences, Inc. and Collaborators at the Harvard School of Public Health
... animal, plant, and microbial research."
About
pressure BioSciences, Inc.
pressure BioSciences, Inc. (PBI) is a publicly traded ... of a novel, enabling technology called
pressure Cycling
Technology (PCT). PCT uses cycles of ...
Pharmacopeia Initiates Second Phase 2 Hypertension Study with PS433540 (DARA)
... from baseline
in mean seated systolic blood
pressure for each dose of PS433540 with
placebo. ... include comparisons of changes in
blood
pressure for each dose of PS433540 with irbesartan.
"We ... as reductions in systolic and
diastolic blood
pressure in non- hypertensive healthy subjects.
PS433540 ...
Financial Results for Full Year 2007: NicOx Significantly Advances Clinical Programs
... 301 study) and data from an Ambulatory Blood
pressure Monitoring trial at the American Heart ... including a
pooled analysis of the Office Blood
pressure Measurements, ahead of a
projected New Drug ... and has provided successful efficacy and blood
pressure results which were presented at the American ...
Pharmacopeia Completes Enrollment in Phase 2 Hypertension Study with PS433540 (DARA)
... that DARA can effectively lower blood
pressure in this patient
population."
Results from Phase ... PS433540 can be expected to lower blood
pressure in hypertensive
patients. Additional data from ... as reductions in systolic and diastolic
blood
pressure in non-hypertensive healthy volunteers.
...