Plasma in Medical Technology

Results From Trials of DHA in Alzheimer's Disease and Age-Related Cognitive Decline

... started the study (-1.63 + or - 0.76, p<0.03). plasma phospholipid DHA levels doubled over the course ... that was highly correlated with week 24 plasma levels (p<0.01). Blood pressure and body weight remained unchanged between groups. plasma levels of Alzheimer's related proteins Abeta ...

King Pharmaceuticals Showcases Data From Pain Pipeline of Medicines Designed to Deter Common Methods of Non-Therapeutic Use

... generally well tolerated. Evaluation of plasma Naltrexone Concentrations Resulting From Use of ... 12 month open-label safety study evaluated the plasma concentrations of naltrexone following use of ... hydrochloride). Samples were drawn to measure plasma concentrations (concs) of morphine (M) naltrexone ...

Scientific Data Relating to Cinryze(TM) Presented at 6th Annual C1 Inhibitor Deficiency Workshop

... Angioedema Patients Reverses Abnormalities of the plasma Bradykinin-forming Pathway and Fibrinolysis,' Dr. K. Joseph et al. described a study of samples of plasma from nine HAE patients experiencing an attack in ... evaluating Efficacy) trial; Samples of plasma were obtained from nine HAE patients at baseline, ...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... did not alter the median time it took for maximum plasma concentration of d -amphetamine to be reached in ... reduction in the median time to reach maximum plasma concentrations of amphetamine, the active medication. Other pharmacokinetic parameters (maximum plasma concentration and area under curve) of active ...

Plasma Products Safe Despite Swine Influenza Outbreak, Assures International Biopharmaceutical Company Octapharma

... to Ensure Adequate Supply of Virally Inactivated plasma Derivatives The impending influenza ... But it has reiterated the safety of its plasma derivatives and is working closely with health authorities and plasma suppliers to maintain the safety profile and ...

PEAK Surgical Announces Completion of First PRECISE Clinical Study, Receipt of Medical Design Excellence Award for PEAK(R) Surgery System and Achievement of Over 1,000 Surgeries Using PEAK PlasmaBlade(TM)

... study in the series known as the PRECISE (Pulsed plasma Radiofrequency Energy to ReduCe Thermal Injury ... cut tissue, the PULSAR Generator supplies pulsed plasma radiofrequency energy to the PlasmaBlade to ... the PULSAR(TM) Generator, which supplies pulsed plasma radiofrequency energy to the PlasmaBlade. The ...

XTL Biopharmaceuticals Announces the Acquisition of the Use Patent on Recombinant Erythropoietin (rHuEPO) for the Treatment of Multiple Myeloma

... of their quality of life. MM is a severe plasma cell malignancy characterized by the accumulation and proliferation of clonal plasma cells in the marrow, leading to the ... Currently incurable, MM is a severe plasma cell malignancy characterized by the accumulation ...

CSL Behring Receives Orphan-Drug Exclusivity for RiaSTAP(TM), First and Only Approved Treatment of Acute Bleeding Episodes in Patients with Congenital Fibrinogen Deficiency

... pooled human plasma. Products made from human plasma may contain infectious agents (e.g., viruses and ... an infectious agent has been reduced by screening plasma donors for prior exposure to certain viruses, by ... Behring CSL Behring is a global leader in the plasma protein biotherapeutics industry. Passionate ...

PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in Expanded Indications

... studies, called the PRECISE Studies (Pulsed plasma Radiofrequency Energy to ReduCe Thermal Injury ... PULSAR(TM) Generator, which provides pulsed plasma radiofrequency energy to the PlasmaBlade to ... the PULSAR(TM) Generator, which supplies pulsed plasma radiofrequency energy to the PlasmaBlade. The ...

Phase III Trial Results Show Elitek(R) (rasburicase) Significantly Reduced Plasma Uric Acid Levels versus Allopurinol in Adults with Hematologic Cancers at Risk for Tumor Lysis Syndrome

... Elitek(R) (rasburicase) significantly reduced plasma uric acid (PUA) levels compared to allopurinol ... allopurinol alone, which showed a reduction in plasma uric acid levels for the sequential combination ... faster than can be eliminated. Elevated levels of plasma uric acid can cause hyperuricemia, a serious ...

Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients

... adverse events were reported. All doses achieved plasma drug concentrations predicted to display ... pharmacokinetic profile demonstrated sustained plasma levels of ANA598 with a half-life of more than 24 ... or twice-daily oral dosing. All doses achieved plasma drug concentrations predicted to display ...

Cara Therapeutics Announces Successful Completion of Phase I Clinical Trial of Novel Analgesic, CR845

... after intravenous infusion, and resulted in plasma levels of CR845 expected to be associated with ... were observed. Low doses of CR845 resulted in plasma levels at or above the plasma levels of drug expected to be associated with ...

Ardea Biosciences Reports Additional Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating Up to 1.9 Log Reduction in Plasma Viral Load with Once-Daily Dosing

... of RDEA806 resulted in significant reductions in plasma viral load that were consistent with ... end point was the change from baseline in plasma viral load. Top-line results from all four ... the following: -- The median reduction in plasma viral load at nadir was 1.9 - 2.1 log copies/ml ...

New Data Demonstrates 5-FU Personalized Chemotherapy Management (PCM(R)) Assay Provides Similar Performance to More Complicated Liquid Chromatography-Mass Spectrometry (LC-MS/MS)

... side effects." To date, analysis of 5-FU blood plasma levels could only be performed by complex, ... The multicenter study evaluated 5-FU blood plasma levels at three sites, according to the Clinical ... Standards Institute (CLSI) protocol. 5-FU blood plasma levels were evaluated using the 5-FU PCM ...

After One Year, Type 2 Diabetes Patients Taking Exenatide Once Weekly Sustained Improvements in Glycemic Control and Weight; DURATION-1 Presented at ADA 2008

... in glucose control [A1C: -2.0%+/-0.08; fasting plasma glucose (FPG) -47+/-3 mg/dL] compared to those ... additional improvements in A1C and fasting plasma glucose. Seventy-four percent of all patients in ... showed sustained improvements in A1C and fasting plasma glucose levels at week 52 [A1C: -2.0%+/-0.1; ...

Ion Mobility Diagnostic Test from Quest Diagnostics is First to Provide Direct Physical Measurement of Lipoprotein Particles, Cardiovascular Disease Indicators, Study Finds

... to directly and accurately measure plasma lipoprotein particles, covering the spectrum of ... Adult Treatment Panel III guidelines for optimal plasma lipid and lipoprotein concentrations were ... HDL cholesterol, LDL cholesterol as well as plasma ApoA1 and ApoB. Results showed that the ion ...

Treprostinil Data Presented at American Thoracic Society Conference Demonstrates Significant Clinical Progress in All Four Routes of Administration

... both quality of life and levels of NT-pro-BNP, a plasma biomarker of cardiac function, in patients ... of the 12-week trial. Oral Treprostinil In plasma Levels with Oral Treprostinil Dietholamine over a ... patient showed a linear correlation with total plasma exposure (AUC) and maximum exposure (Cmax). This ...

Schering-Plough To Initiate Phase III Studies With HCV Protease Inhibitor Boceprevir in Previously Untreated Hepatitis C Patients and Those Who Failed Prior Treatment

... RVR, defined as undetectable virus (HCV-RNA) in plasma at week 4 of boceprevir treatment, will stop all ... RVR, defined as undetectable virus (HCV-RNA) in plasma at week 4 of boceprevir treatment, will stop ... patients who had undetectable virus (HCV-RNA) in plasma after 4 weeks of boceprevir treatment achieving ...

Forest and Almirall Announce Positive Results of Clinical Studies for Aclidinium Bromide, a Novel, Long-Acting Anticholinergic for the Treatment for COPD

... aclidinium was not detectable in the plasma after one hour. Results of two other ... For all doses, aclidinium was undetectable in plasma beyond 3 hours post-dose. Aclidinium was well ... or placebo. Aclidinium was undetectable in plasma after all studied doses beyond 1 hour post-dose. ...

Alpharma Presents Data Addressing Abuse Liability Features, Safety and Efficacy on ALO-01 (EMBEDA(TM)) (morphine sulfate extended-release with sequestered naltrexone hydrochloride) at the American Pain Society Annual Scientific Session

... and subjective drug value. In addition, plasma levels of both morphine and naltrexone were ... exposure, consistent with the time of maximum plasma levels for immediate-release morphine. Scores for ... higher for morphine sulfate solution. plasma levels of morphine and time to maximum ...

Data Show FLECTOR(R) Patch Yields Significant Pain Reduction for Acute Strains, Sprains and Contusions

... Pharmaceuticals LLC. Comparison of plasma Pharmacokinetics of FLECTOR(R) Patch and ... selected times post-dose to determine diclofenac plasma levels. Results indicated that the systemic ... Annual Meeting. (3) Rusca, et al. "Comparison of plasma pharmacokinetics of FLECTOR(R) Patch ...

NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting

... as evidenced by a steep increase of plasma NKTR-118 concentration. plasma concentrations of NKTR-118-glucuronide were approximately 100-fold less than plasma NKTR-118 concentrations. Studies have shown that ...

Phosphagenics Reports Positive Pre-clinical Results for Targeted Delivery of Lidocaine

... delivered to the local area of application. plasma lidocaine concentration was quantified to ... increase in systemic exposure. The average plasma lidocaine concentration peaked 1 hour after the ... body. Mean lidocaine levels in tissue and plasma following treatment Treatment Skin ...

Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL

... patients who had undetectable virus (HCV-RNA) in plasma after 4 weeks of boceprevir treatment achieving ... 1 SVR 12 is defined as undetectable HCV-RNA in plasma at 12 weeks after the end of treatment. The ... is SVR 24, defined as undetectable HCV-RNA in plasma at 24 weeks after the end of treatment. 2 ...

Ardea Biosciences Reports Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating up to 2.0 Log Reduction in Plasma Viral Load

... efficacy endpoint is the change from baseline in plasma viral load. Preliminary results, which ... a 2.0 log placebo-adjusted mean reduction in plasma viral load. -- Patients receiving 600 mg once ... a 1.7 log placebo-adjusted mean reduction in plasma viral load. -- There were no serious adverse ...

Thalidomide Pharmion(R) Receives Positive Opinion for Treatment of First-line Multiple Myeloma from European Medicines Agency

... Multiple myeloma (also known as myeloma or plasma cell myeloma) is a cancer of the blood in which malignant plasma cells are overproduced in the bone marrow. plasma cells are white blood cells that help ...

Portrait(R) Plasma - A New Non-Surgical Option for one of the Most Requested Aesthetic Treatment - Aging Eyes

... Doctors Are Combining Portrait(R) plasma with Fractionated Lasers Or in Place of ... blepharoplasty, Portrait Plasma, a novel plasma skin regeneration technology, and injectables ... Cosmetic Surgery Centre combines Portrait(R) plasma with fractional laser for further results on the ...

Supplemental New Drug Application for PREZISTA(TM) Submitted to U.S. Food and Drug Administration

... This indication is based on Week 24 analyses of plasma HIV RNA levels and CD4+ cell counts from two ... midazolam, or triazolam) and for which elevated plasma concentrations are associated with serious ... with ritonavir and food will result in reduced plasma concentration of PREZISTA that will be ...

Ardea Biosciences, Inc. Announces New Clinical Development Program Directed Toward the Treatment of Gout

... Furthermore, a trend toward a reduction in plasma cholesterol and triglyceride levels ... In the dose group that resulted in the highest plasma drug levels (400 mg modified-release capsule ... This dose group achieved the highest plasma drug levels. The magnitude of the uric acid ...

Anthera Announces Positive Phase II Clinical Results From A-002 Cardiovascular Disease Trial

... on a background of statin therapy. The Phase II plasma trial (Phospholipase Levels And Serological ... journal during 2008. "The results of the plasma trial support our belief that A-002's ... of Michigan and lead investigator for the plasma trial. "Of particular interest was the marked ...

Abbott's m2000(TM) Molecular Diagnostic Instrument and RealTime HIV-1 Test Win Chicago Innovation Award

... antiretroviral therapy are guided by monitoring plasma HIV-1 levels or viral load, CD4-T cell count and ... antiretroviral therapy is to reduce the virus in plasma to below detectable levels. The RealTime HIV-1 ... treatment as measured by changes in plasma HIV-1 RNA levels. The assay is not intended to be ...

Aptivus(R) (tipranavir) Capsules Granted Full Approval by the U.S. FDA

... This indication is based on analyses of plasma HIV-1 RNA levels in two controlled studies of ... shown that ritonavir significantly increases plasma fluticasone propionate exposures. Concomitant ... be less effective due to decreased tipranavir plasma concentrations. -- Caution should be used when ...

Anthera Announces Completion of Enrollment and Dosing in Phase II Trial of A-002 for the Treatment of Cardiovascular Disease

... design." A-002 Clinical Trial Protocol The plasma trial (Phospholipase Levels And Serological ... Trial Based on preliminary data from the plasma Phase II clinical trial, Anthera has initiated a ... "Preliminary data analysis from our original plasma study, which employed twice daily dosing of ...

New Phase 3 Study in Treatment-Naive Adults with HIV Evaluates Efficacy and Safety of Once-Daily PREZISTA(TM)/ritonavir vs. KALETRA(R) as Part of HIV Combination Therapy

... This indication is based on week 24 analyses of plasma HIV RNA levels and CD4+ cell counts from two ... midazolam, or triazolam) and for which elevated plasma concentrations are associated with serious ... with ritonavir and food will result in reduced plasma concentration of PREZISTA that will be ...

Schering-Plough Initiates Phase III Studies with Vicriviroc in Treatment- Experienced HIV Patients

... studies will be the proportion of patients with plasma HIV-1 RNA less than 50 copies/mL at week 48. ... of patients with less than 400 copies/mL of plasma HIV-1 RNA, mean change from baseline in plasma HIV-1 RNA (log10 copies/mL) and mean change ...

Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test

... dynamic range, capable of quantitating HIV-1 in plasma down to as few as 40 RNA copies per mL, ... antiretroviral therapy are guided by monitoring plasma HIV-1 levels or viral load, CD4-T cell count, and ... antiretroviral therapy is to reduce the virus in plasma to below detectable levels. The RealTime test is ...

Octapharma Accepting Applications for Research Grants on Immunotherapy, Coagulation Disorders and Critical Care

... will be reviewed in October. Octapharma AG , the third largest plasma products manufacturer in the world, launched the grants program in ... Octapharma AG Octapharma AG is the third largest plasma products manufacturer in the world and has been committed to patient care ...

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

... HGS that is required for the development of B-lymphocyte cells into mature plasma B cells. plasma B cells produce antibodies, the body's first line of defense against ...

Spherix Announces Positive Phase 2 Study Results

... per day. Ingestion of the tagatose load (75 g) caused no increase in plasma insulin or glucose concentrations in either healthy or diabetic ... it was taken with or before the meal or glucose load, blunted the rise of plasma glucose (Yongming Lu, Gilbert Levin, Thomas Donner. Tagatose, a New ...

ThermoGenesis Announces National Institute of Health Grant

... also being studied for potential use in the preparation of platelet rich plasma (PRP) from peripheral blood. About ThermoGenesis Corp. ... sterile blood processing disposable, used to prepare fibrin sealants from plasma in about an hour. The CryoSeal FS System is approved in the U.S. for ...